TWAS hub - POLR2B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0940	0.0300	2.3e-04	0.054	0.023	0.024	0.025	0.022	3.4e-07	7.6e-04	5.9e-04	4.7e-04	8.7e-04
2	YFS	Blood	0.0503	0.0124	3.4e-11	0.059	0.035	0.053	0.049	0.056	1.6e-18	9.2e-12	7.0e-17	1.2e-15	8.0e-18
3	TCGA	Thyroid Carcinoma	0.0380	0.0210	7.9e-03	0.001	0.008	0.000	NA	0.002	2.2e-01	5.2e-02	2.9e-01	NA	2.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Commuting to job workplace: Cycle	9.7	11.7	18.2	1.8	4.3	3.7
Past tobacco smoking	8.7	15.9	22.4	-4.4	-4.7	-2.3
Smoking status: Previous	8.6	12.9	20.4	3.2	4.5	2.8
Ever smoked	5.4	9.5	14.6	3.8	3.7	0.6
Breast Cancer	5.3	12.9	18.8	1.5	4.3	4.2
Tinnitus: Yes, now most or all of the time	5.2	6.0	10.8	2.3	3.3	1.4
Hearing difficulty/problems: Yes	4.6	7.0	11.9	3.5	2.3	1.9
Illnesses of mother	4.4	5.4	5.5	-2.3	-2.3	-2.3
Impedance of arm (right)	4.2	19.7	56.1	-7.5	-1.4	-0.9
Impedance of arm (left)	4.2	19.4	54.3	-7.4	-1.7	-1.0
Average weekly red wine intake	4.2	6.3	12.2	1.0	3.5	2.3
Qualifications: CSEs or equivalent	4.1	5.4	8.6	-0.6	-2.9	-2.7
Allergy	4.1	9.4	18.2	0.5	4.3	3.1
Deep venous thrombosis (DVT) (self-reported)	4.0	5.2	5.5	-2.3	-2.3	-2.2
Pain all over the body in last month	3.7	4.0	6.8	0.3	-2.6	-2.3
Ever highly irritable/argumentative for 2 days	3.4	4.1	6.8	0.5	-2.3	-2.6
Blood clot in the leg (DVT)	3.4	4.4	5.1	-2.3	-2.1	-2.0
Mother’s age at death	3.4	4.2	6.2	1.3	2.5	2.2
Impedance of whole body	3.4	17.2	50.1	-7.1	-1.3	-0.1
Alzheimer’s Disease (including proxy)	3.2	4.6	7.4	0.9	2.7	2.4
Ulcerative Colitis (UC)	3.2	6.0	8.9	-1.6	-2.6	-3.0
Smoking Status	3.2	7.7	14.4	2.6	3.8	1.4
Heel bone mineral density (BMD) T-score, automated (left)	3.2	7.3	17.6	-4.2	-1.4	1.5
Alzheimer’s Disease (in mother)	3.1	3.6	5.8	1.5	2.4	1.7
Ever had hysterectomy (womb removed)	2.9	3.3	6.3	2.5	1.0	1.6
Heel bone mineral density (BMD) T-score, automated (right)	2.8	6.4	14.4	-3.8	-2.0	1.0
Depression (Nagel 2018)	2.7	4.1	5.5	2.3	2.2	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.7	3.6	7.1	2.7	1.8	0.7
Chest pain or discomfort	2.7	3.9	6.6	-0.0	-2.2	-2.6
Reaction Time	2.5	4.7	6.3	-2.5	-2.4	-1.5
Comparative height size at age 10	2.5	13.9	25.1	-3.0	-2.7	-5.0
Overall health rating	2.5	5.3	6.9	1.9	-2.6	-2.4
Blood Platelet Count	2.4	28.2	63.4	4.3	1.7	8.0
Hearing difficulty/problems with background noise	2.4	3.8	5.4	2.2	2.3	1.1
Angina	2.3	3.0	5.9	-0.7	-1.6	-2.4
Loud music exposure frequency	2.3	2.5	3.8	2.0	1.9	0.4
Risk taking	2.3	3.4	8.5	2.9	1.3	0.3
Bipolar Disorder (2018)	2.2	3.5	5.8	-1.6	-1.5	-2.4
Bipolar Disorder (2011)	2.2	2.1	6.2	-2.5	0.4	0.1
Heel T-Score	2.2	17.8	39.8	-6.3	-2.7	2.5
Hayfever, allergic rhinitis or eczema	2.2	4.8	8.1	-0.1	-2.9	-2.5
Wheeze or whistling in the chest in last year	2.2	4.0	5.5	1.4	-2.1	-2.3
Friendships satisfaction	2.2	2.8	4.0	1.4	2.0	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	9.9	0.7	3.2	1.9
Long-standing illness, disability or infirmity	2.1	3.2	6.2	1.2	-2.5	-1.4
Irritability	2.1	3.6	9.9	3.1	0.3	-0.9
Angina (self-reported)	2.0	2.6	5.3	-0.6	-1.4	-2.3
Breastfed as a baby	1.9	2.4	3.6	1.3	1.9	1.3
Glaucoma (self-reported)	1.9	2.2	3.2	1.5	1.8	1.1
Arm fat-free mass (right)	1.9	9.8	24.8	5.0	0.7	-2.0
Migraine (self-reported)	1.9	2.3	4.6	2.2	1.2	0.9
Relative age of first facial hair	1.8	3.7	5.8	1.7	1.5	2.4
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	5.2	2.3	-0.4	-1.9
Arm predicted mass (right)	1.8	9.0	22.6	4.8	0.5	-2.1
Suffer from ‘nerves’	1.8	2.8	4.5	-0.6	-2.1	-1.9
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	4.5	1.8	-0.9	-2.1
Alzheimer’s Disease (in father)	1.7	1.9	3.4	-0.1	1.8	1.5
Impedance of leg (right)	1.7	8.2	22.6	-4.8	0.3	1.4
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	4.0	0.3	-2.0	-1.6
Gout (self-reported)	1.7	2.3	3.3	0.7	1.8	1.8
Medication: Omeprazole	1.7	2.0	4.1	2.0	1.0	1.0
Mean time to correctly identify matches	1.7	3.2	6.8	-2.6	-1.6	-0.4
Medication: Atorvastatin	1.7	2.1	3.9	-0.7	-2.0	-1.4
Irritable Bowel Disease (IBD)	1.6	3.8	7.4	-0.3	-2.0	-2.7
HbA1C	1.6	1.7	4.0	-2.0	-0.7	-0.9
Type 2 Diabetes (T2D) (2018)	1.6	3.0	4.3	1.9	2.1	1.1
High blood pressure (mother)	1.6	2.2	2.6	1.6	1.2	1.6
Number of incorrect matches in round	1.6	2.6	3.8	-1.9	-1.4	-1.4
Had other major operations	1.6	2.0	3.1	1.8	-0.0	-1.7
Trunk fat-free mass	1.6	9.2	21.2	4.6	0.8	-2.4
High blood pressure (siblings)	1.6	2.4	4.8	0.9	2.2	1.2
Whole body fat-free mass	1.6	9.1	19.4	4.4	0.2	-2.8
Whole body water mass	1.6	9.2	19.6	4.4	0.2	-2.8
Arm predicted mass (left)	1.6	8.3	20.5	4.5	0.7	-2.0
Impedance of leg (left)	1.5	7.1	20.6	-4.5	-0.1	0.8
Trunk predicted mass	1.5	8.8	20.2	4.5	0.7	-2.4
Alcohol intake frequency.	1.5	3.6	7.6	-0.4	-2.8	-1.7
Medication: Aspirin	1.5	2.0	5.3	2.3	0.7	-0.4
Leg fat-free mass (right)	1.5	8.1	12.4	3.5	-0.6	-3.4
Medication: Aspirin	1.5	2.0	5.3	2.3	0.8	-0.2
Leg predicted mass (right)	1.5	8.2	12.5	3.5	-0.6	-3.4
Arm fat-free mass (left)	1.5	7.8	18.7	4.3	0.3	-2.2
Other serious medical condition/disability diagnosed by doctor	1.4	1.8	2.5	1.3	-1.1	-1.6
Chronic bronchitis/emphysema (father)	1.4	1.7	2.6	1.6	0.9	1.2
Falls in the last year	1.4	1.9	2.8	-0.2	-1.7	-1.6
Mouth/teeth dental problems: Dentures	1.4	2.4	4.6	2.1	0.9	1.3
Mood swings	1.4	2.5	4.4	0.8	-1.5	-2.1
Basal metabolic rate	1.4	7.7	15.8	4.0	0.1	-2.7
Neuroticism (2016)	1.3	1.9	4.4	0.6	-0.9	-2.1
Blood White Count	1.3	9.4	16.7	3.3	-0.7	4.1
Respiratory disease	1.3	2.9	8.1	0.4	-2.8	-0.7
Lung FVC	1.3	6.6	14.1	0.3	3.8	2.4
Alcohol intake versus 10 years previously	1.3	1.9	5.6	2.4	0.4	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.8	1.7	-0.0	-1.3
Pulse wave peak to peak time	1.3	1.6	3.9	-2.0	-0.1	-0.9
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.1	-1.8	0.1	1.3
Alcohol drinker status: Previous	1.3	1.4	2.3	-0.2	-1.4	-1.5
Height	1.2	23.2	61.6	-2.6	-1.1	-7.8
Ever used hormone-replacement therapy (HRT)	1.2	1.5	1.8	1.2	1.4	1.1
Leg fat-free mass (left)	1.2	6.5	11.2	3.3	-0.3	-2.9
Maternal smoking around birth	1.2	1.7	2.1	1.5	1.3	1.1
Leg predicted mass (left)	1.2	6.4	10.9	3.3	-0.3	-2.9
Pulse wave Arterial Stiffness index	1.2	1.4	3.8	1.9	-0.1	0.5
Medication for pain relief, constipation, heartburn	1.2	2.0	5.4	-2.3	0.7	0.4
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	3.6	0.1	-0.6	-1.9
Number of self-reported non-cancer illnesses	1.2	2.0	5.7	2.4	-0.2	-0.6
Alcohol drinker status: Never	1.2	1.5	2.3	-1.4	-1.5	-0.5
Average weekly spirits intake	1.1	1.3	3.6	1.9	0.4	0.4
Relative age voice broke	1.1	1.6	3.0	1.2	0.7	1.7
Worrier / anxious feelings	1.1	2.1	2.9	0.8	-1.7	-1.7
Asthma	1.1	2.1	3.8	1.3	-1.9	-0.8
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	4.0	-2.0	-1.0	-0.8
Shortness of breath walking on level ground	1.1	1.3	1.7	1.3	-1.2	-0.8
Medication for cholesterol	1.1	1.7	3.1	-1.8	-1.2	-0.7
Intelligence (Savage-Jansen 2018)	1.0	2.9	7.0	2.6	1.1	-0.8
Rheumatoid Arthritis	1.0	1.3	3.1	0.3	-0.9	-1.8
Number of treatments/medications taken	1.0	1.9	4.2	2.0	0.7	1.0
Current tobacco smoking	1.0	1.7	3.8	-0.3	-1.1	-1.9
Age when periods started (menarche)	1.0	2.3	4.8	2.2	1.4	0.4
Stomach or abdominal pain in last month	1.0	1.2	2.6	1.6	0.8	0.6
Supplements: Glucosamine	1.0	1.3	1.4	1.2	1.2	1.1
Sitting height	1.0	6.9	17.0	-1.3	-1.4	-4.1
Qualifications: A levels/AS levels or equivalent	1.0	2.1	4.7	0.3	2.2	1.3
Birth weight of first child	1.0	1.9	4.3	0.1	-2.1	-1.2
Qualifications: nursing, teaching	1.0	1.6	2.6	1.6	0.9	1.1
Average weekly champagne plus white wine intake	1.0	1.3	2.3	1.1	1.5	0.7
Medication: Lisinopril	1.0	1.2	2.3	0.4	1.5	1.1
Ever had prostate specific antigen (PSA) test	1.0	1.2	1.9	1.0	1.4	0.8
Pain experienced in last month	1.0	1.7	2.0	-1.4	1.2	1.3
Worry (Nagel 2018)	0.9	1.8	2.8	0.5	-1.5	-1.7
Fasting Glucose	0.9	1.1	1.8	-0.5	1.3	1.1
Primary Biliary Cirrhosis	0.9	1.3	3.2	1.8	0.6	-0.6
Ulcerative Colitis	0.9	1.3	2.5	-0.6	-1.1	-1.6
Supplements: Zinc	0.9	0.9	1.6	1.3	0.5	1.0
Mouth/teeth dental problems	0.9	1.4	4.2	-2.0	-0.1	-0.0
Hair/balding pattern: Pattern 3	0.9	1.3	2.0	1.4	0.6	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	6.9	1.2	2.6	-0.2
Qualifications: College or University degree	0.9	2.7	5.4	0.5	2.3	1.6
Illnesses of father: None of the above (group 1)	0.9	1.1	1.6	-1.3	-1.2	-0.6
Ever taken oral contraceptive pill	0.9	1.0	2.4	0.1	1.5	0.9
Neuroticism	0.8	1.9	4.6	2.1	0.4	-1.0
Heart attack	0.8	1.0	2.8	-0.1	-0.5	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.9	1.7	-0.2	-0.2
Worry too long after embarrassment	0.8	1.4	2.3	1.5	1.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.6	0.5	1.6	0.3
Age at first live birth	0.8	1.4	2.2	-1.5	-0.8	-1.1
Number of full sisters	0.8	1.0	2.4	-0.6	-0.3	-1.5
Had major operations	0.8	1.0	1.9	1.4	1.0	0.3
Illnesses of siblings: Diabetes	0.8	1.0	2.1	-0.5	-1.4	-0.7
Wears glasses or contact lenses	0.8	0.9	2.8	-1.7	0.1	0.0
Basal cell carcinoma (self-reported)	0.8	0.9	2.7	1.6	0.0	-0.0
Type 2 Diabetes (T2D) (2012)	0.7	0.9	2.0	0.0	1.4	0.8
Allergy or Eczema	0.7	1.9	3.9	0.3	-2.0	-1.2
Diabetes (mother)	0.7	0.9	1.5	-0.5	1.2	0.9
Waist circumference	0.7	2.7	4.9	2.2	-1.2	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.1	0.9	-0.6	-1.4
Had menopause	0.7	0.9	1.6	0.7	0.7	1.3
Financial difficulties in last 2 years	0.7	1.0	2.6	0.5	0.4	-1.6
Weight	0.7	3.2	5.2	2.3	-0.3	-2.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	5.7	0.9	2.4	-0.9
Standing height	0.7	7.0	20.5	-0.7	-0.1	-4.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.6	0.6	-0.1	-1.6
Peak expiratory flow (PEF)	0.7	1.7	3.0	0.7	1.7	-1.3
Eye problems/disorders: None of the above	0.7	0.9	1.8	-0.4	-1.3	-0.8
Pulse rate, automated reading	0.7	2.1	4.6	1.0	-2.1	-0.9
Asthma (self-reported)	0.7	1.5	2.7	1.6	-1.3	-0.2
Medication: Gliclazide	0.7	0.8	1.5	-0.1	-1.2	-1.0
Smoking status: Current	0.7	1.2	2.8	-0.0	-0.9	-1.7
Commuting to job workplace: Public transport	0.7	0.9	2.5	-1.6	0.1	0.4
Eye problems/disorders: Glaucoma	0.7	0.9	1.6	0.4	1.3	1.0
Number of operations (self-reported)	0.7	1.0	2.5	1.6	0.3	-0.6
Bipolar Disorder or Schizophrenia	0.6	1.6	2.4	-1.2	-0.9	-1.5
Cardiovascular Disease	0.6	2.1	5.5	2.3	0.3	0.8
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.9	1.4	0.8	-0.2
Severe depression (siblings)	0.6	0.7	1.4	1.2	-0.1	-0.8
Trunk fat percentage	0.6	2.6	5.0	-2.2	-1.4	-0.9
Average weekly fortified wine intake	0.6	0.7	0.8	0.6	0.9	0.9
Body mass index (BMI)	0.6	2.7	8.1	2.8	-0.2	-0.0
Father’s age at death	0.6	0.9	1.7	0.4	-1.3	0.9
Number of live births	0.6	0.8	2.2	1.5	0.3	0.3
Pulse rate	0.6	0.9	2.7	-0.1	-1.6	-0.4
Length of working week for main job	0.6	0.7	1.8	1.3	0.5	0.3
Hair/balding pattern: Pattern 4	0.6	1.4	2.0	-1.1	-0.9	-1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.7	-0.6	-1.3	-0.4
Number of full brothers	0.6	0.7	1.7	0.1	-1.3	-0.7
Medication: Blood pressure	0.6	1.0	1.7	1.3	1.0	0.6
Diabetes diagnosed by doctor	0.6	0.9	1.1	1.0	0.9	0.9
Miserableness	0.6	1.0	1.3	1.2	1.0	0.7
Financial situation satisfaction	0.6	0.8	2.1	1.5	0.5	-0.2
Vascular/heart problems diagnosed by doctor	0.6	1.6	4.2	-2.0	-0.7	-0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.1	-0.2	-0.5	-1.4
Depressed Affect (Nagel 2018)	0.5	1.0	2.3	1.5	0.8	0.2
Neuroticism (Nagel 2018)	0.5	1.1	1.7	1.3	-0.1	-1.3
Ovarian Cancer	0.5	0.7	1.7	1.3	0.4	0.5
Body Mass Index (BMI) (2010)	0.5	0.6	1.0	1.0	0.9	0.0
Medication: Co-codamol	0.5	0.6	1.7	-0.2	-1.3	-0.1
Hand grip strength (right)	0.5	1.4	2.5	1.6	1.1	0.5
High blood pressure	0.5	1.5	2.6	1.6	1.1	0.9
Neuroticism score	0.5	1.1	2.0	1.1	-0.3	-1.4
Pulse wave reflection index	0.5	0.6	1.1	1.1	0.2	0.8
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.8	1.4	-0.1	0.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.4	-0.5	-0.3	1.2
Forced vital capacity (FVC), Best measure	0.5	1.8	4.6	0.8	2.1	-0.4
Exposure to tobacco smoke outside home	0.5	0.7	0.9	-0.6	-0.9	-0.9
Number of children fathered	0.5	0.6	1.7	1.3	-0.0	-0.1
Hypertension (Self-reported)	0.5	1.3	2.6	1.6	1.0	0.5
Osteoporosis (self-reported)	0.5	0.6	1.4	1.2	0.3	-0.4
Hearing aid user	0.5	0.5	0.8	0.9	0.8	-0.2
High cholesterol (Self-reported)	0.5	0.9	2.3	1.5	-0.1	0.5
Age started oral contraceptive pill	0.5	0.6	1.6	-0.4	-0.2	1.3
Myopia	0.5	0.8	1.7	0.1	-1.3	-0.8
Cholesterol lowering medication	0.5	0.7	1.4	1.2	-0.4	-0.7
Crohns Disease (2017)	0.4	0.8	1.6	0.6	-0.6	-1.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.7	1.0	0.0	-1.3
Lupus	0.4	0.7	0.9	-0.6	-0.9	-0.9
Lung FEV1/FVC ratio	0.4	2.3	4.7	1.4	2.2	-0.2
Tanning	0.4	4.6	6.9	2.2	2.6	1.5
Sensitivity / hurt feelings	0.4	0.7	2.1	0.1	-0.1	-1.4
Fed-up feelings	0.4	0.7	2.1	1.4	0.0	0.3
Taking other prescription medications	0.4	0.6	1.1	1.0	0.8	0.4
Serious illness, injury or assault to yourself	0.4	0.4	1.2	1.1	0.1	-0.3
Medication: Atenolol	0.4	0.6	1.2	-0.1	-0.7	-1.1
Medication: Levothyroxine sodium	0.4	0.7	1.0	1.0	-1.0	0.5
Alcohol usually taken with meals	0.4	0.7	1.1	-0.1	-1.0	-0.9
Forced vital capacity (FVC)	0.4	1.4	3.1	0.4	1.8	-1.0
Hip circumference	0.4	1.7	2.6	1.6	-1.2	-1.1
Happiness	0.4	0.4	1.2	1.1	-0.2	-0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.6	0.5	-0.4	-1.3
Birth weight	0.4	1.0	1.1	1.0	-0.9	-1.0
Body fat percentage	0.4	1.5	2.3	-1.5	-1.4	-0.6
Medication: Allopurinol	0.4	0.6	1.2	0.0	1.1	0.8
Age at last live birth	0.4	0.6	1.3	-0.4	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.0	-0.7	-0.5	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	-0.2	-1.1	-0.2
Back pain experienced in last month	0.4	0.6	1.3	-0.2	-0.7	-1.1
Breast cancer (self-reported)	0.4	0.5	1.0	0.7	0.0	-1.0
Medication: Blood pressure	0.4	0.7	0.9	0.9	1.0	0.6
Ever depressed for a whole week	0.4	0.5	1.3	0.3	-0.0	-1.1
Unable to work because of sickness or disability	0.4	0.5	0.8	0.9	0.0	-0.9
Supplements: Calcium	0.4	0.4	1.1	1.0	0.4	-0.3
Age at First Birth	0.3	0.4	0.6	0.4	0.7	0.7
Mean Putamen Volume	0.3	0.4	0.8	0.9	0.3	-0.5
Blood Eosinophil Count	0.3	2.4	6.6	-0.2	-2.6	0.8
BMI	0.3	1.8	5.4	2.3	0.2	0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.6	0.7	0.2	0.8
Medication for hormone replacement therapy	0.3	0.3	0.5	0.7	-0.3	0.5
Vitamin and mineral supplements	0.3	0.4	1.1	-1.1	-0.2	0.3
Diabetes (father)	0.3	0.3	0.9	0.9	-0.1	-0.3
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.5	0.6	-0.7	0.2
Trunk fat mass	0.3	1.3	2.2	-0.7	-1.0	-1.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.0	0.0	1.0	0.1
Qualifications: None of the above	0.3	0.6	1.2	1.1	-0.6	0.5
Diabetes (self-reported)	0.3	0.5	0.7	0.8	0.5	0.7
Medication: Simvastatin	0.3	0.5	1.3	1.2	0.2	-0.1
Time employed in main current job	0.3	0.3	0.7	-0.3	-0.8	-0.4
Medication: Cholesterol lowering	0.3	0.4	0.8	0.6	-0.2	-0.9
Depression (self-reported)	0.3	0.4	1.1	1.1	0.2	0.1
Medication: Lansoprazole	0.3	0.4	0.9	-0.9	0.3	-0.3
Medication: Paracetamol	0.3	0.5	0.8	0.9	-0.8	-0.1
Headache pain in last month	0.3	0.6	1.2	1.1	-0.6	0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.1	0.7	-1.0	-0.5
Leg pain on walking	0.3	0.3	0.8	0.3	-0.3	0.9
Ever had bowel cancer screening	0.3	0.4	0.7	-0.8	-0.7	0.1
Commuting to job workplace: Walk	0.3	0.3	0.9	1.0	0.2	-0.3
Osteoarthritis (self-reported)	0.3	0.3	0.6	-0.8	-0.5	0.4
Guilty feelings	0.3	0.5	1.4	0.0	1.2	-0.2
Medication: Paracetamol	0.3	0.5	1.1	1.1	-0.2	0.5
Illnesses of father: High blood pressure	0.3	0.3	0.8	-0.2	-0.4	-0.9
Fractured/broken bones in last 5 years	0.3	0.4	1.1	0.0	1.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.6	0.8	0.4	0.6
Pack years of smoking	0.3	0.4	0.6	0.5	0.5	0.8
Schizophrenia vs Biploar Disorder	0.2	0.3	0.5	0.7	0.6	0.1
Major Depression (MDD)	0.2	0.3	0.7	0.3	0.3	-0.8
Coronary Artery Disease (CAD)	0.2	0.2	0.4	0.3	0.4	-0.7
Crohns Disease (2012)	0.2	0.4	0.9	-0.4	-0.4	-0.9
Triglycerides	0.2	0.2	0.6	-0.8	0.0	-0.4
Waist Hip Ratio (WHR)	0.2	1.1	2.8	0.4	-0.6	-1.7
Chronotype (morning person)	0.2	0.4	0.6	0.6	0.5	0.7
Multivitamins +/- minerals	0.2	0.3	0.8	0.9	0.2	-0.0
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	0.7	0.9	-0.2	-0.1
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	0.1	0.8	0.3
Medication: Ramipril	0.2	0.3	0.3	0.6	-0.5	-0.5
Fluid intelligence score	0.2	0.4	1.1	1.0	0.3	0.1
Illnesses of siblings	0.2	0.2	0.4	0.2	-0.6	-0.5
Arm fat percentage (right)	0.2	0.9	1.2	-1.0	-1.1	-0.6
Noisy workplace	0.2	0.3	0.9	-0.1	0.9	-0.1
Arm fat mass (right)	0.2	0.9	1.3	0.9	-0.7	-1.2
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.2	0.8	-0.3
Comparative body size at age 10	0.2	0.5	1.3	1.1	-0.3	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	-0.9	0.0	0.0
Health satisfaction	0.2	0.2	0.3	0.5	-0.5	0.5
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.5	-0.6	-0.2
Emphysema/chronic bronchitis	0.2	0.3	0.4	0.2	-0.6	0.7
Neck or shoulder pain in last month	0.2	0.3	0.4	-0.5	-0.6	-0.6
Medication: Ibuprofen	0.2	0.2	0.6	0.8	-0.3	0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.4	-0.4	0.5
Heart disease (mother)	0.2	0.3	0.4	0.5	-0.7	-0.1
Whole body fat mass	0.2	0.7	1.6	0.2	-0.7	-1.3
Leg fat mass (right)	0.2	0.7	1.6	1.3	-0.4	-0.5
Family relationship satisfaction	0.2	0.3	0.5	-0.4	-0.3	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	0.1	0.8	0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	-0.0	-0.6	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.6	-0.4	0.2
Illnesses of father: Heart disease	0.2	0.2	0.5	-0.3	0.3	-0.7
Arm fat percentage (left)	0.2	0.8	1.4	-0.8	-1.2	-0.6
Loneliness, isolation	0.2	0.3	0.6	-0.1	-0.4	-0.8
Eye problems/disorders: Cataract	0.2	0.3	0.4	0.4	0.6	0.5
Mineral and other dietary supplements	0.2	0.3	0.4	-0.6	-0.5	-0.5
Arm fat mass (left)	0.2	0.8	1.3	1.1	-0.6	-0.9
Medication: Bendroflumethiazide	0.2	0.3	0.4	0.6	0.5	0.5
Diastolic blood pressure, automated reading	0.2	0.6	0.9	0.8	0.6	0.9
Leg fat mass (left)	0.2	0.9	2.1	1.4	-0.4	-0.6
Prostate Cancer	0.1	0.1	0.4	-0.2	0.0	0.6
HDL Cholesterol	0.1	0.1	0.2	-0.2	0.5	0.2
LDL Cholesterol	0.1	0.2	0.4	-0.1	-0.4	-0.6
Schizophrenia (2014)	0.1	0.1	0.4	-0.6	-0.0	-0.1
Blood Red Count	0.1	1.4	2.3	1.1	-1.5	-0.9
Hair Pigment	0.1	3.1	5.2	1.9	2.3	0.4
Hand grip strength (left)	0.1	0.3	0.7	0.8	0.5	-0.2
Medication: Metformin	0.1	0.1	0.2	0.4	0.3	-0.2
Pack years adult smoking proportion	0.1	0.2	0.5	0.7	0.1	0.2
Townsend deprivation index at recruitment	0.1	0.1	0.3	0.5	-0.2	-0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.0	-0.4	-0.5
Prospective memory result	0.1	0.1	0.2	0.2	-0.3	-0.4
Lung cancer (father)	0.1	0.2	0.5	0.7	0.0	-0.1
Tense / ‘highly strung’	0.1	0.2	0.6	0.1	0.0	-0.7
Leg fat percentage (right)	0.1	0.4	0.9	-0.5	-0.4	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	-0.2	-0.4	0.4
Knee pain experienced in last month	0.1	0.1	0.1	-0.2	-0.3	-0.3
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	-0.5	0.2	0.3
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.2	-0.4	-0.3	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.3	0.4	-0.1
Leg fat percentage (left)	0.1	0.3	0.4	-0.2	-0.7	0.7
Average weekly beer plus cider intake	0.1	0.1	0.2	0.5	0.3	0.1
Heart disease (siblings)	0.1	0.1	0.2	-0.0	-0.4	-0.3
Schizophrenia (2018)	0.0	0.0	0.1	-0.2	0.0	-0.0
Systolic Blood Pressure	0.0	0.0	0.0	0.2	-0.0	-0.0
Hypothyroidism (self reported)	0.0	0.1	0.1	-0.0	0.2	0.4
Systolic blood pressure, automated reading	0.0	0.1	0.2	0.1	0.4	0.4
Nervous feelings	0.0	0.1	0.1	-0.2	-0.3	-0.2
Medication: Amlodipine	0.0	0.0	0.1	0.1	0.0	-0.2
Supplements: Vitamin C	0.0	0.0	0.0	0.0	0.1	0.2

Hub : Genes

POLR2B

Models

Trait associations