[Hub]/) : Traits : Heel T-Score :

chr4:94,430,437-96,770,632

Best TWAS P=9.34e-23 · Best GWAS P=2.51e-28 conditioned to 0.00456

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PDLIM5 0.10 0.08 enet 14 0.09 2.7e-11 -8.01 -9.8 9.3e-23 -0.45 1.00 0.00 TRUE
2 GTEx Adipose Subcutaneous PDLIM5 0.06 0.02 lasso 3 0.01 2.6e-02 0.97 -6.0 1.6e-09 -0.18 0.24 0.11 FALSE
3 GTEx Artery Tibial BMPR1B 0.10 0.00 enet 1 0.01 1.0e-01 -5.38 5.4 7.6e-08 0.05 0.09 0.03 TRUE
4 GTEx Cells Transformed fibroblasts PDLIM5 0.18 0.14 lasso 6 0.19 1.6e-14 -8.01 -6.2 6.7e-10 -0.16 1.00 0.00 FALSE
5 GTEx Ovary BMPR1B 0.32 -0.01 lasso 9 0.00 3.4e-01 9.03 8.5 2.0e-17 0.49 0.09 0.05 FALSE
6 GTEx Skin Sun Exposed Lower leg PDLIM5 0.10 0.07 lasso 5 0.07 2.1e-06 -7.86 -7.1 1.3e-12 -0.22 0.99 0.00 FALSE
7 GTEx Thyroid BMPR1B 0.15 0.02 lasso 7 0.00 2.8e-01 -5.38 5.2 2.0e-07 0.05 0.12 0.06 FALSE
8 YFS Blood SMARCAD1 0.02 0.01 blup 400 0.02 1.6e-06 4.85 8.6 6.2e-18 0.78 0.02 0.98 FALSE
9 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PDLIM5 0.03 0.04 blup 122 0.03 3.6e-04 -7.98 -7.1 1.1e-12 -0.31 0.81 0.06 FALSE
10 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PDLIM5 0.07 0.01 blup 120 0.04 6.0e-05 6.80 -6.9 4.6e-12 -0.49 0.20 0.70 FALSE
11 The Cancer Genome Atlas Brain Lower Grade Glioma PDLIM5 0.03 0.04 lasso 2 0.04 2.8e-05 -7.29 -7.6 3.2e-14 -0.28 0.68 0.04 FALSE
12 The Cancer Genome Atlas Brain Lower Grade Glioma SMARCAD1 0.06 0.04 lasso 4 0.03 9.2e-05 -9.72 9.7 2.5e-22 0.43 0.45 0.18 TRUE
13 The Cancer Genome Atlas Stomach Adenocarcinoma PDLIM5 0.06 0.05 blup 121 0.04 5.4e-04 -8.40 -8.1 3.8e-16 -0.29 0.88 0.04 FALSE
14 The Cancer Genome Atlas Thyroid Carcinoma PDLIM5 0.07 0.04 lasso 5 0.04 7.1e-05 -8.01 -8.5 2.2e-17 -0.38 0.12 0.77 FALSE