Best TWAS P=9.34e-23 · Best GWAS P=2.51e-28 conditioned to 0.00456
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PDLIM5 | 0.10 | 0.08 | enet | 14 | 0.09 | 2.7e-11 | -8.01 | -9.8 | 9.3e-23 | -0.45 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | PDLIM5 | 0.06 | 0.02 | lasso | 3 | 0.01 | 2.6e-02 | 0.97 | -6.0 | 1.6e-09 | -0.18 | 0.24 | 0.11 | FALSE |
| 3 | GTEx | Artery Tibial | BMPR1B | 0.10 | 0.00 | enet | 1 | 0.01 | 1.0e-01 | -5.38 | 5.4 | 7.6e-08 | 0.05 | 0.09 | 0.03 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | PDLIM5 | 0.18 | 0.14 | lasso | 6 | 0.19 | 1.6e-14 | -8.01 | -6.2 | 6.7e-10 | -0.16 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Ovary | BMPR1B | 0.32 | -0.01 | lasso | 9 | 0.00 | 3.4e-01 | 9.03 | 8.5 | 2.0e-17 | 0.49 | 0.09 | 0.05 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | PDLIM5 | 0.10 | 0.07 | lasso | 5 | 0.07 | 2.1e-06 | -7.86 | -7.1 | 1.3e-12 | -0.22 | 0.99 | 0.00 | FALSE |
| 7 | GTEx | Thyroid | BMPR1B | 0.15 | 0.02 | lasso | 7 | 0.00 | 2.8e-01 | -5.38 | 5.2 | 2.0e-07 | 0.05 | 0.12 | 0.06 | FALSE |
| 8 | YFS | Blood | SMARCAD1 | 0.02 | 0.01 | blup | 400 | 0.02 | 1.6e-06 | 4.85 | 8.6 | 6.2e-18 | 0.78 | 0.02 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PDLIM5 | 0.03 | 0.04 | blup | 122 | 0.03 | 3.6e-04 | -7.98 | -7.1 | 1.1e-12 | -0.31 | 0.81 | 0.06 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PDLIM5 | 0.07 | 0.01 | blup | 120 | 0.04 | 6.0e-05 | 6.80 | -6.9 | 4.6e-12 | -0.49 | 0.20 | 0.70 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PDLIM5 | 0.03 | 0.04 | lasso | 2 | 0.04 | 2.8e-05 | -7.29 | -7.6 | 3.2e-14 | -0.28 | 0.68 | 0.04 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SMARCAD1 | 0.06 | 0.04 | lasso | 4 | 0.03 | 9.2e-05 | -9.72 | 9.7 | 2.5e-22 | 0.43 | 0.45 | 0.18 | TRUE |
| 13 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PDLIM5 | 0.06 | 0.05 | blup | 121 | 0.04 | 5.4e-04 | -8.40 | -8.1 | 3.8e-16 | -0.29 | 0.88 | 0.04 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | PDLIM5 | 0.07 | 0.04 | lasso | 5 | 0.04 | 7.1e-05 | -8.01 | -8.5 | 2.2e-17 | -0.38 | 0.12 | 0.77 | FALSE |