TWAS hub - PDLIM5

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1040	0.0300	2.9e-08	0.084	0.070	0.092	0.072	0.083	2.2e-10	7.2e-09	2.7e-11	4.1e-09	2.3e-10
2	GTEx	Adipose Subcutaneous	0.0650	0.0310	8.4e-03	0.021	NA	0.009	NA	0.013	7.2e-03	NA	5.5e-02	NA	2.7e-02
3	GTEx	Cells Transformed fibroblasts	0.1840	0.0450	2.0e-10	0.143	NA	0.186	NA	0.194	7.9e-11	NA	6.0e-14	NA	1.6e-14
4	GTEx	Nerve Tibial	0.0866	0.0371	4.3e-03	0.069	NA	0.014	NA	0.032	1.4e-05	NA	3.5e-02	NA	2.3e-03
5	GTEx	Skin Sun Exposed Lower leg	0.0970	0.0330	1.4e-04	0.072	NA	0.063	NA	0.069	1.4e-06	NA	6.7e-06	NA	2.1e-06
6	ROSMAP	Brain Pre-frontal Cortex	0.2518	0.0411	0.0e+00	0.241	0.220	0.241	0.248	0.242	1.1e-30	9.3e-28	1.3e-30	1.3e-31	9.3e-31
7	TCGA	Esophageal Carcinoma	0.4640	0.1070	9.7e-06	0.016	0.155	0.147	NA	0.085	1.0e-01	1.3e-05	2.1e-05	NA	1.2e-03
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0326	0.0153	1.5e-04	0.036	0.028	0.023	NA	0.028	6.4e-05	3.6e-04	1.2e-03	NA	3.9e-04
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0662	0.0289	6.8e-05	0.014	0.036	0.019	NA	0.020	8.4e-03	6.0e-05	2.8e-03	NA	2.4e-03
10	TCGA	Brain Lower Grade Glioma	0.0330	0.0166	1.5e-03	0.039	0.028	0.026	NA	0.039	3.0e-05	3.6e-04	5.6e-04	NA	2.8e-05
11	TCGA	Stomach Adenocarcinoma	0.0550	0.0260	8.6e-05	0.051	0.042	0.038	NA	0.025	1.3e-04	5.4e-04	9.1e-04	NA	5.9e-03
12	TCGA	Thyroid Carcinoma	0.0700	0.0340	1.6e-04	0.042	0.024	0.027	NA	0.041	5.7e-05	2.0e-03	1.0e-03	NA	7.0e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Prostate Cancer	14.3	20.1	37.2	3.0	2.6	6.1	6.1	5.2	4.9	4.3	4.6	-1.4	4.7	5.1	3.1
Heel T-Score	5.8	45.8	96.4	-9.8	-6.0	-6.2	-3.1	-7.1	-4.7	-1.7	-7.1	-6.9	-7.6	-8.1	-8.5
Relative age voice broke	5.5	8.4	15.5	3.6	2.3	3.0	1.4	2.9	2.7	0.5	3.9	2.6	3.3	3.5	3.2
Birth weight of first child	4.6	8.3	12.6	-3.0	-2.2	-3.3	-2.6	-3.5	-2.8	-1.8	-3.4	-1.0	-3.3	-3.5	-3.0
Eye problems/disorders: Glaucoma	4.1	4.9	7.7	-2.4	-1.9	-2.5	-1.9	-2.5	-1.5	-0.6	-2.5	-2.1	-2.5	-2.8	-2.5
Relative age of first facial hair	4.0	8.2	11.6	3.1	2.9	2.4	1.1	2.7	2.8	1.8	3.4	3.4	3.1	3.2	3.4
Hair/balding pattern: Pattern 4	3.7	8.9	15.3	-3.9	-1.7	-2.6	-1.3	-2.9	-3.0	-2.3	-2.7	-3.5	-3.8	-3.5	-3.4
Glaucoma (self-reported)	3.7	4.4	7.3	-2.2	-1.5	-2.4	-1.8	-2.3	-1.8	-1.3	-2.3	-1.8	-2.5	-2.7	-2.1
Friendships satisfaction	3.7	4.6	8.7	3.0	1.6	1.6	0.1	2.0	1.9	1.1	2.6	2.8	2.4	2.4	2.6
Happiness	3.6	4.3	20.0	3.0	1.6	0.8	-0.6	1.1	1.0	1.1	1.7	4.5	1.9	2.0	2.4
Pulse rate, automated reading	3.5	11.3	25.2	-2.3	-2.7	-4.9	-5.0	-4.1	-3.4	-1.0	-4.0	0.6	-3.1	-3.7	-2.4
Eye problems/disorders: Cataract	3.5	4.1	6.7	-2.6	-1.9	-1.8	-1.8	-2.4	-2.2	-0.2	-2.1	-1.4	-2.5	-2.2	-2.1
Qualifications: nursing, teaching	3.3	5.1	8.2	-1.8	-2.1	-2.4	-2.9	-2.7	-2.7	-1.8	-2.0	0.1	-2.8	-2.5	-1.7
Heel bone mineral density (BMD) T-score, automated (right)	3.0	6.9	13.8	-3.7	-1.9	-2.8	-1.4	-2.8	-2.4	-1.0	-2.5	-2.1	-3.1	-3.2	-3.3
Average weekly red wine intake	3.0	4.4	12.7	2.7	2.1	2.4	1.1	2.4	0.8	-1.9	2.0	0.8	1.7	2.2	3.6
Impedance of leg (left)	2.8	13.8	29.2	-5.4	-3.3	-3.0	-0.9	-3.6	-2.6	-0.4	-4.5	-4.2	-4.4	-4.3	-4.4
Coronary Artery Disease (CAD)	2.5	3.0	11.7	1.4	3.4	2.0	2.3	2.0	1.5	-0.8	1.1	0.5	1.1	1.3	1.4
Number of incorrect matches in round	2.5	4.1	7.3	2.0	1.4	2.7	2.3	2.3	1.5	0.8	2.5	-1.3	1.9	2.7	2.0
Impedance of leg (right)	2.4	11.5	26.3	-5.1	-3.4	-2.4	-0.4	-3.1	-2.0	-0.3	-4.0	-4.3	-3.8	-3.9	-4.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.9	7.0	1.4	1.4	1.7	1.5	2.1	2.6	1.3	1.9	0.1	2.0	1.8	1.3
Ever had bowel cancer screening	2.4	2.8	4.1	-1.8	-1.8	-1.7	-1.5	-1.8	-2.0	-0.7	-1.7	-1.5	-2.0	-1.6	-1.5
Ever had hysterectomy (womb removed)	2.3	2.6	10.3	0.2	0.2	-1.9	-3.2	-1.5	-1.8	-1.4	-1.0	2.3	-1.3	-1.0	0.8
Hand grip strength (right)	2.3	6.3	14.7	3.0	0.9	3.0	0.8	2.4	2.3	1.2	2.9	1.7	2.8	3.2	3.8
Qualifications: CSEs or equivalent	2.3	3.1	8.2	-2.0	-1.6	-1.8	-0.7	-2.0	-1.6	-0.3	-1.6	-1.6	-1.8	-1.8	-2.9
Medication: Levothyroxine sodium	2.3	3.9	6.1	-2.4	-1.9	-2.1	-1.2	-2.3	-2.0	-0.5	-1.9	-2.0	-2.5	-2.1	-2.2
Medication: Simvastatin	2.3	3.4	5.8	-2.4	-1.7	-1.5	-0.9	-1.7	-1.5	-0.4	-1.9	-2.1	-2.3	-2.4	-2.2
Mouth/teeth dental problems: Bleeding gums	2.3	2.9	4.9	-2.0	-2.1	-1.9	-1.0	-2.2	-1.8	-0.2	-0.9	-1.2	-2.1	-1.8	-2.0
Severe depression (siblings)	2.2	2.5	5.2	-1.4	-2.1	-1.5	-1.2	-1.7	-1.7	-1.3	-0.8	-1.3	-1.7	-1.5	-2.3
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.0	9.9	-3.1	-1.6	-2.6	-1.5	-2.4	-1.6	-0.8	-2.5	-1.4	-2.4	-2.8	-2.9
Medication: Lansoprazole	2.2	2.5	5.4	1.1	1.0	2.3	2.3	1.9	1.7	1.2	1.5	-0.1	1.6	1.7	1.0
Hypothyroidism/myxoedema (self-reported)	2.2	4.3	7.3	-2.6	-1.7	-2.0	-0.9	-2.2	-2.0	-0.8	-2.2	-2.7	-2.5	-2.1	-2.2
Sensitivity / hurt feelings	2.1	3.7	8.6	2.3	1.8	1.1	0.1	1.6	1.6	2.0	2.2	2.9	2.1	1.8	2.0
Loud music exposure frequency	1.9	2.1	7.5	-0.9	-0.4	-1.1	-1.9	-1.5	-1.8	-2.7	-1.5	-0.1	-1.3	-1.4	-0.0
Average weekly champagne plus white wine intake	1.9	2.6	5.6	-1.6	-0.9	-1.3	-1.3	-1.9	-1.6	-0.5	-1.9	-1.7	-2.4	-1.5	-2.0
Mouth/teeth dental problems	1.8	2.8	6.4	1.7	2.5	1.8	0.4	2.0	1.2	-1.5	1.5	0.6	1.7	1.5	2.3
Heart disease (mother)	1.8	2.2	6.6	0.6	1.4	2.5	2.6	1.7	1.2	0.9	0.7	-1.0	1.2	1.4	0.9
Hand grip strength (left)	1.7	4.4	9.1	2.4	0.4	2.4	0.7	2.0	2.0	1.4	2.5	1.4	2.5	2.7	3.0
Chronic bronchitis/emphysema (father)	1.7	2.0	4.4	-1.4	-0.3	-1.9	-1.4	-1.8	-2.1	-0.8	-1.4	-0.7	-1.8	-1.3	-1.0
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	4.0	1.8	2.0	1.5	1.0	1.6	1.1	-0.1	1.7	1.2	1.5	1.7	1.5
Heart attack	1.6	2.0	6.0	-1.3	0.9	1.6	2.4	0.8	1.4	1.8	0.6	-2.4	0.4	0.6	-0.7
Lung cancer (father)	1.6	1.8	6.3	1.2	2.5	0.6	0.4	1.4	1.4	0.8	1.7	1.3	1.3	1.0	1.3
Gout (self-reported)	1.6	2.2	4.1	-1.1	-1.3	-2.0	-2.0	-1.8	-1.6	-1.4	-1.5	0.2	-1.5	-1.5	-1.3
Chronic bronchitis/emphysema (mother)	1.6	1.8	3.0	1.0	0.9	1.7	1.7	1.6	1.7	1.0	1.5	-0.2	1.6	1.5	0.4
Comparative body size at age 10	1.6	4.4	9.3	-1.3	-1.1	-2.9	-3.0	-2.6	-1.8	-0.7	-2.7	1.1	-2.2	-2.5	-1.5
Worry too long after embarrassment	1.6	2.7	13.0	2.3	1.5	0.4	-0.9	0.9	0.9	0.8	1.0	3.6	1.4	1.2	1.9
Family relationship satisfaction	1.6	1.9	5.1	1.8	0.6	1.1	0.5	1.1	1.1	0.8	1.5	2.3	1.6	1.5	1.6
Ever had prostate specific antigen (PSA) test	1.6	1.9	5.1	1.5	0.1	1.9	1.4	1.6	0.8	-0.0	2.2	-0.2	1.1	1.6	1.7
Heart attack/myocardial infarction (self-reported)	1.6	2.1	6.1	-1.4	0.9	1.6	2.5	0.7	1.3	2.0	0.6	-2.5	0.3	0.6	-0.8
Schizophrenia vs Biploar Disorder	1.5	2.0	4.1	-0.7	-1.5	-2.0	-1.9	-1.7	-2.0	-0.4	-1.0	0.5	-1.4	-1.2	-1.3
Reaction Time	1.5	2.9	10.7	1.8	1.4	0.8	0.8	1.4	2.6	1.7	0.9	3.3	1.7	1.0	0.8
Pack years adult smoking proportion	1.5	2.3	4.6	-2.1	-1.2	-1.2	-0.7	-1.6	-1.4	-0.1	-1.6	-1.7	-1.9	-1.6	-1.9
Pack years of smoking	1.5	2.2	4.8	-2.2	-1.1	-1.1	-0.5	-1.5	-1.4	-0.2	-1.5	-1.8	-1.9	-1.4	-1.8
Age at First Birth	1.4	2.0	3.4	-1.0	-1.0	-1.5	-1.3	-1.9	-1.8	-1.6	-1.5	-0.2	-1.4	-1.4	-1.6
Neuroticism score	1.4	2.9	11.0	1.9	1.9	0.6	-0.6	1.4	1.2	1.6	1.6	3.3	1.6	1.2	1.8
Blood clot in the leg (DVT)	1.4	1.9	2.7	-1.3	-1.6	-1.4	-1.5	-1.6	-1.6	-0.3	-1.6	0.1	-1.5	-1.6	-1.3
High blood pressure (siblings)	1.4	1.9	4.0	-1.2	-1.0	-1.5	-1.2	-1.6	-1.1	-1.2	-1.7	-0.9	-1.3	-1.6	-2.0
Eye problems/disorders: None of the above	1.4	1.7	2.9	1.7	1.5	1.0	0.9	1.5	1.1	0.2	1.1	1.4	1.7	1.4	1.4
Medication: Aspirin	1.4	1.8	6.0	-1.7	-0.5	1.1	2.3	0.3	0.5	1.1	-0.3	-2.4	-0.4	-0.8	-1.9
Medication: Aspirin	1.4	1.8	6.6	-1.7	-0.3	1.1	2.4	0.3	0.4	1.1	-0.3	-2.6	-0.4	-0.7	-1.9
Wears glasses or contact lenses	1.4	1.6	2.9	-1.3	-0.8	-1.1	-1.0	-1.3	-1.7	-1.5	-1.5	-0.7	-1.4	-1.6	-0.7
Pain experienced in last month	1.4	2.4	3.9	-1.6	-1.5	-1.7	-1.6	-1.8	-1.4	0.1	-1.9	-0.3	-2.0	-1.6	-1.7
Impedance of whole body	1.4	7.4	21.7	-4.4	-1.8	-1.4	0.7	-1.8	-1.1	-0.4	-2.8	-4.7	-2.8	-3.1	-3.4
Systolic Blood Pressure	1.3	6.7	17.9	1.8	1.3	2.9	2.7	3.1	4.2	3.5	1.8	0.1	2.9	2.4	1.6
High blood pressure	1.3	3.6	7.5	2.0	0.9	2.1	1.7	2.3	2.7	2.3	1.0	0.2	2.2	2.1	1.5
Sitting height	1.3	9.4	22.7	-3.5	-4.8	-2.3	-0.9	-3.1	-3.2	-1.1	-2.4	-3.2	-3.7	-2.8	-3.7
Alcohol usually taken with meals	1.3	2.2	4.5	2.1	2.1	1.3	0.4	1.6	1.9	-0.5	0.8	0.8	1.7	1.1	2.0
Length of working week for main job	1.3	1.4	4.8	-0.3	-1.3	-1.2	-1.8	-0.9	-1.6	-2.2	-0.9	0.3	-0.8	-0.8	-0.0
Emphysema/chronic bronchitis	1.3	1.5	4.0	-2.0	-0.8	-0.8	-0.0	-1.2	-1.6	-0.4	-0.6	-1.6	-1.4	-1.2	-1.4
Knee pain experienced in last month	1.3	2.0	3.5	1.7	1.2	1.2	0.9	1.5	1.5	0.1	1.9	1.2	1.8	1.4	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.1	1.4	0.7	0.9	0.6	1.1	1.4	1.5	1.4	1.8	1.5	1.0	0.7
Commuting to job workplace: Public transport	1.3	1.5	3.4	1.8	0.6	1.0	0.3	1.2	1.5	0.1	0.7	1.0	1.9	1.3	1.8
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	2.5	-1.4	-1.4	-1.2	-1.3	-1.5	-1.6	-0.8	-1.4	-0.3	-1.3	-1.6	-1.3
Primary Biliary Cirrhosis	1.2	1.7	3.2	1.5	1.4	1.2	0.6	1.4	0.8	-0.1	1.3	1.5	1.4	1.4	1.8
Lung FEV1/FVC ratio	1.2	5.9	14.4	-2.5	-1.9	-2.9	-1.4	-2.3	-1.6	0.0	-3.2	-1.5	-2.5	-3.0	-3.8
Angina	1.2	1.5	7.3	-1.4	1.2	1.3	2.1	0.4	-0.0	0.3	0.7	-2.7	-0.2	0.5	-0.4
Medication: Bendroflumethiazide	1.2	1.8	5.1	0.3	1.0	1.8	2.2	1.8	1.8	0.3	0.5	-1.1	1.5	1.0	0.5
Myopia	1.2	1.8	9.7	-1.5	-0.2	1.0	2.1	0.4	-0.3	0.5	0.6	-3.1	-0.3	-0.0	-1.6
Cholesterol lowering medication	1.2	1.7	3.3	-1.4	-0.0	-1.1	-0.7	-0.9	-1.3	-1.4	-1.7	-1.8	-1.6	-1.7	-1.1
Hypothyroidism (self reported)	1.1	2.6	5.1	-1.8	-0.6	-1.8	-0.9	-2.0	-2.1	-0.8	-1.6	-1.4	-2.2	-1.6	-1.6
Systolic blood pressure, automated reading	1.1	3.2	8.4	1.5	1.5	1.9	1.4	2.3	2.9	2.0	0.8	0.2	2.0	1.5	1.9
Fed-up feelings	1.1	2.0	4.3	1.7	1.5	1.0	0.7	1.4	1.0	1.6	1.5	2.1	1.4	1.4	0.9
Multivitamins +/- minerals	1.1	1.4	6.2	-0.1	-0.1	1.8	2.5	1.1	0.9	1.1	1.0	-1.1	0.4	1.1	-0.5
Hair/balding pattern: Pattern 2	1.1	1.4	4.1	1.2	2.0	0.5	0.2	0.9	1.3	1.1	0.9	1.6	1.3	0.9	1.1
Hair/balding pattern: Pattern 3	1.1	1.7	3.6	1.3	-0.9	1.5	1.5	1.1	1.2	1.9	1.1	1.0	1.5	1.6	0.6
Tense / ‘highly strung’	1.1	1.8	3.8	1.8	0.7	1.4	0.5	1.5	0.9	0.6	1.7	1.3	1.1	1.5	2.0
Pulse wave reflection index	1.1	1.4	2.3	1.3	1.3	1.2	0.7	1.1	1.5	1.3	0.6	1.5	1.0	1.2	1.2
Birth weight	1.1	2.3	4.2	-1.7	-1.9	-1.3	-1.3	-1.7	-1.3	-0.4	-1.5	-0.6	-1.9	-1.8	-2.0
Angina (self-reported)	1.1	1.4	6.2	-1.3	1.3	1.3	2.1	0.5	0.1	0.3	0.7	-2.5	-0.1	0.4	-0.5
Medication: Gliclazide	1.1	1.2	7.1	-1.2	0.6	0.4	1.1	-0.3	-1.2	-1.1	0.2	-2.7	-0.7	-0.3	-0.9
Ever taken oral contraceptive pill	1.1	1.2	3.2	1.5	1.3	0.5	-0.3	0.9	0.2	-0.3	1.2	1.8	1.2	1.2	1.4
Supplements: Fish oil (including cod liver oil)	1.1	1.5	4.8	0.5	2.2	1.7	1.7	1.4	0.5	-0.2	0.8	-1.4	0.6	1.0	0.6
Alcohol drinker status: Previous	1.1	1.3	4.7	1.7	1.0	1.2	-0.1	0.8	0.0	-0.4	1.1	0.7	0.8	1.6	2.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.8	-0.4	-0.4	-1.4	-2.2	-1.0	-0.9	-0.9	-1.2	1.0	-1.0	-1.0	0.1
Medication: Ramipril	1.0	1.2	4.0	-1.5	-0.6	-0.3	0.5	-0.9	0.0	1.5	-1.2	-1.3	-0.8	-1.0	-2.0
Falls in the last year	1.0	1.3	3.0	0.7	-0.1	1.4	1.7	1.3	1.0	1.3	1.6	-0.9	1.0	1.3	-0.3
Handedness (chirality/laterality): Left-handed	1.0	1.2	3.1	1.1	1.5	0.8	0.6	0.9	0.5	1.8	1.2	1.1	0.7	1.5	1.1
Long-standing illness, disability or infirmity	1.0	1.5	5.6	-0.6	0.4	1.5	2.4	0.9	0.6	0.2	0.7	-2.1	0.2	0.2	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	8.0	0.4	0.1	0.5	0.6	0.4	0.9	2.8	1.2	0.7	0.6	1.0	0.1
Guilty feelings	1.0	1.5	5.1	-0.7	-1.3	-1.7	-2.3	-1.3	-0.9	0.2	-0.8	1.5	-0.9	-1.2	-0.5
Leg fat percentage (left)	1.0	3.5	5.0	-2.0	-2.1	-2.0	-1.5	-2.0	-2.2	-0.5	-2.2	-0.0	-2.0	-2.1	-2.1
Vascular/heart problems diagnosed by doctor	1.0	2.8	6.1	-1.5	-0.9	-2.0	-1.7	-2.0	-2.5	-2.2	-1.0	0.3	-1.8	-1.8	-1.0
Triglycerides	0.9	1.5	3.3	-1.0	-0.5	-1.3	-1.2	-1.2	-1.4	-1.8	-1.3	-0.4	-1.5	-1.5	-0.8
Vitamin and mineral supplements	0.9	1.2	4.0	-0.5	-0.0	-1.7	-2.0	-1.3	-1.0	-1.2	-1.0	0.5	-0.8	-1.4	-0.1
Nervous feelings	0.9	1.6	2.7	-1.6	-1.1	-1.6	-1.0	-1.5	-1.5	-0.8	-1.0	-0.7	-1.2	-1.5	-1.3
Pulse rate	0.9	1.4	3.4	-0.9	-0.4	-1.8	-1.8	-1.0	-0.8	-0.7	-1.9	0.7	-0.8	-1.6	-0.8
Shortness of breath walking on level ground	0.9	1.1	6.1	-1.4	-0.7	-0.1	-0.0	-0.8	-0.4	0.3	-0.5	-2.5	-1.0	-0.6	-1.4
Mean time to correctly identify matches	0.9	1.7	4.3	1.1	1.2	1.1	1.3	1.4	2.1	1.2	0.7	2.0	1.2	0.8	0.6
Comparative height size at age 10	0.9	5.0	8.5	-2.6	-2.5	-1.8	-0.8	-2.2	-2.2	-0.6	-2.3	-2.8	-2.7	-2.1	-2.9
Chest pain or discomfort	0.9	1.3	5.1	-1.7	-1.4	-0.2	0.2	-0.5	-0.7	0.7	-0.5	-2.2	-1.0	-0.8	-1.6
Ever smoked	0.9	1.7	6.1	-1.4	-2.5	-1.2	-1.1	-1.6	-1.4	0.6	-1.0	-0.1	-1.4	-0.9	-0.8
Intelligence (Savage-Jansen 2018)	0.8	2.4	6.9	-0.5	-0.5	-1.9	-2.6	-1.8	-1.9	-2.1	-1.6	0.9	-1.3	-1.3	-0.0
Cardiovascular Disease	0.8	2.5	5.1	1.5	0.5	2.0	1.7	1.9	2.3	2.2	0.7	-0.8	1.6	1.6	1.0
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.8	-0.6	-0.1	-0.9	-1.6	-0.8	-1.7	-1.5	-1.1	0.0	-1.1	-0.7	0.6
Townsend deprivation index at recruitment	0.8	1.1	3.1	-0.1	0.6	0.5	1.4	1.0	1.8	1.7	0.8	-0.3	1.4	0.6	-1.1
Taking other prescription medications	0.8	1.2	8.9	-1.4	-0.4	0.4	1.3	-0.0	-0.3	0.7	-0.2	-3.0	-0.6	-0.3	-0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.0	-1.2	-0.1	-1.7	-1.5	-1.5	-1.3	-1.4	-1.1	-0.1	-1.5	-1.5	-1.5
Prospective memory result	0.8	1.0	4.5	-1.2	-0.4	-0.6	0.4	-0.9	-0.9	0.1	-0.8	-2.1	-0.6	-0.6	-1.4
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.4	0.7	-1.3	1.6	0.7	0.8	0.7	0.2	1.1	-1.2	0.5	1.2	1.2
Leg fat percentage (right)	0.8	3.0	4.6	-2.0	-2.1	-1.7	-1.2	-1.8	-2.0	-0.5	-2.0	-0.3	-1.8	-2.0	-2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.7	1.7	0.4	0.7	0.2	0.8	0.3	0.3	1.4	1.4	1.1	1.3	1.0
Wheeze or whistling in the chest in last year	0.8	1.5	3.3	-1.8	-0.4	-0.4	-0.1	-1.0	-0.7	-1.5	-1.6	-1.6	-0.7	-1.3	-1.6
Medication: Ibuprofen	0.8	0.9	1.7	1.3	1.3	0.9	0.7	0.9	0.3	-0.9	1.3	1.1	0.7	0.9	0.8
Age at last live birth	0.8	1.2	3.9	-1.2	-1.3	-0.9	-0.5	-1.3	-0.6	0.3	-0.8	-1.2	-0.9	-1.0	-2.0
Hypertension (Self-reported)	0.8	2.4	5.1	1.7	0.7	1.7	1.2	1.9	2.3	1.9	0.6	0.2	1.8	1.8	1.3
Illnesses of siblings: Diabetes	0.8	1.0	2.5	0.5	0.1	1.3	1.6	1.1	1.1	1.6	0.7	-1.0	0.7	0.8	0.3
Miserableness	0.8	1.4	5.5	1.1	1.2	0.4	-0.4	0.8	1.2	2.0	0.9	2.4	1.0	0.7	0.8
Mother’s age at death	0.8	1.1	1.5	-1.2	-1.0	-0.9	-0.9	-1.1	-1.1	-1.0	-0.7	-1.1	-1.1	-1.1	-1.0
Medication: Atorvastatin	0.8	1.0	5.3	-1.4	0.7	-0.2	0.4	-0.5	-0.3	-0.5	-0.7	-2.3	-0.7	-0.8	-1.5
Illnesses of father: High blood pressure	0.8	1.0	6.2	0.4	-0.2	0.7	1.1	0.5	1.4	2.5	-0.4	0.3	0.7	0.3	-0.8
Unable to work because of sickness or disability	0.8	1.1	2.0	1.4	1.3	0.5	0.2	0.9	1.1	1.4	1.1	0.5	1.4	1.1	0.8
Heart disease (siblings)	0.8	0.9	2.2	1.5	0.6	0.7	0.5	1.3	1.1	1.2	0.7	0.8	1.2	0.7	0.9
Leg fat mass (left)	0.8	3.0	6.0	-1.4	-2.5	-1.8	-1.6	-1.9	-2.3	-0.7	-1.8	0.4	-1.8	-1.8	-1.9
Ulcerative Colitis (UC)	0.7	1.4	2.6	1.2	0.8	1.6	1.3	1.3	1.0	0.6	1.5	0.6	0.9	1.6	0.9
Verbal and Numeric Reasoning (VNR)	0.7	1.7	4.7	-0.4	0.1	-1.6	-2.0	-1.2	-1.3	-2.2	-1.3	1.2	-0.9	-1.3	-0.2
Bipolar Disorder (2011)	0.7	0.7	1.4	0.6	0.8	1.0	0.9	0.8	0.7	0.4	1.2	-0.5	0.7	1.0	1.0
Mean Putamen Volume	0.7	0.8	1.8	0.8	1.0	0.8	0.9	1.0	1.3	-0.5	1.4	-0.3	1.0	0.7	0.3
Fluid intelligence score	0.7	1.4	3.4	-0.8	-0.8	-1.7	-1.8	-1.1	-1.1	-1.3	-0.7	1.0	-1.1	-1.3	-0.7
Impedance of arm (right)	0.7	3.1	16.4	-2.3	0.7	1.1	2.9	0.8	1.2	0.1	-0.4	-4.0	-0.2	-0.7	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.3	-1.5	-1.3	-1.1	-0.9	-1.1	-1.2	-0.0	-0.9	-0.4	-1.1	-1.3	-0.9
Noisy workplace	0.7	0.9	1.9	0.7	0.7	1.0	1.0	1.1	1.4	1.1	0.5	0.8	0.9	0.8	1.1
Pulse wave Arterial Stiffness index	0.7	0.8	1.5	-0.9	-0.8	-0.7	-0.8	-1.0	-1.0	-0.0	-1.1	0.4	-1.2	-1.0	-1.0
Pulse wave peak to peak time	0.7	0.8	1.4	0.8	0.5	0.8	1.0	1.0	0.9	0.2	1.2	-0.6	1.1	1.1	0.9
Leg fat mass (right)	0.7	2.6	5.9	-1.4	-2.4	-1.6	-1.4	-1.7	-2.1	-0.7	-1.6	0.3	-1.7	-1.7	-1.7
Number of self-reported non-cancer illnesses	0.7	1.1	2.1	1.4	0.6	1.4	0.8	1.1	0.5	0.5	1.3	1.0	0.9	1.3	1.3
Financial situation satisfaction	0.7	0.9	1.8	-1.1	-0.5	-0.8	-0.6	-1.3	-1.1	-0.3	-0.9	-0.4	-1.0	-1.1	-1.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.1	0.6	0.6	1.4	1.3	1.1	0.6	-0.2	1.0	0.1	0.9	1.1	0.6
Basal cell carcinoma (self-reported)	0.7	0.9	2.9	1.1	0.7	-0.4	-1.6	-0.1	-0.6	-1.7	-0.0	0.9	0.3	0.3	1.4
Alzheimer’s Disease (in mother)	0.6	0.7	2.3	-0.3	-0.7	-0.7	-0.8	-0.7	-1.5	-0.3	-1.3	-0.0	-1.4	-0.4	-0.2
Alzheimer’s Disease (in father)	0.6	0.7	2.1	1.2	-0.0	0.2	-0.5	0.7	0.7	-0.8	-0.2	1.3	1.0	0.4	1.5
Crohns Disease (2017)	0.6	1.3	6.0	-0.6	-0.1	1.5	2.0	0.6	-0.0	0.4	1.2	-2.5	-0.4	0.9	-0.0
Irritable Bowel Disease (IBD)	0.6	1.3	3.8	0.4	0.4	1.9	1.9	1.1	0.5	0.5	1.7	-1.1	0.3	1.5	0.5
Crohns Disease (2012)	0.6	0.9	3.3	-0.7	1.0	1.0	1.8	0.8	0.2	-0.5	1.1	-1.7	-0.3	0.3	-0.0
Lupus	0.6	0.9	1.9	0.3	0.6	1.3	1.4	1.2	1.3	0.3	0.9	-0.4	0.9	1.1	1.0
Medication: Metformin	0.6	0.8	3.4	-0.3	0.7	1.3	1.8	0.8	0.1	0.4	0.0	-1.7	0.4	0.5	0.4
Serious illness, injury or assault to yourself	0.6	0.7	2.2	-0.0	-1.5	0.1	-0.4	-0.6	-1.5	-1.3	0.5	-0.7	-1.0	0.1	-0.2
Allergy	0.6	1.5	2.8	1.7	1.2	1.2	0.8	1.4	1.3	0.2	1.1	0.2	1.4	1.5	1.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.2	-0.7	0.5	0.7	1.8	0.6	0.8	1.6	-0.1	-0.7	0.0	-0.0	-0.7
Illnesses of siblings	0.6	0.8	2.5	0.7	1.0	0.9	0.4	0.8	0.6	-0.0	1.3	0.8	0.8	0.8	1.6
Time employed in main current job	0.6	0.7	1.4	-0.8	0.0	-1.0	-1.0	-0.9	-0.9	-1.2	-0.6	-0.6	-0.9	-1.1	-0.6
Illnesses of mother	0.6	0.7	1.2	-1.1	-0.9	-0.7	-0.3	-1.0	-1.0	-0.7	-0.3	-0.9	-1.1	-0.9	-0.6
Impedance of arm (left)	0.6	2.8	16.4	-2.6	-0.1	0.4	2.1	0.2	0.5	-0.6	-0.8	-4.1	-0.7	-1.3	-1.8
Peak expiratory flow (PEF)	0.6	1.3	5.9	1.8	0.6	-0.0	-0.8	0.4	0.6	0.0	0.9	2.4	1.5	0.9	0.9
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.9	-0.6	-0.7	-1.4	-1.2	-1.1	-0.7	-1.1	-0.4	-0.0	-1.1	-1.0	-1.4
Arm fat-free mass (right)	0.6	3.0	8.2	0.3	-2.9	-1.8	-2.8	-1.7	-2.5	-0.9	-0.5	2.0	-1.4	-0.8	-0.5
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.4	-0.1	-0.5	-1.1	-1.1	-0.9	-0.9	-1.5	-0.4	0.6	-0.4	-0.9	-0.5
Loneliness, isolation	0.6	0.8	3.7	0.7	1.9	0.6	0.2	0.6	0.6	-1.1	0.2	1.0	0.8	0.5	1.2
Mineral and other dietary supplements	0.6	0.7	2.5	0.3	-1.2	-1.2	-1.6	-0.8	-0.0	0.6	0.2	1.5	0.0	-0.1	-0.1
LDL Cholesterol	0.5	0.8	2.6	-0.1	1.4	0.9	1.6	0.7	0.5	1.6	0.8	0.3	0.1	0.1	-0.6
Blood Eosinophil Count	0.5	3.6	7.3	2.7	2.1	1.7	0.9	1.9	1.6	0.2	2.5	1.6	1.9	2.3	1.9
Neuroticism	0.5	1.3	8.4	1.2	0.8	-0.6	-1.6	0.2	-0.2	0.3	0.9	2.9	0.4	0.4	0.8
Hearing difficulty/problems: Yes	0.5	0.7	1.8	0.4	-0.3	1.1	1.3	1.0	0.6	1.1	1.0	-0.5	0.8	1.1	0.2
Supplements: Zinc	0.5	0.6	1.4	-1.0	0.0	-0.3	-0.3	-0.6	-1.2	-0.4	-1.0	-0.7	-0.9	-0.8	-0.7
Current tobacco smoking	0.5	0.9	4.8	-1.2	-2.2	-0.2	0.2	-0.7	-0.1	0.8	-0.8	-0.4	-0.9	-0.7	-1.1
Age when periods started (menarche)	0.5	1.3	3.5	1.5	0.3	0.8	-0.6	0.8	0.5	-1.2	1.5	1.5	1.1	0.8	1.9
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.4	-1.6	-0.8	-1.2	-0.8	-1.1	-1.0	-0.4	-1.2	-0.4	-1.2	-1.4	-0.9
Trunk fat mass	0.5	2.2	5.4	-1.6	-2.3	-1.2	-0.7	-1.2	-1.9	-0.9	-1.2	-0.6	-1.5	-1.7	-1.9
Standing height	0.5	5.0	17.6	-2.0	-4.2	-1.9	-1.4	-2.2	-2.6	-0.8	-1.3	-1.3	-2.8	-2.0	-2.4
Exposure to tobacco smoke at home	0.5	0.5	1.2	-0.8	-0.3	-0.4	0.3	-0.7	-0.5	0.5	-1.1	-0.9	-0.9	-0.9	-0.7
Body fat percentage	0.5	1.9	4.0	-1.8	-1.8	-1.0	-0.3	-1.1	-1.5	-0.7	-1.4	-0.9	-1.4	-1.7	-2.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.9	0.9	-0.8	-0.5	-1.1	-0.5	-0.3	-1.4	-0.4	0.9	-0.2	-0.4	0.7
Medication: Blood pressure	0.5	0.8	3.9	-0.5	-1.0	0.7	1.0	0.7	1.1	2.0	-0.0	-1.1	0.2	0.3	-0.6
Migraine (self-reported)	0.5	0.7	3.5	0.4	0.6	-0.6	-1.4	-0.6	-0.7	-1.9	0.1	0.7	-0.8	-0.3	0.2
Medication: Omeprazole	0.5	0.6	2.3	1.0	0.5	-0.3	-0.9	0.0	-0.4	1.1	0.4	1.5	0.3	0.8	0.9
Whole body fat mass	0.5	2.1	4.8	-1.4	-2.2	-1.3	-1.0	-1.3	-2.0	-1.1	-1.2	-0.2	-1.5	-1.6	-1.8
Arm predicted mass (right)	0.5	2.8	7.1	0.2	-2.7	-1.8	-2.6	-1.8	-2.4	-0.7	-0.5	1.9	-1.4	-0.9	-0.6
Suffer from ‘nerves’	0.5	0.8	1.7	-0.9	0.5	-1.3	-0.9	-0.8	-0.5	0.6	-1.1	0.5	-0.8	-1.2	-1.2
Overall health rating	0.5	1.1	3.5	-1.4	-0.7	-1.0	-0.1	-0.7	-0.5	-0.2	-1.1	-1.1	-0.8	-1.4	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.8	0.9	0.1	1.0	0.0	1.0	0.2	-0.0	1.3	0.2	0.6	1.0	1.3
Illnesses of father: Heart disease	0.5	0.8	3.1	0.5	0.8	0.9	1.3	0.7	0.2	-1.0	0.6	-1.8	0.4	0.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	6.7	-0.6	-2.6	-0.1	0.1	-0.2	0.2	1.1	-0.0	-0.4	-0.3	-0.4	-1.5
Commuting to job workplace: Walk	0.5	0.5	1.8	-0.4	0.9	0.7	1.4	0.5	0.5	0.7	0.1	-1.3	0.5	0.3	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.8	-0.0	-0.8	-1.3	-1.2	-1.2	-0.8	0.9	-0.5	1.4	-0.7	-0.4	-0.9
Smoking status: Current	0.5	0.8	5.3	-1.0	-2.3	-0.1	0.2	-0.6	-0.2	0.6	-0.8	-0.3	-0.8	-0.5	-0.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	3.2	0.2	0.3	1.1	1.0	0.7	0.8	1.8	0.6	-0.0	0.5	0.4	0.1
Fractured/broken bones in last 5 years	0.5	0.6	1.7	0.7	-0.5	0.9	0.4	0.7	0.7	1.3	0.9	0.0	0.7	0.9	0.9
Diastolic blood pressure, automated reading	0.5	1.4	6.7	1.4	0.7	-0.9	-2.0	-0.1	1.0	0.0	-1.0	2.6	0.3	-0.2	1.0
Supplements: Calcium	0.5	0.5	1.4	0.5	0.7	1.2	0.7	0.6	0.7	-0.5	0.5	-1.0	0.4	0.6	0.7
Depressed Affect (Nagel 2018)	0.4	0.8	3.7	1.1	1.0	0.4	-0.7	0.4	-0.1	0.6	0.5	1.9	0.5	0.7	1.3
Depression (Nagel 2018)	0.4	0.6	2.3	0.2	-0.8	-0.6	-1.5	-0.5	-1.2	-0.6	-0.6	1.0	-0.5	-0.1	0.9
Neuroticism (Nagel 2018)	0.4	1.0	5.8	0.8	0.1	-0.7	-1.8	-0.2	-0.8	-0.1	0.0	2.4	0.0	-0.0	1.0
HbA1C	0.4	0.4	2.2	-0.5	0.2	0.6	0.8	0.6	0.2	1.5	0.4	-0.9	-0.0	0.2	-0.0
HDL Cholesterol	0.4	0.6	1.6	1.2	0.5	0.9	0.3	0.8	0.6	0.3	0.6	0.6	1.0	0.9	1.2
Schizophrenia (2014)	0.4	1.0	4.1	0.3	-0.4	-1.0	-1.6	-0.9	-1.3	-2.0	-0.3	0.9	-0.5	-0.2	0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	3.3	1.0	0.7	0.0	-0.0	0.4	0.1	0.8	0.1	1.8	-0.1	0.1	-0.3
Ulcerative Colitis	0.4	0.6	1.4	1.0	0.6	0.7	0.5	0.9	0.7	0.3	0.8	1.2	0.8	0.5	1.0
Height	0.4	8.3	21.4	-3.6	-4.6	-1.9	-0.6	-2.4	-2.5	-0.1	-1.5	-3.7	-3.4	-2.7	-3.8
Waist Hip Ratio (WHR)	0.4	1.7	8.6	-2.1	-0.5	-0.6	0.1	-0.6	-0.1	-0.8	-1.4	-2.9	-0.6	-1.4	-1.3
Number of treatments/medications taken	0.4	0.8	4.2	-0.2	0.2	1.4	2.1	1.0	0.5	0.3	0.6	-1.3	0.0	0.3	-0.2
Diabetes (father)	0.4	0.4	2.1	-0.4	0.6	0.7	1.5	0.4	0.5	0.9	0.8	-0.5	0.2	0.1	-0.3
Trunk fat percentage	0.4	1.8	3.8	-1.8	-1.9	-0.7	0.1	-0.8	-1.4	-0.7	-1.2	-1.4	-1.2	-1.5	-2.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.1	-0.5	-0.7	-0.6	-0.2	-0.7	-0.3	-0.0	-1.1	-0.3	-0.9	-0.9	-0.5
Supplements: Glucosamine	0.4	0.5	3.2	-0.9	-0.3	-0.2	0.1	0.1	-0.5	-1.8	-0.2	-0.7	-0.3	-0.8	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.9	-0.7	-0.5	-1.1	-1.4	-0.7	-0.8	-0.3	-0.8	0.3	-0.7	-1.0	-0.5
Had menopause	0.4	0.5	2.2	-0.6	0.2	0.1	0.2	-0.0	-0.6	-1.5	-0.9	-1.0	-0.5	-0.6	0.2
Qualifications: None of the above	0.4	0.8	3.0	-0.3	0.4	0.5	1.4	0.8	1.4	1.7	-0.5	-0.4	0.9	-0.1	-0.2
Financial difficulties in last 2 years	0.4	0.5	2.3	0.8	0.7	0.3	-0.2	0.4	0.4	-0.1	0.4	1.5	0.9	0.7	1.1
Worrier / anxious feelings	0.4	0.7	3.3	0.3	-0.1	-1.1	-1.4	-0.7	-0.5	1.0	-0.5	1.8	-0.2	-0.6	-0.0
Number of live births	0.4	0.5	1.0	0.5	0.7	0.9	0.6	0.7	0.9	0.9	-0.1	-1.0	0.6	0.4	0.8
Mouth/teeth dental problems: Dentures	0.4	0.6	1.9	-0.9	-0.6	-0.1	0.5	-0.3	-0.0	1.4	-1.2	-1.1	-0.3	-0.5	-0.9
Medication: Cholesterol lowering	0.4	0.7	2.8	-0.9	-0.7	0.2	0.8	-0.3	0.7	1.7	0.2	-1.2	-0.2	-0.3	-1.0
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.9	0.3	0.6	-0.8	-1.1	-0.5	-1.2	-1.4	-0.3	1.2	-0.4	-0.2	0.6
Qualifications: College or University degree	0.4	1.2	4.9	1.5	1.0	0.2	-1.0	0.3	-0.0	-0.7	1.0	2.2	0.6	1.0	1.4
Medication: Allopurinol	0.4	0.5	1.1	-0.5	-1.0	-1.0	-0.9	-0.9	-0.7	-0.3	-0.7	-0.0	-0.7	-0.6	-0.8
Mood swings	0.4	0.7	4.4	0.3	0.4	-0.1	-0.5	0.1	0.5	2.1	-0.3	1.6	0.1	-0.2	0.4
Diabetes diagnosed by doctor	0.4	0.6	2.3	-0.0	1.4	0.9	1.5	0.9	0.6	0.3	-0.0	-0.5	0.7	0.3	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.5	1.1	0.0	0.3	-0.1	0.4	0.2	1.1	0.6	-0.1	0.5	1.2	0.7
Hearing aid user	0.4	0.5	1.8	-0.9	-1.1	0.1	0.9	-0.1	-0.2	-0.2	-0.5	-1.4	-0.3	-0.5	-0.6
Medication: Paracetamol	0.4	0.6	1.4	-0.6	-0.7	-0.7	-0.8	-1.0	-1.2	0.3	-0.9	-0.6	-1.0	-0.7	-0.8
Arm fat-free mass (left)	0.4	1.8	5.4	0.4	-2.3	-1.3	-1.9	-1.3	-2.0	-0.4	-0.3	1.8	-1.1	-0.5	-0.6
Number of operations (self-reported)	0.4	0.6	2.1	0.2	-0.3	-0.7	-1.4	-1.1	-1.1	0.0	-0.0	1.2	-0.7	-0.3	-0.4
Average weekly beer plus cider intake	0.4	0.6	3.9	0.2	0.3	-0.7	-0.9	-0.7	-0.9	-0.5	-0.5	2.0	-0.7	-0.4	0.2
Worry (Nagel 2018)	0.3	0.5	2.6	0.8	0.4	-0.4	-1.1	0.1	-0.5	-0.7	0.2	1.6	0.3	0.0	1.0
Major Depression (MDD)	0.3	0.3	1.1	-0.1	0.9	-0.5	-0.6	-0.6	-0.0	0.2	-0.7	1.1	-0.5	-0.4	0.0
Ovarian Cancer	0.3	0.4	1.8	0.0	-1.4	-0.4	-0.1	-0.3	0.1	1.2	-0.5	0.8	-0.1	-0.2	-0.2
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	-0.7	-0.3	-0.7	-0.8	-0.7	-0.8	0.6	-0.6	0.6	-0.8	-0.9	-0.0
Rheumatoid Arthritis	0.3	0.5	1.5	0.7	1.2	0.5	-0.1	0.6	-0.2	-1.0	1.0	0.3	0.4	0.4	0.8
Smoking Status	0.3	0.8	2.1	0.2	-1.1	1.2	1.3	0.9	1.0	1.4	0.7	-0.1	0.8	0.8	0.1
Respiratory disease	0.3	0.7	2.8	-0.9	-0.2	-0.4	-0.2	-1.1	-1.7	-0.7	-0.3	-0.7	-1.4	-0.6	-0.7
Chronotype (morning person)	0.3	0.6	2.4	0.7	1.0	0.3	0.0	0.6	0.3	0.3	0.8	-0.0	1.0	1.1	1.6
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.3	0.5	-0.5	-0.3	-0.9	-0.0	0.4	0.4	-0.3	1.5	0.3	0.2	0.6
Medication for hormone replacement therapy	0.3	0.4	1.9	0.1	0.5	0.9	0.7	0.4	0.4	1.4	0.3	-0.3	0.2	0.6	0.4
Medication: Co-codamol	0.3	0.3	1.5	-0.1	0.9	0.5	0.9	0.2	0.1	1.2	-0.2	-0.5	-0.2	0.2	0.3
Diabetes (mother)	0.3	0.4	1.5	-0.1	-1.1	-0.6	-0.5	-0.3	-0.0	1.2	-0.5	0.8	-0.1	0.0	-0.1
Stomach or abdominal pain in last month	0.3	0.4	1.3	-0.6	-0.9	-0.8	-0.7	-0.5	0.3	1.2	-0.3	0.4	-0.1	-0.4	-0.2
High blood pressure (mother)	0.3	0.4	1.1	0.9	0.4	0.1	-0.4	0.5	1.1	0.3	-0.3	0.9	1.0	0.4	0.4
Weight	0.3	1.3	3.6	-0.0	-1.9	-1.1	-1.4	-1.0	-1.7	-0.5	-0.3	1.5	-0.9	-0.7	-1.0
Trunk fat-free mass	0.3	1.5	5.2	0.8	-2.0	-0.9	-1.9	-1.0	-1.6	-0.3	0.2	2.3	-0.8	-0.1	-0.0
Alcohol intake versus 10 years previously	0.3	0.4	0.9	-0.6	0.8	-0.5	0.2	-0.5	-1.0	-0.5	-0.8	-0.8	-0.6	-0.9	-0.4
Depression (self-reported)	0.3	0.4	2.1	0.0	0.6	-0.3	-0.6	-0.3	-0.9	-1.4	-0.3	0.3	-0.2	-0.5	0.2
Trunk predicted mass	0.3	1.5	5.3	0.8	-1.9	-0.9	-1.9	-1.0	-1.6	-0.3	0.2	2.3	-0.7	-0.1	-0.0
Breastfed as a baby	0.3	0.4	2.2	-0.6	-1.5	-0.4	-0.0	-0.4	-0.8	-0.0	-0.8	-0.6	-0.7	-0.0	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.3	0.8	1.1	0.5	-0.0	0.6	0.4	0.5	0.8	0.7	0.8	0.7	0.6
Medication: Paracetamol	0.3	0.4	1.0	-0.6	-0.1	-0.4	-0.6	-0.7	-1.0	-0.1	-1.0	-0.5	-0.9	-0.7	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.2	-0.9	0.2	-0.1	0.4	-0.2	-0.0	-0.2	-0.7	-1.0	-0.3	-0.7	-1.1
Age at first live birth	0.3	0.6	3.1	-1.0	-1.1	-0.5	0.0	-0.6	0.3	0.3	-0.1	-0.8	-0.6	-0.6	-1.8
Health satisfaction	0.3	0.4	1.4	1.2	0.3	0.1	-0.6	0.3	-0.0	-0.5	0.6	1.0	0.6	0.6	0.6
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	-0.6	-0.9	-0.8	0.0	-0.5	-0.4	0.2	-0.8	-0.8	-0.6	-0.8	-0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	1.7	-0.3	-0.6	-1.3	-1.2	-0.8	-0.5	-0.9	-0.4	0.7	-0.5	-0.6	-0.0
Neck or shoulder pain in last month	0.3	0.4	0.8	0.8	-0.6	0.6	0.9	0.8	0.4	-0.1	0.6	-0.1	0.9	0.6	0.6
Medication: Seretide 50 evohaler	0.3	0.3	1.3	-1.1	-0.2	0.1	0.3	-0.0	-0.4	0.3	-0.4	-1.1	-0.6	-0.5	-0.6
Leg pain on walking	0.3	0.3	0.9	-0.3	-0.8	-0.7	-0.4	-0.6	-0.7	-0.3	-1.0	0.1	-0.5	-0.6	-0.6
Commuting to job workplace: Cycle	0.3	0.3	0.9	0.5	0.4	0.3	0.4	0.5	1.0	0.2	0.8	0.2	0.8	0.4	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	2.8	0.6	0.1	-0.0	-0.1	0.1	-0.4	1.7	0.3	0.9	-0.0	0.6	0.2
Arm predicted mass (left)	0.3	1.6	4.3	0.6	-2.0	-1.1	-1.9	-1.1	-1.8	-0.3	-0.2	2.1	-0.8	-0.3	-0.3
Bipolar Disorder (2018)	0.2	0.3	1.1	0.2	0.3	1.1	0.8	0.5	0.3	0.1	0.6	-0.6	-0.1	0.8	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	1.1	0.4	-0.4	-0.4	-0.6	-0.2	-0.4	-0.4	-1.0	0.6	-0.2	-0.0	0.5
Fasting Glucose	0.2	0.3	1.0	-0.5	0.3	0.4	0.1	0.1	-0.7	0.7	-0.5	-1.0	-0.5	-0.1	0.5
Allergy or Eczema	0.2	0.4	1.1	-1.1	-0.0	-0.5	-0.1	-0.6	-0.5	-0.5	-0.6	-0.8	-0.7	-0.7	-0.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.9	-0.6	-0.0	0.4	1.3	0.3	-0.2	0.2	-0.4	-1.4	0.0	-0.2	-0.5
Average weekly spirits intake	0.2	0.3	1.8	-0.3	-0.4	0.7	0.4	0.3	-0.4	-0.1	0.5	-1.3	0.0	0.5	0.0
Leg fat-free mass (left)	0.2	1.2	5.8	1.7	-0.9	0.1	-0.9	0.3	-0.6	-0.4	1.3	2.4	0.6	0.9	0.8
Average weekly fortified wine intake	0.2	0.3	0.8	0.4	-0.6	-0.7	-0.5	-0.6	-0.0	0.9	-0.4	0.9	-0.3	0.0	0.1
Medication: Atenolol	0.2	0.2	1.6	0.1	0.6	0.0	-0.4	-0.0	-0.3	-1.3	-0.3	-0.1	0.0	-0.3	-0.3
Leg predicted mass (left)	0.2	1.2	5.7	1.7	-1.0	0.0	-1.0	0.3	-0.6	-0.4	1.2	2.4	0.6	0.8	0.8
Past tobacco smoking	0.2	0.5	2.8	0.7	1.7	0.2	0.5	0.6	0.8	-0.5	0.1	0.5	0.5	0.3	0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.3	-0.3	-0.2	0.0	0.2	-0.5	-0.6	-1.2	-0.1	-0.7	-0.1	-0.4	-0.2
Pain all over the body in last month	0.2	0.3	0.9	-0.5	0.3	0.3	0.7	0.2	-0.2	0.2	-0.1	-0.8	-0.6	-0.0	-0.9
Diabetes (self-reported)	0.2	0.4	1.6	-0.1	1.0	0.7	1.3	0.6	0.4	0.2	-0.1	-0.6	0.4	0.3	0.1
Hip circumference	0.2	0.8	5.7	1.2	-0.9	-0.3	-0.8	-0.0	-0.7	0.1	0.4	2.4	0.2	0.1	-0.2
Father’s age at death	0.2	0.3	1.0	0.6	-0.6	0.1	0.1	-0.2	-1.0	-0.6	0.4	0.4	-0.4	0.5	0.9
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.2	-0.5	-1.5	-0.8	-0.3	-0.7	-0.6	0.2	-0.5	-0.2	-0.5	-0.8	-1.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.0	0.0	-0.0	0.1	0.6	0.2	0.4	-0.5	-0.3	-0.8	0.0	-0.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	2.5	-0.4	-1.6	-0.5	-0.3	-0.6	-0.4	0.5	-0.3	-0.2	-0.6	-0.6	-1.2
Medication: Amlodipine	0.2	0.2	1.0	-0.3	-0.2	0.2	0.6	0.4	1.0	0.6	0.0	-0.3	0.5	0.2	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.7	5.2	-0.4	-2.3	-0.1	0.0	-0.5	-0.6	0.6	0.1	-0.6	-0.7	-0.3	-0.8
Number of children fathered	0.2	0.2	0.8	0.4	-0.8	0.1	-0.2	0.2	0.5	0.9	0.0	0.3	-0.0	0.6	0.5
Had major operations	0.2	0.3	0.9	0.6	0.9	0.5	0.4	0.5	0.4	-0.5	0.5	-0.1	0.7	0.3	0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.9	-0.9	-0.5	-0.4	0.1	-0.2	0.3	0.3	-0.5	-0.9	0.1	-0.6	-0.5
Supplements: Vitamin C	0.2	0.2	1.9	0.2	1.4	0.0	-0.2	0.3	0.3	-0.4	-0.5	0.2	0.2	0.2	0.2
Whole body fat-free mass	0.2	1.3	5.8	1.2	-1.7	-0.6	-1.6	-0.5	-1.4	-0.4	0.6	2.4	-0.3	0.3	0.3
Leg fat-free mass (right)	0.2	1.3	6.2	1.9	-0.6	0.1	-1.0	0.4	-0.6	-0.4	1.4	2.5	0.7	1.0	0.8
Medication for cholesterol	0.2	0.2	0.9	-0.3	-0.6	-0.6	-0.7	-0.3	-0.5	-0.2	0.1	1.0	-0.0	-0.2	-0.2
Breast cancer (self-reported)	0.2	0.3	1.1	0.0	0.8	0.2	-0.1	0.0	-1.0	-1.1	0.0	0.1	-0.6	-0.0	0.1
Osteoporosis (self-reported)	0.2	0.3	1.7	0.0	1.3	0.0	-0.4	0.1	-0.5	-0.5	-0.6	-0.4	0.1	-0.1	0.7
Osteoarthritis (self-reported)	0.2	0.3	1.2	0.0	1.1	0.4	0.9	0.6	0.7	0.1	0.6	0.2	0.6	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.3	1.1	0.6	0.3	0.1	0.7	0.8	0.2	0.4	0.8	0.8	0.7	-0.0
Whole body water mass	0.2	1.3	6.1	1.3	-1.5	-0.6	-1.6	-0.5	-1.3	-0.4	0.6	2.5	-0.2	0.3	0.3
Leg predicted mass (right)	0.2	1.3	6.2	1.9	-0.6	0.1	-1.0	0.3	-0.6	-0.3	1.4	2.5	0.7	1.0	0.8
High cholesterol (Self-reported)	0.2	0.4	3.1	-0.2	-0.1	0.6	0.6	0.2	0.6	0.7	0.2	-1.8	-0.2	-0.0	-0.7
Alcohol drinker status: Never	0.2	0.2	1.5	-0.3	-0.2	-0.2	0.7	-0.1	-0.4	-0.1	0.0	0.0	-0.5	-0.3	-1.2
Basal metabolic rate	0.2	1.2	5.3	1.0	-1.7	-0.6	-1.4	-0.5	-1.3	-0.3	0.5	2.3	-0.3	0.1	-0.0
Irritability	0.2	0.3	1.3	0.3	0.2	0.4	0.2	0.7	0.4	0.2	1.1	0.1	0.8	0.5	0.8
Bipolar Disorder or Schizophrenia	0.1	0.1	0.8	0.2	-0.2	0.2	-0.2	-0.1	-0.3	-0.9	0.2	-0.5	-0.3	0.4	0.3
Schizophrenia (2018)	0.1	0.3	1.3	0.1	-0.5	-0.6	-0.9	-0.5	-0.7	-1.1	-0.2	-0.1	-0.3	-0.1	0.0
Breast Cancer	0.1	0.2	0.7	-0.2	-0.5	-0.4	-0.8	-0.8	-0.4	0.3	-0.1	0.2	-0.6	0.3	-0.4
Blood Platelet Count	0.1	1.6	5.3	-1.6	0.1	-0.5	0.2	-0.9	-1.4	-0.9	-2.1	-2.3	-1.0	-1.1	-1.2
Blood Red Count	0.1	1.0	6.5	-1.7	-0.2	-0.2	0.4	-0.5	-0.0	0.1	-0.6	-2.5	-0.7	-0.4	-1.1
Blood White Count	0.1	0.7	1.3	-0.6	0.0	-1.1	-1.1	-0.9	-1.0	-0.6	-0.7	0.3	-1.2	-1.0	-0.8
BMI	0.1	0.8	3.2	1.5	0.4	-0.1	-0.8	0.3	-0.5	-0.4	0.7	1.8	0.9	0.6	1.0
Lung FVC	0.1	0.4	0.9	-0.1	-0.5	-0.9	-0.9	-0.5	-0.5	-0.0	-0.8	0.4	-0.3	-0.6	-0.8
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	1.4	0.3	0.2	0.3	-0.3	0.1	-0.2	-1.2	-0.2	0.5	-0.0	-0.0	0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	-0.5	-0.3	-0.3	0.1	-0.4	-0.1	0.5	-0.4	0.2	-0.1	-0.1	-0.3
Maternal smoking around birth	0.1	0.2	0.9	0.3	1.0	0.3	0.1	0.4	-0.2	-0.1	0.3	0.4	0.1	0.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.6	0.1	-0.5	-0.0	-0.6	-0.0	-0.0	0.8	-0.0	0.7	0.1	0.2	0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.5	-0.3	0.7	0.1	0.2	0.0	-0.1	0.5	-0.6	-0.6	-0.4	-0.2	-0.1
Body mass index (BMI)	0.1	0.6	4.7	0.9	-0.1	-0.3	-0.7	0.0	-0.6	-0.1	0.3	2.2	0.4	0.2	0.0
Waist circumference	0.1	0.5	1.7	-0.2	-1.3	-0.7	-0.8	-0.6	-0.7	-0.0	-0.5	0.7	-0.3	-0.7	-0.9
Hearing difficulty/problems with background noise	0.1	0.2	0.8	-0.4	-0.9	-0.5	0.1	-0.0	0.3	-0.2	-0.4	-0.1	0.2	-0.2	-0.4
Had other major operations	0.1	0.1	0.2	0.3	0.0	0.4	-0.4	-0.3	-0.4	-0.5	-0.2	0.5	0.1	0.3	0.4
Forced vital capacity (FVC)	0.1	0.4	3.8	-0.1	-1.9	-0.1	0.1	-0.3	-0.6	0.4	0.1	-0.5	-0.4	-0.1	-0.6
Arm fat percentage (right)	0.1	0.2	0.9	-0.2	0.2	0.5	1.0	0.7	0.1	-0.0	0.3	0.1	0.4	-0.1	-0.7
Asthma	0.1	0.1	0.3	0.3	0.3	0.4	0.4	0.2	-0.1	-0.3	0.6	0.5	0.3	0.4	0.0
Arm fat mass (right)	0.1	0.3	0.8	-0.1	-0.9	-0.3	-0.2	-0.1	-0.7	-0.0	-0.1	0.9	-0.2	-0.4	-0.9
Headache pain in last month	0.1	0.2	0.7	0.4	0.6	-0.1	-0.8	-0.1	-0.1	-0.3	0.2	0.3	0.2	0.2	0.6
Exposure to tobacco smoke outside home	0.1	0.2	0.5	0.6	0.0	-0.2	-0.7	-0.1	0.0	0.5	-0.7	0.7	0.2	-0.1	0.5
Number of full brothers	0.1	0.1	0.6	0.0	-0.8	-0.0	-0.0	0.2	-0.4	-0.7	-0.2	0.5	0.2	0.0	0.4
Alcohol intake frequency.	0.1	0.3	1.6	0.0	0.8	0.1	0.2	-0.2	-1.3	-0.2	0.2	-0.5	-0.6	0.1	-0.1
Number of full sisters	0.1	0.2	1.0	-0.4	1.0	-0.2	-0.1	-0.3	-0.2	-0.0	-0.1	0.5	0.0	-0.4	0.4
Smoking status: Previous	0.1	0.1	0.6	-0.3	-0.5	0.2	-0.2	0.2	-0.3	0.6	0.5	-0.7	0.0	0.1	0.2
Back pain experienced in last month	0.1	0.1	0.5	-0.2	0.0	0.0	0.5	-0.1	0.2	-0.6	-0.7	0.4	0.1	-0.4	0.1
Asthma (self-reported)	0.1	0.3	0.8	0.6	0.3	0.7	0.5	0.4	0.1	-0.2	0.9	0.7	0.4	0.6	0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.6	0.2	-0.3	0.1	-0.6	0.3	0.0	0.0	0.5	0.3	0.3	0.4	0.8
Arm fat mass (left)	0.1	0.4	1.1	-0.3	-1.0	-0.4	-0.2	-0.2	-1.0	-0.4	-0.1	0.8	-0.3	-0.5	-0.9
Medication: Blood pressure	0.1	0.2	0.5	0.6	0.7	0.5	0.5	0.4	0.7	-0.2	0.2	-0.3	0.5	0.4	0.2
Medication: Lisinopril	0.1	0.1	0.4	-0.1	-0.4	0.1	-0.0	-0.1	-0.1	0.0	0.5	0.6	-0.4	-0.1	-0.1
Risk taking	0.1	0.2	0.5	-0.1	-0.2	0.4	-0.7	-0.1	-0.7	0.1	0.2	0.2	-0.6	0.1	0.7
Age started oral contraceptive pill	0.1	0.1	0.7	-0.0	-0.0	0.1	-0.0	0.5	-0.2	-0.6	0.1	-0.8	0.2	0.0	-0.2
Ever depressed for a whole week	0.1	0.1	0.3	0.1	-0.5	-0.2	-0.6	-0.3	-0.3	0.1	0.5	-0.1	-0.3	-0.0	0.2
Neuroticism (2016)	0.0	0.1	0.2	-0.1	-0.1	0.2	-0.5	0.3	-0.3	-0.3	0.2	0.4	-0.1	0.1	0.3
Hair Pigment	0.0	0.6	1.6	-0.8	0.9	1.1	1.2	0.1	-0.4	-0.5	-0.0	-1.3	-0.5	-0.1	0.0
Tanning	0.0	0.3	2.0	0.4	-0.0	-0.4	-1.4	-0.5	-0.7	-0.6	-0.6	0.0	-0.2	0.3	0.5
Arm fat percentage (left)	0.0	0.1	0.6	-0.4	-0.4	0.0	0.3	0.2	-0.4	-0.5	-0.1	0.2	0.0	-0.5	-0.8

Hub : Genes

PDLIM5

Models

Trait associations