[Hub]/) : Traits : Heel T-Score :

chr4:85,698,680-89,898,476

Best TWAS P=1.51e-58 · Best GWAS P=8.04e-68 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LOC100506746 0.05 0.01 bslmm 325 0.02 4.6e-04 -3.79 8.2 3.0e-16 -0.02 0.05 0.45 TRUE
2 CommonMind Brain Pre-frontal Cortex MEPE 0.15 0.05 bslmm 513 0.07 9.7e-09 -13.82 7.2 5.4e-13 0.11 1.00 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex PKD2 0.17 0.10 enet 15 0.16 2.1e-18 7.55 6.3 3.1e-10 0.35 1.00 0.00 FALSE
4 GTEx Adipose Subcutaneous RP13-514E23.2 0.09 0.03 enet 11 0.04 2.0e-04 11.51 9.0 1.6e-19 0.01 0.06 0.83 TRUE
5 GTEx Artery Aorta ARHGAP24 0.24 0.13 enet 8 0.14 2.2e-08 11.51 13.4 6.3e-41 0.04 0.01 0.99 TRUE
6 GTEx Artery Aorta RP13-514E23.2 0.26 0.09 lasso 6 0.10 2.2e-06 12.67 13.3 2.6e-40 0.04 0.00 1.00 FALSE
7 GTEx Artery Tibial ARHGAP24 0.26 0.19 enet 14 0.21 2.7e-16 12.67 13.1 2.2e-39 0.04 0.00 1.00 TRUE
8 GTEx Artery Tibial AFF1 0.10 0.06 lasso 5 0.06 2.4e-05 -8.97 -6.8 8.9e-12 -0.03 0.82 0.07 FALSE
9 GTEx Artery Tibial RP11-397E7.4 0.07 0.03 lasso 7 0.03 4.2e-03 5.89 -6.4 1.4e-10 0.02 0.38 0.20 FALSE
10 GTEx Artery Tibial RP13-514E23.2 0.22 0.16 enet 10 0.18 1.2e-13 12.67 13.4 5.6e-41 0.03 0.00 1.00 FALSE
11 GTEx Brain Cortex HSD17B13 0.28 0.23 enet 10 0.26 8.9e-08 3.20 5.2 2.6e-07 -0.01 0.44 0.06 TRUE
12 GTEx Breast Mammary Tissue HSD17B11 0.27 0.01 enet 40 0.03 8.1e-03 5.65 5.8 7.7e-09 0.29 0.07 0.44 FALSE
13 GTEx Breast Mammary Tissue RP11-529H2.2 0.22 0.07 enet 9 0.06 6.3e-04 5.65 5.4 7.4e-08 -0.03 0.38 0.03 FALSE
14 GTEx Breast Mammary Tissue (Female) HSD17B11 0.14 -0.01 lasso 2 0.01 2.1e-01 5.62 7.2 6.8e-13 -0.01 0.04 0.11 FALSE
15 GTEx Colon Sigmoid PPM1K 0.25 0.01 lasso 7 0.00 4.8e-01 13.27 9.5 1.5e-21 0.46 0.05 0.21 FALSE
16 GTEx Colon Sigmoid RP11-397E7.4 0.26 0.25 lasso 2 0.23 1.1e-08 6.39 -6.3 3.1e-10 0.03 0.86 0.07 FALSE
17 GTEx Colon Transverse RP11-397E7.4 0.07 0.05 lasso 7 0.02 2.6e-02 6.54 -8.5 2.3e-17 0.01 0.05 0.69 FALSE
18 GTEx Esophagus Gastroesophageal Junction RP11-397E7.4 0.17 0.01 lasso 10 0.02 7.0e-02 6.91 -8.5 1.4e-17 0.00 0.12 0.24 FALSE
19 GTEx Esophagus Muscularis HSD17B13 0.12 0.04 lasso 5 0.02 1.9e-02 -5.30 5.4 6.5e-08 -0.03 0.09 0.04 FALSE
20 GTEx Esophagus Muscularis AFF1 0.11 0.09 lasso 2 0.10 1.3e-06 5.64 -5.3 8.8e-08 -0.04 0.84 0.09 FALSE
21 GTEx Esophagus Muscularis HSD17B11 0.29 0.05 enet 66 0.07 6.9e-05 6.29 7.2 7.6e-13 0.01 0.65 0.03 TRUE
22 GTEx Esophagus Muscularis RP11-397E7.4 0.13 0.15 lasso 2 0.14 1.4e-08 6.39 -6.4 1.4e-10 0.02 0.98 0.01 FALSE
23 GTEx Heart Atrial Appendage SPP1 0.25 0.09 enet 24 0.10 3.6e-05 10.90 9.2 3.2e-20 0.22 0.99 0.00 FALSE
24 GTEx Lung RP11-397E7.4 0.11 0.04 enet 7 0.02 9.0e-03 6.54 -7.3 3.2e-13 -0.01 0.10 0.57 TRUE
25 GTEx Nerve Tibial MAPK10 0.08 0.01 enet 17 0.03 1.7e-03 0.26 -5.4 7.6e-08 0.00 0.40 0.03 TRUE
26 GTEx Nerve Tibial SPP1 0.15 0.08 lasso 3 0.08 2.4e-06 15.89 16.1 1.5e-58 0.82 0.03 0.96 TRUE
27 GTEx Nerve Tibial ARHGAP24 0.24 0.04 enet 47 0.07 5.6e-06 3.71 6.6 3.0e-11 -0.04 0.29 0.18 FALSE
28 GTEx Nerve Tibial HSD17B11 0.26 0.05 enet 16 0.09 4.9e-07 -0.90 5.6 2.5e-08 0.10 0.64 0.10 FALSE
29 GTEx Nerve Tibial RP13-514E23.2 0.17 0.00 lasso 6 0.00 1.9e-01 12.23 8.1 8.4e-16 0.07 0.05 0.28 TRUE
30 GTEx Ovary PTPN13 0.18 -0.01 enet 29 0.07 8.4e-03 0.23 -5.7 1.1e-08 0.02 0.05 0.55 FALSE
31 GTEx Prostate MAPK10 0.30 0.07 lasso 9 0.18 2.4e-05 -3.48 -6.5 7.5e-11 0.01 0.14 0.10 TRUE
32 GTEx Spleen RP11-397E7.4 0.31 0.19 lasso 10 0.18 1.7e-05 4.81 -7.3 2.5e-13 0.00 0.12 0.50 FALSE
33 GTEx Testis PKD2 0.45 0.48 lasso 6 0.47 2.1e-23 8.24 8.3 1.4e-16 0.22 1.00 0.00 FALSE
34 GTEx Testis C4orf36 0.21 0.15 lasso 4 0.14 6.6e-07 7.08 7.0 2.3e-12 0.03 0.58 0.40 FALSE
35 GTEx Thyroid HSD17B13 0.20 0.04 enet 37 0.14 1.4e-10 0.15 -5.8 6.0e-09 0.04 0.40 0.27 FALSE
36 GTEx Thyroid RP11-397E7.4 0.05 0.03 lasso 6 0.03 1.7e-03 6.54 -7.5 5.0e-14 0.01 0.28 0.32 FALSE
37 METSIM Adipose AFF1 0.06 0.05 lasso 11 0.06 8.1e-09 9.65 -10.8 3.8e-27 -0.03 0.01 0.99 TRUE
38 METSIM Adipose HSD17B13 0.20 0.10 bslmm 416 0.12 7.3e-18 -5.30 8.6 5.8e-18 -0.09 1.00 0.00 FALSE
39 NTR Blood PPM1K 0.02 0.00 blup 468 0.00 1.8e-02 5.98 -7.5 7.0e-14 -0.10 0.09 0.02 FALSE
40 NTR Blood SPP1 0.19 0.08 lasso 10 0.18 6.2e-56 -9.59 -5.7 1.4e-08 -0.30 1.00 0.00 TRUE
41 ROSMAP Brain Pre-frontal Cortex PKD2 0.11 0.09 lasso 13 0.11 3.3e-14 6.71 9.9 3.1e-23 0.28 1.00 0.00 TRUE
42 ROSMAP Brain Pre-frontal Cortex KLHL8 0.06 0.06 lasso 2 0.05 7.0e-07 -6.39 -5.8 5.4e-09 0.02 1.00 0.00 TRUE
43 ROSMAP Brain Pre-frontal Cortex MEPE 0.17 0.12 bslmm 496 0.12 1.1e-14 -13.82 11.6 4.3e-31 0.06 1.00 0.00 TRUE
44 The Cancer Genome Atlas Breast Invasive Carcinoma IBSP 0.05 0.05 lasso 6 0.07 1.2e-13 9.62 -13.4 6.0e-41 -0.08 1.00 0.00 TRUE
45 The Cancer Genome Atlas Breast Invasive Carcinoma SPP1 0.04 0.00 enet 11 0.01 3.3e-03 9.08 13.0 1.8e-38 0.74 0.01 0.83 FALSE
46 The Cancer Genome Atlas Colon Adenocarcinoma IBSP 0.09 0.02 enet 15 0.07 9.4e-05 8.93 -8.8 1.4e-18 0.03 0.06 0.05 TRUE
47 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IBSP 0.10 0.05 enet 8 0.09 1.5e-10 5.61 -12.0 4.4e-33 -0.24 1.00 0.00 TRUE
48 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MEPE 0.08 0.01 blup 87 0.05 2.3e-06 16.38 15.5 3.7e-54 0.47 0.25 0.46 TRUE
49 The Cancer Genome Atlas Brain Lower Grade Glioma IBSP 0.06 0.01 blup 78 0.03 8.2e-05 12.95 -10.9 8.7e-28 -0.24 0.19 0.05 FALSE
50 The Cancer Genome Atlas Lung Adenocarcinoma DMP1 0.05 0.04 enet 4 0.04 2.1e-05 6.43 -8.9 5.7e-19 0.15 0.04 0.92 FALSE
51 The Cancer Genome Atlas Lung Adenocarcinoma IBSP 0.06 0.01 blup 78 0.03 7.7e-05 9.62 -8.9 8.0e-19 0.08 0.33 0.03 TRUE
52 The Cancer Genome Atlas Lung Squamous Cell Carcinoma DMP1 0.09 0.04 blup 46 0.05 2.6e-06 6.90 -6.0 2.0e-09 -0.10 0.64 0.02 TRUE
53 The Cancer Genome Atlas Lung Squamous Cell Carcinoma IBSP 0.03 0.01 blup 78 0.03 2.8e-04 -12.09 -12.6 2.1e-36 -0.35 0.08 0.12 TRUE
54 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma IBSP 0.16 0.05 blup 76 0.08 3.6e-06 -10.92 -12.2 3.8e-34 -0.20 0.95 0.00 FALSE
55 The Cancer Genome Atlas Pancreatic Adenocarcinoma SPP1 0.14 0.03 blup 64 0.07 1.0e-03 16.04 8.8 1.1e-18 0.54 0.00 0.86 FALSE