[Hub]/) : Traits : Heel T-Score : ← →

chr4:85,698,680-89,898,476

Best TWAS P=1.51e-58 · Best GWAS P=8.04e-68 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LOC100506746	0.05	0.01	bslmm	325	0.02	4.6e-04	-3.79	8.2	3.0e-16	-0.02	0.05	0.45	TRUE
2	CommonMind	Brain Pre-frontal Cortex	MEPE	0.15	0.05	bslmm	513	0.07	9.7e-09	-13.82	7.2	5.4e-13	0.11	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PKD2	0.17	0.10	enet	15	0.16	2.1e-18	7.55	6.3	3.1e-10	0.35	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	RP13-514E23.2	0.09	0.03	enet	11	0.04	2.0e-04	11.51	9.0	1.6e-19	0.01	0.06	0.83	TRUE
5	GTEx	Artery Aorta	ARHGAP24	0.24	0.13	enet	8	0.14	2.2e-08	11.51	13.4	6.3e-41	0.04	0.01	0.99	TRUE
6	GTEx	Artery Aorta	RP13-514E23.2	0.26	0.09	lasso	6	0.10	2.2e-06	12.67	13.3	2.6e-40	0.04	0.00	1.00	FALSE
7	GTEx	Artery Tibial	ARHGAP24	0.26	0.19	enet	14	0.21	2.7e-16	12.67	13.1	2.2e-39	0.04	0.00	1.00	TRUE
8	GTEx	Artery Tibial	AFF1	0.10	0.06	lasso	5	0.06	2.4e-05	-8.97	-6.8	8.9e-12	-0.03	0.82	0.07	FALSE
9	GTEx	Artery Tibial	RP11-397E7.4	0.07	0.03	lasso	7	0.03	4.2e-03	5.89	-6.4	1.4e-10	0.02	0.38	0.20	FALSE
10	GTEx	Artery Tibial	RP13-514E23.2	0.22	0.16	enet	10	0.18	1.2e-13	12.67	13.4	5.6e-41	0.03	0.00	1.00	FALSE
11	GTEx	Brain Cortex	HSD17B13	0.28	0.23	enet	10	0.26	8.9e-08	3.20	5.2	2.6e-07	-0.01	0.44	0.06	TRUE
12	GTEx	Breast Mammary Tissue	HSD17B11	0.27	0.01	enet	40	0.03	8.1e-03	5.65	5.8	7.7e-09	0.29	0.07	0.44	FALSE
13	GTEx	Breast Mammary Tissue	RP11-529H2.2	0.22	0.07	enet	9	0.06	6.3e-04	5.65	5.4	7.4e-08	-0.03	0.38	0.03	FALSE
14	GTEx	Breast Mammary Tissue (Female)	HSD17B11	0.14	-0.01	lasso	2	0.01	2.1e-01	5.62	7.2	6.8e-13	-0.01	0.04	0.11	FALSE
15	GTEx	Colon Sigmoid	PPM1K	0.25	0.01	lasso	7	0.00	4.8e-01	13.27	9.5	1.5e-21	0.46	0.05	0.21	FALSE
16	GTEx	Colon Sigmoid	RP11-397E7.4	0.26	0.25	lasso	2	0.23	1.1e-08	6.39	-6.3	3.1e-10	0.03	0.86	0.07	FALSE
17	GTEx	Colon Transverse	RP11-397E7.4	0.07	0.05	lasso	7	0.02	2.6e-02	6.54	-8.5	2.3e-17	0.01	0.05	0.69	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	RP11-397E7.4	0.17	0.01	lasso	10	0.02	7.0e-02	6.91	-8.5	1.4e-17	0.00	0.12	0.24	FALSE
19	GTEx	Esophagus Muscularis	HSD17B13	0.12	0.04	lasso	5	0.02	1.9e-02	-5.30	5.4	6.5e-08	-0.03	0.09	0.04	FALSE
20	GTEx	Esophagus Muscularis	AFF1	0.11	0.09	lasso	2	0.10	1.3e-06	5.64	-5.3	8.8e-08	-0.04	0.84	0.09	FALSE
21	GTEx	Esophagus Muscularis	HSD17B11	0.29	0.05	enet	66	0.07	6.9e-05	6.29	7.2	7.6e-13	0.01	0.65	0.03	TRUE
22	GTEx	Esophagus Muscularis	RP11-397E7.4	0.13	0.15	lasso	2	0.14	1.4e-08	6.39	-6.4	1.4e-10	0.02	0.98	0.01	FALSE
23	GTEx	Heart Atrial Appendage	SPP1	0.25	0.09	enet	24	0.10	3.6e-05	10.90	9.2	3.2e-20	0.22	0.99	0.00	FALSE
24	GTEx	Lung	RP11-397E7.4	0.11	0.04	enet	7	0.02	9.0e-03	6.54	-7.3	3.2e-13	-0.01	0.10	0.57	TRUE
25	GTEx	Nerve Tibial	MAPK10	0.08	0.01	enet	17	0.03	1.7e-03	0.26	-5.4	7.6e-08	0.00	0.40	0.03	TRUE
26	GTEx	Nerve Tibial	SPP1	0.15	0.08	lasso	3	0.08	2.4e-06	15.89	16.1	1.5e-58	0.82	0.03	0.96	TRUE
27	GTEx	Nerve Tibial	ARHGAP24	0.24	0.04	enet	47	0.07	5.6e-06	3.71	6.6	3.0e-11	-0.04	0.29	0.18	FALSE
28	GTEx	Nerve Tibial	HSD17B11	0.26	0.05	enet	16	0.09	4.9e-07	-0.90	5.6	2.5e-08	0.10	0.64	0.10	FALSE
29	GTEx	Nerve Tibial	RP13-514E23.2	0.17	0.00	lasso	6	0.00	1.9e-01	12.23	8.1	8.4e-16	0.07	0.05	0.28	TRUE
30	GTEx	Ovary	PTPN13	0.18	-0.01	enet	29	0.07	8.4e-03	0.23	-5.7	1.1e-08	0.02	0.05	0.55	FALSE
31	GTEx	Prostate	MAPK10	0.30	0.07	lasso	9	0.18	2.4e-05	-3.48	-6.5	7.5e-11	0.01	0.14	0.10	TRUE
32	GTEx	Spleen	RP11-397E7.4	0.31	0.19	lasso	10	0.18	1.7e-05	4.81	-7.3	2.5e-13	0.00	0.12	0.50	FALSE
33	GTEx	Testis	PKD2	0.45	0.48	lasso	6	0.47	2.1e-23	8.24	8.3	1.4e-16	0.22	1.00	0.00	FALSE
34	GTEx	Testis	C4orf36	0.21	0.15	lasso	4	0.14	6.6e-07	7.08	7.0	2.3e-12	0.03	0.58	0.40	FALSE
35	GTEx	Thyroid	HSD17B13	0.20	0.04	enet	37	0.14	1.4e-10	0.15	-5.8	6.0e-09	0.04	0.40	0.27	FALSE
36	GTEx	Thyroid	RP11-397E7.4	0.05	0.03	lasso	6	0.03	1.7e-03	6.54	-7.5	5.0e-14	0.01	0.28	0.32	FALSE
37	METSIM	Adipose	AFF1	0.06	0.05	lasso	11	0.06	8.1e-09	9.65	-10.8	3.8e-27	-0.03	0.01	0.99	TRUE
38	METSIM	Adipose	HSD17B13	0.20	0.10	bslmm	416	0.12	7.3e-18	-5.30	8.6	5.8e-18	-0.09	1.00	0.00	FALSE
39	NTR	Blood	PPM1K	0.02	0.00	blup	468	0.00	1.8e-02	5.98	-7.5	7.0e-14	-0.10	0.09	0.02	FALSE
40	NTR	Blood	SPP1	0.19	0.08	lasso	10	0.18	6.2e-56	-9.59	-5.7	1.4e-08	-0.30	1.00	0.00	TRUE
41	ROSMAP	Brain Pre-frontal Cortex	PKD2	0.11	0.09	lasso	13	0.11	3.3e-14	6.71	9.9	3.1e-23	0.28	1.00	0.00	TRUE
42	ROSMAP	Brain Pre-frontal Cortex	KLHL8	0.06	0.06	lasso	2	0.05	7.0e-07	-6.39	-5.8	5.4e-09	0.02	1.00	0.00	TRUE
43	ROSMAP	Brain Pre-frontal Cortex	MEPE	0.17	0.12	bslmm	496	0.12	1.1e-14	-13.82	11.6	4.3e-31	0.06	1.00	0.00	TRUE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	IBSP	0.05	0.05	lasso	6	0.07	1.2e-13	9.62	-13.4	6.0e-41	-0.08	1.00	0.00	TRUE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	SPP1	0.04	0.00	enet	11	0.01	3.3e-03	9.08	13.0	1.8e-38	0.74	0.01	0.83	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	IBSP	0.09	0.02	enet	15	0.07	9.4e-05	8.93	-8.8	1.4e-18	0.03	0.06	0.05	TRUE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IBSP	0.10	0.05	enet	8	0.09	1.5e-10	5.61	-12.0	4.4e-33	-0.24	1.00	0.00	TRUE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MEPE	0.08	0.01	blup	87	0.05	2.3e-06	16.38	15.5	3.7e-54	0.47	0.25	0.46	TRUE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	IBSP	0.06	0.01	blup	78	0.03	8.2e-05	12.95	-10.9	8.7e-28	-0.24	0.19	0.05	FALSE
50	The Cancer Genome Atlas	Lung Adenocarcinoma	DMP1	0.05	0.04	enet	4	0.04	2.1e-05	6.43	-8.9	5.7e-19	0.15	0.04	0.92	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	IBSP	0.06	0.01	blup	78	0.03	7.7e-05	9.62	-8.9	8.0e-19	0.08	0.33	0.03	TRUE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DMP1	0.09	0.04	blup	46	0.05	2.6e-06	6.90	-6.0	2.0e-09	-0.10	0.64	0.02	TRUE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IBSP	0.03	0.01	blup	78	0.03	2.8e-04	-12.09	-12.6	2.1e-36	-0.35	0.08	0.12	TRUE
54	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IBSP	0.16	0.05	blup	76	0.08	3.6e-06	-10.92	-12.2	3.8e-34	-0.20	0.95	0.00	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SPP1	0.14	0.03	blup	64	0.07	1.0e-03	16.04	8.8	1.1e-18	0.54	0.00	0.86	FALSE