[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr2:97,098,095-99,306,504

Best TWAS P=2.06e-09 · Best GWAS P=1.17e-09 conditioned to 0.126

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Breast Mammary Tissue (Female)	ANKRD36B	0.13	0.10	lasso	3	0.14	7.7e-05	5.0	6.0	2.1e-09	0.91	0.00	0.96	TRUE
12	GTEx	Small Intestine Terminal Ileum	TMEM131	0.29	-0.01	enet	28	0.08	9.1e-03	-3.0	-5.8	6.8e-09	-0.53	0.03	0.37	FALSE
4	GTEx	Colon Sigmoid	ANKRD36B	0.35	0.18	lasso	3	0.21	5.7e-08	6.1	5.5	3.6e-08	0.95	0.00	1.00	FALSE
13	GTEx	Small Intestine Terminal Ileum	ANKRD36	0.22	0.03	enet	15	0.11	1.8e-03	3.4	-5.4	5.9e-08	-0.58	0.03	0.42	FALSE
15	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	COX5B	0.03	0.01	lasso	1	0.01	5.0e-02	5.4	-5.4	8.0e-08	-0.72	0.00	0.61	FALSE
9	GTEx	Nerve Tibial	COX5B	0.08	0.05	lasso	4	0.06	6.3e-05	5.1	5.3	1.1e-07	0.72	0.16	0.75	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM131	0.08	0.00	blup	72	0.01	5.4e-02	-1.4	-5.3	1.3e-07	-0.64	0.02	0.53	FALSE
10	GTEx	Pancreas	AC017099.3	0.17	0.19	lasso	5	0.16	2.7e-07	4.8	5.3	1.4e-07	0.80	0.02	0.98	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	ANKRD36B	0.29	0.34	lasso	5	0.33	1.7e-18	5.0	5.2	1.5e-07	0.79	0.26	0.73	FALSE
2	GTEx	Adipose Visceral Omentum	ANKRD36B	0.21	0.18	lasso	6	0.18	1.9e-09	5.0	5.2	1.6e-07	0.77	0.27	0.73	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZAP70	0.06	0.01	blup	38	0.00	2.1e-01	3.3	5.2	1.6e-07	0.76	0.02	0.19	FALSE
5	GTEx	Colon Transverse	AC017099.3	0.13	0.05	enet	6	0.06	7.6e-04	5.0	5.2	1.8e-07	0.78	0.12	0.76	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LOC100506123	0.10	0.11	lasso	5	0.10	1.1e-12	5.0	5.2	2.0e-07	0.74	0.23	0.76	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM131	0.06	0.01	enet	9	0.03	3.0e-06	-3.2	-5.2	2.1e-07	-0.70	0.04	0.91	FALSE
6	GTEx	Esophagus Mucosa	ANKRD36B	0.33	0.25	enet	21	0.25	7.9e-17	5.0	5.2	2.3e-07	0.77	0.27	0.72	FALSE
8	GTEx	Muscle Skeletal	AC159540.1	0.04	0.01	lasso	6	0.01	2.3e-02	4.0	5.2	2.4e-07	0.75	0.04	0.89	FALSE
7	GTEx	Muscle Skeletal	AC017099.3	0.15	0.07	lasso	9	0.10	1.3e-09	5.0	5.2	2.5e-07	0.79	0.11	0.89	FALSE
14	GTEx	Thyroid	ANKRD36	0.11	0.08	lasso	4	0.07	3.9e-06	5.0	-5.2	2.7e-07	-0.75	0.25	0.63	FALSE