Hub : Genes

COX5B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.0812 0.0350 0.00039 0.047 NA 0.050 NA 0.058 0.00028 NA 0.00018 NA 6.3e-05
2 TCGA Bladder Urothelial Carcinoma 0.0280 0.0230 0.00950 0.014 0.009 0.001 NA 0.009 0.02000 0.0510 0.27000 NA 5.0e-02
3 TCGA Cervical Squamous Cell Carcinoma 0.0580 0.0420 0.00760 0.009 0.019 0.025 NA 0.015 0.11000 0.0380 0.02200 NA 5.7e-02
4 TCGA Head and Neck Squamous Cell Carcinoma 0.0430 0.0344 0.00140 0.021 0.015 0.015 NA 0.016 0.00190 0.0075 0.00760 NA 5.3e-03
5 TCGA Lung Squamous Cell Carcinoma 0.0413 0.0284 0.00037 0.007 0.023 0.023 NA 0.020 0.04300 0.0010 0.00110 NA 2.4e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 2.8 4.4 7.6 2.8 -2.2 -0.4 -2.4 -1.9
Bipolar Disorder or Schizophrenia 0.9 2.3 5.5 2.0 -0.5 2.3 -0.6 1.2
Depressed Affect (Nagel 2018) 0.2 0.4 1.0 1.0 -0.5 0.4 -0.7 0.6
Depression (Nagel 2018) 0.6 0.9 2.0 1.4 -0.7 1.0 -0.6 0.8
Intelligence (Savage-Jansen 2018) 0.7 2.2 5.9 0.5 -1.0 -1.7 -0.9 -2.4
Neuroticism (Nagel 2018) 0.7 1.6 3.5 1.9 -1.3 0.2 -1.6 0.1
Schizophrenia (2018) 2.0 4.2 10.5 0.3 1.1 3.2 1.2 2.8
Schizophrenia vs Biploar Disorder 3.2 4.2 5.2 -2.2 2.3 1.1 2.3 2.1
Worry (Nagel 2018) 1.9 3.9 6.4 2.4 -2.5 -0.8 -2.5 -0.8
Alzheimer’s Disease (in mother) 0.5 0.5 1.3 -0.3 0.3 -1.1 -0.6 -0.9
Alzheimer’s Disease (in father) 1.3 1.4 2.4 0.7 -1.1 -1.4 -0.9 -1.6
Alzheimer’s Disease (including proxy) 0.8 1.2 3.0 -0.3 0.1 -1.7 -0.5 -1.6
Crohns Disease (2017) 0.7 1.5 2.1 -1.3 1.1 1.1 1.5 1.2
Irritable Bowel Disease (IBD) 1.8 4.3 7.0 -2.1 1.8 1.8 2.6 1.9
Ulcerative Colitis (UC) 1.4 2.6 5.2 -1.6 1.0 1.4 2.3 1.5
Major Depression (MDD) 3.3 4.0 8.2 2.9 -2.5 0.0 -2.4 -0.3
Reaction Time 0.8 1.4 2.5 -1.1 1.6 0.7 0.8 1.6
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.0 -1.0 0.7 0.7 1.4 0.5
Breast Cancer 0.9 2.2 4.5 -2.1 1.7 -0.1 1.7 0.7
Ovarian Cancer 2.0 2.6 5.4 -2.3 1.3 0.3 2.2 1.1
Prostate Cancer 0.2 0.3 1.0 0.6 -1.0 -0.4 -0.3 0.0
Age at First Birth 0.1 0.1 0.3 -0.5 0.3 -0.1 0.5 -0.3
Bipolar Disorder (2011) 0.5 0.5 1.0 0.9 -0.5 1.0 -0.2 0.5
Body Mass Index (BMI) (2010) 0.3 0.5 1.3 0.9 -0.2 -0.5 -1.1 -0.2
Coronary Artery Disease (CAD) 0.3 0.3 0.8 0.9 -0.5 0.6 -0.4 0.0
Crohns Disease (2012) 1.3 2.1 3.3 -1.3 1.4 1.4 1.4 1.8
Mean Putamen Volume 5.4 6.2 8.1 2.7 -2.5 -1.6 -2.6 -2.9
Fasting Glucose 1.8 2.1 3.4 -0.9 1.6 1.6 1.1 1.9
HbA1C 0.3 0.3 0.9 -0.7 0.2 0.2 0.9 0.3
HDL Cholesterol 1.6 2.6 4.5 -2.0 1.5 0.9 2.1 1.3
LDL Cholesterol 0.2 0.4 0.7 -0.5 0.8 0.5 0.7 0.4
Lupus 2.6 3.9 6.9 2.6 -2.5 -0.8 -2.1 -1.1
Neuroticism (2016) 0.3 0.4 0.9 0.9 -0.5 0.4 -0.8 0.2
Primary Biliary Cirrhosis 1.1 1.5 3.3 1.8 -1.7 0.6 -1.0 -0.3
Rheumatoid Arthritis 5.5 7.5 11.0 2.7 -3.3 -2.0 -3.0 -2.5
Schizophrenia (2014) 1.1 2.4 6.7 1.8 -0.4 2.6 -0.4 1.4
Triglycerides 0.2 0.3 0.7 0.2 -0.1 -0.8 -0.4 -0.7
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.1 1.0 -1.0 0.6 -0.4 0.0
Ulcerative Colitis 1.5 2.2 3.2 -1.3 1.2 1.4 1.8 1.7
Blood Eosinophil Count 0.3 2.2 4.5 0.9 -1.9 -2.1 -1.5 0.1
Blood Platelet Count 0.0 0.2 0.3 0.2 -0.2 -0.6 -0.6 0.3
Blood Red Count 0.2 2.3 5.3 2.3 -1.6 0.1 -1.6 -1.0
Blood White Count 0.5 4.0 8.2 2.9 -2.5 0.8 -2.2 -0.2
Heel T-Score 0.1 1.0 1.9 1.2 -1.4 0.4 -1.1 -0.0
BMI 1.4 8.0 21.0 1.5 -0.3 4.1 0.3 4.6
Height 0.3 6.6 12.4 2.1 -2.3 -2.0 -2.6 -3.5
Waist Hip Ratio (WHR) 0.2 1.0 2.1 0.4 -0.6 -1.5 -0.8 -1.2
Systolic Blood Pressure 0.5 2.7 5.3 -0.7 1.0 2.3 1.6 2.1
Smoking Status 2.6 6.1 9.1 -3.0 3.0 0.7 2.5 2.5
Allergy or Eczema 0.2 0.7 1.7 -0.1 -0.2 -1.3 -0.4 -1.1
Cardiovascular Disease 2.0 6.5 12.0 -1.3 2.1 2.8 2.5 3.5
Hypothyroidism (self reported) 8.0 18.4 28.8 5.3 -5.4 -1.6 -4.9 -2.9
Respiratory disease 0.5 1.2 3.5 1.9 -1.1 0.9 -0.6 0.2
Type 2 Diabetes (T2D) (2018) 1.0 1.8 3.3 -0.7 1.0 1.6 1.3 1.8
Lung FEV1/FVC ratio 0.3 1.6 3.8 -1.9 1.0 -1.5 0.8 -0.6
Lung FVC 0.0 0.2 0.3 0.4 -0.6 -0.4 -0.3 -0.2
Neuroticism 1.9 4.5 8.5 2.9 -2.5 -0.4 -2.7 -0.6
Chronotype (morning person) 0.6 1.4 3.3 1.4 -1.8 -0.1 -1.1 -0.7
Hair Pigment 0.0 0.8 1.5 0.7 -1.1 -0.8 -1.2 0.1
Tanning 0.1 0.9 1.8 1.3 -0.9 1.2 -0.7 0.5
Hand grip strength (left) 0.1 0.1 0.4 0.2 -0.3 0.6 0.4 0.3
Number of treatments/medications taken 0.2 0.4 0.9 1.0 -0.5 0.5 -0.6 0.4
Average weekly spirits intake 0.9 1.1 1.8 -1.1 1.0 0.5 1.0 1.4
Sensitivity / hurt feelings 0.9 1.5 3.2 1.8 -0.9 1.4 -1.1 0.8
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.7 0.8 -0.6 0.1 -0.4 0.2
Hearing difficulty/problems: Yes 0.3 0.4 1.2 0.3 -0.1 0.9 0.1 1.1
Relative age of first facial hair 0.4 0.7 1.9 -1.4 0.6 -0.8 0.9 -0.3
Other serious medical condition/disability diagnosed by doctor 2.9 3.8 5.8 2.4 -2.4 -0.8 -2.2 -1.5
Ever used hormone-replacement therapy (HRT) 0.5 0.7 1.8 -0.6 0.7 0.7 0.5 1.3
Ever had hysterectomy (womb removed) 1.1 1.2 2.4 1.6 -1.1 -0.2 -1.4 -0.6
Systolic blood pressure, automated reading 1.3 3.7 7.0 -0.9 1.4 2.6 1.8 2.3
Eye problems/disorders: Diabetes related eye disease 1.1 1.2 2.9 1.7 -1.1 0.7 -1.1 0.1
Angina 0.1 0.1 0.3 -0.0 0.2 -0.5 -0.2 -0.1
Medication for hormone replacement therapy 0.5 0.6 1.4 0.1 -0.0 1.1 0.2 1.2
Vitamin and mineral supplements 0.8 1.1 3.1 0.8 -0.1 1.8 0.1 1.2
Supplements: Zinc 0.1 0.1 0.2 -0.4 0.4 0.1 -0.1 0.0
Medication: Co-codamol 1.3 1.5 2.7 1.3 -1.2 1.6 -0.1 1.4
Medication: Metformin 0.4 0.6 0.8 -0.7 0.6 0.7 0.9 0.8
Diabetes (father) 0.1 0.1 0.3 0.1 -0.4 0.5 0.3 -0.0
Diabetes (mother) 1.7 2.2 4.2 1.7 -2.1 -0.8 -1.6 -0.6
Severe depression (siblings) 1.8 2.1 4.0 1.6 -2.0 -0.5 -1.7 -0.8
Pack years adult smoking proportion 0.4 0.5 1.3 0.6 0.2 1.0 -0.2 1.1
Impedance of leg (right) 0.3 1.2 2.7 -1.0 0.5 -1.6 0.1 -1.5
Leg fat-free mass (left) 0.5 2.9 6.6 1.1 -0.4 2.6 0.2 2.5
Trunk fat percentage 0.3 1.2 3.3 -0.0 0.3 1.5 0.5 1.8
Hand grip strength (right) 0.2 0.4 1.2 -0.9 0.4 -0.0 1.1 -0.1
Townsend deprivation index at recruitment 1.5 2.2 4.1 2.0 -1.6 -0.4 -1.8 -0.8
Current tobacco smoking 0.0 0.1 0.2 0.3 -0.1 0.0 -0.3 0.4
Average weekly fortified wine intake 2.1 2.5 4.2 2.0 -1.9 -0.4 -1.8 -1.1
Maternal smoking around birth 0.9 1.4 3.6 0.7 0.3 1.9 -0.1 1.6
Fed-up feelings 0.5 0.9 2.6 0.8 0.1 0.8 -0.8 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.4 0.6 -0.4 0.3 -0.4 0.4
Relative age voice broke 1.0 1.6 3.9 -2.0 1.4 -0.4 1.3 0.2
Taking other prescription medications 1.5 2.4 5.1 2.3 -1.7 1.0 -1.5 0.7
Age when periods started (menarche) 0.6 1.5 3.5 -1.9 0.8 -0.8 1.5 -0.3
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.6 0.7 -0.7 -0.9 -1.3 -0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.6 0.2 -0.8 -0.7 -0.6 0.1
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 0.8 -0.0 0.8 -0.3 -0.1
Qualifications: CSEs or equivalent 2.1 2.8 7.1 0.7 -0.3 2.7 0.7 2.4
Serious illness, injury or assault to yourself 2.6 3.1 6.9 2.6 -2.2 -0.1 -1.9 -0.8
High blood pressure 1.4 3.9 8.0 -1.2 1.5 2.0 1.9 2.8
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.3 -0.4 0.5 0.4 0.6 0.3
Multivitamins +/- minerals 0.9 1.2 3.1 -0.4 -0.3 -1.7 -0.5 -1.5
Stomach or abdominal pain in last month 0.3 0.3 0.6 0.6 -0.8 0.0 -0.8 -0.4
Supplements: Glucosamine 0.1 0.1 0.3 -0.0 0.3 -0.2 -0.0 -0.5
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.2 1.1 -1.1 -0.1 -0.8 -1.0
Medication: Atenolol 0.0 0.0 0.1 0.1 0.2 -0.0 -0.2 0.4
Medication: Levothyroxine sodium 4.1 6.9 13.9 3.0 -3.7 -1.4 -2.7 -1.7
Sitting height 0.0 0.3 0.7 -0.8 0.8 -0.1 0.5 0.2
Chronic bronchitis/emphysema (father) 1.3 1.5 2.6 1.6 -1.4 -0.3 -1.6 -0.5
High blood pressure (mother) 0.5 0.8 1.1 -0.9 0.7 0.5 1.1 1.0
Body mass index (BMI) 1.0 4.1 11.2 1.1 -0.3 2.9 0.2 3.3
Impedance of leg (left) 0.5 2.6 5.7 -1.7 1.0 -2.4 0.3 -1.9
Leg predicted mass (left) 0.5 2.9 6.5 1.1 -0.4 2.5 0.2 2.5
Trunk fat mass 0.5 2.0 5.4 0.2 0.2 2.0 0.6 2.3
Waist circumference 0.8 2.8 7.0 1.1 -0.5 2.4 0.0 2.6
Number of incorrect matches in round 0.5 0.9 2.6 -1.0 0.6 -1.6 -0.2 -0.7
Past tobacco smoking 2.8 5.1 9.6 3.1 -2.5 -0.4 -2.3 -2.0
Alcohol usually taken with meals 1.2 1.9 4.6 0.2 -1.2 -1.8 -0.5 -2.1
Nervous feelings 1.1 2.1 4.0 1.9 -2.0 -0.3 -1.6 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.4 -0.9 0.7 1.1 1.1 1.5
Hearing difficulty/problems with background noise 0.1 0.1 0.4 0.6 -0.2 0.6 -0.1 0.1
Hair/balding pattern: Pattern 2 0.6 0.7 1.0 -0.6 0.9 1.0 0.9 0.8
Had menopause 1.6 2.0 3.9 1.1 -1.2 -1.2 -1.2 -2.0
Had other major operations 0.1 0.1 0.5 0.3 -0.2 0.1 -0.7 -0.1
Forced vital capacity (FVC) 0.3 1.2 1.5 0.8 -1.2 -1.1 -1.1 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 3.9 1.6 -1.8 -1.1 -2.0 -0.5
Ever unenthusiastic/disinterested for a whole week 4.3 5.3 8.2 2.0 -2.4 -2.0 -2.1 -2.9
Qualifications: None of the above 0.8 1.8 3.6 -0.1 1.3 1.9 0.7 1.7
Financial difficulties in last 2 years 1.2 1.7 3.0 -0.7 0.9 1.6 1.2 1.7
Mouth/teeth dental problems 1.4 2.1 4.3 -2.1 1.6 -0.2 1.9 -0.2
Heart attack 0.3 0.4 0.9 0.1 0.5 -0.8 -1.0 -0.0
Allergy 0.4 1.0 2.8 -0.1 -0.6 -1.7 -0.7 -1.3
Pain all over the body in last month 0.2 0.2 0.4 0.7 -0.7 0.2 -0.4 0.3
Diabetes (self-reported) 0.3 0.4 1.0 -0.2 0.2 0.9 0.6 1.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 0.7 -0.3 0.5 0.8 0.8 0.5
Medication: Ramipril 0.3 0.3 0.6 0.5 -0.6 -0.8 -0.6 -0.2
Medication: Simvastatin 0.2 0.3 1.1 -0.4 0.1 -1.1 -0.4 -0.3
Fluid intelligence score 0.2 0.5 1.5 -1.2 0.4 -0.2 0.8 -0.3
Illnesses of siblings 0.8 1.1 2.5 0.4 0.3 1.6 0.4 1.6
Neuroticism score 0.6 1.3 2.7 1.6 -1.2 0.2 -1.5 0.3
Weight 0.6 3.0 7.8 0.8 -0.3 2.5 0.4 2.8
Impedance of arm (right) 0.7 3.1 6.7 -1.8 1.1 -2.1 0.7 -2.6
Arm fat percentage (right) 0.4 1.7 4.1 0.9 -0.4 1.9 -0.0 2.0
Trunk fat-free mass 0.4 2.1 4.0 1.4 -0.9 2.0 -0.2 2.0
Hip circumference 0.9 3.7 9.5 0.7 -0.2 2.9 0.6 3.1
Time employed in main current job 0.3 0.4 1.0 0.8 0.1 1.0 -0.0 0.5
Alcohol intake versus 10 years previously 0.7 1.0 1.7 1.1 -0.6 1.2 -0.3 1.3
Father’s age at death 0.2 0.3 0.8 -0.5 -0.3 0.4 0.9 0.1
Worrier / anxious feelings 1.0 1.9 3.7 1.6 -1.1 -0.8 -1.9 -1.2
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.8 0.7 -0.3 0.9 -0.1 0.6
Falls in the last year 1.3 1.7 5.3 1.5 -0.3 2.3 0.0 1.0
Hair/balding pattern: Pattern 3 0.0 0.0 0.0 0.0 -0.2 -0.2 -0.1 -0.1
Number of live births 0.8 1.1 2.1 1.0 -1.2 -0.6 -1.4 -0.8
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 0.6 0.3 -0.7 -0.8 -0.5 -0.7
Pulse rate 2.3 3.9 8.3 -0.4 1.1 2.9 1.6 2.7
Happiness 3.9 4.7 6.9 1.9 -1.9 -2.2 -2.1 -2.6
Noisy workplace 1.3 1.6 2.4 1.5 -1.5 -1.1 -1.1 -0.9
Qualifications: A levels/AS levels or equivalent 0.7 1.6 3.6 0.3 -1.0 -1.7 -0.5 -1.9
Serious illness, injury or assault of a close relative in last 2 years 1.4 1.6 3.8 0.9 -2.0 -1.1 -1.0 -0.9
Mouth/teeth dental problems: Dentures 0.8 1.4 3.0 1.7 -1.2 0.4 -1.5 0.3
Asthma 0.8 1.6 3.6 1.7 -0.9 1.9 -0.4 0.7
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.3 -1.1 1.0 0.2 0.7 0.7
Medication: Cholesterol lowering 0.1 0.2 0.6 -0.5 0.3 -0.8 0.1 0.2
Depression (self-reported) 0.4 0.4 0.7 0.8 -0.9 -0.3 -0.8 -0.4
Medication: Lansoprazole 0.6 0.7 1.5 -1.1 1.2 -0.4 0.2 0.9
Prospective memory result 0.2 0.2 0.5 0.7 -0.7 -0.0 -0.3 0.2
Lung cancer (father) 0.0 0.0 0.0 -0.1 -0.0 0.0 0.2 0.0
Illnesses of mother 0.2 0.3 0.7 -0.2 0.3 -0.7 -0.3 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.7 -0.6 -0.0 -0.8 0.1 -0.7
Pulse wave Arterial Stiffness index 1.9 2.2 2.8 -1.1 1.7 1.5 1.5 1.6
Impedance of arm (left) 0.7 3.1 6.1 -1.9 1.0 -2.0 0.9 -2.5
Arm fat mass (right) 0.7 2.7 7.0 1.0 -0.5 2.3 0.0 2.6
Trunk predicted mass 0.4 2.2 4.2 1.3 -0.8 2.0 -0.2 2.1
Standing height 0.0 0.3 0.6 -0.5 0.1 -0.5 0.3 -0.7
Length of working week for main job 0.4 0.5 0.8 -0.6 0.9 0.6 0.5 0.9
Exposure to tobacco smoke at home 0.2 0.3 0.9 -0.1 0.0 0.6 0.1 1.0
Breastfed as a baby 0.6 0.8 1.6 -1.0 0.7 0.7 1.3 0.6
Tense / ‘highly strung’ 0.4 0.7 1.2 1.1 -1.0 0.5 -0.7 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.2 3.4 6.6 2.6 -2.3 -0.1 -2.1 -0.3
Hair/balding pattern: Pattern 4 0.6 1.4 2.5 1.2 -1.6 -0.7 -1.4 -0.7
Birth weight of first child 0.9 1.6 3.1 1.4 -1.8 -0.6 -1.5 -0.6
Peak expiratory flow (PEF) 0.4 1.0 1.9 0.4 -1.4 -1.3 -0.9 -0.8
Pulse wave reflection index 1.3 1.6 3.3 -1.8 1.5 -0.1 1.2 0.9
Ever highly irritable/argumentative for 2 days 1.3 1.5 4.4 -0.6 0.1 -2.1 -0.4 -1.7
Loud music exposure frequency 0.4 0.4 1.9 0.1 -0.1 -0.5 -0.0 -1.4
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.7 -1.7 0.8 -0.8 1.1 -0.4
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 0.7 0.9 -0.6 0.7 -0.2 0.6
Blood clot in the leg (DVT) 0.4 0.5 1.1 -0.2 0.5 1.1 0.8 0.6
Medication: Paracetamol 0.3 0.5 1.1 0.1 0.5 1.0 -0.1 1.0
Headache pain in last month 0.2 0.3 0.4 0.6 -0.6 -0.2 -0.6 -0.4
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.2 -0.0 0.1 1.1 0.5 0.1
Glaucoma (self-reported) 0.8 0.9 1.6 0.7 -1.2 -0.8 -1.2 -0.7
Gout (self-reported) 0.0 0.0 0.0 -0.2 -0.2 0.0 0.1 0.1
Hypothyroidism/myxoedema (self-reported) 5.6 10.9 17.9 3.8 -4.2 -1.7 -3.7 -2.4
Medication: Amlodipine 0.9 1.2 2.4 -0.8 1.5 0.7 0.7 1.6
Medication: Ventolin 100micrograms inhaler 0.8 1.1 2.1 -0.2 0.8 1.5 0.9 1.3
Birth weight 0.5 1.2 3.0 -1.7 0.5 -0.9 1.3 -0.2
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.6 -0.0 0.3 0.8 0.0 0.7
High blood pressure (siblings) 1.3 1.9 4.8 -0.4 -0.4 -2.2 -0.6 -2.0
Forced vital capacity (FVC), Best measure 0.1 0.2 0.5 0.0 -0.3 -0.7 -0.4 -0.7
Body fat percentage 0.4 1.4 4.2 0.3 0.0 1.6 0.3 2.0
Leg fat percentage (right) 0.7 2.5 6.9 0.8 -0.4 2.2 0.3 2.6
Arm fat-free mass (right) 0.6 3.0 7.5 1.2 -0.6 2.4 0.1 2.7
Exposure to tobacco smoke outside home 0.4 0.5 1.6 0.4 -0.1 0.9 -0.3 1.3
Comparative body size at age 10 0.2 0.5 1.1 -0.0 0.2 1.1 0.7 0.7
Number of full brothers 1.5 1.9 2.9 0.8 -1.2 -1.7 -1.2 -1.7
Worry too long after embarrassment 0.8 1.4 2.1 0.9 -1.0 -1.1 -1.4 -1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 2.3 3.0 5.6 2.1 -2.0 -0.8 -2.4 -0.6
Wheeze or whistling in the chest in last year 0.4 0.7 1.4 -0.4 0.3 1.2 1.0 1.0
Number of children fathered 0.2 0.2 0.5 0.5 -0.3 0.3 -0.2 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.9 -0.1 0.1 -0.9 0.1 -0.5
Age at first live birth 0.6 1.0 2.4 -1.6 0.7 -1.2 0.7 -0.5
Pulse wave peak to peak time 2.1 2.4 2.9 1.1 -1.7 -1.7 -1.6 -1.7
Health satisfaction 0.9 1.2 1.4 1.1 -1.0 -1.1 -1.2 -1.2
Shortness of breath walking on level ground 0.3 0.4 0.6 0.5 -0.8 -0.6 -0.6 -0.5
Qualifications: College or University degree 1.5 4.7 11.2 -0.2 -0.9 -3.2 -1.0 -3.3
Eye problems/disorders: None of the above 1.0 1.2 2.3 0.9 -1.0 -1.2 -0.5 -1.5
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.6 0.8 0.2 0.9 -0.8 1.2
Emphysema/chronic bronchitis 0.9 1.0 2.2 0.5 0.1 1.5 0.4 1.5
Medication for pain relief, constipation, heartburn 0.3 0.5 1.0 0.8 -1.0 -0.3 -0.4 -0.7
Neck or shoulder pain in last month 0.0 0.0 0.1 0.1 -0.1 0.1 -0.4 0.2
Medication: Blood pressure 0.2 0.3 0.8 -0.4 0.5 -0.4 -0.1 0.9
Angina (self-reported) 0.2 0.2 0.6 0.2 -0.1 -0.8 -0.5 -0.4
Migraine (self-reported) 0.1 0.1 0.2 0.2 -0.1 -0.1 -0.4 -0.4
Medication: Ibuprofen 0.3 0.4 0.8 -0.9 0.9 0.0 0.4 0.4
Medication: Allopurinol 0.2 0.2 0.6 0.6 -0.2 0.8 -0.2 0.4
Medication: Omeprazole 0.8 1.0 2.1 1.3 -1.4 -0.0 -0.9 -0.7
Medication: Seretide 50 evohaler 1.0 1.1 3.4 0.1 0.4 1.8 0.7 1.2
Mean time to correctly identify matches 0.6 1.2 2.5 -0.8 1.3 0.9 0.7 1.6
Heart disease (mother) 1.8 2.2 2.7 1.6 -1.5 -1.1 -1.5 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.7 1.6 -1.5 0.3 -1.1 -0.2
Whole body fat mass 0.6 2.5 7.1 0.6 -0.0 2.3 0.4 2.7
Leg fat mass (right) 1.0 3.7 10.2 0.7 -0.0 2.8 0.5 3.2
Arm predicted mass (right) 0.5 2.6 6.2 1.2 -0.7 2.2 -0.0 2.5
Pulse rate, automated reading 1.2 4.0 5.8 -1.6 2.4 1.6 1.8 2.4
Alcohol intake frequency. 1.8 4.2 10.9 3.3 -2.1 1.2 -1.8 -0.9
Comparative height size at age 10 0.1 0.4 0.8 0.4 -0.1 -0.8 -0.6 -0.9
Number of full sisters 0.6 0.8 2.0 -1.0 1.4 0.3 0.6 0.7
Suffer from ‘nerves’ 3.7 5.8 9.7 3.0 -2.8 -1.0 -3.1 -1.2
Overall health rating 1.2 2.6 5.9 2.4 -1.3 1.4 -1.5 1.1
Chest pain or discomfort 0.1 0.2 0.3 0.3 -0.5 0.5 0.4 0.4
Had major operations 0.3 0.4 1.0 -0.1 -0.6 -1.0 -0.5 -0.4
Age at last live birth 0.7 1.0 2.9 -0.7 -0.1 -1.7 0.0 -1.4
Family relationship satisfaction 1.3 1.6 3.9 -0.0 -0.7 -2.0 -0.3 -1.9
Leg pain on walking 0.4 0.6 1.8 -0.3 0.1 0.7 0.6 1.4
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.5 3.8 1.2 -0.5 2.0 -0.1 1.3
Commuting to job workplace: Car/motor vehicle 1.9 2.2 3.1 -1.4 1.6 0.9 1.6 1.8
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.4 -0.5 0.3 -1.2 -0.5 -0.8
Medication: Aspirin 0.6 0.8 1.5 -1.1 0.8 -1.2 0.3 -0.5
Supplements: Vitamin C 0.4 0.4 0.7 0.4 -0.5 -0.9 -0.8 -0.7
Knee pain experienced in last month 0.7 1.1 2.0 1.3 -0.4 1.4 -0.4 1.4
Hypertension (Self-reported) 1.6 4.4 7.3 -1.7 1.9 1.9 2.2 2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.6 0.3 0.1 -0.3 -0.8 0.0
Illnesses of father: Heart disease 0.5 0.6 1.5 1.2 -0.5 0.7 -0.8 0.5
Illnesses of siblings: Diabetes 0.6 0.7 1.8 0.2 -0.4 -1.0 -0.7 -1.3
Smoking status: Previous 3.3 4.9 9.7 -3.1 2.6 0.3 2.6 1.4
Forced expiratory volume in 1-second (FEV1), predicted 1.3 2.8 5.1 0.7 -1.3 -2.1 -1.5 -2.3
Whole body fat-free mass 0.5 2.6 5.8 1.2 -0.6 2.3 0.0 2.4
Leg fat-free mass (right) 0.4 2.0 4.7 0.8 -0.2 2.1 0.3 2.2
Arm fat percentage (left) 0.5 2.1 5.6 0.5 -0.1 2.1 0.5 2.4
Average weekly red wine intake 1.0 1.5 4.1 -2.0 1.0 -1.0 1.1 -0.0
Handedness (chirality/laterality): Left-handed 0.3 0.4 1.0 0.7 -0.6 1.0 0.2 0.2
Mood swings 0.3 0.5 1.3 1.0 -0.2 0.2 -1.1 0.4
Loneliness, isolation 0.2 0.3 0.5 0.6 -0.7 0.5 -0.2 0.4
Long-standing illness, disability or infirmity 1.6 2.4 4.5 2.0 -2.1 -0.6 -1.7 -0.5
Ever had bowel cancer screening 0.2 0.3 0.6 0.4 -0.8 -0.4 -0.3 -0.6
Diabetes diagnosed by doctor 0.6 1.0 1.4 -0.9 0.9 0.9 1.2 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 0.2 0.3 -0.1 -0.5 -0.5
Friendships satisfaction 6.9 8.5 11.8 2.4 -2.7 -2.9 -3.1 -3.4
Qualifications: nursing, teaching 7.7 12.0 20.4 2.3 -3.3 -3.7 -3.1 -4.5
Commuting to job workplace: Walk 0.1 0.1 0.3 0.5 -0.1 0.2 -0.4 -0.3
Eye problems/disorders: Cataract 0.7 0.8 1.3 -0.6 0.9 1.1 0.5 1.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 0.8 -0.8 0.9 0.8 0.5 0.5
Medication for cholesterol 0.3 0.4 0.8 -0.6 0.3 -0.9 0.0 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.1 -0.1 -0.2 0.6 1.0 0.4
Back pain experienced in last month 0.5 0.8 1.3 -0.6 0.9 1.0 0.6 1.1
Mineral and other dietary supplements 0.5 0.7 1.8 -0.6 0.8 0.7 0.5 1.3
Breast cancer (self-reported) 0.6 0.7 1.6 1.2 -0.6 -0.0 -1.3 -0.4
Asthma (self-reported) 0.8 1.6 3.3 1.8 -1.0 1.8 -0.4 0.6
Osteoporosis (self-reported) 0.2 0.2 0.6 0.8 -0.3 0.3 -0.5 0.3
Osteoarthritis (self-reported) 0.8 1.0 2.4 -0.3 0.7 1.3 0.6 1.6
Medication: Aspirin 0.7 0.9 2.0 -1.4 1.1 -0.9 0.7 -0.1
Medication: Gliclazide 0.6 0.7 1.2 -0.4 0.9 1.0 1.1 0.7
Illnesses of father: None of the above (group 1) 1.0 1.3 2.9 -1.7 1.2 -0.0 1.4 0.1
Smoking status: Current 0.1 0.2 0.6 -0.2 0.4 0.0 -0.0 0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.5 -0.5 -0.2 -0.1 0.7 -0.4
Whole body water mass 0.4 2.4 5.0 1.3 -0.7 2.2 -0.1 2.2
Leg predicted mass (right) 0.3 1.9 4.5 0.7 -0.1 2.0 0.3 2.1
Arm fat mass (left) 0.7 3.0 8.1 0.8 -0.3 2.4 0.3 2.8
Number of self-reported non-cancer illnesses 1.9 3.3 6.0 2.3 -2.4 -0.5 -2.1 -0.9
Average weekly champagne plus white wine intake 1.2 1.6 3.3 0.2 -0.8 -1.8 -1.0 -1.8
Miserableness 0.1 0.2 0.5 0.7 -0.5 0.5 -0.2 0.2
Guilty feelings 0.3 0.4 1.1 0.8 -0.1 -0.3 -1.0 -0.6
Wears glasses or contact lenses 0.5 0.6 1.1 -0.7 0.1 -0.9 0.7 -1.0
Ever taken oral contraceptive pill 0.1 0.1 0.3 0.2 -0.6 -0.0 -0.5 0.1
Hearing aid user 0.2 0.3 0.5 0.7 -0.7 0.2 -0.4 0.2
Mother’s age at death 1.8 2.2 5.1 -2.3 1.6 0.1 1.7 0.6
Financial situation satisfaction 0.1 0.2 0.3 -0.5 0.5 -0.0 0.4 0.4
Tinnitus: Yes, now most or all of the time 4.6 5.4 6.8 2.4 -2.5 -1.6 -2.6 -2.3
Commuting to job workplace: Public transport 4.2 5.0 7.8 1.4 -1.9 -2.5 -2.3 -2.8
Eye problems/disorders: Glaucoma 0.1 0.1 0.4 -0.3 -0.2 0.2 0.1 0.6
Medication: Blood pressure 0.7 1.3 3.6 0.8 -0.1 1.9 0.3 1.4
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.6 0.7 -0.1 1.9 0.2 1.7
Supplements: Fish oil (including cod liver oil) 1.9 2.5 5.5 0.8 -1.4 -1.8 -1.2 -2.3
High cholesterol (Self-reported) 0.1 0.2 0.8 0.0 -0.1 -0.9 -0.3 -0.4
Medication: Bendroflumethiazide 0.5 0.7 1.1 -0.8 1.0 0.7 1.1 0.6
Medication: Paracetamol 0.4 0.6 1.2 0.3 0.5 1.1 -0.3 1.1
Medication: Lisinopril 0.7 0.8 2.2 -0.3 0.3 1.0 0.9 1.5
Medication: Atorvastatin 0.2 0.3 0.7 0.8 -0.8 0.1 -0.1 -0.1
Illnesses of father: High blood pressure 1.6 2.0 2.9 -1.6 1.3 0.8 1.7 1.5
Alcohol drinker status: Never 1.5 1.7 4.1 0.7 -0.9 -1.2 -1.3 -2.0
Ever smoked 1.4 2.4 5.1 -2.2 1.7 -0.0 1.4 1.5
Basal metabolic rate 0.5 2.8 6.4 1.2 -0.6 2.4 0.1 2.5
Leg fat percentage (left) 0.6 2.0 6.5 0.2 0.0 1.8 0.5 2.5
Arm fat-free mass (left) 0.5 2.5 4.9 1.6 -1.0 1.9 -0.5 2.2
Number of operations (self-reported) 1.7 2.5 3.8 0.8 -1.3 -2.0 -2.0 -1.6
Average weekly beer plus cider intake 3.1 4.4 6.7 -1.9 2.4 1.8 1.7 2.6
Irritability 0.2 0.4 1.1 0.6 -1.0 -0.2 -0.6 -0.1
Risk taking 1.7 2.5 6.3 -2.5 1.9 -0.6 1.6 0.2
Ever had prostate specific antigen (PSA) test 0.0 0.0 0.1 -0.3 0.2 -0.2 0.1 0.1
Fractured/broken bones in last 5 years 0.2 0.2 0.7 0.8 -0.4 0.0 -0.5 -0.2
Age started oral contraceptive pill 1.5 1.9 4.4 0.2 -1.1 -1.8 -0.6 -2.1
Diastolic blood pressure, automated reading 3.1 9.7 13.1 -3.0 3.0 2.4 3.4 3.6
Ever depressed for a whole week 7.1 8.8 14.1 2.4 -2.9 -2.5 -3.1 -3.8
Unable to work because of sickness or disability 0.4 0.5 1.2 1.1 -0.5 0.3 -0.9 0.4
Commuting to job workplace: Cycle 0.2 0.3 0.8 -0.2 0.5 0.9 0.5 0.4
Myopia 0.3 0.5 1.2 1.1 -0.3 0.9 -0.4 -0.1
Vascular/heart problems diagnosed by doctor 1.9 5.3 10.4 1.4 -1.8 -2.4 -2.2 -3.2
Cholesterol lowering medication 0.5 0.7 1.1 0.9 -0.6 -0.7 -1.0 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.3 0.2 -0.2 0.5 0.3 0.2
Pain experienced in last month 0.3 0.5 1.4 -0.1 -0.3 -1.0 -0.0 -1.2
Supplements: Calcium 0.1 0.1 0.2 0.4 -0.4 0.0 -0.1 -0.3
Basal cell carcinoma (self-reported) 0.3 0.4 1.0 -0.0 -0.3 -1.0 -0.3 -0.8
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.0 0.1 0.4 -0.8 -1.0 0.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 0.8 -0.1 0.4 0.9 0.7 0.4
Heart disease (siblings) 0.8 0.9 2.0 1.1 -1.4 -0.3 -1.0 -0.7
Alcohol drinker status: Previous 2.6 3.0 5.2 -0.9 1.7 2.3 1.9 1.6
Pack years of smoking 0.2 0.3 0.9 0.4 0.1 0.7 -0.1 0.9
Impedance of whole body 0.6 3.3 5.4 -1.9 1.2 -2.3 0.6 -2.3
Leg fat mass (left) 0.8 3.2 9.3 0.5 0.1 2.5 0.6 3.0
Arm predicted mass (left) 0.6 2.9 6.2 1.6 -0.9 2.2 -0.5 2.5