[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr3:11,350,553-12,928,762

Best TWAS P=1.16e-15 · Best GWAS P=8.03e-14 conditioned to 0.407

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Brain Hypothalamus	TIMP4	0.24	0.10	lasso	4	0.11	1.7e-03	7.2	8.0	1.2e-15	0.88	0.02	0.95	TRUE
14	ROSMAP	Brain Pre-frontal Cortex	TIMP4	0.07	0.05	lasso	7	0.06	5.5e-08	6.0	7.6	3.4e-14	0.78	0.05	0.95	FALSE
2	GTEx	Artery Aorta	SYN2	0.14	0.08	enet	15	0.09	1.0e-05	6.7	7.6	3.6e-14	0.63	0.22	0.77	FALSE
19	The Cancer Genome Atlas	Lung Adenocarcinoma	SYN2	0.03	0.02	enet	6	0.02	4.0e-03	7.2	7.3	3.8e-13	0.71	0.03	0.89	FALSE
6	GTEx	Esophagus Gastroesophageal Junction	SYN2	0.23	0.09	lasso	4	0.12	3.3e-05	6.2	7.2	4.9e-13	0.87	0.02	0.97	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SYN2	0.13	0.03	blup	82	0.07	6.3e-04	7.2	7.0	2.3e-12	0.62	0.02	0.74	FALSE
7	GTEx	Esophagus Mucosa	SYN2	0.25	0.17	lasso	6	0.17	1.1e-11	6.2	6.9	6.6e-12	0.66	0.92	0.08	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TIMP4	0.11	0.05	bslmm	508	0.06	6.8e-08	6.2	6.8	8.2e-12	0.54	0.04	0.96	FALSE
12	GTEx	Skin Sun Exposed Lower leg	SYN2	0.12	0.12	lasso	4	0.13	5.5e-11	6.2	6.8	1.0e-11	0.63	0.79	0.21	FALSE
4	GTEx	Artery Tibial	SYN2	0.30	0.32	lasso	2	0.31	1.0e-24	6.7	6.7	1.9e-11	0.52	0.46	0.54	FALSE
3	GTEx	Artery Tibial	TIMP4	0.20	0.24	lasso	2	0.24	1.7e-18	6.7	6.7	2.2e-11	0.53	0.46	0.54	FALSE
10	GTEx	Nerve Tibial	SYN2	0.11	0.11	lasso	2	0.08	1.5e-06	6.2	6.5	7.3e-11	0.48	0.68	0.32	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	SYN2	0.11	0.12	lasso	6	0.11	1.0e-11	5.9	6.3	2.2e-10	0.65	0.75	0.25	FALSE
13	GTEx	Spleen	SYN2	0.34	0.20	lasso	3	0.21	5.4e-06	6.2	6.2	4.1e-10	0.41	0.16	0.45	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SYN2	0.06	0.09	lasso	1	0.09	4.8e-10	6.2	6.2	6.2e-10	0.44	0.46	0.54	FALSE
9	GTEx	Lung	SYN2	0.19	0.12	lasso	6	0.12	2.1e-09	6.2	6.1	8.4e-10	0.68	0.24	0.76	FALSE
18	The Cancer Genome Atlas	Brain Lower Grade Glioma	TIMP4	0.04	0.01	enet	4	0.03	2.2e-04	6.4	6.1	1.2e-09	0.56	0.01	0.91	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	SYN2	0.05	0.04	blup	82	0.04	3.8e-08	5.9	6.1	1.4e-09	0.67	0.81	0.19	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	SYN2	0.12	0.08	lasso	4	0.03	1.4e-02	6.2	6.0	1.5e-09	0.66	0.13	0.83	FALSE
8	GTEx	Esophagus Muscularis	SYN2	0.20	0.18	lasso	6	0.18	5.1e-11	6.2	6.0	1.7e-09	0.67	0.87	0.13	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SYN2	0.04	0.04	lasso	2	0.04	4.9e-05	6.2	6.0	2.5e-09	0.66	0.25	0.35	FALSE