TWAS
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Models
Genes
Traits
[Hub]/) :
Traits
:
Hypothyroidism (self reported)
:
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chr4:148,303,195-150,060,844
Best TWAS P=7.8e-32 · Best GWAS P=2.02e-32 conditioned to 1
148.2M
148.4M
148.6M
148.8M
149M
149.2M
149.4M
149.6M
149.8M
150M
0
10
20
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Thyroid
NR3C2
0.24
0.22
lasso
2
0.21
7e-16
-12
-12
7.8e-32
0.99
0.01
0.99
TRUE