Hub : Genes

NR3C2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Thyroid 0.2370 0.052 2.1e-08 0.216 NA 0.207 NA 0.208 1.7e-16 NA 9.4e-16 NA 7.0e-16
2 YFS Blood 0.0192 0.008 4.0e-03 0.001 0.007 0.000 0.006 -0.001 1.4e-01 0.0022 2.7e-01 0.0035 9.8e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.5 0.8 1.5 1.2 -0.2
Bipolar Disorder or Schizophrenia 0.1 0.2 0.3 -0.4 -0.5
Depressed Affect (Nagel 2018) 0.4 0.8 1.1 1.1 -0.8
Depression (Nagel 2018) 0.5 0.8 1.6 -1.3 0.1
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.4 0.5 -0.6
Neuroticism (Nagel 2018) 0.1 0.3 0.5 0.7 -0.0
Schizophrenia (2018) 0.6 1.2 2.2 -1.5 -0.5
Schizophrenia vs Biploar Disorder 1.1 1.5 2.2 -0.8 -1.5
Worry (Nagel 2018) 0.2 0.5 1.0 -0.1 1.0
Alzheimer’s Disease (in mother) 2.6 3.1 5.3 2.3 0.9
Alzheimer’s Disease (in father) 0.3 0.3 0.6 -0.1 -0.8
Alzheimer’s Disease (including proxy) 1.0 1.4 2.3 1.5 0.7
Crohns Disease (2017) 0.3 0.7 1.3 0.4 1.2
Irritable Bowel Disease (IBD) 0.1 0.2 0.3 -0.6 0.3
Ulcerative Colitis (UC) 0.8 1.4 2.5 -1.6 -0.6
Major Depression (MDD) 0.8 0.9 1.8 0.1 -1.4
Reaction Time 0.7 1.4 2.8 -1.7 -0.2
Verbal and Numeric Reasoning (VNR) 0.0 0.1 0.2 0.4 -0.0
Breast Cancer 0.1 0.2 0.5 -0.7 0.0
Ovarian Cancer 1.6 2.1 2.3 1.5 1.4
Prostate Cancer 1.8 2.5 5.0 0.3 2.2
Age at First Birth 0.8 1.1 2.2 1.5 -0.3
Bipolar Disorder (2011) 0.6 0.6 1.2 -0.2 1.1
Body Mass Index (BMI) (2010) 0.0 0.0 0.1 -0.2 0.1
Coronary Artery Disease (CAD) 0.0 0.0 0.1 0.3 -0.1
Crohns Disease (2012) 0.2 0.2 0.4 0.4 0.6
Mean Putamen Volume 0.7 0.8 0.8 -0.9 -0.9
Fasting Glucose 0.7 0.8 1.5 -0.2 -1.2
HbA1C 0.5 0.5 1.1 -0.1 -1.0
HDL Cholesterol 0.2 0.3 0.4 0.4 0.6
LDL Cholesterol 0.3 0.5 1.0 -1.0 0.2
Lupus 1.0 1.5 2.6 -1.6 0.7
Neuroticism (2016) 0.6 0.9 1.3 0.7 -1.2
Primary Biliary Cirrhosis 0.1 0.1 0.2 -0.5 -0.1
Rheumatoid Arthritis 3.7 5.2 5.9 -2.4 -2.1
Schizophrenia (2014) 1.2 2.6 2.6 -1.6 -1.6
Triglycerides 0.7 1.1 1.6 -0.8 1.3
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.5 0.7 0.4
Ulcerative Colitis 1.3 1.9 2.5 -1.1 -1.6
Blood Eosinophil Count 0.1 0.4 0.7 0.4 0.8
Blood Platelet Count 0.6 6.5 12.5 -3.5 0.6
Blood Red Count 0.4 4.0 6.7 1.1 -2.6
Blood White Count 0.1 0.8 1.2 0.6 -1.1
Heel T-Score 0.7 5.9 11.4 -3.4 -0.7
BMI 0.3 1.5 1.7 1.1 -1.3
Height 1.1 21.6 41.5 6.4 1.3
Waist Hip Ratio (WHR) 0.4 1.8 2.4 -1.1 1.5
Systolic Blood Pressure 0.0 0.1 0.1 -0.4 0.1
Smoking Status 0.5 1.1 2.3 -1.5 0.0
Allergy or Eczema 0.3 0.7 1.1 -0.6 -1.1
Cardiovascular Disease 0.6 1.9 3.7 -0.3 -1.9
Hypothyroidism (self reported) 32.5 74.7 136.9 -11.7 -3.5
Respiratory disease 0.2 0.5 1.0 1.0 0.2
Type 2 Diabetes (T2D) (2018) 1.7 3.1 5.8 0.6 -2.4
Lung FEV1/FVC ratio 0.6 3.2 5.2 -2.3 -1.1
Lung FVC 0.4 2.2 3.5 -1.0 -1.9
Neuroticism 0.1 0.2 0.3 0.6 -0.2
Chronotype (morning person) 1.7 4.0 7.5 2.7 -0.7
Hair Pigment 0.0 0.2 0.3 -0.5 0.2
Tanning 0.1 0.7 1.3 -0.2 1.1
Hand grip strength (left) 0.0 0.0 0.0 -0.2 0.2
Number of treatments/medications taken 1.6 2.8 4.0 -2.0 -1.3
Average weekly spirits intake 0.2 0.2 0.5 -0.1 -0.7
Sensitivity / hurt feelings 0.5 0.9 1.4 -0.6 1.2
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.3 -0.5 0.4
Hearing difficulty/problems: Yes 4.1 6.3 6.4 -2.5 -2.5
Relative age of first facial hair 0.2 0.4 0.6 -0.5 -0.7
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.3 0.5 -1.1
Ever used hormone-replacement therapy (HRT) 0.3 0.3 0.5 0.4 0.7
Ever had hysterectomy (womb removed) 2.8 3.2 5.7 2.4 0.9
Systolic blood pressure, automated reading 0.1 0.4 0.8 -0.2 0.9
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.4 0.6 0.1
Angina 0.4 0.5 0.7 -0.6 -0.8
Medication for hormone replacement therapy 1.1 1.3 2.1 -1.4 0.7
Vitamin and mineral supplements 0.3 0.4 0.8 -0.3 0.9
Supplements: Zinc 0.4 0.4 0.7 0.9 0.3
Medication: Co-codamol 0.2 0.2 0.5 0.7 -0.2
Medication: Metformin 0.4 0.6 0.7 0.7 -0.8
Diabetes (father) 1.7 2.1 3.7 0.7 -1.9
Diabetes (mother) 1.4 1.8 3.4 0.5 -1.8
Severe depression (siblings) 1.2 1.3 2.3 -0.6 1.5
Pack years adult smoking proportion 0.8 1.3 2.3 -1.5 -0.5
Impedance of leg (right) 0.9 4.2 8.3 0.3 2.9
Leg fat-free mass (left) 0.5 2.5 2.6 1.5 -1.6
Trunk fat percentage 0.9 3.8 7.5 2.7 0.2
Hand grip strength (right) 0.1 0.3 0.3 -0.6 -0.5
Townsend deprivation index at recruitment 0.3 0.4 0.7 -0.8 0.3
Current tobacco smoking 1.3 2.1 3.8 -1.9 -0.7
Average weekly fortified wine intake 5.4 6.3 8.1 2.8 2.1
Maternal smoking around birth 0.2 0.3 0.5 0.7 -0.4
Fed-up feelings 1.0 1.9 3.1 1.8 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.0 -0.2 -0.2
Relative age voice broke 0.7 1.0 2.0 -1.4 0.0
Taking other prescription medications 2.7 4.1 7.1 -2.7 -1.1
Age when periods started (menarche) 0.4 1.1 1.9 0.5 1.4
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 0.9 -0.2 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.0 -1.0 -0.5
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.1 1.0 -0.7
Qualifications: CSEs or equivalent 0.6 0.8 1.3 1.1 -0.6
Serious illness, injury or assault to yourself 0.2 0.2 0.5 -0.1 -0.7
High blood pressure 0.7 1.8 2.4 -1.6 -1.1
Hayfever, allergic rhinitis or eczema 0.5 1.0 2.0 0.1 -1.4
Multivitamins +/- minerals 0.2 0.3 0.6 0.7 -0.1
Stomach or abdominal pain in last month 2.5 3.1 6.1 -2.5 -0.0
Supplements: Glucosamine 0.1 0.1 0.2 -0.2 -0.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 0.8 -0.9 -0.7
Medication: Atenolol 1.6 2.0 3.9 0.3 -2.0
Medication: Levothyroxine sodium 20.1 34.0 63.4 -8.0 -2.2
Sitting height 0.6 4.6 8.2 2.9 1.0
Chronic bronchitis/emphysema (father) 0.9 1.0 2.0 0.3 1.4
High blood pressure (mother) 0.8 1.2 2.4 -1.5 0.1
Body mass index (BMI) 0.3 1.1 2.1 -0.2 -1.4
Impedance of leg (left) 1.0 5.0 9.7 0.6 3.1
Leg predicted mass (left) 0.5 2.4 2.7 1.5 -1.6
Trunk fat mass 0.7 3.0 6.0 2.4 -0.3
Waist circumference 0.1 0.3 0.5 0.1 -0.7
Number of incorrect matches in round 0.2 0.3 0.5 0.7 0.1
Past tobacco smoking 0.2 0.3 0.6 0.2 -0.8
Alcohol usually taken with meals 0.1 0.2 0.4 0.7 -0.0
Nervous feelings 0.1 0.2 0.2 -0.5 -0.5
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.3 0.4 0.5
Hearing difficulty/problems with background noise 3.1 5.0 9.3 -3.0 -0.9
Hair/balding pattern: Pattern 2 0.0 0.0 0.0 0.1 0.0
Had menopause 0.1 0.2 0.2 -0.5 -0.3
Had other major operations 2.8 3.4 6.0 -2.5 -0.9
Forced vital capacity (FVC) 0.5 2.0 3.0 1.7 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.4 -1.2 -0.2
Ever unenthusiastic/disinterested for a whole week 1.6 1.9 3.8 -0.1 -2.0
Qualifications: None of the above 0.2 0.5 0.7 -0.5 0.8
Financial difficulties in last 2 years 0.8 1.1 1.2 -1.1 -1.0
Mouth/teeth dental problems 0.4 0.5 1.0 -0.4 -1.0
Heart attack 0.3 0.4 0.6 -0.8 0.5
Allergy 0.1 0.2 0.5 0.1 0.7
Pain all over the body in last month 1.7 1.9 3.0 1.7 0.9
Diabetes (self-reported) 2.6 4.0 7.6 0.6 -2.8
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 -0.1 -0.5
Medication: Ramipril 0.2 0.3 0.5 -0.7 0.2
Medication: Simvastatin 0.3 0.4 0.5 0.7 -0.6
Fluid intelligence score 0.1 0.1 0.2 0.4 0.3
Illnesses of siblings 0.3 0.4 0.4 0.7 0.5
Neuroticism score 0.2 0.3 0.6 0.8 -0.2
Weight 0.3 1.4 2.0 1.4 -0.9
Impedance of arm (right) 2.7 12.7 15.8 4.0 3.1
Arm fat percentage (right) 0.3 1.2 2.2 1.5 -0.4
Trunk fat-free mass 0.2 1.1 2.2 0.2 -1.5
Hip circumference 0.4 1.7 3.4 1.9 -0.2
Time employed in main current job 0.6 0.6 1.0 1.0 0.5
Alcohol intake versus 10 years previously 0.8 1.2 1.9 -0.7 -1.4
Father’s age at death 0.1 0.2 0.2 -0.5 0.3
Worrier / anxious feelings 0.2 0.3 0.6 -0.0 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.5 0.7 0.2
Falls in the last year 1.3 1.7 3.4 0.1 1.8
Hair/balding pattern: Pattern 3 0.2 0.3 0.7 -0.0 -0.8
Number of live births 5.8 8.2 12.5 -3.5 -2.0
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 2.7 1.2 -1.6
Pulse rate 0.4 0.7 1.0 0.6 -1.0
Happiness 0.4 0.4 0.8 0.9 -0.2
Noisy workplace 0.5 0.6 0.9 0.9 0.5
Qualifications: A levels/AS levels or equivalent 0.8 1.8 3.6 -0.1 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.1 1.7 -0.7 -1.3
Mouth/teeth dental problems: Dentures 2.3 3.9 7.4 -0.7 2.7
Asthma 0.2 0.3 0.6 0.2 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.3 -1.1 -0.0
Medication: Cholesterol lowering 0.0 0.0 0.0 0.2 0.1
Depression (self-reported) 0.1 0.2 0.2 0.4 -0.4
Medication: Lansoprazole 1.9 2.2 4.0 2.0 0.6
Prospective memory result 1.6 2.0 3.6 -1.9 0.6
Lung cancer (father) 0.6 0.7 1.4 -1.2 0.2
Illnesses of mother 0.7 0.9 0.9 1.0 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.7 0.3 -0.8
Pulse wave Arterial Stiffness index 2.0 2.3 2.8 1.4 -1.7
Impedance of arm (left) 2.3 10.7 15.1 3.9 2.5
Arm fat mass (right) 0.3 1.3 2.3 1.5 -0.6
Trunk predicted mass 0.2 1.1 2.1 0.1 -1.5
Standing height 0.7 7.4 13.8 3.7 1.0
Length of working week for main job 1.4 1.5 3.0 1.7 0.2
Exposure to tobacco smoke at home 0.1 0.1 0.1 -0.4 -0.1
Breastfed as a baby 0.4 0.5 0.8 -0.3 0.9
Tense / ‘highly strung’ 0.9 1.5 2.8 -1.7 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.5 -0.3 -0.7
Hair/balding pattern: Pattern 4 2.4 5.9 11.7 -0.3 3.4
Birth weight of first child 0.1 0.1 0.2 0.0 0.4
Peak expiratory flow (PEF) 1.7 4.0 5.1 1.7 -2.3
Pulse wave reflection index 1.3 1.6 2.4 1.6 0.9
Ever highly irritable/argumentative for 2 days 0.5 0.6 0.8 -0.5 -0.9
Loud music exposure frequency 0.9 1.0 1.4 -1.2 -0.8
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 1.3 0.4 -1.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.3 0.5 0.7 -0.5
Blood clot in the leg (DVT) 1.4 1.8 2.6 -1.0 -1.6
Medication: Paracetamol 0.6 1.0 1.9 -0.2 -1.4
Headache pain in last month 0.5 0.9 1.7 0.2 -1.3
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.2 1.1 0.8
Glaucoma (self-reported) 0.3 0.3 0.5 0.7 0.4
Gout (self-reported) 1.4 1.9 2.3 1.2 -1.5
Hypothyroidism/myxoedema (self-reported) 24.2 47.2 88.1 -9.4 -2.5
Medication: Amlodipine 0.8 1.1 1.2 -1.0 -1.1
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.0 1.0 -0.1
Birth weight 0.2 0.5 0.6 0.7 0.8
Chronic bronchitis/emphysema (mother) 1.3 1.5 3.1 0.1 -1.8
High blood pressure (siblings) 0.7 1.0 1.0 -1.0 -1.0
Forced vital capacity (FVC), Best measure 0.1 0.4 0.5 0.7 -0.5
Body fat percentage 0.4 1.6 3.3 1.8 0.1
Leg fat percentage (right) 0.0 0.0 0.0 0.2 -0.0
Arm fat-free mass (right) 0.3 1.6 3.3 0.1 -1.8
Exposure to tobacco smoke outside home 0.2 0.3 0.6 -0.2 0.8
Comparative body size at age 10 0.3 0.7 1.3 1.1 0.3
Number of full brothers 5.2 6.6 8.4 -2.9 -2.2
Worry too long after embarrassment 0.9 1.5 1.9 1.1 -1.4
Seen a psychiatrist for nerves, anxiety, tension or depression 2.2 2.9 5.3 -0.7 -2.3
Wheeze or whistling in the chest in last year 0.7 1.3 2.2 -0.7 1.5
Number of children fathered 0.8 0.9 0.9 -1.0 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.1 0.4 -0.3
Age at first live birth 0.6 1.1 1.5 0.8 1.2
Pulse wave peak to peak time 1.8 2.1 3.1 -1.0 1.8
Health satisfaction 0.5 0.7 1.3 -0.2 -1.1
Shortness of breath walking on level ground 1.7 2.0 2.6 -1.6 -1.2
Qualifications: College or University degree 0.0 0.0 0.0 0.2 -0.2
Eye problems/disorders: None of the above 0.5 0.5 0.8 0.5 -0.9
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.4 -0.0 0.7
Emphysema/chronic bronchitis 2.1 2.4 4.5 0.6 2.1
Medication for pain relief, constipation, heartburn 0.4 0.7 1.2 0.4 1.1
Neck or shoulder pain in last month 0.2 0.3 0.5 -0.7 -0.5
Medication: Blood pressure 0.1 0.3 0.4 -0.6 -0.4
Angina (self-reported) 0.1 0.2 0.3 -0.1 -0.6
Migraine (self-reported) 0.1 0.2 0.3 -0.5 0.1
Medication: Ibuprofen 0.0 0.0 0.0 -0.1 0.1
Medication: Allopurinol 0.8 1.0 1.9 0.4 -1.4
Medication: Omeprazole 2.6 3.1 5.2 1.0 2.3
Medication: Seretide 50 evohaler 0.3 0.4 0.5 0.5 0.7
Mean time to correctly identify matches 0.6 1.1 1.8 -1.3 -0.6
Heart disease (mother) 1.2 1.5 3.0 -1.7 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.0 2.4 4.0 -0.9 -2.0
Whole body fat mass 0.4 1.6 3.0 1.7 -0.4
Leg fat mass (right) 0.1 0.4 0.6 0.6 -0.8
Arm predicted mass (right) 0.3 1.6 3.1 -0.2 -1.8
Pulse rate, automated reading 0.4 1.4 2.8 1.7 0.1
Alcohol intake frequency. 0.9 2.1 2.6 -1.3 -1.6
Comparative height size at age 10 2.4 13.0 25.0 5.0 1.0
Number of full sisters 5.6 6.9 8.8 -3.0 -2.2
Suffer from ‘nerves’ 0.1 0.2 0.4 -0.2 0.6
Overall health rating 0.4 0.9 1.8 0.1 -1.3
Chest pain or discomfort 0.7 1.0 1.9 1.4 -0.3
Had major operations 1.3 1.5 2.8 1.7 -0.3
Age at last live birth 1.8 2.6 5.1 -2.3 -0.3
Family relationship satisfaction 0.0 0.0 0.1 -0.1 0.3
Leg pain on walking 0.1 0.1 0.2 -0.2 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.2 0.5 0.4
Commuting to job workplace: Car/motor vehicle 1.6 1.8 3.7 0.0 1.9
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.5 0.7 0.3
Medication: Aspirin 1.6 2.1 2.8 -1.2 -1.7
Supplements: Vitamin C 0.2 0.3 0.5 0.7 -0.0
Knee pain experienced in last month 0.6 0.9 1.8 -0.1 -1.4
Hypertension (Self-reported) 0.7 1.8 2.4 -1.6 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 1.2 1.1 0.8
Illnesses of father: Heart disease 0.0 0.0 0.1 -0.2 0.2
Illnesses of siblings: Diabetes 1.3 1.6 3.1 0.1 -1.8
Smoking status: Previous 0.3 0.4 0.8 0.0 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 0.8 0.8 -0.9
Whole body fat-free mass 0.3 1.5 2.6 0.7 -1.6
Leg fat-free mass (right) 0.4 2.4 2.8 1.7 -1.4
Arm fat percentage (left) 0.3 1.3 2.0 1.4 -0.7
Average weekly red wine intake 0.6 1.0 1.0 1.0 1.0
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.3 0.6 1.2
Mood swings 0.7 1.2 2.4 0.3 -1.5
Loneliness, isolation 0.1 0.1 0.2 -0.1 -0.5
Long-standing illness, disability or infirmity 0.7 1.1 1.8 -0.7 -1.3
Ever had bowel cancer screening 0.5 0.6 0.7 0.7 -0.9
Diabetes diagnosed by doctor 2.3 3.7 7.4 0.2 -2.7
Ever had stillbirth, spontaneous miscarriage or termination 2.4 2.5 4.7 -2.2 -0.6
Friendships satisfaction 0.3 0.3 0.4 -0.6 -0.5
Qualifications: nursing, teaching 0.0 0.0 0.0 -0.0 -0.2
Commuting to job workplace: Walk 0.2 0.2 0.3 -0.5 -0.3
Eye problems/disorders: Cataract 0.1 0.1 0.2 0.5 0.0
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 1.6 -0.7 -1.3
Medication for cholesterol 0.5 0.8 1.4 0.4 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.3 0.1 -0.5
Back pain experienced in last month 0.4 0.6 0.8 0.6 0.9
Mineral and other dietary supplements 2.1 2.9 5.0 0.9 2.2
Breast cancer (self-reported) 1.0 1.1 2.3 -0.1 1.5
Asthma (self-reported) 0.1 0.1 0.2 0.2 0.5
Osteoporosis (self-reported) 0.6 0.8 1.5 -1.2 -0.2
Osteoarthritis (self-reported) 0.0 0.0 0.1 0.3 0.0
Medication: Aspirin 1.0 1.3 1.6 -1.0 -1.2
Medication: Gliclazide 0.1 0.2 0.2 0.5 -0.3
Illnesses of father: None of the above (group 1) 0.2 0.2 0.3 -0.2 -0.6
Smoking status: Current 1.2 2.0 3.5 -1.9 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.4 -0.6 -0.6
Whole body water mass 0.2 1.3 2.1 0.7 -1.4
Leg predicted mass (right) 0.4 2.4 2.8 1.7 -1.4
Arm fat mass (left) 0.2 1.0 1.5 1.2 -0.7
Number of self-reported non-cancer illnesses 1.4 2.4 4.5 -0.6 -2.1
Average weekly champagne plus white wine intake 0.0 0.1 0.1 -0.2 -0.3
Miserableness 0.5 0.8 1.4 -0.4 -1.2
Guilty feelings 1.1 1.7 3.2 -0.4 -1.8
Wears glasses or contact lenses 0.0 0.0 0.0 0.0 -0.2
Ever taken oral contraceptive pill 1.6 1.8 3.1 -1.7 -0.7
Hearing aid user 1.1 1.2 1.6 0.9 1.3
Mother’s age at death 0.0 0.0 0.0 0.1 0.2
Financial situation satisfaction 0.1 0.2 0.3 -0.1 -0.5
Tinnitus: Yes, now most or all of the time 1.2 1.4 2.7 -1.6 -0.3
Commuting to job workplace: Public transport 1.5 1.8 3.6 1.9 -0.3
Eye problems/disorders: Glaucoma 0.6 0.7 1.4 -0.2 1.2
Medication: Blood pressure 0.3 0.5 0.7 -0.9 -0.6
Pain type(s) experienced in last month: Hip pain 2.2 2.8 4.2 -2.1 -1.1
Supplements: Fish oil (including cod liver oil) 0.8 1.0 1.3 -0.8 -1.1
High cholesterol (Self-reported) 0.1 0.2 0.2 -0.5 -0.4
Medication: Bendroflumethiazide 0.4 0.6 0.9 -0.5 -1.0
Medication: Paracetamol 0.4 0.6 1.1 -0.3 -1.1
Medication: Lisinopril 0.3 0.3 0.6 -0.1 -0.8
Medication: Atorvastatin 2.0 2.5 4.7 -2.2 -0.5
Illnesses of father: High blood pressure 0.1 0.1 0.1 -0.3 -0.1
Alcohol drinker status: Never 1.5 1.8 2.7 -1.6 -0.9
Ever smoked 0.7 1.2 2.2 -1.5 0.5
Basal metabolic rate 0.3 1.4 1.8 1.0 -1.3
Leg fat percentage (left) 0.0 0.0 0.1 0.3 -0.1
Arm fat-free mass (left) 0.2 0.9 1.7 0.1 -1.3
Number of operations (self-reported) 0.0 0.1 0.1 -0.3 -0.1
Average weekly beer plus cider intake 0.3 0.4 0.7 -0.2 -0.9
Irritability 0.0 0.0 0.1 -0.2 0.0
Risk taking 2.3 3.4 6.3 -2.5 -0.7
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.5 1.2 -0.0
Fractured/broken bones in last 5 years 0.2 0.3 0.5 -0.1 0.7
Age started oral contraceptive pill 0.7 0.9 1.0 1.0 0.9
Diastolic blood pressure, automated reading 0.3 1.0 1.5 -1.2 -0.7
Ever depressed for a whole week 0.4 0.5 0.9 1.0 -0.0
Unable to work because of sickness or disability 1.0 1.4 2.4 -1.5 0.6
Commuting to job workplace: Cycle 0.2 0.2 0.2 0.5 0.4
Myopia 1.7 2.4 4.8 2.2 -0.2
Vascular/heart problems diagnosed by doctor 0.9 2.5 2.7 1.6 1.5
Cholesterol lowering medication 0.5 0.7 1.4 0.0 -1.2
Medication: Omeprazole (e.g. Zanprol) 2.8 3.4 6.2 0.8 2.5
Pain experienced in last month 0.3 0.6 0.9 0.5 0.9
Supplements: Calcium 4.9 5.4 10.1 -0.8 -3.2
Basal cell carcinoma (self-reported) 1.0 1.2 1.2 1.1 1.1
Heart attack/myocardial infarction (self-reported) 0.5 0.6 0.8 -0.7 0.9
Deep venous thrombosis (DVT) (self-reported) 1.5 1.9 2.9 -1.0 -1.7
Heart disease (siblings) 0.1 0.1 0.2 -0.4 -0.1
Alcohol drinker status: Previous 1.7 1.9 3.7 0.2 -1.9
Pack years of smoking 0.7 1.0 1.9 -1.4 -0.3
Impedance of whole body 1.5 7.7 8.0 2.8 2.7
Leg fat mass (left) 0.1 0.5 0.5 0.6 -0.7
Arm predicted mass (left) 0.1 0.7 1.4 0.3 -1.2