TWAS hub - NR3C2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.2370	0.052	2.1e-08	0.216	NA	0.207	NA	0.208	1.7e-16	NA	9.4e-16	NA	7.0e-16
2	YFS	Blood	0.0192	0.008	4.0e-03	0.001	0.007	0.000	0.006	-0.001	1.4e-01	0.0022	2.7e-01	0.0035	9.8e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hypothyroidism (self reported)	32.5	74.7	136.9	-11.7	-3.5
Hypothyroidism/myxoedema (self-reported)	24.2	47.2	88.1	-9.4	-2.5
Medication: Levothyroxine sodium	20.1	34.0	63.4	-8.0	-2.2
Number of live births	5.8	8.2	12.5	-3.5	-2.0
Number of full sisters	5.6	6.9	8.8	-3.0	-2.2
Average weekly fortified wine intake	5.4	6.3	8.1	2.8	2.1
Number of full brothers	5.2	6.6	8.4	-2.9	-2.2
Supplements: Calcium	4.9	5.4	10.1	-0.8	-3.2
Hearing difficulty/problems: Yes	4.1	6.3	6.4	-2.5	-2.5
Rheumatoid Arthritis	3.7	5.2	5.9	-2.4	-2.1
Hearing difficulty/problems with background noise	3.1	5.0	9.3	-3.0	-0.9
Ever had hysterectomy (womb removed)	2.8	3.2	5.7	2.4	0.9
Had other major operations	2.8	3.4	6.0	-2.5	-0.9
Medication: Omeprazole (e.g. Zanprol)	2.8	3.4	6.2	0.8	2.5
Taking other prescription medications	2.7	4.1	7.1	-2.7	-1.1
Impedance of arm (right)	2.7	12.7	15.8	4.0	3.1
Alzheimer’s Disease (in mother)	2.6	3.1	5.3	2.3	0.9
Diabetes (self-reported)	2.6	4.0	7.6	0.6	-2.8
Medication: Omeprazole	2.6	3.1	5.2	1.0	2.3
Stomach or abdominal pain in last month	2.5	3.1	6.1	-2.5	-0.0
Hair/balding pattern: Pattern 4	2.4	5.9	11.7	-0.3	3.4
Comparative height size at age 10	2.4	13.0	25.0	5.0	1.0
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	4.7	-2.2	-0.6
Mouth/teeth dental problems: Dentures	2.3	3.9	7.4	-0.7	2.7
Impedance of arm (left)	2.3	10.7	15.1	3.9	2.5
Diabetes diagnosed by doctor	2.3	3.7	7.4	0.2	-2.7
Risk taking	2.3	3.4	6.3	-2.5	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	5.3	-0.7	-2.3
Pain type(s) experienced in last month: Hip pain	2.2	2.8	4.2	-2.1	-1.1
Emphysema/chronic bronchitis	2.1	2.4	4.5	0.6	2.1
Mineral and other dietary supplements	2.1	2.9	5.0	0.9	2.2
Pulse wave Arterial Stiffness index	2.0	2.3	2.8	1.4	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	4.0	-0.9	-2.0
Medication: Atorvastatin	2.0	2.5	4.7	-2.2	-0.5
Medication: Lansoprazole	1.9	2.2	4.0	2.0	0.6
Prostate Cancer	1.8	2.5	5.0	0.3	2.2
Pulse wave peak to peak time	1.8	2.1	3.1	-1.0	1.8
Age at last live birth	1.8	2.6	5.1	-2.3	-0.3
Type 2 Diabetes (T2D) (2018)	1.7	3.1	5.8	0.6	-2.4
Chronotype (morning person)	1.7	4.0	7.5	2.7	-0.7
Diabetes (father)	1.7	2.1	3.7	0.7	-1.9
Pain all over the body in last month	1.7	1.9	3.0	1.7	0.9
Peak expiratory flow (PEF)	1.7	4.0	5.1	1.7	-2.3
Shortness of breath walking on level ground	1.7	2.0	2.6	-1.6	-1.2
Myopia	1.7	2.4	4.8	2.2	-0.2
Alcohol drinker status: Previous	1.7	1.9	3.7	0.2	-1.9
Ovarian Cancer	1.6	2.1	2.3	1.5	1.4
Number of treatments/medications taken	1.6	2.8	4.0	-2.0	-1.3
Medication: Atenolol	1.6	2.0	3.9	0.3	-2.0
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	3.8	-0.1	-2.0
Prospective memory result	1.6	2.0	3.6	-1.9	0.6
Commuting to job workplace: Car/motor vehicle	1.6	1.8	3.7	0.0	1.9
Medication: Aspirin	1.6	2.1	2.8	-1.2	-1.7
Ever taken oral contraceptive pill	1.6	1.8	3.1	-1.7	-0.7
Commuting to job workplace: Public transport	1.5	1.8	3.6	1.9	-0.3
Alcohol drinker status: Never	1.5	1.8	2.7	-1.6	-0.9
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	2.9	-1.0	-1.7
Impedance of whole body	1.5	7.7	8.0	2.8	2.7
Diabetes (mother)	1.4	1.8	3.4	0.5	-1.8
Length of working week for main job	1.4	1.5	3.0	1.7	0.2
Blood clot in the leg (DVT)	1.4	1.8	2.6	-1.0	-1.6
Gout (self-reported)	1.4	1.9	2.3	1.2	-1.5
Number of self-reported non-cancer illnesses	1.4	2.4	4.5	-0.6	-2.1
Ulcerative Colitis	1.3	1.9	2.5	-1.1	-1.6
Current tobacco smoking	1.3	2.1	3.8	-1.9	-0.7
Falls in the last year	1.3	1.7	3.4	0.1	1.8
Pulse wave reflection index	1.3	1.6	2.4	1.6	0.9
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.1	0.1	-1.8
Had major operations	1.3	1.5	2.8	1.7	-0.3
Illnesses of siblings: Diabetes	1.3	1.6	3.1	0.1	-1.8
Schizophrenia (2014)	1.2	2.6	2.6	-1.6	-1.6
Severe depression (siblings)	1.2	1.3	2.3	-0.6	1.5
Heart disease (mother)	1.2	1.5	3.0	-1.7	-0.0
Smoking status: Current	1.2	2.0	3.5	-1.9	-0.7
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.7	-1.6	-0.3
Schizophrenia vs Biploar Disorder	1.1	1.5	2.2	-0.8	-1.5
Height	1.1	21.6	41.5	6.4	1.3
Medication for hormone replacement therapy	1.1	1.3	2.1	-1.4	0.7
Guilty feelings	1.1	1.7	3.2	-0.4	-1.8
Hearing aid user	1.1	1.2	1.6	0.9	1.3
Alzheimer’s Disease (including proxy)	1.0	1.4	2.3	1.5	0.7
Lupus	1.0	1.5	2.6	-1.6	0.7
Fed-up feelings	1.0	1.9	3.1	1.8	-0.9
Impedance of leg (left)	1.0	5.0	9.7	0.6	3.1
Breast cancer (self-reported)	1.0	1.1	2.3	-0.1	1.5
Medication: Aspirin	1.0	1.3	1.6	-1.0	-1.2
Unable to work because of sickness or disability	1.0	1.4	2.4	-1.5	0.6
Basal cell carcinoma (self-reported)	1.0	1.2	1.2	1.1	1.1
Impedance of leg (right)	0.9	4.2	8.3	0.3	2.9
Trunk fat percentage	0.9	3.8	7.5	2.7	0.2
Chronic bronchitis/emphysema (father)	0.9	1.0	2.0	0.3	1.4
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.7	-0.7	-1.3
Tense / ‘highly strung’	0.9	1.5	2.8	-1.7	-0.5
Loud music exposure frequency	0.9	1.0	1.4	-1.2	-0.8
Worry too long after embarrassment	0.9	1.5	1.9	1.1	-1.4
Alcohol intake frequency.	0.9	2.1	2.6	-1.3	-1.6
Vascular/heart problems diagnosed by doctor	0.9	2.5	2.7	1.6	1.5
Ulcerative Colitis (UC)	0.8	1.4	2.5	-1.6	-0.6
Major Depression (MDD)	0.8	0.9	1.8	0.1	-1.4
Age at First Birth	0.8	1.1	2.2	1.5	-0.3
Pack years adult smoking proportion	0.8	1.3	2.3	-1.5	-0.5
High blood pressure (mother)	0.8	1.2	2.4	-1.5	0.1
Financial difficulties in last 2 years	0.8	1.1	1.2	-1.1	-1.0
Alcohol intake versus 10 years previously	0.8	1.2	1.9	-0.7	-1.4
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.6	-0.1	-1.9
Medication: Amlodipine	0.8	1.1	1.2	-1.0	-1.1
Number of children fathered	0.8	0.9	0.9	-1.0	-0.9
Medication: Allopurinol	0.8	1.0	1.9	0.4	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.2	1.1	0.8
Supplements: Fish oil (including cod liver oil)	0.8	1.0	1.3	-0.8	-1.1
Reaction Time	0.7	1.4	2.8	-1.7	-0.2
Mean Putamen Volume	0.7	0.8	0.8	-0.9	-0.9
Fasting Glucose	0.7	0.8	1.5	-0.2	-1.2
Triglycerides	0.7	1.1	1.6	-0.8	1.3
Heel T-Score	0.7	5.9	11.4	-3.4	-0.7
Relative age voice broke	0.7	1.0	2.0	-1.4	0.0
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.1	1.0	-0.7
High blood pressure	0.7	1.8	2.4	-1.6	-1.1
Trunk fat mass	0.7	3.0	6.0	2.4	-0.3
Illnesses of mother	0.7	0.9	0.9	1.0	1.0
Standing height	0.7	7.4	13.8	3.7	1.0
High blood pressure (siblings)	0.7	1.0	1.0	-1.0	-1.0
Wheeze or whistling in the chest in last year	0.7	1.3	2.2	-0.7	1.5
Chest pain or discomfort	0.7	1.0	1.9	1.4	-0.3
Hypertension (Self-reported)	0.7	1.8	2.4	-1.6	-1.1
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.3	0.6	1.2
Mood swings	0.7	1.2	2.4	0.3	-1.5
Long-standing illness, disability or infirmity	0.7	1.1	1.8	-0.7	-1.3
Ever smoked	0.7	1.2	2.2	-1.5	0.5
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.5	1.2	-0.0
Age started oral contraceptive pill	0.7	0.9	1.0	1.0	0.9
Pack years of smoking	0.7	1.0	1.9	-1.4	-0.3
Schizophrenia (2018)	0.6	1.2	2.2	-1.5	-0.5
Bipolar Disorder (2011)	0.6	0.6	1.2	-0.2	1.1
Neuroticism (2016)	0.6	0.9	1.3	0.7	-1.2
Blood Platelet Count	0.6	6.5	12.5	-3.5	0.6
Cardiovascular Disease	0.6	1.9	3.7	-0.3	-1.9
Lung FEV1/FVC ratio	0.6	3.2	5.2	-2.3	-1.1
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.3	0.5	-1.1
Qualifications: CSEs or equivalent	0.6	0.8	1.3	1.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	0.8	-0.9	-0.7
Sitting height	0.6	4.6	8.2	2.9	1.0
Time employed in main current job	0.6	0.6	1.0	1.0	0.5
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	2.7	1.2	-1.6
Lung cancer (father)	0.6	0.7	1.4	-1.2	0.2
Medication: Paracetamol	0.6	1.0	1.9	-0.2	-1.4
Age at first live birth	0.6	1.1	1.5	0.8	1.2
Mean time to correctly identify matches	0.6	1.1	1.8	-1.3	-0.6
Knee pain experienced in last month	0.6	0.9	1.8	-0.1	-1.4
Average weekly red wine intake	0.6	1.0	1.0	1.0	1.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.6	-0.7	-1.3
Osteoporosis (self-reported)	0.6	0.8	1.5	-1.2	-0.2
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	-0.2	1.2
Bipolar Disorder (2018)	0.5	0.8	1.5	1.2	-0.2
Depression (Nagel 2018)	0.5	0.8	1.6	-1.3	0.1
HbA1C	0.5	0.5	1.1	-0.1	-1.0
Smoking Status	0.5	1.1	2.3	-1.5	0.0
Sensitivity / hurt feelings	0.5	0.9	1.4	-0.6	1.2
Leg fat-free mass (left)	0.5	2.5	2.6	1.5	-1.6
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.0	0.1	-1.4
Leg predicted mass (left)	0.5	2.4	2.7	1.5	-1.6
Forced vital capacity (FVC)	0.5	2.0	3.0	1.7	-1.0
Noisy workplace	0.5	0.6	0.9	0.9	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.3	-1.1	-0.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	0.8	-0.5	-0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.3	0.4	-1.2
Headache pain in last month	0.5	0.9	1.7	0.2	-1.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.2	1.1	0.8
Health satisfaction	0.5	0.7	1.3	-0.2	-1.1
Eye problems/disorders: None of the above	0.5	0.5	0.8	0.5	-0.9
Ever had bowel cancer screening	0.5	0.6	0.7	0.7	-0.9
Medication for cholesterol	0.5	0.8	1.4	0.4	1.2
Miserableness	0.5	0.8	1.4	-0.4	-1.2
Cholesterol lowering medication	0.5	0.7	1.4	0.0	-1.2
Heart attack/myocardial infarction (self-reported)	0.5	0.6	0.8	-0.7	0.9
Depressed Affect (Nagel 2018)	0.4	0.8	1.1	1.1	-0.8
Blood Red Count	0.4	4.0	6.7	1.1	-2.6
Waist Hip Ratio (WHR)	0.4	1.8	2.4	-1.1	1.5
Lung FVC	0.4	2.2	3.5	-1.0	-1.9
Angina	0.4	0.5	0.7	-0.6	-0.8
Supplements: Zinc	0.4	0.4	0.7	0.9	0.3
Medication: Metformin	0.4	0.6	0.7	0.7	-0.8
Age when periods started (menarche)	0.4	1.1	1.9	0.5	1.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-0.2	0.9
Mouth/teeth dental problems	0.4	0.5	1.0	-0.4	-1.0
Hip circumference	0.4	1.7	3.4	1.9	-0.2
Pulse rate	0.4	0.7	1.0	0.6	-1.0
Happiness	0.4	0.4	0.8	0.9	-0.2
Breastfed as a baby	0.4	0.5	0.8	-0.3	0.9
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	1.0	-0.1
Body fat percentage	0.4	1.6	3.3	1.8	0.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.2	0.4	1.1
Whole body fat mass	0.4	1.6	3.0	1.7	-0.4
Pulse rate, automated reading	0.4	1.4	2.8	1.7	0.1
Overall health rating	0.4	0.9	1.8	0.1	-1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	0.8	0.8	-0.9
Leg fat-free mass (right)	0.4	2.4	2.8	1.7	-1.4
Back pain experienced in last month	0.4	0.6	0.8	0.6	0.9
Leg predicted mass (right)	0.4	2.4	2.8	1.7	-1.4
Medication: Bendroflumethiazide	0.4	0.6	0.9	-0.5	-1.0
Medication: Paracetamol	0.4	0.6	1.1	-0.3	-1.1
Ever depressed for a whole week	0.4	0.5	0.9	1.0	-0.0
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.1	-0.8
Crohns Disease (2017)	0.3	0.7	1.3	0.4	1.2
LDL Cholesterol	0.3	0.5	1.0	-1.0	0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.5	0.7	0.4
BMI	0.3	1.5	1.7	1.1	-1.3
Allergy or Eczema	0.3	0.7	1.1	-0.6	-1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.5	0.4	0.7
Vitamin and mineral supplements	0.3	0.4	0.8	-0.3	0.9
Townsend deprivation index at recruitment	0.3	0.4	0.7	-0.8	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.0	-1.0	-0.5
Body mass index (BMI)	0.3	1.1	2.1	-0.2	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.4	-1.2	-0.2
Heart attack	0.3	0.4	0.6	-0.8	0.5
Medication: Simvastatin	0.3	0.4	0.5	0.7	-0.6
Illnesses of siblings	0.3	0.4	0.4	0.7	0.5
Weight	0.3	1.4	2.0	1.4	-0.9
Arm fat percentage (right)	0.3	1.2	2.2	1.5	-0.4
Arm fat mass (right)	0.3	1.3	2.3	1.5	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.5	0.7	-0.5
Glaucoma (self-reported)	0.3	0.3	0.5	0.7	0.4
Arm fat-free mass (right)	0.3	1.6	3.3	0.1	-1.8
Comparative body size at age 10	0.3	0.7	1.3	1.1	0.3
Medication: Seretide 50 evohaler	0.3	0.4	0.5	0.5	0.7
Arm predicted mass (right)	0.3	1.6	3.1	-0.2	-1.8
Smoking status: Previous	0.3	0.4	0.8	0.0	0.9
Whole body fat-free mass	0.3	1.5	2.6	0.7	-1.6
Arm fat percentage (left)	0.3	1.3	2.0	1.4	-0.7
Friendships satisfaction	0.3	0.3	0.4	-0.6	-0.5
Medication: Blood pressure	0.3	0.5	0.7	-0.9	-0.6
Medication: Lisinopril	0.3	0.3	0.6	-0.1	-0.8
Basal metabolic rate	0.3	1.4	1.8	1.0	-1.3
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.2	-0.9
Diastolic blood pressure, automated reading	0.3	1.0	1.5	-1.2	-0.7
Pain experienced in last month	0.3	0.6	0.9	0.5	0.9
Worry (Nagel 2018)	0.2	0.5	1.0	-0.1	1.0
Crohns Disease (2012)	0.2	0.2	0.4	0.4	0.6
HDL Cholesterol	0.2	0.3	0.4	0.4	0.6
Respiratory disease	0.2	0.5	1.0	1.0	0.2
Average weekly spirits intake	0.2	0.2	0.5	-0.1	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.3	-0.5	0.4
Relative age of first facial hair	0.2	0.4	0.6	-0.5	-0.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.6	0.1
Medication: Co-codamol	0.2	0.2	0.5	0.7	-0.2
Maternal smoking around birth	0.2	0.3	0.5	0.7	-0.4
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.1	-0.7
Multivitamins +/- minerals	0.2	0.3	0.6	0.7	-0.1
Number of incorrect matches in round	0.2	0.3	0.5	0.7	0.1
Past tobacco smoking	0.2	0.3	0.6	0.2	-0.8
Qualifications: None of the above	0.2	0.5	0.7	-0.5	0.8
Medication: Ramipril	0.2	0.3	0.5	-0.7	0.2
Neuroticism score	0.2	0.3	0.6	0.8	-0.2
Trunk fat-free mass	0.2	1.1	2.2	0.2	-1.5
Worrier / anxious feelings	0.2	0.3	0.6	-0.0	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.5	0.7	0.2
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	-0.0	-0.8
Asthma	0.2	0.3	0.6	0.2	0.8
Trunk predicted mass	0.2	1.1	2.1	0.1	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.3	-0.7
Birth weight	0.2	0.5	0.6	0.7	0.8
Exposure to tobacco smoke outside home	0.2	0.3	0.6	-0.2	0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.0	0.7
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.7	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.2	0.5	0.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	0.7	0.3
Supplements: Vitamin C	0.2	0.3	0.5	0.7	-0.0
Commuting to job workplace: Walk	0.2	0.2	0.3	-0.5	-0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.3	-0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.4	-0.6	-0.6
Whole body water mass	0.2	1.3	2.1	0.7	-1.4
Arm fat mass (left)	0.2	1.0	1.5	1.2	-0.7
Arm fat-free mass (left)	0.2	0.9	1.7	0.1	-1.3
Fractured/broken bones in last 5 years	0.2	0.3	0.5	-0.1	0.7
Commuting to job workplace: Cycle	0.2	0.2	0.2	0.5	0.4
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	-0.4	-0.5
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	0.5	-0.6
Neuroticism (Nagel 2018)	0.1	0.3	0.5	0.7	-0.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.3	-0.6	0.3
Breast Cancer	0.1	0.2	0.5	-0.7	0.0
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.5	-0.1
Blood Eosinophil Count	0.1	0.4	0.7	0.4	0.8
Blood White Count	0.1	0.8	1.2	0.6	-1.1
Neuroticism	0.1	0.2	0.3	0.6	-0.2
Tanning	0.1	0.7	1.3	-0.2	1.1
Systolic blood pressure, automated reading	0.1	0.4	0.8	-0.2	0.9
Hand grip strength (right)	0.1	0.3	0.3	-0.6	-0.5
Supplements: Glucosamine	0.1	0.1	0.2	-0.2	-0.4
Waist circumference	0.1	0.3	0.5	0.1	-0.7
Alcohol usually taken with meals	0.1	0.2	0.4	0.7	-0.0
Nervous feelings	0.1	0.2	0.2	-0.5	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.4	0.5
Had menopause	0.1	0.2	0.2	-0.5	-0.3
Allergy	0.1	0.2	0.5	0.1	0.7
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.1	-0.5
Fluid intelligence score	0.1	0.1	0.2	0.4	0.3
Father’s age at death	0.1	0.2	0.2	-0.5	0.3
Depression (self-reported)	0.1	0.2	0.2	0.4	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.7	0.3	-0.8
Exposure to tobacco smoke at home	0.1	0.1	0.1	-0.4	-0.1
Birth weight of first child	0.1	0.1	0.2	0.0	0.4
Forced vital capacity (FVC), Best measure	0.1	0.4	0.5	0.7	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	0.4	-0.3
Medication: Blood pressure	0.1	0.3	0.4	-0.6	-0.4
Angina (self-reported)	0.1	0.2	0.3	-0.1	-0.6
Migraine (self-reported)	0.1	0.2	0.3	-0.5	0.1
Leg fat mass (right)	0.1	0.4	0.6	0.6	-0.8
Suffer from ‘nerves’	0.1	0.2	0.4	-0.2	0.6
Leg pain on walking	0.1	0.1	0.2	-0.2	0.4
Loneliness, isolation	0.1	0.1	0.2	-0.1	-0.5
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.5	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.1	-0.5
Asthma (self-reported)	0.1	0.1	0.2	0.2	0.5
Medication: Gliclazide	0.1	0.2	0.2	0.5	-0.3
Financial situation satisfaction	0.1	0.2	0.3	-0.1	-0.5
High cholesterol (Self-reported)	0.1	0.2	0.2	-0.5	-0.4
Illnesses of father: High blood pressure	0.1	0.1	0.1	-0.3	-0.1
Heart disease (siblings)	0.1	0.1	0.2	-0.4	-0.1
Leg fat mass (left)	0.1	0.5	0.5	0.6	-0.7
Arm predicted mass (left)	0.1	0.7	1.4	0.3	-1.2
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.2	0.4	-0.0
Body Mass Index (BMI) (2010)	0.0	0.0	0.1	-0.2	0.1
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.3	-0.1
Systolic Blood Pressure	0.0	0.1	0.1	-0.4	0.1
Hair Pigment	0.0	0.2	0.3	-0.5	0.2
Hand grip strength (left)	0.0	0.0	0.0	-0.2	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	-0.2	-0.2
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.1	0.0
Medication: Cholesterol lowering	0.0	0.0	0.0	0.2	0.1
Leg fat percentage (right)	0.0	0.0	0.0	0.2	-0.0
Qualifications: College or University degree	0.0	0.0	0.0	0.2	-0.2
Medication: Ibuprofen	0.0	0.0	0.0	-0.1	0.1
Family relationship satisfaction	0.0	0.0	0.1	-0.1	0.3
Illnesses of father: Heart disease	0.0	0.0	0.1	-0.2	0.2
Qualifications: nursing, teaching	0.0	0.0	0.0	-0.0	-0.2
Osteoarthritis (self-reported)	0.0	0.0	0.1	0.3	0.0
Average weekly champagne plus white wine intake	0.0	0.1	0.1	-0.2	-0.3
Wears glasses or contact lenses	0.0	0.0	0.0	0.0	-0.2
Mother’s age at death	0.0	0.0	0.0	0.1	0.2
Leg fat percentage (left)	0.0	0.0	0.1	0.3	-0.1
Number of operations (self-reported)	0.0	0.1	0.1	-0.3	-0.1
Irritability	0.0	0.0	0.1	-0.2	0.0

Hub : Genes

NR3C2

Models

Trait associations