Best TWAS P=3.73e-10 · Best GWAS P=1.88e-09 conditioned to 0.063
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hippocampus | AHI1 | 0.28 | 0.10 | lasso | 5 | 0.05 | 2.9e-02 | 4.3 | -5.8 | 5.9e-09 | -0.80 | 0.06 | 0.56 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | AHI1 | 0.38 | 0.24 | enet | 19 | 0.23 | 5.4e-08 | 6.0 | -5.5 | 4.1e-08 | -0.48 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | RP3-388E23.2 | 0.26 | 0.05 | lasso | 6 | 0.02 | 7.1e-02 | 5.8 | -5.7 | 9.5e-09 | -0.50 | 0.03 | 0.88 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | AHI1 | 0.41 | 0.31 | lasso | 7 | 0.40 | 9.1e-24 | 5.7 | -5.1 | 3.1e-07 | -0.41 | 0.04 | 0.96 | FALSE |
| 5 | NTR | Blood | AHI1 | 0.11 | 0.14 | lasso | 6 | 0.15 | 3.2e-47 | 5.8 | -5.6 | 2.5e-08 | -0.55 | 0.04 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C6orf217 | 0.02 | 0.02 | blup | 80 | 0.02 | 1.2e-05 | 5.1 | -6.2 | 7.5e-10 | -0.74 | 0.03 | 0.97 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | AHI1 | 0.18 | 0.19 | lasso | 4 | 0.18 | 6.4e-20 | 5.7 | -5.8 | 5.6e-09 | -0.49 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C6orf217 | 0.05 | 0.06 | lasso | 7 | 0.05 | 5.1e-06 | 5.7 | -5.8 | 4.8e-09 | -0.93 | 0.03 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C6orf217 | 0.10 | 0.09 | lasso | 4 | 0.08 | 2.9e-05 | 5.5 | -5.7 | 1.2e-08 | -0.89 | 0.04 | 0.94 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C6orf217 | 0.08 | 0.08 | lasso | 5 | 0.07 | 1.6e-08 | 5.7 | -6.0 | 2.3e-09 | -0.91 | 0.02 | 0.98 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | AHI1 | 0.13 | 0.16 | lasso | 3 | 0.16 | 1.2e-17 | 5.6 | -5.6 | 2.1e-08 | -0.47 | 0.01 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C6orf217 | 0.04 | 0.03 | blup | 81 | 0.01 | 1.7e-02 | 6.0 | -6.3 | 3.7e-10 | -0.77 | 0.01 | 0.96 | TRUE |
| 13 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | AHI1 | 0.05 | 0.05 | lasso | 1 | 0.04 | 1.5e-03 | 6.0 | -6.0 | 2.1e-09 | -0.50 | 0.00 | 0.97 | FALSE |
| 14 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf217 | 0.06 | 0.06 | enet | 9 | 0.07 | 1.6e-05 | 5.1 | -6.2 | 7.9e-10 | -0.81 | 0.06 | 0.93 | FALSE |
| 15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C6orf217 | 0.10 | 0.00 | blup | 82 | 0.04 | 6.8e-03 | 5.0 | -6.0 | 2.0e-09 | -0.72 | 0.02 | 0.64 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C6orf217 | 0.07 | 0.07 | blup | 81 | 0.09 | 4.3e-10 | 5.7 | -5.8 | 8.4e-09 | -0.75 | 0.02 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Stomach Adenocarcinoma | C6orf217 | 0.06 | 0.02 | lasso | 3 | 0.02 | 7.7e-03 | 5.5 | -5.3 | 1.3e-07 | -0.54 | 0.02 | 0.52 | FALSE |
| 18 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | AHI1 | 0.36 | 0.30 | lasso | 3 | 0.29 | 1.0e-10 | 6.0 | -5.7 | 1.4e-08 | -0.46 | 0.00 | 1.00 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | C6orf217 | 0.30 | 0.24 | enet | 16 | 0.26 | 1.5e-25 | 5.5 | -6.1 | 9.7e-10 | -0.89 | 0.03 | 0.97 | FALSE |