[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr6:134,905,567-136,516,257

Best TWAS P=3.73e-10 · Best GWAS P=1.88e-09 conditioned to 0.063

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C6orf217	0.04	0.03	blup	81	0.01	1.7e-02	6.0	-6.3	3.7e-10	-0.77	0.01	0.96	TRUE
6	The Cancer Genome Atlas	Breast Invasive Carcinoma	C6orf217	0.02	0.02	blup	80	0.02	1.2e-05	5.1	-6.2	7.5e-10	-0.74	0.03	0.97	FALSE
14	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C6orf217	0.06	0.06	enet	9	0.07	1.6e-05	5.1	-6.2	7.9e-10	-0.81	0.06	0.93	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	C6orf217	0.30	0.24	enet	16	0.26	1.5e-25	5.5	-6.1	9.7e-10	-0.89	0.03	0.97	FALSE
15	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C6orf217	0.10	0.00	blup	82	0.04	6.8e-03	5.0	-6.0	2.0e-09	-0.72	0.02	0.64	FALSE
13	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	AHI1	0.05	0.05	lasso	1	0.04	1.5e-03	6.0	-6.0	2.1e-09	-0.50	0.00	0.97	FALSE
10	The Cancer Genome Atlas	Brain Lower Grade Glioma	C6orf217	0.08	0.08	lasso	5	0.07	1.6e-08	5.7	-6.0	2.3e-09	-0.91	0.02	0.98	FALSE
8	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C6orf217	0.05	0.06	lasso	7	0.05	5.1e-06	5.7	-5.8	4.8e-09	-0.93	0.03	0.97	FALSE
7	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AHI1	0.18	0.19	lasso	4	0.18	6.4e-20	5.7	-5.8	5.6e-09	-0.49	0.00	1.00	FALSE
1	GTEx	Brain Hippocampus	AHI1	0.28	0.10	lasso	5	0.05	2.9e-02	4.3	-5.8	5.9e-09	-0.80	0.06	0.56	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	C6orf217	0.07	0.07	blup	81	0.09	4.3e-10	5.7	-5.8	8.4e-09	-0.75	0.02	0.98	FALSE
3	GTEx	Cells EBV-transformed lymphocytes	RP3-388E23.2	0.26	0.05	lasso	6	0.02	7.1e-02	5.8	-5.7	9.5e-09	-0.50	0.03	0.88	FALSE
9	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C6orf217	0.10	0.09	lasso	4	0.08	2.9e-05	5.5	-5.7	1.2e-08	-0.89	0.04	0.94	FALSE
18	The Cancer Genome Atlas	Testicular Germ Cell Tumors	AHI1	0.36	0.30	lasso	3	0.29	1.0e-10	6.0	-5.7	1.4e-08	-0.46	0.00	1.00	FALSE
11	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	AHI1	0.13	0.16	lasso	3	0.16	1.2e-17	5.6	-5.6	2.1e-08	-0.47	0.01	0.99	FALSE
5	NTR	Blood	AHI1	0.11	0.14	lasso	6	0.15	3.2e-47	5.8	-5.6	2.5e-08	-0.55	0.04	0.96	FALSE
2	GTEx	Cells EBV-transformed lymphocytes	AHI1	0.38	0.24	enet	19	0.23	5.4e-08	6.0	-5.5	4.1e-08	-0.48	0.02	0.98	FALSE
17	The Cancer Genome Atlas	Stomach Adenocarcinoma	C6orf217	0.06	0.02	lasso	3	0.02	7.7e-03	5.5	-5.3	1.3e-07	-0.54	0.02	0.52	FALSE
4	GTEx	Skin Not Sun Exposed Suprapubic	AHI1	0.41	0.31	lasso	7	0.40	9.1e-24	5.7	-5.1	3.1e-07	-0.41	0.04	0.96	FALSE