TWAS
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Traits
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Traits
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Hypothyroidism (self reported)
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chr6:89,941,356-91,704,536
Best TWAS P=2.99e-33 · Best GWAS P=1.53e-38 conditioned to 7.79e-16
90M
90.2M
90.4M
90.6M
90.8M
91M
91.2M
91.4M
91.6M
91.8M
0
10
20
30
40
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
NTR
Blood
BACH2
0.03
0.02
lasso
3
0.02
2.1e-06
12.1
-12
3.0e-33
0.41
0.98
0.00
TRUE
2
YFS
Blood
BACH2
0.03
0.01
lasso
4
0.01
6.9e-04
6.4
-9
2.3e-19
0.63
0.05
0.94
TRUE