[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr6:165,045,334-167,841,508

Best TWAS P=8.05e-36 · Best GWAS P=2.55e-34 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	AL133458.1	0.11	0.02	enet	18	0.01	2.5e-02	9.2	-8.5	2.5e-17	0.55	0.25	0.35	FALSE
2	GTEx	Brain Cerebellar Hemisphere	AL133458.1	0.29	0.00	enet	19	0.00	3.6e-01	-11.1	-11.5	1.4e-30	0.83	0.02	0.91	FALSE
3	GTEx	Brain Cerebellum	AL133458.1	0.42	0.32	lasso	6	0.31	1.0e-09	-12.2	-12.0	2.2e-33	0.94	0.00	1.00	FALSE
4	GTEx	Cells Transformed fibroblasts	RNASET2	0.29	0.30	enet	31	0.29	1.0e-21	-11.1	10.9	1.3e-27	-0.73	1.00	0.00	FALSE
5	GTEx	Cells Transformed fibroblasts	AL133458.1	0.16	0.14	enet	13	0.14	1.7e-10	-11.1	10.3	1.1e-24	-0.73	0.99	0.01	FALSE
6	GTEx	Colon Transverse	RNASET2	0.21	0.02	enet	18	0.07	3.1e-04	-3.4	-7.6	3.8e-14	0.56	0.02	0.80	FALSE
7	GTEx	Esophagus Mucosa	RNASET2	0.29	0.31	lasso	9	0.32	1.6e-21	-12.2	-12.5	8.1e-36	0.97	0.00	1.00	TRUE
8	GTEx	Esophagus Mucosa	AL133458.1	0.15	0.01	enet	12	0.02	1.3e-02	-10.9	-10.0	1.8e-23	0.70	0.03	0.90	FALSE
9	GTEx	Esophagus Mucosa	FGFR1OP	0.10	0.07	lasso	4	0.03	4.4e-03	10.2	10.2	1.3e-24	-0.67	0.28	0.43	FALSE
10	GTEx	Lung	RNASET2	0.21	0.13	lasso	10	0.13	4.0e-10	-11.1	-12.0	4.4e-33	0.85	0.23	0.77	FALSE
11	GTEx	Lung	AL133458.1	0.17	0.09	lasso	5	0.12	3.9e-09	-8.1	-10.9	1.7e-27	0.72	0.90	0.10	FALSE
12	GTEx	Nerve Tibial	RNASET2	0.19	0.07	lasso	8	0.09	4.4e-07	9.2	-10.2	1.4e-24	0.69	0.28	0.71	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	RNASET2	0.14	0.07	enet	25	0.08	3.6e-05	10.4	-9.6	6.9e-22	0.65	0.08	0.91	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	AL133458.1	0.13	0.05	lasso	2	0.01	5.4e-02	9.2	-9.2	3.0e-20	0.55	0.10	0.72	FALSE
15	GTEx	Skin Sun Exposed Lower leg	RNASET2	0.32	0.23	enet	48	0.24	3.3e-20	-11.1	-11.8	2.7e-32	0.86	0.31	0.69	FALSE
16	GTEx	Skin Sun Exposed Lower leg	AL133458.1	0.13	0.08	enet	10	0.03	1.0e-03	-11.1	-11.7	1.2e-31	0.80	0.13	0.87	FALSE
17	GTEx	Stomach	RNASET2	0.22	0.12	lasso	6	0.16	6.5e-08	-10.1	-10.9	8.7e-28	0.89	0.00	0.99	FALSE
18	GTEx	Thyroid	RNASET2	0.16	0.06	enet	33	0.04	3.8e-04	10.2	-9.3	1.2e-20	0.60	0.87	0.10	FALSE
19	GTEx	Thyroid	PDE10A	0.21	0.12	enet	26	0.15	1.1e-11	-6.2	5.3	9.3e-08	0.03	0.00	1.00	TRUE
20	GTEx	Thyroid	AL133458.1	0.09	0.07	lasso	5	0.07	2.9e-06	-8.1	-9.0	2.0e-19	0.50	0.98	0.00	FALSE
21	GTEx	Whole Blood	RNASET2	0.20	0.18	enet	23	0.18	3.4e-16	-11.1	-12.3	9.6e-35	0.85	0.99	0.01	FALSE
22	GTEx	Whole Blood	AL133458.1	0.20	0.14	enet	7	0.18	1.4e-16	-10.9	-11.6	3.7e-31	0.80	1.00	0.00	FALSE
23	METSIM	Adipose	CCR6	0.06	0.02	lasso	3	0.04	5.6e-07	8.6	8.1	5.4e-16	-0.45	0.93	0.01	FALSE
24	METSIM	Adipose	FGFR1OP	0.05	0.00	blup	606	0.02	1.5e-03	2.4	7.8	4.9e-15	-0.57	0.06	0.84	FALSE
25	METSIM	Adipose	RNASET2	0.09	0.09	lasso	4	0.12	8.7e-18	-11.1	-12.0	2.4e-33	0.86	0.14	0.86	FALSE
26	NTR	Blood	RNASET2	0.28	0.42	lasso	13	0.43	5.3e-155	-11.1	-11.8	4.9e-32	0.84	1.00	0.00	FALSE
27	YFS	Blood	RNASET2	0.45	0.60	enet	24	0.61	1.8e-260	-11.1	-11.3	1.0e-29	0.83	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RNASET2	0.08	0.05	enet	12	0.07	2.0e-06	-12.2	-11.3	1.4e-29	0.86	0.00	1.00	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	RNASET2	0.07	0.05	lasso	4	0.04	5.1e-09	-12.2	-12.1	1.0e-33	1.00	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	RNASET2	0.12	0.05	enet	7	0.08	2.4e-05	-12.1	-8.4	3.9e-17	0.83	0.00	0.98	FALSE
31	The Cancer Genome Atlas	Esophageal Carcinoma	RNASET2	0.17	0.11	lasso	3	0.09	8.7e-04	-12.2	-12.4	1.6e-35	0.97	0.01	0.98	FALSE
32	The Cancer Genome Atlas	Glioblastoma Multiforme	GPR31	0.17	0.06	enet	10	0.09	1.3e-03	-6.2	6.7	1.6e-11	-0.29	0.02	0.20	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RNASET2	0.09	0.08	lasso	2	0.08	2.9e-09	-12.2	-12.1	6.1e-34	1.00	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	RNASET2	0.05	0.03	lasso	3	0.03	9.2e-05	-11.1	-12.5	8.0e-36	0.92	0.00	0.99	FALSE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	RNASET2	0.06	0.04	lasso	2	0.03	2.6e-04	-12.2	-12.1	6.8e-34	1.00	0.00	0.99	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RNASET2	0.13	0.09	lasso	9	0.10	1.4e-11	-12.1	-12.0	5.5e-33	0.93	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RNASET2	0.08	0.00	enet	8	0.01	6.5e-02	-3.5	-9.3	1.6e-20	0.73	0.01	0.71	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	RNASET2	0.24	0.15	lasso	3	0.14	5.6e-15	-12.1	-11.7	1.5e-31	0.96	0.00	1.00	FALSE
39	The Cancer Genome Atlas	Rectum Adenocarcinoma	RNASET2	0.14	0.19	lasso	3	0.15	2.1e-04	-12.1	-12.1	7.1e-34	0.99	0.00	0.93	FALSE