Best TWAS P=1.33e-07 · Best GWAS P=9.6e-08 conditioned to 0.19
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | PTPN12 | 0.16 | 0.10 | lasso | 4 | 0.04 | 1.0e-02 | 5.3 | -5.2 | 1.6e-07 | -0.96 | 0.02 | 0.96 | FALSE |
| 2 | GTEx | Artery Tibial | PTPN12 | 0.25 | 0.13 | lasso | 8 | 0.12 | 1.8e-09 | 5.2 | -5.3 | 1.4e-07 | -0.91 | 0.02 | 0.98 | TRUE |
| 3 | GTEx | Colon Transverse | PTPN12 | 0.17 | 0.12 | lasso | 6 | 0.10 | 1.8e-05 | 5.3 | -5.2 | 2.4e-07 | -0.93 | 0.02 | 0.97 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PHTF2 | 0.02 | 0.01 | lasso | 1 | 0.01 | 3.0e-03 | 5.2 | -5.2 | 2.2e-07 | -0.89 | 0.01 | 0.98 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | PTPN12 | 0.04 | 0.04 | enet | 4 | 0.04 | 1.0e-04 | 5.2 | -5.3 | 1.3e-07 | -0.99 | 0.01 | 0.98 | FALSE |