Best TWAS P=2.81e-11 · Best GWAS P=7.9e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | GIGYF1 | 0.14 | 0.10 | enet | 22 | 0.14 | 1.9e-11 | -6.5 | -6.2 | 4.4e-10 | 0.85 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | GIGYF1 | 0.12 | 0.07 | lasso | 3 | 0.04 | 5.0e-03 | -6.2 | -6.3 | 2.6e-10 | 0.97 | 0.01 | 0.93 | FALSE |
| 3 | GTEx | Adrenal Gland | GIGYF1 | 0.23 | 0.14 | lasso | 1 | 0.07 | 1.2e-03 | -6.5 | -6.5 | 1.0e-10 | 0.98 | 0.00 | 0.97 | FALSE |
| 4 | GTEx | Artery Aorta | GIGYF1 | 0.14 | 0.11 | enet | 9 | 0.11 | 1.1e-06 | -6.5 | -6.2 | 4.5e-10 | 0.92 | 0.00 | 0.99 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | GIGYF1 | 0.23 | 0.07 | enet | 14 | 0.09 | 2.4e-05 | -6.2 | -5.2 | 2.0e-07 | 0.67 | 0.01 | 0.96 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | GIGYF1 | 0.21 | 0.16 | lasso | 9 | 0.19 | 6.2e-14 | -6.5 | -6.2 | 5.1e-10 | 0.92 | 0.00 | 1.00 | FALSE |
| 7 | GTEx | Colon Transverse | GIGYF1 | 0.20 | 0.05 | enet | 19 | 0.09 | 4.9e-05 | -6.2 | -5.8 | 5.1e-09 | 0.74 | 0.01 | 0.98 | FALSE |
| 8 | GTEx | Esophagus Gastroesophageal Junction | GIGYF1 | 0.29 | 0.09 | lasso | 3 | 0.12 | 5.6e-05 | -4.9 | -6.0 | 2.6e-09 | 0.90 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Esophagus Muscularis | GIGYF1 | 0.22 | 0.12 | enet | 13 | 0.15 | 3.3e-09 | -6.5 | -5.4 | 6.0e-08 | 0.74 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Lung | GIGYF1 | 0.25 | 0.13 | lasso | 7 | 0.14 | 4.0e-11 | -6.2 | -6.2 | 7.5e-10 | 0.94 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Muscle Skeletal | GIGYF1 | 0.10 | 0.03 | enet | 14 | 0.06 | 6.8e-07 | -6.4 | -6.6 | 3.1e-11 | 0.76 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Nerve Tibial | GIGYF1 | 0.17 | 0.14 | enet | 7 | 0.14 | 2.3e-10 | -6.4 | -6.4 | 1.3e-10 | 0.98 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Ovary | GIGYF1 | 0.23 | 0.15 | lasso | 5 | 0.14 | 2.9e-04 | -3.2 | -5.2 | 1.7e-07 | 0.74 | 0.02 | 0.90 | FALSE |
| 14 | GTEx | Pituitary | GIGYF1 | 0.24 | 0.01 | lasso | 7 | 0.03 | 5.7e-02 | -5.0 | -5.5 | 4.2e-08 | 0.90 | 0.02 | 0.84 | FALSE |
| 15 | GTEx | Prostate | GIGYF1 | 0.51 | 0.06 | lasso | 10 | 0.05 | 2.0e-02 | -6.4 | -5.8 | 6.2e-09 | 0.81 | 0.02 | 0.78 | FALSE |
| 16 | GTEx | Skin Not Sun Exposed Suprapubic | GIGYF1 | 0.11 | 0.00 | lasso | 5 | 0.00 | 2.2e-01 | -4.3 | -5.2 | 2.0e-07 | 0.67 | 0.03 | 0.70 | FALSE |
| 17 | GTEx | Thyroid | GIGYF1 | 0.33 | 0.24 | lasso | 7 | 0.24 | 1.5e-18 | -6.2 | -6.4 | 1.6e-10 | 0.98 | 0.00 | 1.00 | FALSE |
| 18 | GTEx | Whole Blood | GIGYF1 | 0.04 | 0.02 | lasso | 5 | 0.01 | 5.5e-02 | -6.4 | -6.7 | 2.8e-11 | 0.96 | 0.01 | 0.96 | TRUE |
| 19 | METSIM | Adipose | GIGYF1 | 0.15 | 0.08 | blup | 297 | 0.13 | 3.9e-19 | -3.8 | -5.2 | 2.3e-07 | 0.62 | 0.12 | 0.88 | FALSE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GNB2 | 0.03 | 0.01 | blup | 31 | 0.02 | 1.3e-03 | -4.9 | 5.3 | 1.0e-07 | -0.77 | 0.01 | 0.55 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | GNB2 | 0.15 | 0.01 | blup | 32 | 0.01 | 1.0e-01 | -6.4 | -5.6 | 2.7e-08 | 0.78 | 0.00 | 0.45 | FALSE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GIGYF1 | 0.05 | 0.06 | lasso | 3 | 0.06 | 4.7e-07 | -6.4 | -6.4 | 1.3e-10 | 0.98 | 0.00 | 1.00 | FALSE |
| 23 | The Cancer Genome Atlas | Lung Adenocarcinoma | GIGYF1 | 0.03 | 0.02 | blup | 30 | 0.02 | 4.7e-03 | -6.4 | -6.3 | 3.8e-10 | 0.90 | 0.00 | 0.86 | FALSE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GIGYF1 | 0.04 | 0.03 | blup | 29 | 0.03 | 1.7e-04 | -4.9 | -5.5 | 3.2e-08 | 0.83 | 0.02 | 0.85 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | GIGYF1 | 0.04 | 0.03 | blup | 30 | 0.03 | 8.4e-04 | -6.4 | -5.8 | 7.2e-09 | 0.84 | 0.01 | 0.84 | FALSE |