Best TWAS P=8.11e-09 · Best GWAS P=5.89e-08 conditioned to 0.000772
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | METSIM | Adipose | IRF5 | 0.05 | 0.04 | lasso | 7 | 0.04 | 2.2e-06 | 4.5 | 5.1 | 2.9e-07 | 0.42 | 0.11 | 0.87 | FALSE |
| 2 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IRF5 | 0.11 | 0.05 | blup | 30 | 0.07 | 2.2e-08 | 4.5 | 5.8 | 8.1e-09 | 0.41 | 0.05 | 0.92 | TRUE |
| 3 | The Cancer Genome Atlas | Lung Adenocarcinoma | IRF5 | 0.18 | 0.11 | enet | 9 | 0.14 | 1.6e-15 | 4.5 | 5.6 | 2.3e-08 | 0.36 | 0.05 | 0.92 | FALSE |
| 4 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | IRF5 | 0.14 | 0.15 | enet | 6 | 0.14 | 7.0e-10 | -4.7 | 5.4 | 7.4e-08 | 0.37 | 0.03 | 0.95 | FALSE |