[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr8:60,736,025-62,477,554

Best TWAS P=2.08e-10 · Best GWAS P=4.71e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RAB2A	0.05	0.02	bslmm	454	0.02	1.7e-03	5.9	5.2	1.7e-07	0.86	0.02	0.97	FALSE
2	GTEx	Artery Aorta	RAB2A	0.13	0.19	lasso	3	0.19	1.7e-10	6.1	6.1	8.5e-10	0.99	0.02	0.98	FALSE
3	GTEx	Artery Tibial	RAB2A	0.10	0.14	lasso	6	0.12	2.9e-09	6.1	6.1	9.8e-10	0.98	0.02	0.98	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	RAB2A	0.26	0.15	enet	22	0.14	2.7e-05	6.1	6.2	7.0e-10	0.96	0.02	0.98	FALSE
5	GTEx	Cells Transformed fibroblasts	RAB2A	0.35	0.21	lasso	9	0.24	2.5e-18	6.1	6.1	1.0e-09	0.95	0.02	0.98	FALSE
6	GTEx	Cells Transformed fibroblasts	CHD7	0.07	0.00	lasso	8	0.01	3.7e-02	4.7	-5.4	7.7e-08	-0.61	0.08	0.26	FALSE
7	GTEx	Esophagus Muscularis	RAB2A	0.21	0.16	lasso	5	0.12	1.2e-07	6.1	6.1	8.2e-10	0.97	0.02	0.98	FALSE
8	GTEx	Lung	RAB2A	0.06	0.03	lasso	6	0.02	9.1e-03	5.9	5.9	3.2e-09	0.96	0.02	0.95	FALSE
9	GTEx	Nerve Tibial	RAB2A	0.10	0.02	lasso	6	0.02	1.4e-02	6.1	5.9	4.7e-09	0.94	0.02	0.96	FALSE
10	GTEx	Skin Sun Exposed Lower leg	RAB2A	0.08	0.09	lasso	2	0.06	1.0e-05	6.1	6.2	7.0e-10	0.98	0.02	0.98	FALSE
11	GTEx	Spleen	RAB2A	0.32	0.19	lasso	4	0.16	7.9e-05	6.1	6.3	2.8e-10	0.98	0.02	0.95	FALSE
12	GTEx	Thyroid	RAB2A	0.06	0.04	enet	8	0.04	9.5e-04	6.2	6.2	6.7e-10	0.97	0.02	0.97	FALSE
13	METSIM	Adipose	RAB2A	0.09	0.10	lasso	8	0.09	9.3e-14	6.1	6.3	2.3e-10	0.95	0.02	0.98	FALSE
14	YFS	Blood	RAB2A	0.08	0.08	bslmm	447	0.11	4.5e-34	6.1	5.5	4.7e-08	0.86	0.02	0.98	FALSE
15	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RAB2A	0.08	0.05	lasso	2	0.06	7.3e-06	6.2	5.5	3.2e-08	0.90	0.02	0.98	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	RAB2A	0.01	0.02	lasso	3	0.01	7.5e-04	6.1	6.4	2.1e-10	0.97	0.02	0.96	TRUE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAB2A	0.03	0.02	blup	53	0.03	3.0e-04	6.1	6.0	1.7e-09	0.93	0.02	0.96	FALSE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RAB2A	0.05	0.09	lasso	7	0.08	2.0e-09	4.7	5.5	4.3e-08	0.75	0.13	0.87	FALSE
19	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	RAB2A	0.10	0.06	blup	51	0.07	3.4e-04	6.2	6.2	5.4e-10	0.97	0.02	0.95	FALSE
20	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB2A	0.03	0.03	enet	4	0.03	6.1e-05	-5.2	5.7	1.2e-08	0.79	0.05	0.92	FALSE
21	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RAB2A	0.07	0.06	blup	51	0.06	2.5e-07	6.2	5.9	4.7e-09	0.95	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Stomach Adenocarcinoma	RAB2A	0.04	0.04	blup	51	0.04	5.3e-04	6.2	6.3	2.3e-10	0.96	0.02	0.96	FALSE
23	The Cancer Genome Atlas	Thyroid Carcinoma	RAB2A	0.06	0.03	blup	53	0.05	6.1e-06	3.4	6.3	3.1e-10	0.93	0.02	0.98	FALSE