Best TWAS P=3.07e-25 · Best GWAS P=1.58e-26 conditioned to 0.00845
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FN3KRP | 0.49 | 0.28 | bslmm | 365 | 0.41 | 5.6e-54 | -8.4 | -8.2 | 3.7e-16 | -0.67 | 0.99 | 0.01 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | TBCD | 0.12 | 0.05 | lasso | 4 | 0.06 | 6.7e-06 | -5.8 | 5.4 | 6.0e-08 | 0.23 | 0.96 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | FN3KRP | 0.56 | 0.23 | lasso | 11 | 0.48 | 1.2e-44 | 6.7 | -8.1 | 4.9e-16 | -0.62 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | FN3KRP | 0.52 | 0.40 | enet | 26 | 0.47 | 3.5e-27 | 6.7 | -7.3 | 2.6e-13 | -0.56 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Adrenal Gland | FN3KRP | 0.41 | 0.35 | enet | 33 | 0.36 | 8.7e-14 | 6.7 | -8.1 | 4.6e-16 | -0.67 | 0.76 | 0.24 | FALSE |
| 6 | GTEx | Artery Aorta | FN3KRP | 0.60 | 0.33 | lasso | 14 | 0.52 | 1.4e-32 | 6.7 | -8.5 | 1.4e-17 | -0.65 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Artery Coronary | FN3KRP | 0.60 | 0.29 | enet | 72 | 0.33 | 9.0e-12 | 6.7 | -7.2 | 6.5e-13 | -0.63 | 0.46 | 0.53 | FALSE |
| 8 | GTEx | Artery Tibial | FN3KRP | 0.51 | 0.36 | enet | 32 | 0.61 | 3.7e-59 | 6.7 | -8.2 | 3.4e-16 | -0.53 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Brain Cortex | FN3KRP | 0.25 | 0.06 | enet | 16 | 0.16 | 2.7e-05 | 6.7 | -8.3 | 1.4e-16 | -0.71 | 0.04 | 0.77 | FALSE |
| 10 | GTEx | Brain Cortex | B3GNTL1 | 0.54 | 0.04 | enet | 25 | 0.22 | 1.0e-06 | 7.7 | 6.4 | 1.7e-10 | 0.52 | 0.03 | 0.57 | FALSE |
| 11 | GTEx | Brain Cortex | METRNL | 0.15 | 0.00 | enet | 9 | 0.00 | 2.8e-01 | 9.5 | 5.5 | 4.0e-08 | 0.71 | 0.02 | 0.63 | FALSE |
| 12 | GTEx | Brain Frontal Cortex BA9 | FN3KRP | 0.24 | 0.04 | enet | 28 | 0.10 | 1.4e-03 | 8.2 | -8.3 | 1.0e-16 | -0.59 | 0.07 | 0.30 | FALSE |
| 13 | GTEx | Brain Hippocampus | FN3KRP | 0.26 | -0.01 | lasso | 2 | -0.01 | 4.6e-01 | 6.7 | -7.1 | 1.7e-12 | -0.68 | 0.05 | 0.21 | FALSE |
| 14 | GTEx | Brain Hypothalamus | FN3KRP | 0.41 | -0.01 | enet | 28 | 0.24 | 2.7e-06 | -1.2 | -5.6 | 2.7e-08 | -0.30 | 0.07 | 0.07 | FALSE |
| 15 | GTEx | Breast Mammary Tissue | FN3KRP | 0.54 | 0.26 | lasso | 10 | 0.41 | 1.3e-22 | -6.3 | -8.0 | 1.4e-15 | -0.70 | 0.99 | 0.01 | FALSE |
| 16 | GTEx | Breast Mammary Tissue (Female) | FN3KRP | 0.45 | 0.25 | lasso | 3 | 0.32 | 3.6e-10 | -6.3 | -7.8 | 7.2e-15 | -0.70 | 0.72 | 0.24 | FALSE |
| 17 | GTEx | Cells EBV-transformed lymphocytes | FN3KRP | 0.26 | 0.14 | lasso | 2 | 0.18 | 1.9e-06 | -6.3 | -7.5 | 4.3e-14 | -0.61 | 0.18 | 0.47 | FALSE |
| 18 | GTEx | Cells Transformed fibroblasts | FN3KRP | 0.30 | 0.14 | enet | 23 | 0.28 | 7.6e-21 | 8.2 | -7.9 | 2.2e-15 | -0.61 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Colon Sigmoid | FN3KRP | 0.47 | 0.33 | enet | 22 | 0.35 | 4.5e-13 | 6.7 | -8.0 | 9.7e-16 | -0.67 | 0.65 | 0.35 | FALSE |
| 20 | GTEx | Colon Transverse | FN3KRP | 0.48 | 0.36 | enet | 47 | 0.41 | 9.0e-21 | 6.7 | -7.5 | 7.5e-14 | -0.65 | 0.58 | 0.42 | FALSE |
| 21 | GTEx | Esophagus Gastroesophageal Junction | FN3KRP | 0.34 | 0.29 | lasso | 5 | 0.33 | 8.0e-13 | 8.2 | -8.0 | 1.6e-15 | -0.69 | 0.55 | 0.45 | FALSE |
| 22 | GTEx | Esophagus Mucosa | FN3KRP | 0.39 | 0.33 | lasso | 5 | 0.35 | 1.6e-24 | -6.3 | -7.7 | 1.4e-14 | -0.64 | 1.00 | 0.00 | FALSE |
| 23 | GTEx | Esophagus Mucosa | FN3K | 0.15 | 0.07 | lasso | 3 | 0.07 | 3.0e-05 | 9.2 | -10.4 | 3.1e-25 | -0.94 | 0.01 | 0.99 | TRUE |
| 24 | GTEx | Esophagus Muscularis | FN3KRP | 0.66 | 0.34 | enet | 47 | 0.48 | 5.6e-33 | 8.2 | -8.4 | 3.8e-17 | -0.60 | 1.00 | 0.00 | FALSE |
| 25 | GTEx | Heart Atrial Appendage | B3GNTL1 | 0.19 | 0.03 | enet | 22 | 0.04 | 4.8e-03 | -2.1 | 5.3 | 1.0e-07 | 0.41 | 0.07 | 0.10 | FALSE |
| 26 | GTEx | Liver | FN3KRP | 0.36 | 0.32 | enet | 8 | 0.23 | 4.1e-07 | 6.7 | -7.7 | 1.5e-14 | -0.74 | 0.79 | 0.10 | FALSE |
| 27 | GTEx | Lung | FN3KRP | 0.38 | 0.30 | enet | 19 | 0.36 | 5.1e-29 | 6.7 | -8.2 | 3.1e-16 | -0.70 | 1.00 | 0.00 | FALSE |
| 28 | GTEx | Muscle Skeletal | FN3KRP | 0.29 | 0.15 | lasso | 6 | 0.14 | 1.0e-13 | -6.3 | -7.0 | 1.9e-12 | -0.64 | 1.00 | 0.00 | FALSE |
| 29 | GTEx | Nerve Tibial | FN3KRP | 0.49 | 0.37 | enet | 36 | 0.56 | 3.5e-47 | 6.7 | -7.8 | 6.5e-15 | -0.56 | 1.00 | 0.00 | FALSE |
| 30 | GTEx | Nerve Tibial | FN3K | 0.18 | 0.10 | enet | 21 | 0.12 | 1.3e-08 | 6.7 | 5.3 | 9.5e-08 | 0.43 | 0.91 | 0.05 | FALSE |
| 31 | GTEx | Ovary | B3GNTL1 | 0.54 | -0.01 | enet | 40 | 0.21 | 5.9e-06 | 8.6 | 5.7 | 9.7e-09 | 0.44 | 0.03 | 0.26 | FALSE |
| 32 | GTEx | Pancreas | FN3KRP | 0.33 | 0.28 | lasso | 5 | 0.26 | 2.3e-11 | 8.2 | -7.9 | 3.0e-15 | -0.68 | 0.96 | 0.04 | FALSE |
| 33 | GTEx | Skin Not Sun Exposed Suprapubic | FN3KRP | 0.39 | 0.32 | lasso | 3 | 0.34 | 3.4e-19 | -6.3 | -7.2 | 8.3e-13 | -0.63 | 1.00 | 0.00 | FALSE |
| 34 | GTEx | Skin Sun Exposed Lower leg | FN3KRP | 0.47 | 0.43 | enet | 37 | 0.46 | 7.8e-42 | -6.3 | -7.2 | 4.3e-13 | -0.61 | 1.00 | 0.00 | FALSE |
| 35 | GTEx | Spleen | FN3KRP | 0.59 | 0.40 | enet | 19 | 0.32 | 4.4e-09 | 6.7 | -8.3 | 6.7e-17 | -0.76 | 0.13 | 0.87 | FALSE |
| 36 | GTEx | Stomach | FN3KRP | 0.49 | 0.12 | enet | 37 | 0.29 | 1.7e-14 | 6.7 | -7.5 | 8.0e-14 | -0.59 | 0.69 | 0.30 | FALSE |
| 37 | GTEx | Testis | FN3KRP | 0.49 | 0.38 | lasso | 3 | 0.42 | 3.4e-20 | -6.3 | -7.6 | 2.5e-14 | -0.69 | 0.95 | 0.05 | FALSE |
| 38 | GTEx | Thyroid | FN3KRP | 0.43 | 0.15 | enet | 24 | 0.43 | 1.8e-35 | 6.7 | -7.2 | 6.8e-13 | -0.49 | 1.00 | 0.00 | FALSE |
| 39 | GTEx | Thyroid | RP11-388C12.8 | 0.09 | 0.04 | enet | 17 | 0.07 | 5.0e-06 | -6.0 | -5.7 | 1.5e-08 | -0.34 | 0.90 | 0.00 | FALSE |
| 40 | GTEx | Uterus | FN3KRP | 0.34 | 0.26 | lasso | 8 | 0.23 | 1.7e-05 | -8.3 | -8.5 | 2.4e-17 | -0.73 | 0.10 | 0.45 | FALSE |
| 41 | GTEx | Vagina | FN3KRP | 0.36 | 0.12 | lasso | 4 | 0.28 | 3.9e-07 | 6.7 | -7.4 | 1.0e-13 | -0.69 | 0.07 | 0.75 | FALSE |
| 42 | GTEx | Whole Blood | FN3KRP | 0.20 | 0.14 | lasso | 2 | 0.17 | 2.9e-15 | 8.2 | -8.4 | 3.6e-17 | -0.72 | 0.92 | 0.08 | FALSE |
| 43 | GTEx | Whole Blood | B3GNTL1 | 0.15 | 0.01 | enet | 15 | 0.06 | 2.3e-06 | -2.7 | 5.7 | 1.1e-08 | 0.38 | 0.17 | 0.18 | FALSE |
| 44 | NTR | Blood | FN3K | 0.04 | 0.02 | bslmm | 354 | 0.02 | 1.4e-07 | 9.5 | -7.9 | 2.3e-15 | -0.77 | 0.00 | 1.00 | FALSE |
| 45 | NTR | Blood | FN3KRP | 0.04 | 0.04 | bslmm | 362 | 0.04 | 1.3e-13 | -6.3 | -7.3 | 2.8e-13 | -0.46 | 1.00 | 0.00 | FALSE |
| 46 | YFS | Blood | FN3KRP | 0.77 | 0.61 | enet | 49 | 0.75 | 0.0e+00 | -6.3 | -7.9 | 2.1e-15 | -0.54 | 1.00 | 0.00 | FALSE |
| 47 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FN3K | 0.03 | 0.01 | blup | 32 | 0.03 | 3.0e-03 | -5.8 | -6.4 | 1.2e-10 | -0.54 | 0.06 | 0.20 | FALSE |
| 48 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | FN3KRP | 0.26 | 0.12 | enet | 10 | 0.18 | 6.3e-15 | 8.1 | -7.5 | 4.7e-14 | -0.42 | 1.00 | 0.00 | FALSE |
| 49 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FN3K | 0.02 | 0.01 | blup | 32 | 0.03 | 3.9e-06 | 6.7 | -7.6 | 2.7e-14 | -0.78 | 0.01 | 0.98 | FALSE |
| 50 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FN3KRP | 0.46 | 0.23 | enet | 15 | 0.33 | 2.7e-70 | 8.1 | -8.0 | 1.2e-15 | -0.54 | 1.00 | 0.00 | FALSE |
| 51 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FN3KRP | 0.25 | 0.05 | blup | 33 | 0.17 | 8.0e-09 | 8.0 | -5.7 | 9.5e-09 | -0.40 | 0.75 | 0.02 | FALSE |
| 52 | The Cancer Genome Atlas | Colon Adenocarcinoma | FN3K | 0.21 | 0.16 | lasso | 4 | 0.15 | 3.3e-09 | -8.0 | -7.9 | 2.0e-15 | -0.71 | 0.98 | 0.02 | FALSE |
| 53 | The Cancer Genome Atlas | Colon Adenocarcinoma | FN3KRP | 0.37 | 0.19 | enet | 9 | 0.30 | 1.9e-17 | -8.1 | -8.3 | 1.1e-16 | -0.61 | 1.00 | 0.00 | FALSE |
| 54 | The Cancer Genome Atlas | Glioblastoma Multiforme | FN3KRP | 0.27 | 0.19 | lasso | 4 | 0.18 | 5.3e-06 | 8.0 | -6.9 | 4.1e-12 | -0.57 | 0.35 | 0.09 | FALSE |
| 55 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FN3K | 0.03 | 0.01 | blup | 32 | 0.02 | 4.0e-03 | 9.5 | -7.7 | 2.1e-14 | -0.82 | 0.00 | 0.95 | FALSE |
| 56 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FN3KRP | 0.45 | 0.26 | enet | 12 | 0.30 | 1.5e-33 | -6.3 | -7.8 | 5.0e-15 | -0.53 | 1.00 | 0.00 | FALSE |
| 57 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FN3KRP | 0.67 | 0.28 | lasso | 10 | 0.48 | 1.3e-60 | 8.0 | -7.4 | 1.4e-13 | -0.45 | 1.00 | 0.00 | FALSE |
| 58 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FN3KRP | 0.68 | 0.16 | lasso | 9 | 0.41 | 5.8e-25 | 6.7 | -8.0 | 1.3e-15 | -0.52 | 1.00 | 0.00 | FALSE |
| 59 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FN3KRP | 0.55 | 0.30 | lasso | 8 | 0.44 | 6.8e-55 | 8.1 | -8.0 | 9.0e-16 | -0.55 | 1.00 | 0.00 | FALSE |
| 60 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | FN3KRP | 0.50 | 0.11 | enet | 13 | 0.27 | 4.4e-13 | 6.7 | -6.4 | 1.4e-10 | -0.27 | 0.96 | 0.01 | FALSE |
| 61 | The Cancer Genome Atlas | Lung Adenocarcinoma | FN3K | 0.07 | 0.03 | blup | 32 | 0.05 | 1.7e-06 | -8.0 | -8.0 | 1.6e-15 | -0.82 | 0.03 | 0.97 | FALSE |
| 62 | The Cancer Genome Atlas | Lung Adenocarcinoma | FN3KRP | 0.53 | 0.21 | blup | 33 | 0.35 | 1.9e-42 | 8.1 | -7.9 | 3.2e-15 | -0.46 | 1.00 | 0.00 | FALSE |
| 63 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FN3K | 0.04 | 0.01 | blup | 32 | 0.03 | 1.4e-04 | 8.0 | -7.3 | 1.9e-13 | -0.74 | 0.01 | 0.76 | FALSE |
| 64 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FN3KRP | 0.26 | 0.16 | enet | 13 | 0.16 | 4.0e-18 | -6.3 | -7.4 | 1.2e-13 | -0.55 | 1.00 | 0.00 | FALSE |
| 65 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FN3KRP | 0.17 | 0.08 | blup | 33 | 0.09 | 1.7e-06 | -8.1 | -6.8 | 8.3e-12 | -0.45 | 0.94 | 0.02 | FALSE |
| 66 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | FN3KRP | 0.52 | 0.26 | enet | 14 | 0.37 | 1.1e-16 | 8.1 | -7.9 | 3.5e-15 | -0.48 | 1.00 | 0.00 | FALSE |
| 67 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | B3GNTL1 | 0.27 | 0.00 | blup | 115 | 0.08 | 3.2e-04 | -2.7 | 6.0 | 1.9e-09 | 0.46 | 0.06 | 0.30 | FALSE |
| 68 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | FN3KRP | 0.87 | 0.40 | lasso | 10 | 0.50 | 1.2e-22 | 8.1 | -7.6 | 2.9e-14 | -0.47 | 1.00 | 0.00 | FALSE |
| 69 | The Cancer Genome Atlas | Prostate Adenocarcinoma | B3GNTL1 | 0.05 | 0.00 | blup | 117 | 0.02 | 4.6e-03 | 8.6 | 5.2 | 1.7e-07 | 0.54 | 0.01 | 0.78 | FALSE |
| 70 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FN3K | 0.11 | 0.11 | lasso | 5 | 0.12 | 1.2e-12 | 8.0 | -7.3 | 2.5e-13 | -0.67 | 1.00 | 0.00 | FALSE |
| 71 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FN3KRP | 0.78 | 0.46 | enet | 14 | 0.64 | 1.9e-86 | 8.1 | -7.9 | 2.9e-15 | -0.52 | 1.00 | 0.00 | FALSE |
| 72 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FN3KRP | 0.39 | 0.29 | enet | 15 | 0.36 | 2.2e-09 | 8.1 | -8.8 | 2.0e-18 | -0.73 | 0.05 | 0.92 | FALSE |
| 73 | The Cancer Genome Atlas | Soft Tissue Sarcoma | B3GNTL1 | 0.07 | 0.01 | blup | 115 | 0.05 | 3.8e-04 | 5.8 | 5.7 | 1.5e-08 | 0.60 | 0.01 | 0.71 | FALSE |
| 74 | The Cancer Genome Atlas | Soft Tissue Sarcoma | FN3KRP | 0.37 | 0.14 | enet | 8 | 0.25 | 8.5e-15 | -6.3 | -7.8 | 8.9e-15 | -0.50 | 0.99 | 0.01 | FALSE |
| 75 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | FN3KRP | 0.67 | 0.26 | enet | 14 | 0.40 | 8.5e-12 | -6.3 | -7.5 | 6.8e-14 | -0.50 | 0.62 | 0.29 | FALSE |
| 76 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FN3KRP | 0.65 | 0.24 | lasso | 6 | 0.33 | 2.1e-24 | -6.3 | -7.6 | 2.3e-14 | -0.49 | 1.00 | 0.00 | FALSE |
| 77 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | FN3KRP | 0.44 | 0.14 | enet | 15 | 0.25 | 2.7e-09 | 8.1 | -7.9 | 3.3e-15 | -0.55 | 0.89 | 0.03 | FALSE |
| 78 | The Cancer Genome Atlas | Thyroid Carcinoma | FN3KRP | 0.75 | 0.37 | lasso | 10 | 0.56 | 7.5e-65 | 8.1 | -8.2 | 1.7e-16 | -0.59 | 1.00 | 0.00 | FALSE |
| 79 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | FN3KRP | 0.20 | 0.06 | enet | 8 | 0.09 | 1.9e-03 | -8.1 | -6.1 | 1.3e-09 | -0.39 | 0.06 | 0.08 | FALSE |