[Hub]/) : Traits : HbA1C :

chr17:79,977,970-81,051,007

Best TWAS P=3.07e-25 · Best GWAS P=1.58e-26 conditioned to 0.00845

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FN3KRP 0.49 0.28 bslmm 365 0.41 5.6e-54 -8.4 -8.2 3.7e-16 -0.67 0.99 0.01 FALSE
2 GTEx Adipose Subcutaneous TBCD 0.12 0.05 lasso 4 0.06 6.7e-06 -5.8 5.4 6.0e-08 0.23 0.96 0.00 FALSE
3 GTEx Adipose Subcutaneous FN3KRP 0.56 0.23 lasso 11 0.48 1.2e-44 6.7 -8.1 4.9e-16 -0.62 1.00 0.00 FALSE
4 GTEx Adipose Visceral Omentum FN3KRP 0.52 0.40 enet 26 0.47 3.5e-27 6.7 -7.3 2.6e-13 -0.56 1.00 0.00 FALSE
5 GTEx Adrenal Gland FN3KRP 0.41 0.35 enet 33 0.36 8.7e-14 6.7 -8.1 4.6e-16 -0.67 0.76 0.24 FALSE
6 GTEx Artery Aorta FN3KRP 0.60 0.33 lasso 14 0.52 1.4e-32 6.7 -8.5 1.4e-17 -0.65 1.00 0.00 FALSE
7 GTEx Artery Coronary FN3KRP 0.60 0.29 enet 72 0.33 9.0e-12 6.7 -7.2 6.5e-13 -0.63 0.46 0.53 FALSE
8 GTEx Artery Tibial FN3KRP 0.51 0.36 enet 32 0.61 3.7e-59 6.7 -8.2 3.4e-16 -0.53 1.00 0.00 FALSE
9 GTEx Brain Cortex FN3KRP 0.25 0.06 enet 16 0.16 2.7e-05 6.7 -8.3 1.4e-16 -0.71 0.04 0.77 FALSE
10 GTEx Brain Cortex B3GNTL1 0.54 0.04 enet 25 0.22 1.0e-06 7.7 6.4 1.7e-10 0.52 0.03 0.57 FALSE
11 GTEx Brain Cortex METRNL 0.15 0.00 enet 9 0.00 2.8e-01 9.5 5.5 4.0e-08 0.71 0.02 0.63 FALSE
12 GTEx Brain Frontal Cortex BA9 FN3KRP 0.24 0.04 enet 28 0.10 1.4e-03 8.2 -8.3 1.0e-16 -0.59 0.07 0.30 FALSE
13 GTEx Brain Hippocampus FN3KRP 0.26 -0.01 lasso 2 -0.01 4.6e-01 6.7 -7.1 1.7e-12 -0.68 0.05 0.21 FALSE
14 GTEx Brain Hypothalamus FN3KRP 0.41 -0.01 enet 28 0.24 2.7e-06 -1.2 -5.6 2.7e-08 -0.30 0.07 0.07 FALSE
15 GTEx Breast Mammary Tissue FN3KRP 0.54 0.26 lasso 10 0.41 1.3e-22 -6.3 -8.0 1.4e-15 -0.70 0.99 0.01 FALSE
16 GTEx Breast Mammary Tissue (Female) FN3KRP 0.45 0.25 lasso 3 0.32 3.6e-10 -6.3 -7.8 7.2e-15 -0.70 0.72 0.24 FALSE
17 GTEx Cells EBV-transformed lymphocytes FN3KRP 0.26 0.14 lasso 2 0.18 1.9e-06 -6.3 -7.5 4.3e-14 -0.61 0.18 0.47 FALSE
18 GTEx Cells Transformed fibroblasts FN3KRP 0.30 0.14 enet 23 0.28 7.6e-21 8.2 -7.9 2.2e-15 -0.61 1.00 0.00 FALSE
19 GTEx Colon Sigmoid FN3KRP 0.47 0.33 enet 22 0.35 4.5e-13 6.7 -8.0 9.7e-16 -0.67 0.65 0.35 FALSE
20 GTEx Colon Transverse FN3KRP 0.48 0.36 enet 47 0.41 9.0e-21 6.7 -7.5 7.5e-14 -0.65 0.58 0.42 FALSE
21 GTEx Esophagus Gastroesophageal Junction FN3KRP 0.34 0.29 lasso 5 0.33 8.0e-13 8.2 -8.0 1.6e-15 -0.69 0.55 0.45 FALSE
22 GTEx Esophagus Mucosa FN3KRP 0.39 0.33 lasso 5 0.35 1.6e-24 -6.3 -7.7 1.4e-14 -0.64 1.00 0.00 FALSE
23 GTEx Esophagus Mucosa FN3K 0.15 0.07 lasso 3 0.07 3.0e-05 9.2 -10.4 3.1e-25 -0.94 0.01 0.99 TRUE
24 GTEx Esophagus Muscularis FN3KRP 0.66 0.34 enet 47 0.48 5.6e-33 8.2 -8.4 3.8e-17 -0.60 1.00 0.00 FALSE
25 GTEx Heart Atrial Appendage B3GNTL1 0.19 0.03 enet 22 0.04 4.8e-03 -2.1 5.3 1.0e-07 0.41 0.07 0.10 FALSE
26 GTEx Liver FN3KRP 0.36 0.32 enet 8 0.23 4.1e-07 6.7 -7.7 1.5e-14 -0.74 0.79 0.10 FALSE
27 GTEx Lung FN3KRP 0.38 0.30 enet 19 0.36 5.1e-29 6.7 -8.2 3.1e-16 -0.70 1.00 0.00 FALSE
28 GTEx Muscle Skeletal FN3KRP 0.29 0.15 lasso 6 0.14 1.0e-13 -6.3 -7.0 1.9e-12 -0.64 1.00 0.00 FALSE
29 GTEx Nerve Tibial FN3KRP 0.49 0.37 enet 36 0.56 3.5e-47 6.7 -7.8 6.5e-15 -0.56 1.00 0.00 FALSE
30 GTEx Nerve Tibial FN3K 0.18 0.10 enet 21 0.12 1.3e-08 6.7 5.3 9.5e-08 0.43 0.91 0.05 FALSE
31 GTEx Ovary B3GNTL1 0.54 -0.01 enet 40 0.21 5.9e-06 8.6 5.7 9.7e-09 0.44 0.03 0.26 FALSE
32 GTEx Pancreas FN3KRP 0.33 0.28 lasso 5 0.26 2.3e-11 8.2 -7.9 3.0e-15 -0.68 0.96 0.04 FALSE
33 GTEx Skin Not Sun Exposed Suprapubic FN3KRP 0.39 0.32 lasso 3 0.34 3.4e-19 -6.3 -7.2 8.3e-13 -0.63 1.00 0.00 FALSE
34 GTEx Skin Sun Exposed Lower leg FN3KRP 0.47 0.43 enet 37 0.46 7.8e-42 -6.3 -7.2 4.3e-13 -0.61 1.00 0.00 FALSE
35 GTEx Spleen FN3KRP 0.59 0.40 enet 19 0.32 4.4e-09 6.7 -8.3 6.7e-17 -0.76 0.13 0.87 FALSE
36 GTEx Stomach FN3KRP 0.49 0.12 enet 37 0.29 1.7e-14 6.7 -7.5 8.0e-14 -0.59 0.69 0.30 FALSE
37 GTEx Testis FN3KRP 0.49 0.38 lasso 3 0.42 3.4e-20 -6.3 -7.6 2.5e-14 -0.69 0.95 0.05 FALSE
38 GTEx Thyroid FN3KRP 0.43 0.15 enet 24 0.43 1.8e-35 6.7 -7.2 6.8e-13 -0.49 1.00 0.00 FALSE
39 GTEx Thyroid RP11-388C12.8 0.09 0.04 enet 17 0.07 5.0e-06 -6.0 -5.7 1.5e-08 -0.34 0.90 0.00 FALSE
40 GTEx Uterus FN3KRP 0.34 0.26 lasso 8 0.23 1.7e-05 -8.3 -8.5 2.4e-17 -0.73 0.10 0.45 FALSE
41 GTEx Vagina FN3KRP 0.36 0.12 lasso 4 0.28 3.9e-07 6.7 -7.4 1.0e-13 -0.69 0.07 0.75 FALSE
42 GTEx Whole Blood FN3KRP 0.20 0.14 lasso 2 0.17 2.9e-15 8.2 -8.4 3.6e-17 -0.72 0.92 0.08 FALSE
43 GTEx Whole Blood B3GNTL1 0.15 0.01 enet 15 0.06 2.3e-06 -2.7 5.7 1.1e-08 0.38 0.17 0.18 FALSE
44 NTR Blood FN3K 0.04 0.02 bslmm 354 0.02 1.4e-07 9.5 -7.9 2.3e-15 -0.77 0.00 1.00 FALSE
45 NTR Blood FN3KRP 0.04 0.04 bslmm 362 0.04 1.3e-13 -6.3 -7.3 2.8e-13 -0.46 1.00 0.00 FALSE
46 YFS Blood FN3KRP 0.77 0.61 enet 49 0.75 0.0e+00 -6.3 -7.9 2.1e-15 -0.54 1.00 0.00 FALSE
47 The Cancer Genome Atlas Bladder Urothelial Carcinoma FN3K 0.03 0.01 blup 32 0.03 3.0e-03 -5.8 -6.4 1.2e-10 -0.54 0.06 0.20 FALSE
48 The Cancer Genome Atlas Bladder Urothelial Carcinoma FN3KRP 0.26 0.12 enet 10 0.18 6.3e-15 8.1 -7.5 4.7e-14 -0.42 1.00 0.00 FALSE
49 The Cancer Genome Atlas Breast Invasive Carcinoma FN3K 0.02 0.01 blup 32 0.03 3.9e-06 6.7 -7.6 2.7e-14 -0.78 0.01 0.98 FALSE
50 The Cancer Genome Atlas Breast Invasive Carcinoma FN3KRP 0.46 0.23 enet 15 0.33 2.7e-70 8.1 -8.0 1.2e-15 -0.54 1.00 0.00 FALSE
51 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma FN3KRP 0.25 0.05 blup 33 0.17 8.0e-09 8.0 -5.7 9.5e-09 -0.40 0.75 0.02 FALSE
52 The Cancer Genome Atlas Colon Adenocarcinoma FN3K 0.21 0.16 lasso 4 0.15 3.3e-09 -8.0 -7.9 2.0e-15 -0.71 0.98 0.02 FALSE
53 The Cancer Genome Atlas Colon Adenocarcinoma FN3KRP 0.37 0.19 enet 9 0.30 1.9e-17 -8.1 -8.3 1.1e-16 -0.61 1.00 0.00 FALSE
54 The Cancer Genome Atlas Glioblastoma Multiforme FN3KRP 0.27 0.19 lasso 4 0.18 5.3e-06 8.0 -6.9 4.1e-12 -0.57 0.35 0.09 FALSE
55 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FN3K 0.03 0.01 blup 32 0.02 4.0e-03 9.5 -7.7 2.1e-14 -0.82 0.00 0.95 FALSE
56 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FN3KRP 0.45 0.26 enet 12 0.30 1.5e-33 -6.3 -7.8 5.0e-15 -0.53 1.00 0.00 FALSE
57 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FN3KRP 0.67 0.28 lasso 10 0.48 1.3e-60 8.0 -7.4 1.4e-13 -0.45 1.00 0.00 FALSE
58 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FN3KRP 0.68 0.16 lasso 9 0.41 5.8e-25 6.7 -8.0 1.3e-15 -0.52 1.00 0.00 FALSE
59 The Cancer Genome Atlas Brain Lower Grade Glioma FN3KRP 0.55 0.30 lasso 8 0.44 6.8e-55 8.1 -8.0 9.0e-16 -0.55 1.00 0.00 FALSE
60 The Cancer Genome Atlas Liver Hepatocellular Carcinoma FN3KRP 0.50 0.11 enet 13 0.27 4.4e-13 6.7 -6.4 1.4e-10 -0.27 0.96 0.01 FALSE
61 The Cancer Genome Atlas Lung Adenocarcinoma FN3K 0.07 0.03 blup 32 0.05 1.7e-06 -8.0 -8.0 1.6e-15 -0.82 0.03 0.97 FALSE
62 The Cancer Genome Atlas Lung Adenocarcinoma FN3KRP 0.53 0.21 blup 33 0.35 1.9e-42 8.1 -7.9 3.2e-15 -0.46 1.00 0.00 FALSE
63 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FN3K 0.04 0.01 blup 32 0.03 1.4e-04 8.0 -7.3 1.9e-13 -0.74 0.01 0.76 FALSE
64 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FN3KRP 0.26 0.16 enet 13 0.16 4.0e-18 -6.3 -7.4 1.2e-13 -0.55 1.00 0.00 FALSE
65 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma FN3KRP 0.17 0.08 blup 33 0.09 1.7e-06 -8.1 -6.8 8.3e-12 -0.45 0.94 0.02 FALSE
66 The Cancer Genome Atlas Pancreatic Adenocarcinoma FN3KRP 0.52 0.26 enet 14 0.37 1.1e-16 8.1 -7.9 3.5e-15 -0.48 1.00 0.00 FALSE
67 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma B3GNTL1 0.27 0.00 blup 115 0.08 3.2e-04 -2.7 6.0 1.9e-09 0.46 0.06 0.30 FALSE
68 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma FN3KRP 0.87 0.40 lasso 10 0.50 1.2e-22 8.1 -7.6 2.9e-14 -0.47 1.00 0.00 FALSE
69 The Cancer Genome Atlas Prostate Adenocarcinoma B3GNTL1 0.05 0.00 blup 117 0.02 4.6e-03 8.6 5.2 1.7e-07 0.54 0.01 0.78 FALSE
70 The Cancer Genome Atlas Prostate Adenocarcinoma FN3K 0.11 0.11 lasso 5 0.12 1.2e-12 8.0 -7.3 2.5e-13 -0.67 1.00 0.00 FALSE
71 The Cancer Genome Atlas Prostate Adenocarcinoma FN3KRP 0.78 0.46 enet 14 0.64 1.9e-86 8.1 -7.9 2.9e-15 -0.52 1.00 0.00 FALSE
72 The Cancer Genome Atlas Rectum Adenocarcinoma FN3KRP 0.39 0.29 enet 15 0.36 2.2e-09 8.1 -8.8 2.0e-18 -0.73 0.05 0.92 FALSE
73 The Cancer Genome Atlas Soft Tissue Sarcoma B3GNTL1 0.07 0.01 blup 115 0.05 3.8e-04 5.8 5.7 1.5e-08 0.60 0.01 0.71 FALSE
74 The Cancer Genome Atlas Soft Tissue Sarcoma FN3KRP 0.37 0.14 enet 8 0.25 8.5e-15 -6.3 -7.8 8.9e-15 -0.50 0.99 0.01 FALSE
75 The Cancer Genome Atlas Skin Cutaneous Melanoma FN3KRP 0.67 0.26 enet 14 0.40 8.5e-12 -6.3 -7.5 6.8e-14 -0.50 0.62 0.29 FALSE
76 The Cancer Genome Atlas Stomach Adenocarcinoma FN3KRP 0.65 0.24 lasso 6 0.33 2.1e-24 -6.3 -7.6 2.3e-14 -0.49 1.00 0.00 FALSE
77 The Cancer Genome Atlas Testicular Germ Cell Tumors FN3KRP 0.44 0.14 enet 15 0.25 2.7e-09 8.1 -7.9 3.3e-15 -0.55 0.89 0.03 FALSE
78 The Cancer Genome Atlas Thyroid Carcinoma FN3KRP 0.75 0.37 lasso 10 0.56 7.5e-65 8.1 -8.2 1.7e-16 -0.59 1.00 0.00 FALSE
79 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma FN3KRP 0.20 0.06 enet 8 0.09 1.9e-03 -8.1 -6.1 1.3e-09 -0.39 0.06 0.08 FALSE