Hub : Genes

FN3K

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.1510	0.0480	2.4e-05	0.075	NA	0.043	NA	0.067	1.0e-05	NA	6.8e-04	NA	3.0e-05
2	GTEx	Nerve Tibial	0.1845	0.0580	4.8e-06	0.104	NA	0.117	NA	0.114	8.6e-08	NA	1.3e-08	NA	1.8e-08
3	GTEx	Pancreas	0.2970	0.0800	3.8e-05	0.036	NA	0.079	NA	0.059	1.2e-02	NA	3.2e-04	NA	1.7e-03
4	NTR	Blood	0.0390	0.0130	1.3e-06	0.016	0.020	0.014	0.021	0.020	3.8e-06	3.4e-07	1.6e-05	1.4e-07	3.8e-07
5	TCGA	Bladder Urothelial Carcinoma	0.0330	0.0200	1.6e-03	0.009	0.025	0.005	NA	0.012	4.8e-02	3.0e-03	1.2e-01	NA	3.1e-02
6	TCGA	Breast Invasive Carcinoma	0.0231	0.0114	2.4e-06	0.014	0.026	0.023	NA	0.020	4.5e-04	3.9e-06	1.3e-05	NA	4.1e-05
7	TCGA	Colon Adenocarcinoma	0.2140	0.0990	1.0e-07	0.158	0.116	0.133	NA	0.154	2.1e-09	3.2e-07	4.3e-08	NA	3.3e-09
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.0334	0.0202	7.9e-04	0.006	0.017	0.016	NA	0.011	5.7e-02	4.0e-03	5.2e-03	NA	1.8e-02
9	TCGA	Lung Adenocarcinoma	0.0738	0.0395	1.1e-05	0.035	0.050	0.038	NA	0.035	5.6e-05	1.7e-06	2.9e-05	NA	4.9e-05
10	TCGA	Lung Squamous Cell Carcinoma	0.0422	0.0225	6.5e-04	0.009	0.032	0.023	NA	0.017	2.6e-02	1.4e-04	9.8e-04	NA	4.0e-03
11	TCGA	Prostate Adenocarcinoma	0.1097	0.0432	2.7e-11	0.114	0.116	0.121	NA	0.122	5.7e-12	3.9e-12	1.3e-12	NA	1.2e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.2	1.9	4.9	-2.2	-0.1	0.3	-2.2	-1.0	-1.4	-1.3	-1.8	-1.4	-1.0	-0.6
Bipolar Disorder or Schizophrenia	0.4	1.0	3.1	-1.8	1.0	0.8	-1.2	-0.6	-1.0	-1.0	-1.4	-0.7	-0.9	-0.2
Depressed Affect (Nagel 2018)	0.4	0.9	3.1	0.2	-0.4	-1.1	0.8	1.0	0.9	1.8	0.4	0.8	0.8	1.2
Depression (Nagel 2018)	0.5	0.8	1.4	1.0	-0.1	-1.0	1.1	1.2	1.0	0.8	0.7	0.6	0.3	1.1
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.7	-0.9	0.9	-0.5	-1.0	-1.0	-0.7	-1.7	-0.4	-1.1	-1.1	-1.0
Neuroticism (Nagel 2018)	0.4	0.9	3.2	0.6	0.0	-0.1	1.2	0.7	0.9	1.8	0.4	0.9	0.7	1.5
Schizophrenia (2018)	0.2	0.3	2.0	-0.5	1.4	0.9	0.2	0.0	-0.1	-0.2	-0.3	0.4	-0.3	0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.8	0.3	1.4	0.1	0.1	0.6	0.7	-0.2	0.8	0.2	-1.1	-0.1
Worry (Nagel 2018)	0.2	0.5	3.3	0.4	1.1	1.8	0.6	-0.1	0.4	0.1	0.1	0.3	-0.7	0.1
Alzheimer’s Disease (in mother)	0.5	0.6	3.1	0.4	-0.0	0.1	0.3	-0.6	-0.6	0.7	-1.0	0.7	1.7	0.9
Alzheimer’s Disease (in father)	2.2	2.4	5.2	1.9	-1.4	2.3	2.0	1.0	1.2	1.9	0.6	1.7	0.8	1.4
Alzheimer’s Disease (including proxy)	1.1	1.5	4.6	1.1	-0.9	0.8	1.6	0.2	0.3	1.5	-0.3	1.5	2.1	1.6
Crohns Disease (2017)	0.7	1.5	4.3	-0.5	1.5	2.1	-1.4	-0.9	-0.6	-1.3	0.3	-1.2	-1.1	-1.4
Irritable Bowel Disease (IBD)	0.2	0.6	3.1	0.5	1.1	0.3	-0.2	0.5	0.8	-0.6	1.8	-0.2	-0.2	-0.2
Ulcerative Colitis (UC)	0.9	1.6	6.4	1.6	0.5	-1.4	1.2	1.3	1.7	-0.1	2.5	0.4	0.6	0.3
Major Depression (MDD)	0.8	0.9	3.0	-0.3	1.3	1.2	0.1	-1.7	-1.3	-0.4	-1.3	-0.3	-0.2	-0.6
Reaction Time	0.8	1.4	2.2	-1.3	0.1	1.4	-1.5	-0.9	-1.4	-1.0	-1.4	-1.2	-1.0	-1.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.8	0.3	-1.0	-1.7	-0.2	0.9	1.0	0.4	0.8	0.4	0.4	0.9
Breast Cancer	0.5	1.2	2.9	0.9	-0.5	1.1	0.9	-1.7	-1.3	1.2	-1.7	0.3	1.3	-0.1
Ovarian Cancer	0.7	0.9	2.1	0.4	-0.7	-0.8	1.1	1.4	1.4	0.5	1.3	0.7	0.4	0.9
Prostate Cancer	0.9	1.3	2.1	1.2	-1.3	-0.3	1.0	0.9	1.1	1.2	1.1	1.2	1.3	1.4
Age at First Birth	2.1	3.1	4.3	-1.5	2.0	0.4	-1.8	-2.1	-1.9	-2.0	-1.4	-2.0	-1.6	-1.9
Bipolar Disorder (2011)	0.5	0.5	1.8	0.0	0.0	0.0	0.0	-0.7	-0.8	-1.2	-0.9	-0.7	-1.4	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.9	-0.6	0.2	-0.6	0.5	0.5	0.0	-0.3	-0.2	-0.4	-0.9	-0.2
Coronary Artery Disease (CAD)	0.9	1.1	3.2	-0.4	0.8	-0.4	-0.9	-0.9	-0.8	-1.8	-0.2	-1.5	-1.1	-1.4
Crohns Disease (2012)	1.0	1.7	3.2	-1.0	0.8	1.8	-1.1	-1.1	-1.0	-1.7	-0.2	-1.7	-1.1	-1.7
Mean Putamen Volume	0.4	0.4	1.6	-0.4	-0.5	-0.0	0.5	0.6	0.4	1.2	-0.1	0.4	0.6	1.3
Fasting Glucose	1.5	1.8	7.3	-1.2	-1.4	-2.7	-1.0	1.9	1.4	-0.0	1.4	0.5	-0.8	0.2
HbA1C	48.5	53.9	108.2	-10.4	5.3	1.2	-7.9	-6.4	-7.6	-7.9	-7.7	-8.0	-7.3	-7.3
HDL Cholesterol	0.4	0.7	2.0	-1.0	0.7	0.2	-1.0	-1.3	-1.2	-0.3	-1.4	-0.2	0.5	0.1
LDL Cholesterol	0.3	0.4	2.1	-0.7	-0.7	0.3	-0.7	0.5	-0.0	-0.1	-0.3	-0.6	-1.4	-0.3
Lupus	0.3	0.5	2.2	0.3	0.4	-0.6	-1.5	-0.4	-0.3	-0.8	0.3	-1.0	-0.2	-0.7
Neuroticism (2016)	0.8	1.1	3.8	-0.2	2.0	1.2	0.5	-0.8	-0.8	-0.8	-0.7	-0.8	-1.6	-1.1
Primary Biliary Cirrhosis	0.3	0.4	1.2	0.6	-0.3	-1.1	0.3	0.7	0.8	-0.3	1.1	0.3	-0.5	0.1
Rheumatoid Arthritis	0.2	0.3	1.0	0.2	-0.9	-0.2	-0.2	0.8	0.7	0.4	1.0	0.3	0.1	-0.0
Schizophrenia (2014)	0.2	0.4	1.2	-0.6	1.1	0.6	-0.2	0.7	0.5	0.2	0.2	0.6	-0.5	0.8
Triglycerides	0.3	0.6	1.3	0.3	-0.9	0.2	1.1	0.9	0.7	1.2	0.2	0.9	0.3	0.6
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.8	-0.1	1.3	-0.1	-0.9	-0.4	-0.2	-0.7	-0.1	-0.6	-0.7	-0.7
Ulcerative Colitis	0.6	0.8	3.5	1.0	0.9	-0.7	0.9	0.6	1.0	-0.8	1.9	0.0	0.4	-0.1
Blood Eosinophil Count	0.5	3.5	9.8	-1.4	3.1	1.7	-1.0	-2.2	-2.1	-2.3	-1.6	-1.6	-0.8	-1.7
Blood Platelet Count	1.3	15.5	32.7	-4.6	2.3	2.5	-1.7	-4.7	-5.2	-3.6	-5.7	-3.9	-3.3	-3.7
Blood Red Count	0.4	3.7	15.5	0.2	-3.9	-2.1	-0.4	2.9	2.3	0.1	2.5	0.2	-0.1	0.4
Blood White Count	0.0	0.2	1.0	0.6	0.7	-1.0	0.1	-0.3	-0.0	-0.1	0.4	0.0	0.4	-0.5
Heel T-Score	0.4	3.0	8.5	0.8	-2.9	-0.4	1.4	1.7	1.7	1.5	1.7	1.8	2.0	1.9
BMI	0.1	0.8	2.9	0.8	-0.2	-0.2	1.7	1.1	1.0	0.3	1.2	0.8	0.7	0.6
Height	1.7	33.0	48.7	-4.6	6.3	2.1	-6.0	-6.0	-5.8	-6.9	-4.5	-7.0	-5.4	-6.8
Waist Hip Ratio (WHR)	0.3	1.6	3.3	-1.3	1.8	0.7	-1.5	-1.1	-0.8	-1.3	-0.9	-1.1	-1.7	-1.0
Systolic Blood Pressure	0.2	0.9	2.1	-0.3	-1.4	-1.2	0.7	1.3	1.0	1.2	0.5	0.6	0.3	0.9
Smoking Status	0.1	0.3	0.5	0.6	0.7	-0.7	0.5	-0.5	-0.0	-0.3	0.5	-0.5	0.1	-0.6
Allergy or Eczema	1.8	4.7	9.9	-2.0	3.1	0.7	-2.4	-2.1	-2.2	-2.1	-2.3	-2.2	-1.9	-1.9
Cardiovascular Disease	0.1	0.3	1.3	-0.5	0.3	0.3	0.6	-0.4	-0.7	0.3	-1.1	0.1	0.4	0.7
Hypothyroidism (self reported)	1.8	4.2	8.8	-2.4	2.1	0.2	-3.0	-0.7	-1.4	-2.5	-1.6	-2.3	-2.5	-2.0
Respiratory disease	1.5	3.3	6.9	-2.1	2.2	1.3	-1.2	-2.0	-2.1	-1.2	-2.6	-1.6	-1.6	-1.6
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.0	-0.3	1.0	-0.6	-0.8	-0.4	-0.7	-0.4	-0.3	-0.6	-0.4	-0.4
Lung FEV1/FVC ratio	0.5	2.3	3.6	-1.5	1.9	1.5	-1.4	-1.7	-1.7	-1.5	-1.5	-1.5	-1.2	-1.2
Lung FVC	0.4	1.9	8.9	0.2	-2.6	-3.0	0.7	1.6	1.1	0.3	1.3	-0.0	0.0	0.2
Neuroticism	0.4	1.0	2.3	1.2	0.2	1.2	1.4	0.2	0.7	1.5	0.3	1.2	0.9	1.2
Chronotype (morning person)	0.8	1.8	4.7	-2.2	0.0	-0.3	-1.8	-1.5	-1.9	-1.2	-1.8	-0.9	0.1	-0.8
Hair Pigment	0.4	11.1	24.1	2.1	-3.3	4.3	4.4	-0.4	0.1	4.9	-1.5	4.2	3.4	3.7
Tanning	0.2	2.7	8.2	-1.4	1.9	-1.1	-2.1	-0.2	-0.2	-2.1	-0.0	-1.3	-2.9	-1.8
Hand grip strength (left)	0.5	1.3	3.6	-0.0	1.0	-0.2	0.2	-0.1	0.2	-1.9	1.2	-1.7	-1.4	-1.7
Number of treatments/medications taken	1.7	3.0	5.7	-2.4	1.6	-0.1	-1.4	-1.8	-2.1	-1.7	-2.4	-1.8	-1.1	-1.6
Average weekly spirits intake	0.5	0.6	1.8	0.2	0.4	0.1	-1.3	-0.5	-0.5	-1.1	-0.1	-1.1	-0.6	-1.1
Sensitivity / hurt feelings	0.2	0.3	1.0	-0.4	-0.8	0.1	0.5	0.6	0.5	1.0	-0.2	0.7	0.1	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.5	3.0	0.6	1.7	0.4	0.8	-0.6	-0.2	-0.5	-0.3	-0.3	-0.6	-0.3
Hearing difficulty/problems: Yes	0.9	1.4	3.6	1.7	-0.2	0.5	0.8	0.3	1.0	1.0	1.0	1.9	1.6	1.3
Relative age of first facial hair	0.2	0.5	1.3	-0.3	-0.2	-1.0	-0.2	-0.7	-1.0	-0.2	-1.2	-0.4	0.9	-0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.9	-1.0	0.2	-1.0	0.4	0.6	0.3	-0.4	0.1	-0.5	-0.9	-0.3
Ever used hormone-replacement therapy (HRT)	1.9	2.4	4.5	1.2	-0.7	-0.8	2.0	1.4	1.3	2.1	0.6	1.9	1.9	2.0
Ever had hysterectomy (womb removed)	0.2	0.3	1.2	0.2	-0.3	1.1	0.2	-0.3	-0.2	0.3	-0.4	0.5	1.0	0.5
Systolic blood pressure, automated reading	0.0	0.0	0.2	-0.2	-0.1	-0.2	0.4	-0.1	-0.0	0.1	-0.0	0.2	0.4	0.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.0	0.4	-0.2	-1.4	0.5	1.3	1.1	0.3	1.1	0.8	0.5	0.9
Angina	0.8	1.0	3.0	-0.6	1.7	0.2	-1.0	-1.5	-1.4	-0.3	-1.5	-0.3	0.2	-0.6
Medication for hormone replacement therapy	0.5	0.6	2.3	-1.5	0.9	-0.7	-0.7	-0.4	-0.7	-0.6	-0.9	-0.6	-0.3	-0.2
Vitamin and mineral supplements	0.5	0.7	4.2	1.0	2.0	0.4	0.1	-0.1	0.4	-0.4	0.9	-0.5	-0.7	-0.8
Supplements: Zinc	2.3	2.5	5.8	-2.1	-0.4	0.7	-1.9	-1.4	-1.9	-1.0	-2.4	-1.8	-1.3	-1.1
Medication: Co-codamol	1.5	1.8	3.4	-1.5	1.8	0.2	-0.7	-1.6	-1.5	-1.2	-1.7	-1.2	-1.1	-1.3
Medication: Metformin	0.8	1.1	2.2	-1.5	0.9	-0.5	-1.2	-0.6	-1.1	-1.2	-0.9	-1.3	-0.9	-0.9
Diabetes (father)	1.4	1.7	5.7	-0.7	2.4	-0.2	-1.4	-1.0	-0.9	-1.6	-0.6	-1.4	-1.1	-1.6
Diabetes (mother)	3.1	4.0	6.4	2.2	-0.9	-2.0	1.1	2.1	2.5	1.6	2.5	2.1	1.9	2.3
Severe depression (siblings)	5.5	6.2	13.0	-2.0	2.5	-0.1	-2.0	-2.6	-2.7	-3.6	-2.1	-3.0	-2.0	-3.0
Pack years adult smoking proportion	0.3	0.4	2.1	0.7	1.4	0.4	1.0	0.1	0.4	-0.3	0.7	-0.3	-0.3	-0.0
Impedance of leg (right)	0.1	0.6	1.8	-0.6	-0.1	1.2	-0.7	-1.3	-0.8	0.6	-1.3	0.2	0.0	0.2
Leg fat-free mass (left)	0.3	1.4	4.0	-0.3	2.0	0.1	0.3	-0.5	-0.6	-1.9	0.2	-1.4	-1.3	-1.8
Trunk fat percentage	0.1	0.5	1.3	0.8	0.1	0.4	1.1	0.4	0.4	0.5	0.3	1.0	0.9	0.8
Hand grip strength (right)	0.5	1.4	3.8	-0.2	1.5	0.3	0.1	-1.0	-0.6	-1.9	0.4	-1.7	-1.0	-1.9
Townsend deprivation index at recruitment	1.0	1.4	3.0	1.7	-0.7	0.0	1.6	0.7	1.2	1.1	1.0	1.5	1.2	1.4
Current tobacco smoking	0.6	0.9	2.3	-0.8	-0.3	1.1	-0.1	-1.1	-0.9	-0.9	-0.6	-1.5	-0.9	-1.4
Average weekly fortified wine intake	1.8	2.1	5.5	-1.5	1.1	0.8	-2.3	-1.6	-1.8	-1.3	-1.8	-1.1	-0.2	-1.0
Maternal smoking around birth	1.8	2.7	6.0	2.4	-0.7	-0.6	1.8	0.6	1.2	1.3	1.6	2.1	2.4	1.8
Fed-up feelings	0.2	0.3	1.1	0.3	0.5	0.4	0.7	0.2	0.4	0.8	0.4	0.7	1.1	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	2.3	1.1	-0.4	0.0	1.5	0.7	0.7	1.0	0.4	1.1	0.7	1.1
Relative age voice broke	1.0	1.6	3.3	-1.1	0.7	-0.3	-0.7	-1.2	-1.8	-1.6	-1.7	-1.8	-0.5	-1.2
Taking other prescription medications	1.2	1.8	5.2	-2.3	0.8	-0.6	-1.2	-0.9	-1.7	-1.0	-2.0	-1.6	-0.7	-0.8
Age when periods started (menarche)	0.3	0.7	3.4	0.6	1.8	0.1	1.1	-1.1	-0.7	-0.4	-0.5	-0.0	0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.8	-0.8	0.5	0.8	-0.6	-0.5	-0.6	-0.6	-0.9	-0.6	-0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	3.8	-1.3	-1.9	-0.7	0.0	0.7	0.2	0.0	-0.1	-0.1	-0.2	0.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.2	1.1	-0.8	0.6	1.0	0.8	0.7	1.1	0.5	0.9	-0.1	0.8
Qualifications: CSEs or equivalent	0.2	0.3	1.7	-0.2	0.8	1.3	0.4	-0.2	0.1	0.1	0.2	0.2	-0.8	-0.0
Serious illness, injury or assault to yourself	0.3	0.3	1.3	-0.3	-0.4	-0.1	-0.2	-0.6	-0.9	0.4	-0.8	-0.0	1.1	0.3
High blood pressure	0.3	0.9	4.0	-1.3	0.2	1.4	0.2	-0.9	-1.1	0.3	-2.0	-0.0	-0.1	0.2
Hayfever, allergic rhinitis or eczema	2.2	4.7	6.2	-2.2	2.4	1.5	-1.8	-2.3	-2.4	-2.2	-2.5	-2.3	-2.0	-2.1
Multivitamins +/- minerals	0.6	0.7	3.6	-0.1	-1.9	-0.8	-0.1	0.4	0.2	0.7	-0.3	0.7	1.0	1.2
Stomach or abdominal pain in last month	0.4	0.5	2.0	-0.3	0.1	1.3	1.4	-0.4	-0.3	-0.0	-0.5	-0.5	-0.6	-0.6
Supplements: Glucosamine	0.5	0.6	2.0	-0.6	0.5	0.2	-0.7	-1.4	-1.2	-0.6	-0.9	-0.4	0.4	-0.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.5	1.0	0.6	1.1	0.5	0.4	0.9	0.7	0.6	1.2	-0.1	0.6
Medication: Atenolol	0.5	0.6	1.7	-0.1	1.3	0.2	-0.2	-1.1	-0.6	-0.6	-0.6	-0.7	-1.0	-1.2
Medication: Levothyroxine sodium	2.2	3.8	7.3	-1.6	2.3	0.3	-2.6	-1.0	-1.3	-2.7	-1.2	-2.4	-2.3	-2.2
Sitting height	1.2	8.3	13.9	-2.4	3.0	0.2	-2.3	-3.3	-3.4	-3.1	-2.8	-3.5	-2.2	-3.7
Chronic bronchitis/emphysema (father)	0.9	1.1	3.4	1.9	-0.4	0.2	1.4	0.0	0.5	0.9	0.9	1.0	1.8	0.7
High blood pressure (mother)	0.7	1.0	5.7	0.2	-0.3	2.4	1.0	-0.8	-0.7	1.0	-1.1	0.7	0.7	0.5
Body mass index (BMI)	0.7	2.8	5.9	2.1	-0.5	-0.6	2.4	1.9	1.9	1.0	2.2	1.7	1.3	1.4
Impedance of leg (left)	0.2	1.0	3.2	-0.4	0.3	1.7	-0.8	-1.8	-1.2	0.4	-1.7	0.0	0.3	0.0
Leg predicted mass (left)	0.3	1.4	4.2	-0.2	2.0	0.4	0.3	-0.6	-0.7	-1.8	0.1	-1.4	-1.2	-1.8
Trunk fat mass	0.1	0.3	0.9	0.7	0.9	0.4	1.0	0.1	0.1	-0.2	0.4	0.4	0.4	0.1
Waist circumference	0.1	0.4	2.2	0.8	1.5	0.8	0.7	-0.1	0.1	-0.6	0.5	0.0	-0.1	-0.3
Number of incorrect matches in round	0.1	0.2	0.7	-0.0	-0.8	0.5	0.2	-0.2	-0.3	0.7	-0.7	0.2	0.4	0.3
Past tobacco smoking	0.7	1.2	4.1	-1.5	-1.2	-1.6	-2.0	1.1	0.1	-0.3	-0.5	-0.7	-1.1	0.1
Alcohol usually taken with meals	0.3	0.5	1.5	-1.0	-0.8	0.2	-1.2	-0.4	-0.6	-0.0	-0.9	0.0	0.9	-0.1
Nervous feelings	0.3	0.5	1.3	-0.0	1.1	0.8	0.1	-0.7	-0.2	-0.9	-0.1	-0.8	-0.7	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.6	0.7	1.5	1.4	1.6	-1.0	-0.6	0.5	-1.0	0.6	0.6	0.3
Hearing difficulty/problems with background noise	0.6	1.0	2.7	1.6	0.8	1.6	0.7	-1.3	-0.3	0.4	-0.2	1.0	1.4	0.3
Hair/balding pattern: Pattern 2	1.3	1.6	5.7	1.5	-1.0	0.4	2.4	0.4	0.5	1.5	0.4	1.3	1.5	1.3
Had menopause	0.2	0.2	0.9	-0.3	-0.3	-0.0	-0.1	0.6	0.1	0.4	-0.3	0.4	0.7	1.0
Had other major operations	0.1	0.2	0.3	-0.3	0.3	0.6	-0.5	-0.4	-0.6	-0.5	-0.5	-0.2	-0.3	-0.1
Forced vital capacity (FVC)	0.3	1.0	3.0	-0.7	0.2	-1.7	-1.0	-0.6	-0.6	-0.9	-0.1	-1.4	-1.0	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.9	-0.7	-1.4	-1.0	-0.2	1.1	0.6	0.0	0.4	-0.1	0.0	0.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	4.2	-0.9	0.1	0.4	0.5	-1.8	-1.9	0.0	-2.0	-0.8	0.5	-0.7
Qualifications: None of the above	3.4	7.2	14.9	2.7	-2.2	-0.5	3.9	2.4	2.6	3.3	2.1	3.1	2.2	3.1
Financial difficulties in last 2 years	1.4	1.9	3.6	0.6	-1.9	-0.8	1.3	1.4	1.3	1.9	1.1	1.4	1.1	1.7
Mouth/teeth dental problems	0.5	0.7	3.4	0.4	0.9	1.5	-1.8	-0.7	-0.5	-0.7	-0.1	-0.4	-0.0	-0.3
Heart attack	0.7	0.9	2.5	-0.1	1.4	0.2	-0.2	-1.6	-1.3	-0.8	-1.5	-0.5	0.1	-0.6
Allergy	2.1	4.9	9.1	2.4	-1.9	-1.3	1.7	2.5	2.8	2.1	3.0	2.3	1.6	2.1
Pain all over the body in last month	1.0	1.1	3.9	0.4	-1.4	-0.8	-0.7	0.6	0.3	1.1	0.1	1.3	2.0	1.4
Diabetes (self-reported)	0.2	0.2	1.4	0.1	1.2	-1.0	-0.2	-0.2	-0.2	-0.2	0.2	-0.1	0.3	-0.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	4.8	-1.2	1.6	0.0	-2.2	-0.8	-1.1	-1.1	-1.2	-1.3	-0.8	-0.9
Medication: Ramipril	0.9	1.2	2.4	-1.5	1.4	0.1	-1.3	-0.4	-0.7	-1.2	-1.2	-1.0	-1.4	-0.5
Medication: Simvastatin	0.7	1.0	6.1	-0.3	2.5	0.6	-0.5	-1.4	-1.0	-0.5	-1.0	0.0	0.7	0.1
Fluid intelligence score	0.2	0.3	0.8	0.4	-0.4	-0.6	-0.6	0.4	0.7	0.3	0.7	0.9	0.3	0.7
Illnesses of siblings	0.4	0.5	1.7	1.2	0.5	1.3	1.3	0.0	0.3	0.8	0.4	0.3	0.4	0.2
Neuroticism score	0.4	0.9	3.0	0.9	1.0	1.5	1.7	-0.4	0.4	1.0	0.1	0.9	0.5	0.4
Weight	0.1	0.7	2.8	0.5	1.7	0.3	0.6	-0.3	-0.2	-1.2	0.6	-0.6	-0.5	-1.1
Impedance of arm (right)	0.6	2.8	8.5	-2.7	0.0	-0.2	-2.1	-1.7	-2.2	-0.2	-2.9	-1.3	-0.8	-0.4
Arm fat percentage (right)	0.6	2.5	4.1	1.2	-1.1	-1.2	1.9	2.0	1.7	1.4	1.6	1.7	1.3	2.0
Trunk fat-free mass	0.4	2.2	5.7	-0.1	2.4	0.4	-0.4	-1.1	-1.0	-2.2	0.1	-1.9	-1.4	-2.3
Hip circumference	0.1	0.5	1.4	0.9	1.2	-0.3	1.0	0.4	0.3	-0.7	1.1	-0.2	0.1	-0.6
Time employed in main current job	1.4	1.6	7.9	-1.5	-0.6	-2.8	-1.3	1.3	0.8	-0.2	0.6	-0.4	-1.4	-0.5
Alcohol intake versus 10 years previously	2.9	4.4	6.3	-2.5	1.9	0.1	-2.0	-1.8	-2.2	-2.3	-2.2	-2.4	-2.1	-2.2
Father’s age at death	0.2	0.3	2.3	-0.2	-1.5	-0.2	-0.3	0.4	0.2	-0.4	0.4	-0.3	0.1	-0.3
Worrier / anxious feelings	0.2	0.4	1.5	0.3	0.7	1.2	1.2	-0.4	-0.2	0.4	-0.6	0.3	0.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.7	-0.5	1.6	0.1	0.6	-0.9	-0.8	-0.8	-1.0	-0.4	-0.2	-0.2
Falls in the last year	1.1	1.5	4.3	-0.5	1.0	2.1	0.6	-1.9	-1.6	0.1	-1.9	-0.0	0.9	-0.3
Hair/balding pattern: Pattern 3	0.5	0.8	2.6	-0.5	0.3	-1.6	-1.6	0.4	0.1	-1.2	0.4	-0.6	-0.8	-0.9
Number of live births	0.2	0.4	1.2	-1.1	-0.3	-0.2	0.1	0.2	-0.4	-0.6	-0.3	-0.3	-1.1	-0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.0	-0.7	0.4	-1.2	-1.1	-0.7	-0.7	-1.0	-0.2	-1.6	-1.2	-1.7
Pulse rate	0.5	0.9	2.0	-1.4	-0.2	0.3	-0.4	-0.6	-1.1	-1.2	-1.1	-1.4	-0.9	-1.0
Happiness	1.2	1.4	4.8	1.8	1.1	1.1	2.2	0.4	1.1	0.7	1.5	0.8	-0.2	0.0
Noisy workplace	0.4	0.5	2.9	0.9	1.7	0.0	1.0	-0.1	0.1	0.1	0.4	0.2	-0.2	-0.3
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.8	-1.3	-0.3	0.1	-1.8	-1.3	-1.5	-1.5	-1.0	-1.7	-0.6	-2.0
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	2.8	0.8	1.7	0.4	0.2	-0.4	0.2	-0.5	0.5	0.0	-0.2	-0.6
Mouth/teeth dental problems: Dentures	0.9	1.5	3.0	-1.5	0.8	-0.5	-0.1	-0.9	-1.0	-1.7	-1.1	-1.5	-1.5	-1.6
Asthma	2.3	4.5	7.7	-1.8	2.3	0.7	-1.9	-2.4	-2.6	-2.0	-2.8	-2.3	-1.7	-2.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.2	0.8	-0.7	-0.1	1.5	0.3	0.6	0.7	0.7	1.0	1.0	0.7
Medication: Cholesterol lowering	0.3	0.4	1.4	-0.7	0.5	-0.6	-0.7	-0.5	-0.8	0.2	-1.2	-0.3	0.8	0.4
Depression (self-reported)	2.9	3.5	5.3	-2.0	1.7	1.0	-1.4	-1.9	-2.2	-1.8	-2.3	-2.2	-1.7	-1.8
Medication: Lansoprazole	2.1	2.4	5.7	-1.1	1.4	1.9	-1.0	-2.4	-2.2	-1.3	-1.8	-1.3	-0.0	-1.1
Prospective memory result	1.2	1.4	3.1	1.0	-1.1	-1.6	0.5	1.8	1.4	1.0	1.3	0.9	0.9	1.1
Lung cancer (father)	1.5	1.7	4.3	1.9	-1.6	-0.0	2.1	0.3	0.5	1.4	0.6	1.0	1.9	1.0
Illnesses of mother	0.8	0.9	4.0	0.7	-0.1	-1.0	-0.3	1.3	1.5	-0.5	2.0	0.1	-0.6	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	4.0	-0.6	0.6	0.0	-1.0	-0.7	-0.6	-1.2	-0.2	-1.7	-2.0	-2.0
Pulse wave Arterial Stiffness index	2.3	2.6	6.6	1.8	-0.5	-0.1	2.6	1.3	1.4	1.2	1.8	1.5	2.2	1.6
Impedance of arm (left)	0.7	3.1	8.5	-2.4	0.3	0.2	-2.3	-2.1	-2.3	-0.6	-2.9	-1.4	-0.9	-0.9
Arm fat mass (right)	0.3	1.2	3.1	1.1	-0.3	-0.7	1.8	1.3	1.1	0.7	1.3	1.0	1.0	1.1
Trunk predicted mass	0.4	2.1	5.6	-0.1	2.4	0.4	-0.4	-1.1	-1.0	-2.1	0.1	-1.8	-1.4	-2.2
Standing height	1.5	15.2	23.4	-2.9	4.7	1.8	-3.3	-4.5	-4.2	-4.4	-3.2	-4.5	-3.5	-4.8
Length of working week for main job	0.3	0.3	1.0	-0.0	-1.0	-0.3	0.3	0.3	0.3	0.8	-0.1	0.5	1.0	0.8
Exposure to tobacco smoke at home	0.2	0.2	0.9	0.5	0.7	0.9	0.7	-0.2	-0.0	0.1	0.1	0.1	0.2	0.3
Breastfed as a baby	0.5	0.6	1.6	-0.3	0.1	-0.7	-0.8	0.5	0.0	-1.0	0.3	-1.3	-1.2	-0.9
Tense / ‘highly strung’	0.3	0.6	1.6	0.9	1.2	1.3	1.2	-0.7	0.1	0.1	0.0	0.2	0.3	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	6.2	-1.6	1.7	0.1	-1.0	-1.9	-2.2	-1.1	-2.5	-1.7	-0.9	-1.2
Hair/balding pattern: Pattern 4	0.5	1.2	3.4	-0.7	1.9	0.3	-1.8	-0.2	-0.3	-1.5	-0.0	-0.9	-1.3	-1.0
Birth weight of first child	0.4	0.7	1.3	-0.1	1.0	0.1	-0.5	-0.8	-1.2	-1.1	-1.1	-0.7	-0.6	-0.9
Peak expiratory flow (PEF)	0.3	0.6	1.8	0.6	1.0	-0.6	0.5	0.2	0.4	-0.8	1.0	-0.7	-1.0	-1.3
Pulse wave reflection index	2.0	2.4	4.2	1.6	-1.0	-1.2	2.1	1.5	1.8	1.5	2.0	1.4	1.4	1.2
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.8	1.7	-0.3	-1.2	1.6	0.8	1.0	1.2	1.1	1.1	1.4	1.0
Loud music exposure frequency	0.1	0.1	0.5	-0.3	-0.7	0.2	0.1	-0.3	-0.2	0.2	-0.1	-0.1	0.5	-0.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.3	-0.5	-0.5	0.0	-0.2	-0.9	-0.7	-1.1	-0.3	-1.1	-0.4	-1.5
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.3	-1.5	0.0	0.2	0.7	-0.6	-0.9	0.7	-1.5	-0.4	-0.2	-0.0
Blood clot in the leg (DVT)	0.3	0.4	1.0	-0.2	-1.0	-0.3	0.7	-0.1	-0.4	0.6	-0.8	0.2	1.0	0.5
Medication: Paracetamol	0.2	0.3	1.2	0.4	1.1	-0.3	0.7	0.1	0.4	0.1	0.8	0.4	-0.1	-0.1
Headache pain in last month	0.2	0.4	1.7	-1.3	-0.2	-0.8	0.1	0.8	0.1	0.5	-0.7	-0.2	-0.5	0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.8	1.3	0.3	0.6	0.5	0.6	1.0	-0.5	1.7	0.3	-0.8	-0.5
Glaucoma (self-reported)	0.2	0.2	0.7	-0.8	-0.2	-0.0	-0.5	-0.3	-0.6	-0.2	-0.8	-0.2	-0.3	-0.1
Gout (self-reported)	0.2	0.3	1.2	-0.4	0.7	1.1	-0.0	-0.3	-0.2	-0.4	-0.1	-0.8	-0.0	-0.2
Hypothyroidism/myxoedema (self-reported)	2.9	5.7	11.8	-2.4	2.9	-0.2	-3.4	-1.2	-1.8	-3.2	-1.6	-2.7	-2.5	-2.4
Medication: Amlodipine	1.1	1.5	4.3	-1.4	0.2	1.4	-0.9	-1.6	-1.7	-0.5	-2.1	-0.9	-0.8	-0.9
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.7	0.4	-0.6	0.5	0.9	-0.2	0.1	0.0	0.1	0.2	0.1	0.1
Birth weight	0.2	0.3	1.5	0.8	0.7	0.3	1.2	-0.0	0.0	0.7	-0.3	0.3	-0.2	0.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.2	-0.3	0.5	1.5	0.2	-1.1	-1.3	-0.5	-1.2	-0.3	0.2	-0.4
High blood pressure (siblings)	2.2	3.2	6.7	-2.6	0.6	-0.3	-2.3	-1.4	-1.8	-2.2	-1.7	-1.8	-1.5	-2.1
Forced vital capacity (FVC), Best measure	0.3	1.0	3.7	-0.2	0.4	-0.1	-0.7	-0.8	-0.6	-1.0	-0.1	-1.5	-1.7	-1.9
Body fat percentage	0.4	1.5	3.1	1.5	-0.3	0.3	1.8	1.1	1.2	1.0	1.1	1.6	1.3	1.4
Leg fat percentage (right)	0.8	2.9	5.6	2.1	-0.5	0.2	2.4	1.6	1.8	1.4	1.9	2.2	1.4	1.7
Arm fat-free mass (right)	0.3	1.5	4.5	0.5	2.1	1.0	0.3	-1.1	-0.8	-1.8	0.3	-1.2	-0.7	-1.9
Exposure to tobacco smoke outside home	0.1	0.1	0.5	-0.2	0.3	0.7	0.5	-0.3	-0.1	-0.2	-0.2	-0.1	-0.2	-0.2
Comparative body size at age 10	0.0	0.1	0.2	0.4	0.3	-0.3	-0.2	0.3	0.2	0.5	0.1	-0.0	-0.2	0.2
Number of full brothers	0.8	1.0	2.4	-0.3	-0.6	-1.6	1.3	1.4	1.1	0.9	0.7	0.7	0.4	1.0
Worry too long after embarrassment	1.0	1.6	3.7	1.7	0.4	0.7	1.8	-0.1	0.6	1.9	0.2	1.5	1.7	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	2.0	4.2	-1.4	1.5	0.6	-1.6	-1.4	-1.8	-1.2	-2.0	-1.3	-1.2	-0.9
Wheeze or whistling in the chest in last year	0.6	1.1	2.8	-0.4	1.7	0.9	0.9	-1.5	-1.1	-0.9	-1.1	-0.9	-0.3	-1.1
Number of children fathered	2.3	2.5	4.7	1.8	-1.8	0.5	1.7	0.9	1.3	2.1	0.9	2.2	1.4	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.2	-0.7	0.6	-0.3	0.0	-0.8	-0.9	-0.7	-0.9	-1.1	-0.5	-0.5
Age at first live birth	2.4	4.3	7.5	-1.3	2.0	0.9	-2.2	-2.1	-2.0	-2.3	-1.6	-2.5	-2.4	-2.7
Pulse wave peak to peak time	2.9	3.4	7.3	-2.0	0.6	0.4	-2.7	-1.6	-1.7	-1.5	-2.0	-1.8	-2.6	-2.0
Health satisfaction	0.4	0.5	1.2	0.1	-1.0	-0.8	0.8	0.9	0.2	1.1	-0.3	0.5	0.3	0.7
Shortness of breath walking on level ground	0.1	0.1	0.4	0.2	0.4	-0.5	0.7	-0.3	-0.1	0.2	-0.3	-0.1	0.2	-0.0
Qualifications: College or University degree	0.6	1.9	7.6	-0.7	0.6	-1.1	-2.8	-1.5	-1.6	-1.5	-1.2	-1.3	0.2	-1.1
Eye problems/disorders: None of the above	0.1	0.1	0.7	0.1	-0.2	0.8	0.1	-0.6	-0.1	0.0	0.0	-0.1	0.2	-0.3
Mouth/teeth dental problems: Loose teeth	3.6	4.3	9.2	-0.8	3.0	2.6	-0.9	-2.8	-2.1	-2.0	-1.6	-1.8	-1.2	-2.5
Emphysema/chronic bronchitis	3.3	3.7	6.6	-2.6	1.5	0.0	-1.5	-2.1	-2.3	-1.9	-2.5	-2.0	-1.6	-1.9
Medication for pain relief, constipation, heartburn	0.2	0.4	2.5	0.5	0.2	1.6	-0.8	-0.6	-0.3	-0.1	-0.3	-0.1	-0.5	-0.6
Neck or shoulder pain in last month	0.9	1.2	2.1	-0.6	1.1	1.2	-0.2	-1.3	-1.3	-0.7	-1.2	-1.4	-1.1	-1.4
Medication: Blood pressure	0.2	0.3	0.9	-0.5	-0.5	-1.0	0.1	0.1	-0.0	0.6	-0.6	0.2	0.8	0.7
Angina (self-reported)	0.6	0.8	2.1	-0.7	1.4	-0.1	-1.0	-1.3	-1.2	-0.3	-1.4	-0.3	0.4	-0.5
Migraine (self-reported)	0.4	0.5	1.5	0.0	-0.9	-0.5	1.2	0.1	-0.1	0.8	-0.2	0.6	1.2	0.6
Medication: Ibuprofen	0.1	0.1	0.9	0.4	-0.0	-0.2	0.9	-0.1	0.2	-0.3	0.4	0.0	0.2	-0.4
Medication: Allopurinol	0.1	0.1	0.3	-0.2	-0.2	0.2	-0.4	0.6	0.5	-0.1	0.6	-0.2	-0.1	0.4
Medication: Omeprazole	1.8	2.2	5.9	-1.7	1.0	2.1	-0.2	-1.6	-1.9	-0.5	-2.4	-1.1	-1.0	-1.1
Medication: Seretide 50 evohaler	0.5	0.6	1.0	1.0	0.2	-0.7	1.0	0.6	0.9	0.3	1.0	0.6	0.5	0.9
Mean time to correctly identify matches	1.3	2.5	6.0	-1.4	0.9	0.9	-2.4	-1.1	-1.6	-1.9	-1.3	-1.6	-1.5	-1.9
Heart disease (mother)	2.3	2.8	6.9	-1.2	1.0	0.7	-0.5	-2.6	-2.4	-1.4	-2.4	-1.5	-1.1	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.1	1.4	0.3	0.5	0.5	0.2	0.4	0.9	0.6	0.8	1.0	0.8
Whole body fat mass	0.2	0.8	2.4	1.3	0.4	-0.0	1.6	0.7	0.8	0.3	1.1	0.9	1.0	0.7
Leg fat mass (right)	0.3	1.1	3.4	1.5	0.6	0.2	1.8	0.8	1.0	0.4	1.3	1.1	0.7	0.6
Arm predicted mass (right)	0.3	1.4	4.0	0.3	2.0	0.5	0.1	-0.9	-0.7	-1.9	0.3	-1.3	-0.8	-1.9
Pulse rate, automated reading	0.2	0.6	1.8	-1.1	-0.0	0.2	-0.3	0.1	-0.5	-1.2	-0.7	-0.9	-1.3	-0.7
Alcohol intake frequency.	0.5	1.2	4.3	-0.7	-1.6	-2.1	0.2	1.7	1.0	0.6	0.8	-0.1	-0.2	0.7
Comparative height size at age 10	0.6	3.0	6.8	-1.2	2.0	0.3	-2.2	-1.3	-1.0	-2.1	-0.5	-1.7	-2.6	-2.4
Number of full sisters	0.6	0.8	2.8	-0.1	-0.7	-0.1	1.0	1.0	0.4	1.7	-0.6	0.8	0.2	1.3
Suffer from ‘nerves’	0.2	0.3	0.9	0.0	0.9	1.0	0.2	-0.5	-0.1	-0.8	-0.1	-0.3	-0.8	-0.6
Overall health rating	0.4	0.9	2.4	-0.7	1.6	1.5	0.1	-1.3	-1.0	-0.4	-1.3	-0.5	-0.6	-0.4
Chest pain or discomfort	3.8	5.5	7.8	-2.3	2.7	1.9	-0.6	-2.8	-2.8	-1.9	-2.7	-2.6	-1.9	-2.6
Had major operations	0.9	1.1	3.2	0.5	1.6	0.6	0.2	-1.8	-1.2	-1.5	-0.8	-0.2	0.9	-0.6
Age at last live birth	1.8	2.6	6.5	-0.9	1.6	0.5	-1.2	-1.4	-1.0	-2.2	-0.3	-1.9	-2.2	-2.5
Family relationship satisfaction	0.8	0.9	5.0	0.8	1.5	2.2	1.0	-1.0	-0.4	0.1	-0.0	-0.2	-0.1	-0.3
Leg pain on walking	1.2	1.5	2.7	-0.5	1.6	0.4	-1.6	-1.6	-1.5	-1.2	-1.2	-1.4	-0.5	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.7	4.1	0.7	1.1	2.0	0.8	-0.5	-0.4	0.1	-0.2	0.5	0.1	0.3
Commuting to job workplace: Car/motor vehicle	1.7	1.9	7.2	0.5	2.7	1.4	-0.5	-2.2	-1.5	-1.0	-0.9	-0.7	-0.4	-1.4
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.7	-0.5	-0.7	-0.3	-0.8	0.8	0.4	0.3	-0.0	0.4	-0.4	0.4
Medication: Aspirin	0.9	1.2	2.7	-1.6	1.0	-1.4	-1.1	-0.7	-1.0	-1.5	-1.1	-1.2	-0.0	-0.3
Supplements: Vitamin C	0.7	0.8	2.7	-1.5	-0.2	0.6	-0.6	-1.0	-1.3	-0.2	-1.6	-0.1	0.6	-0.1
Knee pain experienced in last month	0.1	0.1	0.4	0.0	-0.6	-0.1	0.6	0.2	0.2	0.1	0.2	-0.1	-0.4	-0.1
Hypertension (Self-reported)	0.3	0.7	2.5	-0.9	-0.1	1.3	0.5	-0.4	-0.6	0.8	-1.6	0.6	0.5	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	4.4	-0.9	-0.2	2.1	0.5	-1.5	-1.6	-0.4	-2.1	-1.1	-1.1	-1.1
Illnesses of father: Heart disease	0.3	0.4	1.2	0.1	0.6	-0.1	0.1	-0.9	-0.7	-0.4	-0.7	-0.7	-0.7	-1.1
Illnesses of siblings: Diabetes	1.1	1.4	2.9	1.3	-1.4	0.6	1.3	0.7	1.2	1.4	0.8	1.7	0.6	1.4
Smoking status: Previous	1.1	1.7	4.9	2.2	0.9	1.0	1.9	-0.4	0.3	1.2	0.7	1.5	1.7	0.6
Forced expiratory volume in 1-second (FEV1), predicted	3.8	7.9	16.2	-1.8	2.7	0.7	-1.5	-2.7	-2.8	-3.5	-2.1	-3.7	-3.3	-4.0
Whole body fat-free mass	0.3	1.8	4.9	-0.2	2.2	0.4	-0.2	-1.0	-0.9	-2.1	0.1	-1.7	-1.2	-2.1
Leg fat-free mass (right)	0.3	1.8	4.7	-0.3	2.2	0.3	0.1	-0.9	-1.0	-2.0	-0.2	-1.7	-1.3	-2.1
Arm fat percentage (left)	0.5	2.2	3.4	1.4	-0.9	-1.0	1.8	1.8	1.6	1.2	1.6	1.6	1.3	1.6
Average weekly red wine intake	1.6	2.3	5.1	-1.6	0.2	-0.3	-2.0	-1.7	-2.2	-1.1	-2.3	-1.8	-0.0	-1.5
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.4	0.1	-0.6	-0.3	0.3	0.2	0.4	-0.2	0.6	-0.1	-0.5	-0.5
Mood swings	0.2	0.3	1.0	-0.0	1.0	-1.0	0.7	0.3	0.3	0.5	0.3	0.2	0.6	0.0
Loneliness, isolation	0.5	0.7	2.6	1.3	1.6	0.9	1.3	-0.3	0.3	0.4	0.6	0.1	-0.1	-0.1
Long-standing illness, disability or infirmity	0.3	0.4	1.0	-0.8	0.8	0.6	-0.5	-0.4	-0.7	-0.3	-1.0	-0.2	-0.8	-0.1
Ever had bowel cancer screening	1.3	1.5	4.0	1.0	-1.0	0.3	1.2	0.6	1.0	1.1	1.1	1.6	2.0	1.7
Diabetes diagnosed by doctor	0.2	0.3	1.3	0.4	0.6	-1.1	-0.1	0.4	0.2	0.4	0.5	0.4	0.5	0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.6	0.6	0.3	1.2	1.2	-0.1	0.3	0.6	0.4	0.4	0.6	0.5
Friendships satisfaction	2.6	3.2	12.2	2.4	-0.1	1.0	3.5	1.0	1.8	1.8	1.9	1.7	0.7	1.3
Qualifications: nursing, teaching	2.4	3.7	5.3	-1.7	2.1	1.1	-2.2	-2.3	-2.2	-2.2	-1.9	-1.9	-0.9	-2.2
Commuting to job workplace: Walk	1.7	1.8	5.2	0.4	-1.8	-1.6	-0.0	2.3	1.9	0.5	1.8	0.8	-0.6	0.4
Eye problems/disorders: Cataract	0.3	0.3	0.8	0.8	-0.7	-0.4	0.4	0.6	0.6	0.1	0.9	0.1	0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	5.1	0.2	-1.5	-1.9	1.1	2.3	1.5	1.5	1.0	1.0	0.3	1.4
Medication for cholesterol	0.5	0.8	2.0	0.6	-1.1	-1.4	-0.0	1.1	1.1	0.3	1.4	0.1	0.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	2.9	0.1	0.1	-1.7	-0.8	0.7	0.4	-0.4	0.7	-0.3	0.0	0.1
Back pain experienced in last month	1.0	1.5	3.4	-0.9	-0.0	1.8	0.4	-1.1	-1.3	-0.8	-1.5	-1.4	-1.3	-1.5
Mineral and other dietary supplements	0.8	1.1	4.6	2.1	0.8	0.8	1.4	0.4	1.1	0.2	1.5	0.6	-0.3	-0.0
Breast cancer (self-reported)	3.2	3.8	6.8	-2.3	1.5	2.2	-1.1	-2.4	-2.6	-1.7	-2.6	-1.3	-1.1	-1.8
Asthma (self-reported)	2.2	4.3	8.0	-1.6	2.3	1.1	-1.6	-2.6	-2.6	-1.8	-2.8	-2.1	-1.4	-2.0
Osteoporosis (self-reported)	0.3	0.4	0.8	-0.2	0.6	-0.2	-0.3	-0.9	-0.8	-0.8	-0.5	-0.9	-0.3	-0.5
Osteoarthritis (self-reported)	0.1	0.2	1.0	0.1	-0.1	1.0	0.4	-0.6	-0.2	-0.2	-0.0	0.1	0.2	-0.4
Medication: Aspirin	0.5	0.7	1.6	-1.1	1.1	-1.2	-0.4	-0.6	-0.7	-1.3	-0.7	-0.8	0.4	0.0
Medication: Gliclazide	0.6	0.7	3.8	-0.1	1.9	-1.0	-0.7	0.0	-0.1	-0.9	0.2	-0.4	-0.7	-0.8
Illnesses of father: None of the above (group 1)	1.4	1.7	3.2	0.5	-1.6	-0.6	0.8	1.8	1.6	1.2	1.3	1.5	0.6	1.8
Smoking status: Current	0.7	1.1	3.3	-1.1	-0.0	0.4	-0.3	-1.1	-0.9	-1.3	-0.5	-1.8	-1.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.4	-0.2	-1.6	-0.9	-1.0	1.0	0.4	0.6	0.2	0.1	-0.4	0.5
Whole body water mass	0.3	1.7	4.4	-0.1	2.1	0.4	-0.2	-0.9	-0.9	-2.0	0.1	-1.6	-1.1	-2.0
Leg predicted mass (right)	0.3	1.7	4.6	-0.3	2.1	0.4	0.1	-0.9	-0.9	-2.0	-0.1	-1.6	-1.2	-2.1
Arm fat mass (left)	0.3	1.4	3.2	1.2	-0.3	-0.7	1.8	1.4	1.2	0.7	1.4	1.2	1.1	1.1
Number of self-reported non-cancer illnesses	4.6	8.0	11.7	-2.9	3.1	1.9	-2.0	-3.3	-3.4	-3.0	-3.4	-3.1	-1.8	-2.5
Average weekly champagne plus white wine intake	0.7	1.0	1.9	-1.4	-0.6	0.5	-1.3	-1.0	-1.1	-0.9	-0.9	-1.2	-0.2	-0.9
Miserableness	0.3	0.6	2.7	0.5	0.1	-0.5	1.6	0.5	0.9	0.9	0.9	0.5	0.5	0.3
Guilty feelings	0.6	0.9	2.8	1.1	-0.6	-0.2	1.7	0.2	0.4	1.1	0.1	1.0	1.3	1.2
Wears glasses or contact lenses	1.6	1.8	7.0	0.3	2.7	0.3	-0.8	-0.9	-0.5	-2.1	0.2	-1.2	-1.2	-1.8
Ever taken oral contraceptive pill	2.4	2.7	5.9	-1.3	2.4	1.0	-1.3	-1.6	-1.3	-1.6	-1.2	-1.6	-1.9	-2.0
Hearing aid user	0.4	0.4	1.4	-1.1	-1.2	-0.2	0.6	0.6	0.2	0.7	-0.5	0.3	0.1	0.6
Mother’s age at death	0.3	0.4	1.3	-0.3	-0.8	-0.0	0.4	0.6	0.5	0.5	0.4	0.7	0.6	1.2
Financial situation satisfaction	0.2	0.2	0.9	-0.3	1.0	0.3	0.8	-0.5	-0.2	-0.2	-0.0	-0.0	-0.2	-0.1
Tinnitus: Yes, now most or all of the time	1.4	1.7	4.2	-0.8	2.1	0.1	-1.7	-0.8	-0.8	-1.8	-0.6	-1.4	-1.2	-1.5
Commuting to job workplace: Public transport	0.6	0.7	2.5	-1.6	-0.5	-0.8	-1.0	0.4	-0.0	-0.9	-0.3	-0.7	-1.1	-0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.1	0.1	-0.3	-0.2	0.0	0.0	0.3	-0.1	0.5	0.4	0.4
Medication: Blood pressure	0.5	1.0	7.5	0.1	-0.0	2.7	0.7	-0.5	-0.5	0.7	-1.2	0.6	-0.1	0.5
Pain type(s) experienced in last month: Hip pain	0.3	0.4	2.0	0.6	-0.3	0.7	1.4	-0.3	-0.1	0.1	0.2	0.3	0.9	0.2
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.8	-0.5	-1.1	-0.4	0.4	0.6	0.2	1.2	-0.4	0.8	1.0	1.3
High cholesterol (Self-reported)	0.3	0.5	1.9	-0.0	1.1	1.4	-0.1	-0.9	-0.8	-0.2	-0.9	-0.1	0.2	0.0
Medication: Bendroflumethiazide	0.2	0.2	0.9	-0.5	0.9	0.2	0.3	0.0	-0.4	0.2	-0.9	0.1	-0.6	-0.0
Medication: Paracetamol	0.6	0.9	2.2	1.5	0.8	-0.8	1.4	0.5	0.9	0.3	1.4	0.8	0.3	0.1
Medication: Lisinopril	0.4	0.5	1.2	0.6	-1.0	-1.1	0.2	0.8	0.7	-0.1	0.5	0.3	0.5	1.0
Medication: Atorvastatin	0.3	0.4	1.2	0.2	0.3	-0.4	-0.0	-0.1	-0.2	-0.9	0.2	-1.0	-1.1	-1.0
Illnesses of father: High blood pressure	0.5	0.6	2.0	-1.4	-0.5	-0.2	-0.1	-0.7	-1.1	-0.2	-1.4	-0.4	0.5	-0.3
Alcohol drinker status: Never	1.5	1.8	4.7	0.6	-2.2	0.1	1.3	1.5	1.4	1.7	1.2	1.5	0.9	1.4
Ever smoked	0.5	0.9	2.9	1.2	1.0	1.7	1.4	-1.1	-0.2	-0.3	0.4	0.1	0.5	-0.9
Basal metabolic rate	0.2	1.4	4.1	-0.0	2.0	0.4	0.2	-0.8	-0.7	-1.9	0.2	-1.4	-1.0	-1.8
Leg fat percentage (left)	0.9	3.1	5.9	2.3	-0.6	0.5	2.4	1.5	1.8	1.6	1.8	2.3	1.7	1.7
Arm fat-free mass (left)	0.2	1.0	3.3	0.1	1.8	0.7	0.3	-0.6	-0.6	-1.6	0.3	-1.1	-0.7	-1.5
Number of operations (self-reported)	0.6	0.9	2.4	-0.4	0.8	1.5	0.4	-1.6	-1.2	-1.4	-0.9	-0.2	0.1	-0.7
Average weekly beer plus cider intake	0.7	1.1	2.4	0.8	-0.5	-0.3	1.4	1.0	1.1	1.6	1.1	1.1	0.7	1.3
Irritability	0.5	0.9	3.5	1.4	0.8	-0.0	1.9	-0.3	0.6	0.6	0.6	0.9	1.2	0.5
Risk taking	1.1	1.6	4.1	-0.5	1.5	-0.2	-1.1	-1.2	-1.1	-2.0	-0.5	-1.5	-0.8	-2.0
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.7	0.3	-0.3	0.0	0.6	0.6	0.8	0.5	0.5	0.8	0.2	0.6
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-1.1	0.9	-0.5	0.2	-0.9	-1.0	-0.3	-1.1	0.0	0.1	-0.0
Age started oral contraceptive pill	0.5	0.6	1.4	-0.7	-1.0	-1.0	-0.1	0.6	0.4	0.7	-0.0	0.6	1.1	1.2
Diastolic blood pressure, automated reading	0.1	0.2	0.6	-0.1	-0.5	-0.8	0.0	0.6	0.3	0.1	0.5	0.3	0.4	0.5
Ever depressed for a whole week	0.7	0.8	2.4	0.3	0.6	1.0	0.7	-1.6	-1.2	-0.4	-1.2	-0.5	-0.3	-1.2
Unable to work because of sickness or disability	0.2	0.2	0.7	-0.8	0.0	0.1	0.4	0.1	-0.3	-0.4	-0.6	-0.7	-0.8	-0.3
Commuting to job workplace: Cycle	0.2	0.2	0.8	-0.8	-0.4	-0.9	-0.7	0.2	-0.1	-0.1	-0.1	-0.4	0.5	0.1
Myopia	0.2	0.3	0.9	0.5	-0.6	-0.6	0.7	0.6	0.8	-0.0	0.7	-0.0	-0.9	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	4.0	1.0	0.1	-1.1	-0.4	0.8	1.0	-0.6	2.0	-0.1	-0.4	-0.6
Cholesterol lowering medication	0.2	0.3	2.1	0.4	1.4	0.3	-0.4	-0.6	-0.3	-0.5	-0.1	-0.3	-0.4	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.7	-1.4	0.5	1.8	0.0	-1.1	-1.4	0.1	-1.9	-0.6	-0.5	-0.5
Pain experienced in last month	0.2	0.3	1.4	0.2	0.1	-0.7	-1.2	0.5	0.4	-0.1	0.7	0.3	0.1	0.6
Supplements: Calcium	1.7	1.9	4.4	-2.1	0.7	1.0	-1.5	-1.5	-1.6	-1.2	-1.9	-1.1	-0.8	-1.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	0.3	-0.9	-1.2	0.3	0.9	0.8	0.3	0.9	0.9	1.2	0.6
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.3	-0.1	1.6	0.3	-0.3	-1.8	-1.4	-0.9	-1.5	-0.6	0.3	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.3	-0.3	-1.0	-0.3	0.8	-0.1	-0.5	0.7	-1.0	0.3	1.2	0.6
Heart disease (siblings)	0.5	0.6	3.5	0.5	-0.3	-1.9	0.3	0.9	0.8	0.0	0.9	-0.2	0.4	0.4
Alcohol drinker status: Previous	0.6	0.7	4.1	-1.0	-0.8	-2.0	-0.1	0.9	0.2	0.2	0.1	-0.4	0.4	0.6
Pack years of smoking	0.4	0.5	2.5	0.9	1.6	0.4	1.0	0.2	0.5	-0.3	0.9	-0.1	-0.1	0.1
Impedance of whole body	0.6	3.0	8.4	-1.9	0.7	1.4	-1.8	-2.5	-2.4	-0.5	-2.9	-1.2	-0.8	-1.0
Leg fat mass (left)	0.3	1.1	3.6	1.6	0.6	0.5	1.9	0.7	0.9	0.4	1.2	1.1	0.9	0.6
Arm predicted mass (left)	0.2	0.9	2.8	0.1	1.7	0.8	0.2	-0.7	-0.7	-1.5	0.2	-1.0	-0.5	-1.4