Best TWAS P=1.68e-11 · Best GWAS P=1.44e-11 conditioned to 0.0702
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | KIAA1109 | 0.11 | 0.00 | lasso | 7 | 0.01 | 5.1e-02 | 6.1 | -5.4 | 8.5e-08 | -0.63 | 0.06 | 0.62 | FALSE |
| 2 | GTEx | Artery Tibial | KIAA1109 | 0.16 | 0.07 | lasso | 6 | 0.05 | 5.1e-05 | 6.2 | -5.9 | 4.8e-09 | -0.74 | 0.05 | 0.91 | FALSE |
| 3 | GTEx | Brain Nucleus accumbens basal ganglia | KIAA1109 | 0.22 | 0.07 | lasso | 7 | 0.03 | 5.9e-02 | 6.2 | -6.2 | 6.5e-10 | -0.70 | 0.04 | 0.44 | FALSE |
| 4 | GTEx | Colon Transverse | KIAA1109 | 0.25 | -0.01 | enet | 16 | 0.00 | 4.1e-01 | 6.7 | -6.4 | 1.7e-10 | -0.79 | 0.03 | 0.64 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | KIAA1109 | 0.08 | 0.08 | lasso | 7 | 0.07 | 2.5e-09 | 6.2 | -5.8 | 6.2e-09 | -0.74 | 0.13 | 0.87 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIAA1109 | 0.03 | 0.03 | lasso | 1 | 0.02 | 1.2e-05 | 6.2 | -6.2 | 4.4e-10 | -0.73 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Esophageal Carcinoma | KIAA1109 | 0.32 | 0.02 | blup | 45 | 0.02 | 7.4e-02 | 6.7 | -6.7 | 2.6e-11 | -0.60 | 0.00 | 0.87 | TRUE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | KIAA1109 | 0.05 | 0.05 | enet | 8 | 0.04 | 1.3e-05 | 6.2 | -6.0 | 2.4e-09 | -0.76 | 0.01 | 0.98 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | KIAA1109 | 0.06 | 0.05 | lasso | 2 | 0.03 | 7.1e-05 | 6.2 | -6.6 | 5.7e-11 | -0.75 | 0.02 | 0.97 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | KIAA1109 | 0.05 | 0.04 | enet | 3 | 0.05 | 5.4e-06 | 6.7 | -6.7 | 1.7e-11 | -0.83 | 0.00 | 1.00 | TRUE |