Best TWAS P=5.61e-11 · Best GWAS P=3.6e-40 conditioned to 2.24e-27
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CARD6 | 0.27 | 0.12 | lasso | 8 | 0.12 | 2.5e-10 | 5.5 | -5.2 | 1.6e-07 | 0.21 | 1.0 | 0.00 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | CARD6 | 0.18 | 0.17 | lasso | 2 | 0.18 | 4.2e-13 | 5.5 | -5.7 | 1.4e-08 | 0.15 | 1.0 | 0.00 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | PTGER4 | 0.05 | 0.06 | lasso | 3 | 0.04 | 3.9e-04 | -6.2 | 6.5 | 5.6e-11 | -0.30 | 0.5 | 0.13 | TRUE |
| 4 | GTEx | Nerve Tibial | CARD6 | 0.23 | 0.14 | lasso | 5 | 0.12 | 7.4e-09 | 5.4 | -5.1 | 2.8e-07 | 0.13 | 1.0 | 0.00 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | CARD6 | 0.13 | 0.07 | lasso | 2 | 0.07 | 4.2e-06 | 5.1 | -5.4 | 7.8e-08 | 0.16 | 0.9 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CARD6 | 0.03 | 0.02 | enet | 6 | 0.01 | 2.1e-03 | 5.4 | -6.1 | 8.5e-10 | 0.19 | 0.0 | 0.98 | TRUE |