[Hub]/) : Traits : Irritable Bowel Disease (IBD) :

chr5:39,986,432-41,555,158

Best TWAS P=5.61e-11 · Best GWAS P=3.6e-40 conditioned to 2.24e-27

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous CARD6 0.27 0.12 lasso 8 0.12 2.5e-10 5.5 -5.2 1.6e-07 0.21 1.0 0.00 FALSE
2 GTEx Cells Transformed fibroblasts CARD6 0.18 0.17 lasso 2 0.18 4.2e-13 5.5 -5.7 1.4e-08 0.15 1.0 0.00 FALSE
3 GTEx Cells Transformed fibroblasts PTGER4 0.05 0.06 lasso 3 0.04 3.9e-04 -6.2 6.5 5.6e-11 -0.30 0.5 0.13 TRUE
4 GTEx Nerve Tibial CARD6 0.23 0.14 lasso 5 0.12 7.4e-09 5.4 -5.1 2.8e-07 0.13 1.0 0.00 FALSE
5 GTEx Skin Sun Exposed Lower leg CARD6 0.13 0.07 lasso 2 0.07 4.2e-06 5.1 -5.4 7.8e-08 0.16 0.9 0.00 FALSE
6 The Cancer Genome Atlas Breast Invasive Carcinoma CARD6 0.03 0.02 enet 6 0.01 2.1e-03 5.4 -6.1 8.5e-10 0.19 0.0 0.98 TRUE