Best TWAS P=3.64e-27 · Best GWAS P=4.45e-32 conditioned to 1.86e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | RNF145 | 0.10 | 0.09 | lasso | 5 | 0.08 | 9.5e-11 | -5.2 | 5.5 | 4.6e-08 | -0.53 | 1.00 | 0.00 | FALSE |
| 2 | The Cancer Genome Atlas | Lung Adenocarcinoma | IL12B | 0.07 | 0.00 | blup | 48 | 0.04 | 8.0e-06 | -6.7 | 10.8 | 3.6e-27 | -0.89 | 0.02 | 0.64 | TRUE |
| 3 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | IL12B | 0.15 | 0.04 | blup | 48 | 0.08 | 8.9e-10 | -6.7 | 8.7 | 3.8e-18 | -0.51 | 0.03 | 0.97 | FALSE |