[Hub]/) : Traits : Irritable Bowel Disease (IBD) :

chr5:149,577,574-151,024,052

Best TWAS P=1.05e-16 · Best GWAS P=5.19e-16 conditioned to 0.019

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ZNF300P1 0.36 0.18 lasso 6 0.36 9.5e-46 7.9 5.5 4.0e-08 0.77 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous ZNF300P1 0.64 0.54 lasso 9 0.63 5.3e-66 7.6 7.7 1.5e-14 0.95 0.07 0.93 FALSE
3 GTEx Adipose Visceral Omentum ZNF300P1 0.67 0.43 enet 12 0.54 5.2e-33 7.9 7.8 6.1e-15 0.96 0.03 0.97 FALSE
4 GTEx Adrenal Gland ZNF300P1 0.53 0.15 enet 16 0.14 1.0e-05 7.9 7.0 3.6e-12 0.90 0.02 0.98 FALSE
5 GTEx Artery Coronary ZNF300P1 0.73 0.71 lasso 3 0.70 5.9e-32 7.9 7.9 3.2e-15 0.93 0.02 0.98 FALSE
6 GTEx Artery Tibial ZNF300P1 0.66 0.65 enet 14 0.69 1.5e-74 7.9 7.8 6.1e-15 0.95 0.02 0.98 FALSE
7 GTEx Brain Cerebellar Hemisphere ZNF300P1 0.72 0.55 lasso 8 0.52 9.1e-16 7.9 7.6 3.9e-14 0.92 0.02 0.98 FALSE
8 GTEx Brain Cortex ZNF300P1 0.41 0.15 lasso 4 0.31 2.7e-09 7.6 5.4 5.3e-08 0.75 0.06 0.86 FALSE
9 GTEx Brain Frontal Cortex BA9 ZNF300P1 0.34 0.15 enet 22 0.32 4.4e-09 7.9 5.6 2.1e-08 0.77 0.02 0.96 FALSE
10 GTEx Brain Hypothalamus ZNF300P1 0.68 0.24 lasso 16 0.35 4.1e-09 7.9 5.2 2.0e-07 0.76 0.02 0.95 FALSE
11 GTEx Brain Putamen basal ganglia ZNF300P1 0.44 0.28 lasso 4 0.34 4.9e-09 7.6 6.5 1.1e-10 0.86 0.03 0.97 FALSE
12 GTEx Breast Mammary Tissue ZNF300P1 0.49 0.39 enet 20 0.47 7.7e-27 7.6 7.7 1.4e-14 0.94 0.08 0.92 FALSE
13 GTEx Breast Mammary Tissue (Male) ZNF300P1 0.36 0.24 lasso 3 0.21 1.1e-05 7.6 7.4 1.4e-13 0.91 0.05 0.89 FALSE
14 GTEx Breast Mammary Tissue (Female) ZNF300P1 0.66 0.33 enet 22 0.44 1.1e-14 7.9 7.2 4.3e-13 0.90 0.03 0.97 FALSE
15 GTEx Colon Sigmoid ZNF300P1 0.65 0.34 enet 24 0.50 3.4e-20 7.6 6.9 4.5e-12 0.88 0.09 0.91 FALSE
16 GTEx Colon Transverse ZNF300P1 0.51 0.41 enet 8 0.47 9.2e-25 7.6 7.6 3.2e-14 0.95 0.19 0.81 FALSE
17 GTEx Esophagus Gastroesophageal Junction ZNF300P1 0.74 0.64 lasso 4 0.69 2.7e-33 7.9 7.8 6.8e-15 0.95 0.04 0.96 FALSE
18 GTEx Esophagus Mucosa ZNF300P1 0.55 0.44 enet 20 0.50 4.0e-38 7.6 7.4 1.2e-13 0.94 0.18 0.82 FALSE
19 GTEx Esophagus Muscularis ZNF300 0.10 0.10 enet 12 0.10 9.6e-07 8.0 6.9 6.1e-12 0.88 0.02 0.98 FALSE
20 GTEx Esophagus Muscularis ZNF300P1 0.61 0.61 enet 17 0.62 9.7e-48 7.6 7.7 1.0e-14 0.94 0.10 0.90 FALSE
21 GTEx Heart Atrial Appendage ZNF300P1 0.61 0.39 enet 19 0.47 2.0e-23 7.9 7.4 1.7e-13 0.95 0.04 0.96 FALSE
22 GTEx Heart Left Ventricle ZNF300P1 0.53 0.47 enet 20 0.51 3.3e-31 7.6 7.8 8.8e-15 0.91 0.08 0.92 FALSE
23 GTEx Liver ZNF300P1 0.32 0.18 lasso 4 0.15 7.3e-05 7.6 7.6 2.3e-14 0.95 0.03 0.97 FALSE
24 GTEx Lung ZNF300P1 0.57 0.46 lasso 8 0.58 8.1e-54 7.6 7.7 1.2e-14 0.95 0.08 0.92 FALSE
25 GTEx Muscle Skeletal ZNF300P1 0.49 0.41 enet 20 0.51 2.9e-58 7.9 8.0 1.2e-15 0.94 0.02 0.98 FALSE
26 GTEx Nerve Tibial ZNF300P1 0.70 0.63 lasso 4 0.70 5.8e-68 7.6 7.7 1.6e-14 0.95 0.19 0.81 FALSE
27 GTEx Ovary ZNF300P1 0.36 0.12 lasso 5 0.11 1.2e-03 7.6 8.0 1.6e-15 0.96 0.02 0.94 FALSE
28 GTEx Pancreas ZNF300P1 0.58 0.60 lasso 4 0.60 7.6e-31 7.9 7.8 6.6e-15 0.95 0.02 0.98 FALSE
29 GTEx Pituitary ZNF300P1 0.72 0.41 lasso 14 0.46 4.1e-13 7.6 7.4 1.3e-13 0.92 0.03 0.97 FALSE
30 GTEx Skin Not Sun Exposed Suprapubic ZNF300P1 0.53 0.49 lasso 5 0.50 7.4e-31 7.6 7.6 3.2e-14 0.94 0.19 0.81 FALSE
31 GTEx Skin Sun Exposed Lower leg ZNF300P1 0.44 0.44 lasso 3 0.46 1.3e-41 7.9 7.5 5.3e-14 0.93 0.02 0.98 FALSE
32 GTEx Spleen ZNF300P1 0.69 0.50 lasso 7 0.47 9.8e-14 7.6 7.5 8.1e-14 0.93 0.07 0.92 FALSE
33 GTEx Stomach ZNF300P1 0.57 0.41 enet 31 0.48 7.4e-26 7.6 7.8 6.2e-15 0.90 0.12 0.88 FALSE
34 GTEx Testis ZNF300 0.28 0.18 lasso 6 0.18 2.1e-08 7.9 7.7 2.0e-14 0.91 0.01 0.99 FALSE
35 GTEx Thyroid ZNF300P1 0.57 0.58 lasso 9 0.60 7.8e-57 7.9 7.8 5.4e-15 0.94 0.02 0.98 FALSE
36 GTEx Vagina ZNF300P1 0.61 0.17 lasso 11 0.27 6.2e-07 7.6 8.2 2.6e-16 0.96 0.03 0.97 FALSE
37 ROSMAP Brain Pre-frontal Cortex ZNF300P1 0.36 0.31 bslmm 516 0.48 2.8e-69 7.9 5.8 7.7e-09 0.85 0.01 0.99 FALSE
38 The Cancer Genome Atlas Bladder Urothelial Carcinoma LOC134466 0.13 0.09 lasso 4 0.09 8.0e-08 7.6 7.8 5.7e-15 0.96 0.01 0.99 FALSE
39 The Cancer Genome Atlas Breast Invasive Carcinoma DCTN4 0.10 0.02 enet 11 0.03 1.9e-07 6.6 7.8 8.6e-15 0.77 0.00 1.00 FALSE
40 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DCTN4 0.18 0.03 blup 51 0.03 1.8e-04 6.6 8.3 1.1e-16 0.81 0.00 0.99 TRUE
41 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IRGM 0.17 0.09 lasso 4 0.08 1.2e-09 8.0 8.0 1.8e-15 0.93 0.01 0.99 FALSE
42 The Cancer Genome Atlas Brain Lower Grade Glioma ZNF300 0.05 0.04 lasso 2 0.03 9.3e-05 7.9 7.9 3.9e-15 0.92 0.02 0.98 FALSE
43 The Cancer Genome Atlas Liver Hepatocellular Carcinoma LOC134466 0.12 0.09 lasso 5 0.08 2.0e-04 7.9 7.6 3.2e-14 0.93 0.01 0.94 FALSE
44 The Cancer Genome Atlas Lung Squamous Cell Carcinoma LOC134466 0.10 0.05 enet 7 0.05 2.1e-06 7.9 6.7 1.7e-11 0.88 0.00 1.00 FALSE
45 The Cancer Genome Atlas Rectum Adenocarcinoma DCTN4 0.83 -0.01 lasso 16 0.08 6.8e-03 6.5 6.8 7.5e-12 0.60 0.00 0.42 FALSE
46 The Cancer Genome Atlas Soft Tissue Sarcoma IRGM 0.08 0.05 lasso 8 0.05 5.3e-04 7.8 7.8 4.8e-15 0.93 0.02 0.92 FALSE
47 The Cancer Genome Atlas Testicular Germ Cell Tumors LOC134466 0.43 0.04 enet 15 0.08 7.2e-04 7.9 7.3 2.4e-13 0.91 0.01 0.95 FALSE
48 The Cancer Genome Atlas Thyroid Carcinoma ZNF300 0.03 0.01 blup 45 0.01 8.1e-02 6.7 7.6 3.7e-14 0.86 0.02 0.43 FALSE