TWAS hub - IL12B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Lung Adenocarcinoma	0.0697	0.0353	1.3e-04	0.003	0.043	0.025	NA	0.024	1.2e-01	8.0e-06	6.0e-04	NA	6.7e-04
2	TCGA	Lung Squamous Cell Carcinoma	0.1538	0.0624	1.2e-07	0.038	0.084	0.082	NA	0.077	3.8e-05	8.9e-10	1.5e-09	NA	4.2e-09

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Irritable Bowel Disease (IBD)	40.3	96.0	116.6	10.8	8.7
Ulcerative Colitis (UC)	31.9	59.9	70.2	8.4	7.0
Crohns Disease (2017)	29.1	63.8	77.8	8.8	7.1
Crohns Disease (2012)	28.7	46.3	58.1	7.6	5.9
Ulcerative Colitis	18.0	26.1	31.2	5.6	4.6
Mouth/teeth dental problems: Mouth ulcers	16.0	25.4	35.5	6.0	3.9
Mother’s age at death	4.8	6.0	8.1	2.0	2.8
Exposure to tobacco smoke at home	4.1	4.6	5.8	-1.9	-2.4
Loud music exposure frequency	4.1	4.5	5.9	-1.8	-2.4
Tinnitus: Yes, but not now, but have in the past	3.7	3.9	4.2	-2.0	-1.9
Hair/balding pattern: Pattern 4	3.7	8.9	13.5	2.1	3.7
Medication: Aspirin	3.5	4.5	7.2	-2.7	-1.3
Heart attack	3.3	4.2	6.1	-1.5	-2.5
Heart attack/myocardial infarction (self-reported)	3.3	4.3	6.2	-1.5	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.2	3.9	6.1	1.3	2.5
Alcohol drinker status: Never	3.2	3.8	4.7	1.7	2.2
Cholesterol lowering medication	3.2	4.7	6.9	1.6	2.6
Medication: Cholesterol lowering	3.1	4.8	6.9	-2.6	-1.7
Fed-up feelings	3.0	5.4	5.9	2.4	2.2
Medication: Aspirin	3.0	4.0	6.9	-2.6	-1.0
Prostate Cancer	2.9	4.0	6.2	2.5	1.4
Medication: Lansoprazole	2.8	3.2	5.0	-2.2	-1.2
Pulse wave Arterial Stiffness index	2.8	3.3	3.5	-1.7	-1.9
Wheeze or whistling in the chest in last year	2.8	5.0	5.7	-2.1	-2.4
Medication: Gliclazide	2.5	2.9	3.6	1.9	1.5
Smoking status: Current	2.5	3.9	5.1	-1.7	-2.3
Mouth/teeth dental problems	2.4	3.6	5.0	-2.2	-1.5
Pulse wave peak to peak time	2.3	2.8	3.1	1.8	1.6
Depressed Affect (Nagel 2018)	2.2	4.6	5.7	2.4	1.9
Current tobacco smoking	2.2	3.6	4.8	-1.6	-2.2
Medication: Ramipril	2.2	2.8	4.3	-2.1	-1.2
Age started oral contraceptive pill	2.2	2.8	4.6	1.0	2.1
Hearing difficulty/problems with background noise	2.1	3.4	5.0	-2.2	-1.3
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	2.8	-1.5	-1.7
Mouth/teeth dental problems: Loose teeth	2.1	2.5	2.7	1.5	1.6
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	4.4	-2.1	-0.6
Back pain experienced in last month	1.9	2.8	3.3	-1.5	-1.8
Tinnitus: Yes, now most or all of the time	1.8	2.1	2.3	1.5	1.4
Hypothyroidism/myxoedema (self-reported)	1.7	3.4	6.0	0.8	2.5
Angina (self-reported)	1.7	2.3	4.4	-2.1	-0.5
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.3	-1.8	-0.6
Emphysema/chronic bronchitis	1.6	1.8	2.8	-1.7	-0.9
Breastfed as a baby	1.5	1.8	2.1	-1.3	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.5	1.9	2.6	1.1	1.6
Health satisfaction	1.5	1.9	3.6	-1.9	-0.4
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.2	1.8	0.6
Osteoporosis (self-reported)	1.5	1.8	2.6	-1.6	-1.0
Breast Cancer	1.4	3.4	5.5	-1.1	-2.4
Angina	1.4	1.9	3.7	-1.9	-0.2
Average weekly fortified wine intake	1.4	1.6	2.9	-1.7	-0.6
Allergy	1.4	3.2	4.9	-1.2	-2.2
Pulse rate	1.4	2.4	3.3	-1.2	-1.8
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.0	-1.7	-0.8
Mean time to correctly identify matches	1.4	2.6	4.8	0.7	2.2
Loneliness, isolation	1.4	1.9	2.6	1.6	1.1
Hearing aid user	1.4	1.6	2.4	0.9	1.6
Medication: Atorvastatin	1.4	1.7	2.6	-1.6	-0.9
Age at First Birth	1.3	1.8	2.0	1.4	1.3
Average weekly spirits intake	1.3	1.6	3.2	-1.8	0.2
Neck or shoulder pain in last month	1.3	1.8	2.4	-1.6	-1.1
Leg pain on walking	1.3	1.6	2.6	-0.8	-1.6
Mood swings	1.3	2.4	3.3	1.8	1.3
Medication: Lisinopril	1.3	1.7	2.7	0.8	1.7
Ever depressed for a whole week	1.3	1.6	2.7	-1.6	-0.7
Hypothyroidism (self reported)	1.2	2.8	5.3	0.5	2.3
Chronic bronchitis/emphysema (father)	1.2	1.3	1.6	1.3	1.0
Had menopause	1.2	1.5	2.1	0.9	1.5
Miserableness	1.2	2.2	2.4	1.5	1.4
Schizophrenia (2018)	1.1	2.2	4.1	-0.6	-2.0
Smoking Status	1.1	2.6	4.5	-0.9	-2.1
Medication: Paracetamol	1.1	1.8	2.2	1.5	1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	3.3	1.8	0.6
Gout (self-reported)	1.1	1.5	1.8	-1.3	-1.1
Birth weight	1.1	2.5	3.8	-1.0	-2.0
Alcohol intake frequency.	1.1	2.5	3.8	2.0	1.0
Chest pain or discomfort	1.1	1.5	2.8	-1.7	-0.6
Ovarian Cancer	1.0	1.3	2.4	1.6	0.4
Blood Red Count	1.0	9.7	11.6	2.8	3.4
Number of treatments/medications taken	1.0	1.8	3.3	-1.8	-0.6
Maternal smoking around birth	1.0	1.4	2.2	1.5	0.8
Hayfever, allergic rhinitis or eczema	1.0	2.1	3.4	0.9	1.8
Medication: Levothyroxine sodium	1.0	1.7	3.0	0.6	1.7
Ever had bowel cancer screening	1.0	1.2	1.5	0.9	1.2
Vascular/heart problems diagnosed by doctor	1.0	2.8	4.9	2.2	0.8
Basal cell carcinoma (self-reported)	1.0	1.2	2.1	0.5	1.4
Bipolar Disorder or Schizophrenia	0.9	2.2	4.1	-0.5	-2.0
Lung FEV1/FVC ratio	0.9	4.6	5.2	2.0	2.3
Medication for hormone replacement therapy	0.9	1.0	1.5	0.7	1.2
Illnesses of siblings	0.9	1.2	2.1	-0.5	-1.4
Father’s age at death	0.9	1.1	1.3	1.2	1.0
Depression (self-reported)	0.9	1.0	1.2	0.9	1.1
Qualifications: College or University degree	0.9	2.9	3.2	1.8	1.6
Comparative height size at age 10	0.9	4.7	9.1	3.0	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.0	-1.4	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.2	-0.9	-1.1
Average weekly champagne plus white wine intake	0.9	1.2	1.3	-1.1	-1.1
Medication: Paracetamol	0.9	1.3	1.4	1.2	1.2
BMI	0.8	4.5	8.8	-3.0	-0.5
Hand grip strength (left)	0.8	2.0	3.4	-0.8	-1.8
Alcohol intake versus 10 years previously	0.8	1.1	1.4	1.2	0.9
Peak expiratory flow (PEF)	0.8	1.9	2.3	1.5	1.2
Exposure to tobacco smoke outside home	0.8	1.0	1.5	1.2	0.8
Number of children fathered	0.8	0.9	1.4	-1.2	-0.6
Age at first live birth	0.8	1.4	2.6	0.5	1.6
Heart disease (mother)	0.8	1.0	1.9	-1.4	-0.3
Overall health rating	0.8	1.7	3.1	-1.8	-0.6
Risk taking	0.8	1.1	2.1	0.4	-1.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.1	-1.0	-0.9
Heart disease (siblings)	0.8	0.9	1.7	0.5	1.3
Pack years of smoking	0.8	1.2	2.1	-0.4	-1.5
Major Depression (MDD)	0.7	0.9	1.2	0.7	1.1
Bipolar Disorder (2011)	0.7	0.6	1.2	1.1	0.2
HDL Cholesterol	0.7	1.1	1.5	-0.9	-1.2
Respiratory disease	0.7	1.5	2.7	-1.6	-0.6
Pack years adult smoking proportion	0.7	1.1	2.3	0.0	-1.5
Number of incorrect matches in round	0.7	1.2	1.3	-1.1	-1.1
Had other major operations	0.7	0.9	1.6	-1.3	-0.5
Hair/balding pattern: Pattern 3	0.7	1.1	2.0	0.3	1.4
Number of full brothers	0.7	0.8	1.0	-0.8	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	0.9	0.9	0.9
Age at last live birth	0.7	1.1	1.9	0.5	1.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.4	-0.5	-1.2
Knee pain experienced in last month	0.7	1.1	1.9	0.5	1.4
Hypertension (Self-reported)	0.7	1.9	3.7	-1.9	-0.3
Average weekly red wine intake	0.7	1.1	2.0	-1.4	0.3
Medication: Co-codamol	0.6	0.7	1.2	-1.1	0.4
Serious illness, injury or assault to yourself	0.6	0.8	0.9	-0.8	-1.0
Diabetes (self-reported)	0.6	0.9	1.1	0.9	1.1
Happiness	0.6	0.7	1.4	-1.2	-0.2
Birth weight of first child	0.6	1.1	1.7	1.3	0.7
Medication: Ibuprofen	0.6	0.8	1.2	-0.5	-1.1
Illnesses of father: Heart disease	0.6	0.8	1.5	0.3	1.2
Arm fat percentage (left)	0.6	2.2	4.4	-2.1	0.2
Medication for cholesterol	0.6	1.0	1.8	-0.4	-1.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.2	-1.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	1.7	-1.3	-0.9
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.2	0.6	1.1
Illnesses of father: High blood pressure	0.6	0.8	1.3	1.1	0.5
Number of operations (self-reported)	0.6	0.8	1.5	-0.4	-1.2
Pain experienced in last month	0.6	1.0	1.5	0.7	1.2
Mean Putamen Volume	0.5	0.5	0.9	-0.4	-0.9
Triglycerides	0.5	0.8	1.1	1.0	0.7
Cardiovascular Disease	0.5	1.6	2.7	-1.7	-0.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.4	-0.2	1.2
Supplements: Zinc	0.5	0.5	0.9	1.0	-0.2
Hand grip strength (right)	0.5	1.3	1.3	-1.2	-1.1
High blood pressure	0.5	1.4	2.8	-1.7	-0.1
Alcohol usually taken with meals	0.5	0.8	0.9	1.0	0.8
Hair/balding pattern: Pattern 2	0.5	0.6	0.8	0.7	0.9
Arm fat percentage (right)	0.5	1.9	3.7	-1.9	0.3
Tense / ‘highly strung’	0.5	0.8	1.6	-1.3	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.3	-1.2	0.4
Pulse wave reflection index	0.5	0.7	1.1	0.5	1.0
Medication: Blood pressure	0.5	0.8	1.7	-1.3	0.0
Qualifications: nursing, teaching	0.5	0.7	1.1	-1.0	-0.6
Number of self-reported non-cancer illnesses	0.5	0.9	0.9	-0.9	-1.0
Guilty feelings	0.5	0.8	1.5	-0.2	1.2
Wears glasses or contact lenses	0.5	0.6	1.2	0.1	1.1
Reaction Time	0.4	0.8	1.4	0.4	1.2
Fasting Glucose	0.4	0.4	0.8	0.9	0.3
Schizophrenia (2014)	0.4	0.9	1.7	-0.3	-1.3
Systolic Blood Pressure	0.4	1.8	3.6	-1.9	-0.0
Lung FVC	0.4	2.1	3.6	-1.9	-0.8
Hearing difficulty/problems: Yes	0.4	0.7	1.3	-1.2	0.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	0.9	-1.0	0.0
Diabetes (father)	0.4	0.5	0.8	0.9	0.4
Taking other prescription medications	0.4	0.6	1.2	-1.1	-0.0
Medication: Atenolol	0.4	0.5	1.0	-1.0	0.3
Body mass index (BMI)	0.4	1.6	3.2	-1.8	0.3
Pain all over the body in last month	0.4	0.5	0.9	-1.0	-0.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	0.1	-1.0
Time employed in main current job	0.4	0.5	0.5	-0.7	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	1.1	-1.0	0.5
Arm fat mass (right)	0.4	1.5	2.9	-1.7	0.1
Glaucoma (self-reported)	0.4	0.5	0.5	-0.6	0.7
Body fat percentage	0.4	1.4	2.6	-1.6	0.5
Leg fat percentage (right)	0.4	1.4	2.2	-0.7	1.5
Smoking status: Previous	0.4	0.5	1.1	1.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.6	1.3	-0.5
Eye problems/disorders: Cataract	0.4	0.4	0.8	0.3	0.9
Breast cancer (self-reported)	0.4	0.5	0.6	0.6	0.8
Ever taken oral contraceptive pill	0.4	0.4	0.9	0.2	-0.9
High cholesterol (Self-reported)	0.4	0.7	1.2	-1.1	-0.5
Leg fat percentage (left)	0.4	1.4	1.6	-1.1	1.3
Depression (Nagel 2018)	0.3	0.4	0.5	-0.5	0.7
Worry (Nagel 2018)	0.3	0.6	0.8	-0.9	-0.6
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	0.1	0.8
Neuroticism (2016)	0.3	0.4	0.8	0.2	0.9
Relative age of first facial hair	0.3	0.7	1.1	-1.1	0.4
Ever had hysterectomy (womb removed)	0.3	0.3	0.6	-0.8	0.2
Systolic blood pressure, automated reading	0.3	0.9	1.5	-1.2	0.5
Medication: Metformin	0.3	0.4	0.7	0.8	-0.2
Severe depression (siblings)	0.3	0.3	0.6	-0.7	-0.0
Impedance of leg (right)	0.3	1.7	2.8	1.7	0.8
Trunk fat percentage	0.3	1.3	2.4	-1.6	0.4
Townsend deprivation index at recruitment	0.3	0.4	0.8	-0.9	0.0
Qualifications: CSEs or equivalent	0.3	0.4	0.8	0.9	-0.1
Stomach or abdominal pain in last month	0.3	0.3	0.4	0.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.7	-0.8	-0.5
Forced vital capacity (FVC)	0.3	1.0	1.8	-0.4	-1.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.3	1.2	0.1
Prospective memory result	0.3	0.4	0.5	-0.7	0.5
Shortness of breath walking on level ground	0.3	0.4	0.7	-0.2	0.9
Eye problems/disorders: None of the above	0.3	0.4	0.4	0.6	-0.5
Whole body fat mass	0.3	1.1	2.1	-1.4	0.2
Pulse rate, automated reading	0.3	0.9	1.6	-0.4	-1.3
Number of full sisters	0.3	0.3	0.5	-0.7	-0.3
Friendships satisfaction	0.3	0.3	0.5	-0.7	-0.4
Commuting to job workplace: Walk	0.3	0.3	0.4	-0.6	-0.5
Osteoarthritis (self-reported)	0.3	0.4	0.8	0.1	0.9
Arm fat mass (left)	0.3	1.3	2.5	-1.6	0.4
Medication: Blood pressure	0.3	0.6	1.0	-1.0	-0.3
Medication: Bendroflumethiazide	0.3	0.5	0.6	0.6	0.8
Average weekly beer plus cider intake	0.3	0.4	0.8	-0.2	-0.9
Bipolar Disorder (2018)	0.2	0.3	0.5	-0.2	-0.7
Alzheimer’s Disease (in father)	0.2	0.2	0.3	0.3	-0.6
Lupus	0.2	0.4	0.7	-0.8	-0.1
Rheumatoid Arthritis	0.2	0.3	0.4	-0.6	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.3	-0.2	-0.6
Blood Platelet Count	0.2	2.2	2.8	-1.7	-1.2
Height	0.2	3.1	5.9	2.4	-0.6
Allergy or Eczema	0.2	0.5	0.9	-0.1	1.0
Vitamin and mineral supplements	0.2	0.2	0.5	-0.0	-0.7
Age when periods started (menarche)	0.2	0.5	0.5	-0.7	-0.6
Supplements: Glucosamine	0.2	0.3	0.5	-0.7	0.3
High blood pressure (mother)	0.2	0.2	0.3	0.4	0.5
Impedance of leg (left)	0.2	0.9	1.6	1.2	0.4
Trunk fat mass	0.2	0.9	1.6	-1.3	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	0.6	0.4
Lung cancer (father)	0.2	0.3	0.5	-0.3	-0.7
Standing height	0.2	2.2	4.2	2.1	-0.5
Headache pain in last month	0.2	0.3	0.4	0.7	-0.5
Medication: Amlodipine	0.2	0.3	0.6	-0.7	-0.3
Forced vital capacity (FVC), Best measure	0.2	0.8	1.2	-0.5	-1.1
Comparative body size at age 10	0.2	0.6	1.2	-1.1	-0.3
Medication: Seretide 50 evohaler	0.2	0.2	0.3	0.6	-0.3
Leg fat mass (right)	0.2	0.6	0.6	-0.8	0.8
Had major operations	0.2	0.2	0.5	0.7	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.5	-0.7	0.2
Supplements: Vitamin C	0.2	0.2	0.4	-0.0	-0.6
Illnesses of siblings: Diabetes	0.2	0.3	0.4	0.4	0.6
Diabetes diagnosed by doctor	0.2	0.3	0.3	0.5	0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	0.0	0.7
Fractured/broken bones in last 5 years	0.2	0.3	0.4	-0.7	-0.5
Diastolic blood pressure, automated reading	0.2	0.5	0.9	-1.0	-0.3
Myopia	0.2	0.3	0.5	-0.7	0.2
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.4	-0.6	-0.3
Leg fat mass (left)	0.2	0.8	1.2	-1.1	0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.3	-0.3	0.6
Neuroticism (Nagel 2018)	0.1	0.2	0.3	0.6	0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	0.1	-0.5
Coronary Artery Disease (CAD)	0.1	0.1	0.2	-0.1	-0.5
HbA1C	0.1	0.1	0.1	0.4	-0.1
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.5	0.3
Blood Eosinophil Count	0.1	0.8	1.5	-1.2	-0.3
Blood White Count	0.1	1.0	1.3	-0.8	-1.1
Heel T-Score	0.1	0.4	0.7	-0.8	0.3
Waist Hip Ratio (WHR)	0.1	0.6	1.1	1.0	-0.4
Neuroticism	0.1	0.3	0.4	0.6	0.5
Chronotype (morning person)	0.1	0.1	0.2	0.5	0.2
Leg fat-free mass (left)	0.1	0.3	0.3	-0.5	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.5	-0.1
Relative age voice broke	0.1	0.2	0.3	-0.6	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.4	0.6	-0.4
Multivitamins +/- minerals	0.1	0.1	0.1	0.1	0.3
Sitting height	0.1	0.4	0.4	0.6	-0.6
Leg predicted mass (left)	0.1	0.3	0.4	-0.6	-0.6
Waist circumference	0.1	0.3	0.6	-0.8	0.0
Past tobacco smoking	0.1	0.3	0.3	-0.5	0.5
Nervous feelings	0.1	0.1	0.2	-0.3	-0.4
Qualifications: None of the above	0.1	0.2	0.4	-0.6	-0.2
Neuroticism score	0.1	0.3	0.3	0.5	0.5
Weight	0.1	0.3	0.6	-0.8	0.1
Impedance of arm (right)	0.1	0.4	0.7	0.8	-0.2
Trunk fat-free mass	0.1	0.4	0.8	0.9	0.2
Hip circumference	0.1	0.4	0.8	-0.9	0.3
Number of live births	0.1	0.1	0.2	0.4	0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.2	0.4	0.6	0.0
Mouth/teeth dental problems: Dentures	0.1	0.2	0.2	-0.3	0.5
Asthma	0.1	0.3	0.6	0.0	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.4	-0.2
Illnesses of mother	0.1	0.1	0.2	0.3	-0.5
Trunk predicted mass	0.1	0.5	0.9	0.9	0.3
Length of working week for main job	0.1	0.1	0.2	0.4	-0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.4	0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.5	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	0.6	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.3	0.4
Suffer from ‘nerves’	0.1	0.2	0.3	-0.4	-0.5
Family relationship satisfaction	0.1	0.2	0.2	0.4	0.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	0.5	-0.3
Leg fat-free mass (right)	0.1	0.4	0.5	-0.6	-0.7
Long-standing illness, disability or infirmity	0.1	0.2	0.3	-0.5	-0.1
Leg predicted mass (right)	0.1	0.5	0.6	-0.6	-0.8
Supplements: Calcium	0.1	0.1	0.2	-0.4	-0.1
Impedance of whole body	0.1	0.7	1.4	1.2	0.1
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	-0.2	0.2
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	-0.0	0.0
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.0	0.1	0.2
LDL Cholesterol	0.0	0.0	0.0	0.2	-0.0
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.0	0.0	-0.1
Hair Pigment	0.0	1.2	1.4	1.2	1.0
Tanning	0.0	0.6	1.1	-0.2	1.0
Sensitivity / hurt feelings	0.0	0.0	0.1	-0.0	-0.2
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.0	-0.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.3	0.2
Diabetes (mother)	0.0	0.0	0.1	0.2	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	0.1	-0.3
Financial difficulties in last 2 years	0.0	0.0	0.0	-0.0	0.0
Medication: Simvastatin	0.0	0.1	0.1	0.0	0.4
Fluid intelligence score	0.0	0.0	0.0	0.1	-0.0
Worrier / anxious feelings	0.0	0.1	0.1	-0.3	-0.2
Falls in the last year	0.0	0.0	0.0	-0.2	0.1
Noisy workplace	0.0	0.0	0.1	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.0	0.0	-0.1
Impedance of arm (left)	0.0	0.2	0.3	0.6	-0.4
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.1	-0.2
High blood pressure (siblings)	0.0	0.0	0.0	-0.2	0.2
Arm fat-free mass (right)	0.0	0.0	0.0	0.1	0.1
Worry too long after embarrassment	0.0	0.0	0.0	-0.2	-0.1
Medication for pain relief, constipation, heartburn	0.0	0.0	0.1	-0.0	-0.3
Migraine (self-reported)	0.0	0.0	0.0	0.2	-0.1
Medication: Allopurinol	0.0	0.1	0.1	-0.3	0.1
Medication: Omeprazole	0.0	0.0	0.0	0.1	0.0
Arm predicted mass (right)	0.0	0.0	0.0	0.2	-0.1
Whole body fat-free mass	0.0	0.1	0.1	0.3	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.1	0.3	-0.1
Mineral and other dietary supplements	0.0	0.0	0.0	-0.1	-0.1
Asthma (self-reported)	0.0	0.1	0.1	-0.1	0.3
Whole body water mass	0.0	0.0	0.0	0.2	-0.2
Financial situation satisfaction	0.0	0.0	0.0	-0.0	-0.2
Commuting to job workplace: Public transport	0.0	0.1	0.1	-0.2	-0.3
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.0	-0.1
Ever smoked	0.0	0.0	0.1	0.1	-0.3
Basal metabolic rate	0.0	0.0	0.0	-0.0	-0.2
Arm fat-free mass (left)	0.0	0.1	0.1	0.3	0.2
Irritability	0.0	0.0	0.1	0.2	-0.2
Unable to work because of sickness or disability	0.0	0.0	0.0	0.2	0.2
Commuting to job workplace: Cycle	0.0	0.1	0.1	-0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.1	0.1	0.3	0.1
Alcohol drinker status: Previous	0.0	0.0	0.1	0.3	-0.1
Arm predicted mass (left)	0.0	0.1	0.1	0.2	0.3

Hub : Genes

IL12B

Models

Trait associations