Best TWAS P=5.6e-13 · Best GWAS P=5.6e-13 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | DCAF16 | 0.10 | 0.01 | enet | 6 | 0.02 | 4.7e-02 | -6.8 | 7.0 | 3.1e-12 | -0.84 | 0.04 | 0.85 | FALSE |
2 | GTEx | Breast Mammary Tissue | DCAF16 | 0.12 | 0.08 | lasso | 4 | 0.10 | 6.4e-06 | 3.5 | 5.4 | 7.3e-08 | -0.57 | 0.05 | 0.87 | FALSE |
3 | GTEx | Breast Mammary Tissue (Male) | DCAF16 | 0.24 | 0.03 | enet | 18 | -0.01 | 4.4e-01 | -6.6 | 6.1 | 1.1e-09 | -0.75 | 0.03 | 0.66 | FALSE |
4 | GTEx | Spleen | DCAF16 | 0.35 | 0.02 | lasso | 5 | 0.11 | 8.5e-04 | 3.6 | 6.0 | 2.1e-09 | -0.61 | 0.07 | 0.43 | FALSE |
5 | ROSMAP | Brain Pre-frontal Cortex | DCAF16 | 0.04 | 0.02 | bslmm | 379 | 0.01 | 3.9e-02 | -6.6 | 5.6 | 2.6e-08 | -0.85 | 0.06 | 0.80 | FALSE |
6 | The Cancer Genome Atlas | Colon Adenocarcinoma | NCAPG | 0.08 | 0.04 | blup | 34 | 0.09 | 1.1e-05 | -7.2 | -6.4 | 1.5e-10 | 0.92 | 0.01 | 0.99 | FALSE |
7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NCAPG | 0.14 | 0.07 | lasso | 3 | 0.07 | 5.2e-08 | -6.6 | -6.5 | 7.6e-11 | 0.97 | 0.14 | 0.86 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DCAF16 | 0.09 | 0.02 | lasso | 3 | 0.04 | 5.2e-05 | 3.7 | 6.2 | 5.1e-10 | -0.70 | 0.17 | 0.58 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCAPG | 0.02 | 0.03 | lasso | 1 | 0.02 | 9.0e-04 | -7.2 | -7.2 | 5.6e-13 | 1.00 | 0.00 | 0.92 | TRUE |
10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DCAF16 | 0.04 | 0.04 | blup | 31 | 0.04 | 2.2e-05 | 3.6 | 6.0 | 2.3e-09 | -0.63 | 0.27 | 0.23 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NCAPG | 0.02 | 0.02 | blup | 34 | 0.02 | 3.4e-03 | -6.9 | -6.4 | 1.6e-10 | 0.85 | 0.02 | 0.64 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | DCAF16 | 0.07 | 0.04 | blup | 31 | 0.07 | 4.9e-07 | 3.7 | 5.7 | 9.7e-09 | -0.74 | 0.17 | 0.74 | FALSE |