Best TWAS P=1.29e-09 · Best GWAS P=1.28e-09 conditioned to 1.75e-06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | RP11-731C17.2 | 0.16 | 0.03 | enet | 13 | 0.06 | 1.1e-04 | -5.1 | -5.6 | 2.4e-08 | 0.42 | 0.20 | 0.69 | FALSE |
| 2 | GTEx | Stomach | PPP2R3A | 0.08 | 0.02 | lasso | 4 | 0.05 | 1.9e-03 | -5.4 | 5.3 | 1.4e-07 | -0.20 | 0.12 | 0.78 | FALSE |
| 3 | YFS | Blood | MSL2 | 0.02 | 0.04 | lasso | 2 | 0.03 | 9.9e-11 | -5.3 | 5.3 | 1.5e-07 | -0.18 | 0.08 | 0.92 | FALSE |
| 4 | The Cancer Genome Atlas | Colon Adenocarcinoma | PCCB | 0.11 | 0.03 | blup | 54 | 0.04 | 2.3e-03 | 4.8 | 5.3 | 1.3e-07 | -0.23 | 0.02 | 0.34 | FALSE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | PCCB | 0.15 | 0.03 | blup | 54 | 0.05 | 9.6e-03 | 4.8 | 5.7 | 1.1e-08 | -0.25 | 0.02 | 0.41 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | PCCB | 0.10 | 0.03 | blup | 53 | 0.02 | 5.8e-02 | 4.8 | 5.2 | 2.6e-07 | -0.21 | 0.02 | 0.34 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MSL2 | 0.07 | 0.02 | enet | 6 | 0.03 | 1.7e-04 | 4.3 | 5.2 | 2.4e-07 | -0.27 | 0.06 | 0.24 | FALSE |
| 8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STAG1 | 0.04 | 0.02 | lasso | 3 | 0.02 | 4.1e-03 | -5.8 | 6.1 | 1.3e-09 | -0.23 | 0.02 | 0.95 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | STAG1 | 0.05 | 0.00 | blup | 151 | 0.01 | 2.9e-02 | 5.0 | 5.5 | 3.5e-08 | -0.23 | 0.37 | 0.56 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PCCB | 0.06 | 0.02 | lasso | 2 | 0.03 | 2.3e-04 | -5.3 | 5.7 | 1.3e-08 | -0.28 | 0.02 | 0.96 | FALSE |