Best TWAS P=1.46e-09 · Best GWAS P=5.22e-09 conditioned to 0.023
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | RP11-316M21.6 | 0.17 | 0.16 | lasso | 5 | 0.16 | 3.9e-11 | 5.8 | 5.4 | 5.1e-08 | 0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Esophagus Mucosa | PHBP9 | 0.07 | 0.05 | enet | 13 | 0.05 | 3.6e-04 | 4.4 | 5.5 | 5.0e-08 | 0.79 | 0.04 | 0.79 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | CWF19L1 | 0.13 | 0.09 | lasso | 5 | 0.10 | 3.2e-05 | 5.8 | 5.3 | 1.2e-07 | 0.97 | 0.00 | 1.00 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | CWF19L1 | 0.29 | 0.33 | bslmm | 392 | 0.34 | 9.3e-45 | 4.5 | 5.1 | 3.1e-07 | 0.87 | 0.52 | 0.48 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CWF19L1 | 0.13 | 0.13 | enet | 7 | 0.13 | 6.2e-26 | 4.5 | 5.2 | 2.0e-07 | 0.88 | 0.04 | 0.94 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CWF19L1 | 0.06 | 0.02 | lasso | 9 | 0.04 | 8.2e-06 | -4.9 | 6.0 | 1.5e-09 | 0.70 | 0.02 | 0.83 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CWF19L1 | 0.06 | 0.03 | blup | 56 | 0.04 | 1.6e-05 | 4.5 | 5.5 | 3.8e-08 | 0.56 | 0.02 | 0.74 | FALSE |