TWAS hub - PHBP9

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.110	0.0490	5.7e-03	-0.001	NA	0.010	NA	0.001	4.4e-01	NA	4.6e-02	NA	2.7e-01
2	GTEx	Brain Frontal Cortex BA9	0.169	0.0786	5.3e-03	-0.004	NA	0.020	NA	0.011	4.3e-01	NA	9.6e-02	NA	1.6e-01
3	GTEx	Brain Nucleus accumbens basal ganglia	0.463	0.1150	4.1e-03	0.012	NA	-0.003	NA	0.000	1.5e-01	NA	3.9e-01	NA	3.1e-01
4	GTEx	Cells Transformed fibroblasts	0.130	0.0470	4.5e-04	0.081	NA	0.052	NA	0.061	1.1e-06	NA	9.5e-05	NA	2.3e-05
5	GTEx	Esophagus Mucosa	0.074	0.0330	2.6e-03	0.051	NA	0.048	NA	0.047	2.4e-04	NA	3.6e-04	NA	4.4e-04
6	GTEx	Esophagus Muscularis	0.191	0.0530	2.0e-06	0.095	NA	0.064	NA	0.047	2.1e-06	NA	9.2e-05	NA	7.4e-04
7	GTEx	Nerve Tibial	0.182	0.0610	4.9e-04	0.023	NA	0.023	NA	0.029	8.4e-03	NA	8.6e-03	NA	3.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Type 2 Diabetes (T2D) (2018)	7.1	13.4	24.2	-4.5	-2.5	-0.0	-4.9	-3.1	-4.7	-3.4
Lupus	7.0	10.6	16.2	-0.7	-3.5	-1.9	-3.6	-3.7	-4.0	-3.8
Headache pain in last month	6.0	10.3	18.9	1.5	3.5	1.2	3.7	4.3	3.7	3.2
Supplements: Zinc	5.9	6.4	10.0	-2.0	-2.9	1.9	-2.8	-2.5	-3.2	-2.1
Diabetes diagnosed by doctor	5.6	9.1	16.1	-3.9	-1.8	-0.2	-4.0	-2.5	-3.9	-2.9
Seen doctor (GP) for nerves, anxiety, tension or depression	5.3	8.1	12.0	2.8	2.7	1.0	3.3	2.7	3.5	3.2
Type 2 Diabetes (T2D) (2012)	5.2	6.0	11.4	-1.3	-2.7	2.0	-3.4	-2.5	-3.0	-1.7
Verbal and Numeric Reasoning (VNR)	5.1	12.3	23.1	1.2	3.2	2.7	3.7	4.5	3.2	4.8
Supplements: Calcium	5.1	5.6	10.7	-1.9	-2.6	1.0	-2.6	-3.3	-2.6	-1.8
Number of live births	4.9	6.9	13.8	-0.8	-3.0	1.1	-2.7	-3.7	-3.1	-2.7
Intelligence (Savage-Jansen 2018)	4.6	14.2	29.7	1.8	3.7	1.3	4.0	5.5	3.7	4.6
HDL Cholesterol	4.6	7.7	12.2	1.4	2.8	0.4	3.5	3.5	3.2	3.0
Illnesses of father: Heart disease	4.5	6.3	13.7	0.8	3.0	-1.1	2.5	3.7	2.9	2.2
Diabetes (self-reported)	4.4	6.8	12.7	-3.3	-1.5	-0.6	-3.6	-1.8	-3.1	-3.0
Fluid intelligence score	4.2	8.8	16.3	1.3	2.8	1.5	3.3	3.9	2.9	4.0
Age when periods started (menarche)	4.1	9.8	15.4	-3.4	-3.2	-1.4	-3.1	-3.9	-3.7	-2.5
Pulse rate, automated reading	4.0	13.1	38.5	1.2	3.9	0.8	3.3	6.2	3.8	3.3
Primary Biliary Cirrhosis	3.8	5.4	10.1	0.1	-2.1	-0.1	-3.2	-3.0	-2.6	-2.7
Number of incorrect matches in round	3.8	6.3	14.9	-0.9	-2.9	0.0	-2.7	-3.9	-2.5	-2.6
Depression (Nagel 2018)	3.7	5.5	10.7	1.0	3.3	0.5	2.2	3.2	2.6	2.2
Ever used hormone-replacement therapy (HRT)	3.6	4.6	6.9	-1.9	-1.9	-1.0	-2.6	-2.5	-2.1	-2.5
Family relationship satisfaction	3.6	4.5	9.4	1.9	2.7	0.2	1.9	3.1	2.3	1.3
Eye problems/disorders: None of the above	3.5	4.1	7.8	-1.4	-2.8	-0.4	-2.0	-2.7	-2.4	-1.3
Average weekly beer plus cider intake	3.3	4.8	9.4	-1.5	-1.7	0.8	-2.7	-3.1	-2.4	-2.3
Osteoporosis (self-reported)	3.2	3.9	7.4	-0.4	-2.7	0.7	-2.1	-2.6	-2.7	-1.1
Miserableness	3.2	5.5	12.6	1.4	3.6	0.4	2.1	3.2	2.7	1.5
Stomach or abdominal pain in last month	3.1	3.8	5.8	2.2	1.9	-0.2	2.4	2.4	2.1	1.6
LDL Cholesterol	2.9	4.5	7.4	2.4	2.3	0.3	2.3	2.0	2.7	1.9
Maternal smoking around birth	2.9	4.2	7.8	-1.5	-2.6	2.0	-1.7	-2.8	-2.4	-0.3
Glaucoma (self-reported)	2.9	3.4	8.0	1.2	2.8	0.5	1.8	2.0	2.3	1.4
Frequency of depressed mood in last 2 weeks	2.8	3.9	7.9	1.5	2.8	1.2	1.9	2.0	2.1	1.9
Prospective memory result	2.8	3.4	6.9	-1.0	-2.2	-0.7	-1.7	-2.6	-1.9	-2.0
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	6.4	2.1	2.0	-0.4	1.3	2.5	1.7	1.4
Qualifications: O levels/GCSEs or equivalent	2.6	4.2	10.0	0.3	1.4	2.2	2.4	2.1	1.6	3.2
Shortness of breath walking on level ground	2.5	2.9	5.2	2.0	1.7	0.2	1.5	2.3	1.9	1.6
Risk taking	2.5	3.7	9.0	-0.5	-3.0	0.3	-1.6	-2.7	-2.0	-1.4
High cholesterol (Self-reported)	2.4	4.3	7.1	2.0	1.6	1.9	2.7	1.6	2.3	2.4
Pain experienced in last month	2.4	4.0	7.9	-2.2	-2.6	0.6	-1.1	-2.8	-2.5	-0.4
Migraine (self-reported)	2.3	2.9	4.5	0.8	1.6	0.7	2.1	2.0	2.0	2.0
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	4.2	1.1	1.8	-0.4	1.9	1.8	2.1	1.7
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	4.3	1.5	1.3	2.1	1.6	1.0	1.6	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	4.4	-0.8	-1.0	0.4	-2.1	-2.1	-1.9	-1.9
Worry too long after embarrassment	2.1	3.5	7.6	0.5	2.8	-0.4	1.9	1.8	2.6	1.5
Neuroticism	2.0	4.8	12.7	-0.6	3.6	0.3	1.9	2.9	2.4	1.6
Had menopause	2.0	2.5	6.7	-1.6	-0.4	-1.6	-1.7	-1.0	-1.2	-2.6
Frequency of tiredness / lethargy in last 2 weeks	2.0	3.2	5.3	0.4	2.3	1.4	1.6	2.3	1.9	1.9
Standing height	2.0	19.5	34.6	-3.5	-4.9	1.6	-5.5	-4.2	-5.9	-4.1
Number of full brothers	2.0	2.5	4.9	-0.8	-1.3	-1.3	-2.1	-1.3	-1.7	-2.2
Mother’s age at death	2.0	2.5	5.2	0.4	0.8	0.4	2.0	1.6	2.3	2.2
Average weekly fortified wine intake	1.9	2.2	3.9	1.4	1.6	0.2	1.5	2.0	1.5	1.6
Alcohol usually taken with meals	1.9	3.1	4.9	0.7	2.0	1.0	2.2	1.8	2.1	2.0
Forced expiratory volume in 1-second (FEV1)	1.9	6.2	11.6	-3.1	-1.3	-0.6	-3.2	-1.9	-3.4	-2.6
Lung cancer (father)	1.9	2.3	5.9	-1.2	-2.4	-0.0	-1.2	-1.8	-1.9	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.2	12.7	-2.8	-1.6	0.1	-3.2	-2.2	-3.6	-2.3
Mean time to correctly identify matches	1.9	3.7	6.4	0.5	2.3	0.2	2.4	1.8	2.5	2.2
Age at First Birth	1.8	2.6	6.7	-0.8	2.6	-1.0	1.2	2.2	1.3	1.4
Lung FEV1/FVC ratio	1.8	9.0	14.7	-3.8	-1.4	-1.9	-3.1	-2.9	-3.8	-3.1
Father’s age at death	1.8	2.4	4.3	2.1	1.3	-0.4	1.5	2.0	1.8	1.0
Qualifications: A levels/AS levels or equivalent	1.8	3.9	8.6	-0.1	2.2	0.6	2.2	2.9	2.1	2.1
Medication: Seretide 50 evohaler	1.8	2.1	4.5	0.2	-1.6	0.5	-1.6	-1.9	-2.1	-1.2
Medication: Ventolin 100micrograms inhaler	1.7	2.2	5.4	2.0	-0.3	2.3	1.2	0.5	1.0	1.9
Exposure to tobacco smoke outside home	1.7	2.2	4.6	1.2	1.4	-0.9	1.6	2.1	1.8	0.8
Medication: Gliclazide	1.7	1.9	5.7	-2.4	-0.0	0.3	-1.8	-1.1	-1.6	-0.8
Smoking status: Current	1.7	2.8	5.5	0.2	-2.2	0.5	-1.6	-2.3	-1.9	-1.6
Depressed Affect (Nagel 2018)	1.6	3.3	5.3	0.6	2.3	0.8	2.0	2.2	2.1	1.9
Neuroticism (Nagel 2018)	1.6	3.8	7.8	-0.2	2.8	-0.2	2.1	2.5	2.4	1.7
Bipolar Disorder (2011)	1.6	1.6	4.3	-0.1	-0.9	-0.3	-1.5	-1.1	-1.4	-2.1
Triglycerides	1.6	2.7	5.2	1.9	0.8	0.8	2.3	1.7	1.7	1.7
Height	1.6	30.6	54.0	-2.3	-6.2	1.9	-7.0	-5.7	-7.3	-5.6
Diabetes (father)	1.6	1.9	3.5	-0.9	-1.5	0.8	-1.9	-1.0	-1.9	-1.3
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	4.3	0.1	-1.1	-0.7	-1.8	-1.5	-1.2	-2.1
Sitting height	1.6	11.1	23.0	-2.5	-3.6	1.9	-3.9	-3.1	-4.8	-2.6
Had other major operations	1.6	1.9	5.5	-2.2	0.1	-2.3	-0.7	-0.4	-0.9	-1.3
Forced vital capacity (FVC)	1.6	6.0	11.6	-2.6	-1.9	0.1	-3.1	-2.1	-3.4	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.2	0.4	-1.6	0.2	-1.5	-1.6	-1.8	-1.1
Eye problems/disorders: Cataract	1.6	1.9	3.4	0.8	1.6	-0.5	1.7	1.8	1.5	1.3
Mean Putamen Volume	1.5	1.7	3.2	-1.5	-1.2	0.7	-1.6	-0.8	-1.8	-1.1
Smoking Status	1.5	3.6	7.0	-0.7	-2.6	1.8	-1.6	-2.4	-2.3	-1.1
Chronotype (morning person)	1.5	3.4	5.9	2.3	1.5	-1.0	2.0	2.4	2.1	1.0
Breastfed as a baby	1.5	1.8	12.3	-3.5	0.1	-0.0	-0.2	-0.3	-0.5	0.2
Tense / ‘highly strung’	1.5	2.5	5.4	-1.1	-1.2	-0.6	-2.2	-1.7	-1.3	-2.3
Forced vital capacity (FVC), Best measure	1.5	5.6	12.0	-2.0	-2.0	1.0	-3.0	-2.2	-3.5	-2.0
Knee pain experienced in last month	1.5	2.3	4.8	1.9	2.2	-0.5	0.8	1.9	1.8	0.3
Bipolar Disorder (2018)	1.4	2.2	3.0	-1.2	-1.0	1.5	-1.7	-1.7	-1.6	-1.6
Ovarian Cancer	1.4	1.8	3.7	-0.5	-0.4	-0.5	-1.9	-1.4	-1.7	-1.8
Ulcerative Colitis	1.4	2.0	5.2	1.0	0.1	1.0	-1.7	-1.5	-1.3	-2.3
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.7	-1.9	-0.4	-0.5	-1.6	-0.5	-1.5	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	4.7	0.9	2.2	-0.1	0.7	2.2	1.4	0.3
Medication: Cholesterol lowering	1.4	2.2	4.0	-0.1	2.0	-0.1	1.6	1.9	1.8	1.5
Depression (self-reported)	1.4	1.6	2.3	1.3	1.5	0.9	1.4	1.1	1.4	1.2
Commuting to job workplace: Car/motor vehicle	1.4	1.6	3.1	-0.8	-1.2	0.5	-1.6	-1.8	-1.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	5.5	-1.3	-1.0	2.0	-2.4	-1.2	-2.3	-1.0
Eye problems/disorders: Glaucoma	1.4	1.7	3.8	0.8	1.9	-0.0	1.2	1.4	1.8	0.6
Illnesses of father: High blood pressure	1.4	1.8	3.4	-0.5	-0.8	1.5	-1.8	-1.6	-1.5	-1.0
Age started oral contraceptive pill	1.4	1.8	3.6	1.9	1.4	0.9	1.1	1.5	1.3	0.9
Heart attack/myocardial infarction (self-reported)	1.4	1.8	3.6	0.2	1.7	0.5	1.2	1.9	1.7	1.2
Systolic Blood Pressure	1.3	6.6	13.7	-0.1	3.5	-1.6	2.2	3.7	3.1	1.8
Medication: Co-codamol	1.3	1.5	3.3	-0.2	-1.0	-0.6	-1.8	-1.1	-1.3	-1.8
Medication: Metformin	1.3	1.8	3.5	-1.8	0.0	1.3	-1.9	-0.3	-1.6	-1.2
Current tobacco smoking	1.3	2.1	4.5	0.5	-2.1	0.7	-1.2	-2.1	-1.5	-1.2
Hair/balding pattern: Pattern 2	1.3	1.6	4.1	2.0	0.9	0.2	1.2	1.7	1.0	1.0
Medication: Lansoprazole	1.3	1.5	2.5	0.8	-0.8	1.6	-1.1	-1.6	-1.6	-0.6
Ever highly irritable/argumentative for 2 days	1.3	1.6	3.0	0.2	1.5	0.3	1.5	1.7	1.3	1.3
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.3	0.1	1.4	-1.8	1.5	1.1	1.7	0.2
Medication: Paracetamol	1.3	2.1	4.2	1.3	1.2	0.7	1.6	1.5	1.5	2.1
Wheeze or whistling in the chest in last year	1.3	2.3	5.9	2.4	0.6	0.6	1.5	1.5	1.8	1.4
Guilty feelings	1.3	1.9	3.6	0.0	1.7	-0.4	1.9	1.6	1.8	0.8
Wears glasses or contact lenses	1.3	1.5	3.8	0.8	1.9	0.6	1.2	1.3	1.3	1.1
Irritability	1.3	2.3	5.2	-1.6	2.0	-1.7	0.1	2.3	0.9	-0.4
Bipolar Disorder or Schizophrenia	1.2	3.0	5.2	-0.2	-0.6	1.6	-2.2	-2.3	-1.6	-2.3
Reaction Time	1.2	2.2	4.6	0.2	1.2	0.6	1.9	1.2	2.0	2.2
Blood Red Count	1.2	11.1	18.3	1.4	3.9	-1.6	3.8	3.9	4.3	3.2
Impedance of leg (left)	1.2	6.0	14.5	-1.3	-3.4	-2.2	-1.7	-3.8	-2.2	-1.3
Pain all over the body in last month	1.2	1.3	3.4	0.6	-0.4	0.1	-1.7	-0.9	-1.2	-1.9
Mouth/teeth dental problems: Dentures	1.2	2.1	3.6	1.6	0.7	0.3	1.9	1.7	1.4	1.7
Alcohol intake frequency.	1.2	2.8	4.2	1.5	2.0	0.3	1.7	2.0	2.0	1.4
Age at last live birth	1.2	1.7	4.3	-1.2	-0.6	0.7	-1.4	-1.8	-2.1	-0.6
Diastolic blood pressure, automated reading	1.2	3.7	11.0	-0.2	2.5	0.4	1.6	3.3	1.9	1.5
Qualifications: CSEs or equivalent	1.1	1.5	3.7	-0.6	-1.8	0.2	-0.9	-1.9	-1.4	-0.6
Neuroticism score	1.1	2.4	5.2	-0.9	2.3	-0.9	1.4	2.0	1.7	1.0
Falls in the last year	1.1	1.5	6.4	2.5	1.1	-0.2	0.0	1.0	1.2	-0.1
Peak expiratory flow (PEF)	1.1	2.6	6.6	-1.5	-0.5	-0.1	-2.2	-1.0	-2.6	-1.8
High blood pressure (siblings)	1.1	1.6	2.1	1.2	1.1	-0.9	1.4	1.5	1.4	1.2
Mood swings	1.1	2.0	3.1	1.1	1.5	1.5	1.6	1.4	1.1	1.8
Friendships satisfaction	1.1	1.3	3.5	0.4	1.7	-0.3	0.9	1.9	1.0	1.0
Number of self-reported non-cancer illnesses	1.1	1.9	3.0	0.3	1.6	1.7	1.4	1.3	1.2	1.6
Hearing aid user	1.1	1.3	3.6	-0.5	1.9	-0.4	1.1	1.5	1.1	0.6
Medication: Paracetamol	1.1	1.7	3.4	1.1	0.9	1.0	1.6	1.2	1.3	1.9
Medication: Lisinopril	1.1	1.4	1.9	-1.3	-1.4	-0.3	-1.4	-1.3	-1.3	-0.9
Impedance of whole body	1.1	5.7	11.6	-2.1	-3.0	-2.1	-1.7	-3.4	-2.3	-1.3
Prostate Cancer	1.0	1.4	2.9	0.3	-1.4	1.6	-0.7	-1.7	-1.3	0.5
Systolic blood pressure, automated reading	1.0	2.8	5.0	0.3	2.2	-0.4	1.8	2.2	2.1	1.1
Impedance of leg (right)	1.0	5.0	9.6	-1.5	-2.7	-2.7	-1.6	-3.1	-2.0	-1.5
Serious illness, injury or assault to yourself	1.0	1.2	3.7	-0.8	-0.1	-1.2	-1.3	-0.3	-0.9	-1.9
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.7	1.6	1.6	-0.3	1.1	1.6	1.4	0.5
Heart attack	1.0	1.3	2.8	0.0	1.7	0.3	0.8	1.6	1.5	0.7
Time employed in main current job	1.0	1.1	3.8	0.4	2.0	-0.6	0.6	1.6	0.9	-0.1
Hair/balding pattern: Pattern 3	1.0	1.5	3.2	0.2	1.5	-0.4	1.5	1.6	1.8	0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.1	2.2	0.2	-1.3	0.0	-1.1	-1.5	-1.2	-1.1
Qualifications: College or University degree	1.0	3.1	6.3	1.1	2.5	0.2	1.7	2.5	1.9	1.5
Medication: Blood pressure	1.0	1.8	5.1	-0.1	2.2	-1.6	0.7	1.4	1.6	-0.1
Comparative height size at age 10	1.0	5.6	9.7	-2.1	-2.5	1.2	-3.1	-1.7	-2.9	-2.5
Leg pain on walking	1.0	1.2	2.2	0.6	0.7	-0.7	1.3	1.5	1.4	1.2
Average weekly red wine intake	1.0	1.5	4.8	-1.3	2.2	-0.2	0.5	1.4	1.0	0.6
Alzheimer’s Disease (in mother)	0.9	1.0	2.6	-0.3	0.9	-1.6	1.0	0.7	1.3	0.6
HbA1C	0.9	1.0	2.6	-0.1	-0.4	-1.3	-1.5	-0.5	-0.4	-1.6
Schizophrenia (2014)	0.9	1.9	4.9	-0.1	-0.5	0.2	-1.9	-1.9	-1.1	-2.2
Average weekly spirits intake	0.9	1.1	4.0	-1.1	0.7	-2.0	0.3	1.1	0.6	0.1
Fed-up feelings	0.9	1.6	3.3	0.8	1.7	-0.3	1.2	1.8	1.4	0.7
Impedance of arm (right)	0.9	4.1	7.6	-2.0	-2.0	-2.8	-1.5	-2.3	-1.8	-1.5
Supplements: Vitamin C	0.9	1.1	4.9	-2.2	-0.1	-0.7	-0.9	-0.4	-0.8	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	2.6	-0.8	-0.6	-1.5	-1.5	-1.2	-0.7	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	6.1	-2.5	0.9	-1.6	-0.9	-0.4	-1.0	-1.1
Financial situation satisfaction	0.9	1.1	2.3	1.5	0.4	1.2	0.9	0.4	0.7	1.4
Basal cell carcinoma (self-reported)	0.9	1.0	4.5	-0.0	-2.1	-0.5	-0.4	-1.3	-0.7	-0.1
Heart disease (siblings)	0.9	1.1	1.9	1.3	0.5	0.9	1.1	1.0	1.4	1.0
Schizophrenia vs Biploar Disorder	0.8	1.0	3.2	0.1	-1.1	-1.8	-0.9	-0.8	-0.6	-0.9
Crohns Disease (2012)	0.8	1.3	2.6	0.2	-1.1	-1.1	-1.2	-1.4	-0.9	-1.6
Heel T-Score	0.8	6.5	14.5	3.8	1.7	0.3	3.5	0.9	2.9	2.5
Medication for hormone replacement therapy	0.8	0.9	2.2	-0.0	-0.2	-0.6	-1.5	-0.8	-1.0	-1.5
Hearing difficulty/problems with background noise	0.8	1.3	3.9	0.7	2.0	0.2	0.8	1.5	1.0	1.0
Blood clot in the leg (DVT)	0.8	1.0	2.8	-0.5	-0.5	-0.2	-1.4	-0.8	-0.9	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	2.1	-0.1	-1.4	-0.7	-0.9	-1.1	-1.1	-0.9
Pain type(s) experienced in last month: Hip pain	0.8	1.1	2.6	0.7	1.6	0.5	0.6	1.3	1.1	1.0
Cholesterol lowering medication	0.8	1.2	8.4	-0.2	-0.0	2.9	-0.3	-0.3	-0.1	0.1
Schizophrenia (2018)	0.7	1.5	4.3	0.7	0.1	0.2	-1.6	-1.5	-0.7	-2.1
Coronary Artery Disease (CAD)	0.7	0.9	1.6	0.1	1.1	-0.6	1.2	1.3	1.0	0.4
Tanning	0.7	9.1	20.0	-1.3	-3.4	-0.2	-3.9	-3.4	-4.5	-2.1
Ever had hysterectomy (womb removed)	0.7	0.8	1.7	-0.6	-0.2	-1.2	-1.1	-0.9	-0.3	-1.3
Worrier / anxious feelings	0.7	1.3	2.3	-0.0	1.2	0.2	1.5	1.5	1.1	1.4
Impedance of arm (left)	0.7	3.1	6.5	-2.5	-1.9	-1.7	-1.1	-2.0	-1.8	-0.7
Exposure to tobacco smoke at home	0.7	0.8	4.6	2.1	-0.3	0.5	0.5	-0.2	0.4	-0.0
Gout (self-reported)	0.7	0.9	2.8	1.1	0.6	1.7	0.6	0.2	0.7	1.1
Medication: Amlodipine	0.7	1.0	1.7	-1.0	0.3	-1.3	-1.1	-0.6	-0.9	-1.2
Chronic bronchitis/emphysema (mother)	0.7	0.9	1.5	1.1	-1.2	0.2	-0.5	-1.2	-1.0	-0.8
Arm fat-free mass (right)	0.7	3.4	7.1	-0.4	-0.8	2.4	-2.7	-0.7	-2.1	-2.2
Pulse wave peak to peak time	0.7	0.9	1.8	-1.3	-0.8	-0.7	-1.0	-0.8	-0.8	-1.0
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.6	-0.9	1.1	0.9	0.7	0.2	0.8	1.3
Qualifications: nursing, teaching	0.7	1.0	2.1	0.2	0.6	-0.8	1.5	1.2	1.2	0.9
Medication: Aspirin	0.7	0.9	2.9	-1.7	0.8	1.4	-0.6	-0.3	-0.5	-0.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.4	0.3	-0.3	-0.9	1.6	0.3	0.8	1.0
Alcohol drinker status: Never	0.7	0.8	1.9	1.0	1.4	-0.3	0.7	1.1	0.9	0.3
Fractured/broken bones in last 5 years	0.7	0.8	2.6	-0.2	1.0	-1.4	0.4	1.6	0.3	-0.1
Alcohol drinker status: Previous	0.7	0.8	1.8	0.9	-1.3	1.0	-0.6	-1.1	-0.5	-0.3
Waist Hip Ratio (WHR)	0.6	2.9	5.5	-2.3	-1.5	-0.2	-2.0	-2.3	-1.6	-0.9
Respiratory disease	0.6	1.3	1.9	1.0	1.1	0.4	1.3	1.2	1.4	1.3
Vitamin and mineral supplements	0.6	0.7	4.2	2.0	0.5	-0.3	0.4	0.6	0.4	0.1
Severe depression (siblings)	0.6	0.6	2.0	1.4	0.1	-0.5	1.1	0.4	0.7	0.6
Leg fat-free mass (left)	0.6	3.0	6.4	-1.1	-0.1	2.2	-2.5	0.0	-2.0	-2.1
Townsend deprivation index at recruitment	0.6	0.8	1.3	-0.1	-1.1	-0.1	-1.0	-1.0	-0.8	-1.2
Relative age voice broke	0.6	0.9	1.9	-0.9	-1.0	-0.8	-0.6	-1.4	-1.2	-0.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.9	0.9	-0.5	-0.2	-0.7	-0.9	-0.6	-1.4
Multivitamins +/- minerals	0.6	0.8	2.1	-0.5	-0.3	1.4	1.0	0.4	0.7	1.3
Supplements: Glucosamine	0.6	0.7	3.0	0.4	1.2	1.7	-0.7	0.4	-0.0	-0.1
Leg predicted mass (left)	0.6	3.0	6.4	-1.0	-0.1	2.3	-2.5	0.0	-2.1	-2.1
Trunk fat-free mass	0.6	3.5	7.5	-0.1	-1.0	2.4	-2.7	-0.8	-2.2	-2.2
Alcohol intake versus 10 years previously	0.6	0.9	2.5	-1.6	-0.6	-0.9	-0.8	-0.6	-1.0	-0.8
Pulse rate	0.6	1.0	2.5	1.6	0.7	0.5	0.6	1.5	0.8	0.6
Trunk predicted mass	0.6	3.5	7.5	-0.1	-1.0	2.4	-2.7	-0.8	-2.2	-2.2
Comparative body size at age 10	0.6	1.8	4.2	0.2	2.0	0.6	1.5	1.4	1.7	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.5	0.7	1.2	-0.1	1.1	0.5	1.1	0.8
Neck or shoulder pain in last month	0.6	0.8	2.2	1.1	0.7	1.0	0.4	1.5	0.8	0.4
Arm predicted mass (right)	0.6	3.0	6.2	-0.2	-0.8	2.4	-2.5	-0.5	-2.0	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	2.5	-0.2	1.6	-1.2	0.5	1.0	0.6	0.2
Medication: Aspirin	0.6	0.8	2.6	-1.4	0.7	1.6	-0.6	-0.2	-0.5	0.0
Whole body fat-free mass	0.6	3.1	7.0	-0.4	-0.6	2.3	-2.6	-0.4	-2.1	-2.1
Leg fat-free mass (right)	0.6	3.2	7.0	-0.9	-0.5	2.6	-2.5	-0.2	-2.1	-1.9
Asthma (self-reported)	0.6	1.3	2.2	1.1	1.4	-0.2	0.9	1.5	1.1	1.1
Leg predicted mass (right)	0.6	3.2	7.0	-0.9	-0.5	2.7	-2.5	-0.2	-2.1	-1.9
Myopia	0.6	0.9	3.2	1.2	0.4	-1.8	0.5	0.5	0.8	-0.2
Arm predicted mass (left)	0.6	2.9	6.9	-0.1	-0.6	1.8	-2.6	-0.5	-2.0	-2.4
Neuroticism (2016)	0.5	0.7	1.3	0.7	1.1	-0.3	0.8	1.1	0.8	0.5
Number of treatments/medications taken	0.5	0.8	1.8	-1.3	0.9	1.2	0.5	0.5	0.5	1.0
Angina	0.5	0.6	1.5	-0.7	-0.3	-0.2	-1.2	-0.4	-0.8	-1.2
Diabetes (mother)	0.5	0.7	1.8	0.6	-0.7	-0.9	-0.9	-0.5	-0.3	-1.3
Pack years adult smoking proportion	0.5	0.8	1.7	1.1	-1.2	0.2	-0.7	-1.3	-0.4	-0.8
High blood pressure (mother)	0.5	0.8	3.1	-1.7	-0.2	-0.9	-0.4	-0.8	-0.1	-0.8
Body mass index (BMI)	0.5	2.3	7.0	1.3	2.6	0.7	0.5	2.2	1.3	0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	4.4	0.6	0.8	2.1	1.0	0.2	0.6	0.8
Loud music exposure frequency	0.5	0.5	1.3	1.2	-0.2	-1.1	-0.6	-0.3	-0.1	-0.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.9	0.7	-1.3	1.4	-0.7	-0.7	-1.0	-0.2
Birth weight	0.5	1.0	2.6	-1.5	0.9	0.2	0.6	1.6	-0.0	1.0
Health satisfaction	0.5	0.7	1.8	1.3	1.3	0.0	-0.3	1.0	0.3	-0.0
Medication: Allopurinol	0.5	0.6	2.2	-0.0	-0.8	1.5	-0.6	-0.9	-0.7	-0.1
Ever had bowel cancer screening	0.5	0.5	2.1	-0.9	-0.0	-1.5	0.2	-0.6	-0.6	-0.1
Whole body water mass	0.5	3.1	6.9	-0.4	-0.6	2.2	-2.6	-0.4	-2.1	-2.2
Average weekly champagne plus white wine intake	0.5	0.7	1.4	-0.3	-1.0	0.0	-0.9	-1.2	-1.0	-0.6
Basal metabolic rate	0.5	2.9	6.8	-0.5	-0.3	2.1	-2.6	-0.3	-2.0	-2.2
Arm fat-free mass (left)	0.5	2.5	6.1	-0.0	-0.3	1.7	-2.5	-0.3	-1.8	-2.3
Worry (Nagel 2018)	0.4	0.9	1.4	-1.2	1.0	-0.1	1.0	0.9	0.8	1.1
Ulcerative Colitis (UC)	0.4	0.8	1.8	0.5	0.7	1.0	-1.1	-0.5	-0.8	-1.3
Breast Cancer	0.4	1.0	6.4	-0.6	0.2	-2.5	-0.1	0.5	-0.0	-0.4
Blood Eosinophil Count	0.4	3.5	8.4	1.3	-0.2	-0.7	-2.7	-1.9	-1.6	-2.9
Hypothyroidism (self reported)	0.4	1.0	2.7	-0.9	0.6	-1.6	-0.5	0.9	0.5	-1.4
Relative age of first facial hair	0.4	0.8	1.3	-1.1	-0.3	-0.6	-1.0	-1.1	-1.0	-0.9
Taking other prescription medications	0.4	0.6	1.2	0.7	0.7	1.1	0.8	0.2	0.9	1.0
Medication: Atenolol	0.4	0.5	0.8	-0.3	0.9	0.9	0.5	0.6	0.7	0.8
Nervous feelings	0.4	0.7	1.5	-1.2	1.2	-1.1	0.1	0.9	0.3	0.1
Qualifications: None of the above	0.4	0.9	1.9	1.1	-1.4	0.7	-0.6	-1.3	-0.3	-0.7
Medication: Simvastatin	0.4	0.6	3.5	-0.1	-0.5	1.9	-0.5	-0.2	-0.3	-0.2
Illnesses of siblings	0.4	0.6	1.3	-1.0	-0.2	-0.1	-0.9	-0.6	-1.0	-1.1
Arm fat percentage (right)	0.4	1.6	6.0	0.7	2.4	-0.5	0.1	1.8	0.9	-0.5
Noisy workplace	0.4	0.5	1.1	0.4	0.1	-1.0	0.8	1.0	0.4	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.8	-1.0	-0.2	-1.3	-0.5	0.3	-0.4	-0.4
Illnesses of mother	0.4	0.5	1.5	0.6	0.1	0.4	0.8	0.9	0.3	1.2
Pulse wave Arterial Stiffness index	0.4	0.4	0.9	1.0	0.5	0.7	0.7	0.6	0.4	0.7
Hair/balding pattern: Pattern 4	0.4	0.9	1.3	1.1	0.5	-1.0	1.2	0.7	1.0	0.9
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.5	-0.3	-1.2	-0.7	-0.2	-0.7	-0.4	-0.7
Emphysema/chronic bronchitis	0.4	0.4	1.6	0.8	-0.4	1.3	-0.1	-0.4	-0.6	0.0
Angina (self-reported)	0.4	0.6	1.5	-0.6	-0.2	0.0	-1.2	-0.3	-0.7	-1.2
Medication: Ibuprofen	0.4	0.5	1.9	-1.4	-0.2	-0.9	-0.7	-0.0	-0.7	-0.3
Suffer from ‘nerves’	0.4	0.6	1.9	-1.1	-0.0	1.4	0.3	-0.0	-0.1	0.9
Overall health rating	0.4	0.8	2.0	0.5	1.4	-1.0	-0.1	0.8	0.9	-0.9
Chest pain or discomfort	0.4	0.6	3.2	0.7	0.3	1.8	-0.0	0.2	-0.1	0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.3	-0.3	-0.1	1.2	-1.0	-0.6	-0.7	-0.0
Arm fat percentage (left)	0.4	1.5	6.1	0.4	2.5	-0.0	0.2	1.8	0.8	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	0.1	0.5	0.5	-1.1	-0.6	-0.4	-1.1
Osteoarthritis (self-reported)	0.4	0.5	1.5	0.0	1.2	1.0	-0.8	0.1	-0.2	-0.5
Illnesses of father: None of the above (group 1)	0.4	0.4	1.0	0.1	-0.9	-1.0	0.7	-0.8	0.1	0.2
Medication: Atorvastatin	0.4	0.5	1.6	-1.2	1.3	0.5	-0.4	-0.3	0.4	0.1
Commuting to job workplace: Cycle	0.4	0.5	1.0	0.1	0.5	0.4	0.7	0.9	1.0	0.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.7	-0.4	-0.3	-0.4	-1.1	-0.4	-0.7	-1.3
Pack years of smoking	0.4	0.5	1.6	1.2	-0.9	0.5	-0.3	-0.9	0.0	-0.4
Allergy or Eczema	0.3	0.8	3.2	-1.0	0.5	-1.8	0.0	1.2	0.3	-0.2
Sensitivity / hurt feelings	0.3	0.5	1.2	-0.3	1.1	-1.0	0.3	0.4	0.8	0.2
Hearing difficulty/problems: Yes	0.3	0.4	1.0	0.6	0.2	-1.0	-0.5	1.0	-0.2	-0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.0	1.0	-0.2	0.9	0.5	0.3	0.3	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	0.4	0.7	1.1	1.0	0.6	0.9	0.7
High blood pressure	0.3	0.8	2.4	-0.1	1.6	-0.7	0.7	1.0	1.2	0.1
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	0.8	0.1	-0.1	0.7	-0.3	0.9	0.6
Trunk fat mass	0.3	1.3	3.3	-0.8	0.4	0.3	-1.8	-0.2	-1.2	-1.8
Mouth/teeth dental problems	0.3	0.4	1.4	-0.6	-0.2	1.2	-0.5	-0.3	-0.7	0.3
Medication: Ramipril	0.3	0.3	0.6	-0.7	0.8	-0.3	0.3	0.8	0.6	0.3
Weight	0.3	1.6	3.9	-0.2	0.4	1.4	-2.0	0.2	-1.4	-1.8
Asthma	0.3	0.7	1.7	0.8	1.3	-0.2	0.5	1.0	0.7	0.8
Birth weight of first child	0.3	0.5	2.7	-1.7	0.2	0.5	-0.5	0.5	-0.3	-0.1
Medication for pain relief, constipation, heartburn	0.3	0.5	2.0	0.7	-1.4	0.2	-0.3	-0.6	-0.6	-0.4
Medication: Omeprazole	0.3	0.4	1.1	-0.6	1.0	-0.1	0.2	0.7	0.8	0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.3	0.3	0.1	-0.1	1.1	0.4	0.3	1.1
Long-standing illness, disability or infirmity	0.3	0.4	0.6	0.7	0.6	0.8	-0.8	0.4	-0.4	-0.6
Commuting to job workplace: Walk	0.3	0.4	2.0	0.1	-1.4	0.1	-0.4	-0.4	-0.4	-0.2
Mineral and other dietary supplements	0.3	0.4	2.4	0.2	0.0	-1.6	0.4	0.6	0.1	-0.2
Arm fat mass (left)	0.3	1.0	3.5	0.4	1.9	0.7	-0.7	1.4	0.1	-0.9
Ever taken oral contraceptive pill	0.3	0.3	0.6	-0.5	0.8	0.6	0.3	0.7	0.7	0.4
Medication: Blood pressure	0.3	0.5	2.4	-1.6	0.9	0.4	0.0	0.2	0.1	0.3
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	-1.0	0.4	0.0	-0.8	-0.6	-0.3	-0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.9	-0.5	0.3	0.1	-0.5	0.1	-0.1	-1.0
Alzheimer’s Disease (including proxy)	0.2	0.3	0.8	-0.7	-0.1	-0.9	-0.2	-0.5	0.2	-0.8
Irritable Bowel Disease (IBD)	0.2	0.6	1.1	0.8	0.5	1.0	-0.9	-0.5	-0.5	-0.9
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	-0.8	-0.0	0.4	-0.5	-0.4	-0.3	-0.6
Rheumatoid Arthritis	0.2	0.3	0.9	1.0	-0.4	0.1	-0.4	-0.5	-0.4	-0.5
Blood White Count	0.2	1.6	5.0	2.2	0.3	2.2	0.4	-0.5	0.8	0.6
BMI	0.2	1.1	3.2	0.7	1.5	1.8	-0.6	1.0	0.0	-0.6
Hand grip strength (left)	0.2	0.4	1.0	0.7	0.4	1.0	-0.7	0.2	-0.8	-0.6
Hand grip strength (right)	0.2	0.6	1.7	-0.0	0.8	1.3	0.5	1.1	0.2	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.6	-0.5	0.6	-1.1	0.1	1.3	0.2	-0.1
Medication: Levothyroxine sodium	0.2	0.3	0.9	-0.1	0.6	-0.5	0.6	0.9	0.6	-0.0
Waist circumference	0.2	0.8	3.1	0.1	1.8	-0.0	-0.5	1.3	0.4	-0.6
Past tobacco smoking	0.2	0.4	1.3	0.4	1.1	-0.9	0.3	0.2	0.5	0.1
Allergy	0.2	0.4	1.6	0.0	-0.6	0.1	-0.4	-1.3	-0.4	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	-0.0	0.2	-1.0	0.1	0.8	0.5	-0.2
Happiness	0.2	0.2	0.8	-0.2	0.9	0.0	-0.0	0.6	0.1	0.4
Arm fat mass (right)	0.2	0.9	2.8	0.5	1.7	0.7	-0.5	1.3	0.1	-0.8
Length of working week for main job	0.2	0.2	0.7	0.4	0.1	-0.6	-0.3	0.3	0.1	-0.8
Leg fat percentage (right)	0.2	0.7	3.2	0.3	1.8	-0.7	-0.3	0.8	0.3	-0.8
Number of children fathered	0.2	0.3	0.6	-0.2	-0.5	-0.8	0.6	-0.3	0.1	0.6
Heart disease (mother)	0.2	0.2	1.0	0.1	-0.1	-0.0	-0.6	-0.1	-0.1	-1.0
Whole body fat mass	0.2	1.0	2.7	-0.3	0.7	0.3	-1.6	0.2	-0.9	-1.6
Leg fat mass (right)	0.2	0.7	1.8	-0.4	1.1	0.3	-1.2	0.4	-0.6	-1.4
Number of full sisters	0.2	0.3	1.2	0.5	0.0	1.1	-0.2	0.6	-0.3	0.3
Hypertension (Self-reported)	0.2	0.5	1.1	-0.2	1.1	-0.5	0.7	0.8	1.0	0.2
Smoking status: Previous	0.2	0.3	0.5	-0.5	-0.3	0.7	0.5	0.7	0.3	0.5
Medication for cholesterol	0.2	0.3	0.6	0.8	-0.6	-0.8	0.5	0.1	0.1	0.3
Commuting to job workplace: Public transport	0.2	0.3	0.6	0.2	-0.2	-0.5	0.7	0.8	0.8	0.0
Medication: Bendroflumethiazide	0.2	0.3	1.1	-1.1	0.6	0.6	-0.4	0.3	-0.4	-0.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.4	0.4	-0.7	0.5	-0.5	0.5	0.4
Ever depressed for a whole week	0.2	0.3	1.0	0.3	0.6	-1.0	0.3	0.1	0.5	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.6	2.3	0.4	-1.5	0.2	-0.2	-0.7	-0.9	0.3
Leg fat mass (left)	0.2	0.6	1.6	-0.2	0.7	0.5	-1.2	0.2	-0.7	-1.3
Crohns Disease (2017)	0.1	0.2	0.9	0.9	-0.4	0.5	-0.3	-0.6	-0.2	-0.1
Major Depression (MDD)	0.1	0.2	0.4	-0.5	0.5	-0.6	0.3	0.3	0.2	0.2
Fasting Glucose	0.1	0.1	0.2	-0.4	0.2	-0.0	-0.4	-0.4	0.2	-0.1
Blood Platelet Count	0.1	1.0	4.3	0.0	2.1	0.1	-0.8	1.3	0.5	-0.2
Cardiovascular Disease	0.1	0.2	0.7	-0.5	0.0	0.9	-0.0	0.2	0.1	0.3
Lung FVC	0.1	0.6	1.5	0.8	1.1	-0.8	0.3	1.2	0.6	0.2
Hair Pigment	0.1	2.6	6.1	-1.0	1.0	-2.5	1.4	1.9	2.1	-0.2
Trunk fat percentage	0.1	0.6	1.3	-0.6	1.0	-0.3	-1.0	0.2	-0.4	-1.1
Financial difficulties in last 2 years	0.1	0.1	0.3	0.4	0.1	0.5	0.1	-0.3	0.4	0.5
Hip circumference	0.1	0.6	1.1	0.5	1.0	0.9	-0.7	1.1	-0.2	-0.7
Pulse wave reflection index	0.1	0.1	0.3	-0.2	-0.1	0.6	-0.4	-0.4	-0.5	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	0.0	0.4	-0.6	0.2	0.7	0.5	-0.4
Body fat percentage	0.1	0.5	1.7	0.1	1.3	-0.4	-0.7	0.5	-0.1	-1.0
Age at first live birth	0.1	0.2	0.5	-0.7	0.6	-0.1	-0.2	-0.2	-0.3	0.2
Had major operations	0.1	0.1	0.4	0.1	-0.4	0.7	-0.5	0.1	-0.3	0.0
Loneliness, isolation	0.1	0.1	0.4	-0.0	-0.2	0.3	-0.2	-0.3	-0.1	-0.6
Back pain experienced in last month	0.1	0.1	0.2	-0.2	0.3	-0.0	-0.3	-0.4	0.5	-0.0
Breast cancer (self-reported)	0.1	0.1	0.2	0.0	-0.4	-0.4	0.1	-0.4	-0.4	-0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.5	-0.7	-0.1	0.4	-0.1	-0.5	0.1	0.6
Ever smoked	0.1	0.2	0.4	0.2	-0.4	0.5	0.6	0.5	0.2	0.6
Leg fat percentage (left)	0.1	0.4	1.8	0.5	1.4	-0.4	-0.2	0.5	0.3	-0.6
Number of operations (self-reported)	0.0	0.0	0.1	-0.3	-0.1	-0.1	0.2	0.1	0.0	0.2
Unable to work because of sickness or disability	0.0	0.1	0.3	0.5	-0.2	0.0	0.0	-0.2	-0.0	0.3

Hub : Genes

PHBP9

Models

Trait associations