Best TWAS P=3.56e-13 · Best GWAS P=1.89e-16 conditioned to 0.0181
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | NPM3 | 0.03 | 0.01 | lasso | 2 | 0.03 | 1.2e-04 | 6.8 | -6.1 | 9.2e-10 | 0.55 | 0.19 | 0.38 | FALSE |
| 2 | GTEx | Liver | ACTR1A | 0.15 | 0.00 | lasso | 10 | 0.00 | 4.6e-01 | 7.4 | 5.3 | 1.2e-07 | -0.30 | 0.07 | 0.17 | FALSE |
| 3 | GTEx | Lung | C10orf76 | 0.07 | 0.00 | lasso | 3 | 0.00 | 7.4e-01 | -6.2 | -5.4 | 8.4e-08 | 0.85 | 0.06 | 0.36 | FALSE |
| 4 | GTEx | Pancreas | NPM3 | 0.20 | 0.15 | lasso | 4 | 0.07 | 5.4e-04 | 6.8 | -6.2 | 5.0e-10 | 0.49 | 0.50 | 0.03 | FALSE |
| 5 | GTEx | Testis | NPM3 | 0.13 | 0.15 | lasso | 3 | 0.13 | 2.5e-06 | 6.8 | -6.8 | 1.1e-11 | 0.55 | 0.49 | 0.29 | FALSE |
| 6 | METSIM | Adipose | HPS6 | 0.05 | 0.03 | bslmm | 284 | 0.02 | 1.6e-03 | 5.7 | 5.9 | 2.7e-09 | -0.59 | 0.03 | 0.84 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | NPM3 | 0.05 | 0.01 | blup | 257 | 0.04 | 1.5e-05 | 6.6 | -5.9 | 3.7e-09 | 0.68 | 0.04 | 0.91 | FALSE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GBF1 | 0.03 | 0.01 | enet | 8 | 0.04 | 2.1e-04 | 5.9 | -7.2 | 7.6e-13 | 0.34 | 0.03 | 0.76 | TRUE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CUEDC2 | 0.07 | 0.03 | lasso | 1 | 0.03 | 4.8e-03 | 5.8 | -5.8 | 8.6e-09 | 0.37 | 0.00 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NPM3 | 0.02 | 0.03 | lasso | 3 | 0.02 | 9.2e-04 | 6.8 | -7.3 | 3.6e-13 | 0.65 | 0.02 | 0.44 | TRUE |
| 11 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C10orf76 | 0.19 | 0.20 | lasso | 1 | 0.18 | 4.6e-07 | 6.8 | 6.8 | 1.3e-11 | -0.55 | 0.50 | 0.38 | FALSE |