Best TWAS P=8.58e-13 · Best GWAS P=2.52e-14 conditioned to 0.00106
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | CCDC65 | 0.13 | 0.00 | enet | 26 | 0.01 | 1.8e-01 | -3.7 | 5.2 | 2.4e-07 | 0.37 | 0.15 | 0.14 | FALSE |
| 2 | GTEx | Artery Aorta | CCDC65 | 0.19 | 0.08 | enet | 7 | 0.11 | 1.9e-06 | 3.7 | 5.9 | 4.1e-09 | 0.82 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Artery Tibial | CCDC65 | 0.14 | 0.08 | enet | 39 | 0.11 | 7.9e-09 | 7.6 | 5.7 | 1.1e-08 | 0.80 | 0.01 | 0.99 | FALSE |
| 4 | GTEx | Esophagus Mucosa | LMBR1L | 0.07 | 0.03 | lasso | 5 | 0.04 | 1.8e-03 | 5.4 | -5.9 | 4.0e-09 | -0.72 | 0.01 | 0.96 | FALSE |
| 5 | GTEx | Lung | LMBR1L | 0.05 | 0.02 | lasso | 2 | 0.00 | 1.5e-01 | 5.4 | -5.2 | 2.2e-07 | -0.61 | 0.09 | 0.51 | FALSE |
| 6 | GTEx | Muscle Skeletal | RP11-386G11.5 | 0.09 | 0.07 | enet | 17 | 0.08 | 7.4e-08 | 7.1 | -7.2 | 8.6e-13 | -0.78 | 0.01 | 0.99 | TRUE |
| 7 | GTEx | Nerve Tibial | LMBR1L | 0.08 | 0.04 | lasso | 4 | 0.06 | 3.1e-05 | 6.6 | -5.7 | 1.4e-08 | -0.65 | 0.05 | 0.94 | FALSE |
| 8 | GTEx | Testis | PRKAG1 | 0.17 | 0.11 | lasso | 5 | 0.09 | 1.2e-04 | 5.4 | -6.6 | 5.2e-11 | -0.69 | 0.01 | 0.98 | FALSE |