Best TWAS P=6.41e-08 · Best GWAS P=1.59e-07 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | SUOX | 0.24 | 0.19 | enet | 16 | 0.15 | 2.3e-09 | 4.5 | -5.3 | 1.1e-07 | -0.90 | 0.08 | 0.90 | FALSE |
| 2 | GTEx | Heart Atrial Appendage | SUOX | 0.09 | 0.10 | enet | 8 | 0.09 | 1.1e-04 | 5.1 | -5.1 | 2.8e-07 | -0.93 | 0.01 | 0.96 | FALSE |
| 3 | METSIM | Adipose | IKZF4 | 0.04 | 0.04 | enet | 3 | 0.04 | 1.0e-06 | 5.0 | 5.1 | 3.0e-07 | 0.99 | 0.01 | 0.99 | FALSE |
| 4 | METSIM | Adipose | RPS26 | 0.30 | 0.40 | lasso | 5 | 0.41 | 7.2e-66 | 5.2 | 5.2 | 2.2e-07 | 0.99 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RPS26 | 0.14 | 0.22 | lasso | 2 | 0.23 | 4.8e-19 | 5.2 | 5.2 | 1.5e-07 | 1.00 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPS26 | 0.30 | 0.44 | enet | 10 | 0.45 | 5.2e-104 | 5.1 | 5.2 | 2.7e-07 | 0.97 | 0.00 | 0.99 | FALSE |
| 7 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RPS26 | 0.23 | 0.40 | lasso | 2 | 0.39 | 1.5e-20 | 5.1 | 5.2 | 1.7e-07 | 0.97 | 0.00 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | RPS26 | 0.43 | 0.48 | lasso | 4 | 0.47 | 1.8e-30 | 5.1 | 5.2 | 1.8e-07 | 0.97 | 0.00 | 0.99 | FALSE |
| 9 | The Cancer Genome Atlas | Esophageal Carcinoma | RPS26 | 0.19 | 0.13 | lasso | 5 | 0.11 | 2.4e-04 | 5.1 | 5.2 | 2.1e-07 | 0.97 | 0.01 | 0.97 | FALSE |
| 10 | The Cancer Genome Atlas | Glioblastoma Multiforme | RPS26 | 0.41 | 0.38 | enet | 9 | 0.39 | 7.9e-13 | 5.2 | 5.2 | 2.6e-07 | 0.99 | 0.00 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RPS26 | 0.17 | 0.29 | lasso | 4 | 0.29 | 6.2e-33 | 5.2 | 5.2 | 2.0e-07 | 0.99 | 0.00 | 1.00 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPS26 | 0.31 | 0.53 | enet | 8 | 0.55 | 1.7e-74 | 5.1 | 5.1 | 3.0e-07 | 0.98 | 0.00 | 0.99 | FALSE |
| 13 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | RPS26 | 0.18 | 0.31 | lasso | 2 | 0.29 | 3.9e-14 | 5.1 | 5.1 | 2.9e-07 | 0.97 | 0.00 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | RPS26 | 0.26 | 0.45 | enet | 9 | 0.47 | 3.6e-61 | 5.1 | 5.2 | 2.4e-07 | 0.98 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RPS26 | 0.22 | 0.31 | lasso | 3 | 0.31 | 1.6e-35 | 5.1 | 5.2 | 1.5e-07 | 0.97 | 0.00 | 0.99 | FALSE |
| 16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RPS26 | 0.30 | 0.20 | lasso | 4 | 0.24 | 3.9e-16 | 5.1 | 5.1 | 3.1e-07 | 0.94 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPS26 | 0.33 | 0.52 | enet | 9 | 0.54 | 5.6e-66 | 5.1 | 5.4 | 6.4e-08 | 0.98 | 0.00 | 0.99 | TRUE |
| 18 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RPS26 | 0.23 | 0.31 | lasso | 3 | 0.30 | 2.4e-18 | 5.1 | 5.2 | 2.2e-07 | 0.97 | 0.00 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RPS26 | 0.19 | 0.32 | lasso | 5 | 0.34 | 2.0e-25 | 5.2 | 5.2 | 1.5e-07 | 0.99 | 0.00 | 0.99 | FALSE |
| 20 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | RPS26 | 0.46 | 0.64 | lasso | 4 | 0.65 | 8.5e-30 | 5.1 | 5.2 | 1.9e-07 | 0.98 | 0.00 | 0.99 | FALSE |