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chr12:57,249,600-59,046,845

Best TWAS P=1.1e-11 · Best GWAS P=8.92e-12 conditioned to 0.00494

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adrenal Gland	XRCC6BP1	0.25	0.38	lasso	7	0.37	2.3e-14	-5.0	5.3	9.0e-08	-0.77	0.87	0.13	FALSE
2	GTEx	Artery Coronary	XRCC6BP1	0.52	0.51	lasso	6	0.51	5.7e-20	-5.0	5.2	2.2e-07	-0.75	0.53	0.47	FALSE
3	GTEx	Brain Caudate basal ganglia	XRCC6BP1	0.27	0.35	lasso	4	0.33	3.7e-10	-5.0	5.7	1.3e-08	-0.85	0.02	0.98	FALSE
4	GTEx	Brain Hippocampus	XRCC6BP1	0.28	0.04	enet	21	0.05	2.4e-02	-3.8	5.6	2.5e-08	-0.75	0.16	0.67	FALSE
5	GTEx	Breast Mammary Tissue (Female)	XRCC6BP1	0.40	0.30	enet	40	0.29	2.0e-09	-5.0	5.9	3.8e-09	-0.59	0.57	0.40	FALSE
6	GTEx	Esophagus Gastroesophageal Junction	XRCC6BP1	0.39	0.56	lasso	4	0.57	8.3e-25	-5.0	5.3	8.6e-08	-0.80	0.90	0.10	FALSE
7	GTEx	Esophagus Muscularis	XRCC6BP1	0.49	0.54	lasso	10	0.54	1.2e-38	-5.0	5.1	2.7e-07	-0.75	0.99	0.01	FALSE
8	GTEx	Heart Atrial Appendage	XRCC6BP1	0.42	0.47	lasso	5	0.47	1.8e-23	-5.0	5.1	3.0e-07	-0.77	0.90	0.10	FALSE
9	GTEx	Heart Left Ventricle	XRCC6BP1	0.34	0.44	lasso	11	0.43	1.4e-24	-5.0	5.3	1.1e-07	-0.78	0.97	0.03	FALSE
10	GTEx	Heart Left Ventricle	RP11-571M6.17	0.06	0.02	lasso	6	0.01	1.3e-01	-6.4	6.1	8.3e-10	-0.87	0.03	0.72	FALSE
11	GTEx	Nerve Tibial	TSPAN31	0.07	0.08	lasso	4	0.07	7.4e-06	-6.4	5.9	4.5e-09	-0.89	0.02	0.98	FALSE
12	GTEx	Nerve Tibial	XRCC6BP1	0.43	0.59	enet	15	0.59	5.3e-51	-5.0	5.2	1.7e-07	-0.76	0.99	0.01	FALSE
13	GTEx	Pituitary	XRCC6BP1	0.35	0.33	lasso	5	0.33	4.1e-09	-5.0	5.4	8.1e-08	-0.74	0.33	0.53	FALSE
14	GTEx	Stomach	TSPAN31	0.19	0.00	enet	17	0.00	4.6e-01	-6.8	6.8	1.1e-11	-0.72	0.01	0.90	TRUE
15	GTEx	Thyroid	XRCC6BP1	0.35	0.44	enet	6	0.43	5.0e-36	-5.0	5.4	6.2e-08	-0.80	0.99	0.01	FALSE
16	GTEx	Uterus	XRCC6BP1	0.27	0.24	lasso	6	0.28	1.4e-06	-5.0	5.8	5.2e-09	-0.89	0.04	0.90	FALSE
17	GTEx	Whole Blood	XRCC6BP1	0.16	0.15	lasso	6	0.16	1.6e-14	-5.0	5.4	8.0e-08	-0.78	0.95	0.05	FALSE
18	NTR	Blood	KIF5A	0.01	0.00	blup	340	0.00	5.7e-02	-5.3	5.7	1.0e-08	-0.75	0.08	0.38	FALSE
19	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	XRCC6BP1	0.11	0.06	enet	9	0.10	1.5e-08	-6.4	6.4	1.3e-10	-0.86	0.01	0.99	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	XRCC6BP1	0.14	0.12	enet	10	0.13	7.7e-26	-4.5	5.3	1.1e-07	-0.73	1.00	0.00	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	XRCC6BP1	0.07	0.02	blup	24	0.03	9.9e-03	-6.8	5.1	2.7e-07	-0.67	0.00	0.73	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	XRCC6BP1	0.18	0.15	enet	6	0.16	1.5e-17	-4.5	5.3	8.9e-08	-0.76	1.00	0.00	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	XRCC6BP1	0.33	0.34	enet	15	0.42	1.5e-51	-4.5	5.6	1.8e-08	-0.82	0.97	0.03	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	XRCC6BP1	0.32	0.29	lasso	6	0.34	7.7e-40	-4.5	5.5	4.9e-08	-0.80	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	XRCC6BP1	0.15	0.10	enet	10	0.12	5.9e-13	-4.5	5.3	1.3e-07	-0.77	0.68	0.32	FALSE
26	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	XRCC6BP1	0.23	0.17	enet	12	0.21	2.8e-09	-4.5	5.4	6.9e-08	-0.81	0.28	0.71	FALSE
27	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	XRCC6BP1	0.27	0.15	enet	16	0.19	4.5e-08	-4.5	5.3	9.2e-08	-0.75	0.03	0.97	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	XRCC6BP1	0.29	0.23	lasso	3	0.27	4.2e-28	-4.5	5.1	2.8e-07	-0.74	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Soft Tissue Sarcoma	XRCC6BP1	0.13	0.05	enet	9	0.08	1.7e-05	-6.4	5.8	6.1e-09	-0.80	0.01	0.97	FALSE
30	The Cancer Genome Atlas	Skin Cutaneous Melanoma	XRCC6BP1	0.26	0.18	enet	14	0.24	3.9e-07	-6.4	6.0	1.7e-09	-0.86	0.01	0.98	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	XRCC6BP1	0.29	0.17	enet	10	0.28	1.5e-27	-4.5	5.2	2.5e-07	-0.75	0.18	0.82	FALSE