TWAS hub - KIF5A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.1340	0.0490	0.0015	-0.001	NA	0.032	NA	0.032	0.39	NA	0.0068	NA	0.0068
2	NTR	Blood	0.0058	0.0034	0.0160	0.001	0.002	-0.001	0.002	0.002	0.11	0.057	0.8000	0.064	0.0830

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Gout (self-reported)	20.3	27.8	49.8	-7.1	2.4
Medication: Allopurinol	13.3	17.7	33.6	-5.8	1.3
Asthma (self-reported)	9.1	18.2	34.6	5.9	-1.3
Triglycerides	8.9	14.5	26.4	-5.1	1.6
Asthma	8.9	17.5	33.3	5.8	-1.3
Respiratory disease	8.8	19.5	38.4	6.2	-0.8
HDL Cholesterol	8.6	14.3	26.0	5.1	-1.6
Intelligence (Savage-Jansen 2018)	7.0	21.5	32.8	-3.2	5.7
Heart attack	7.0	8.9	17.3	-4.2	-0.7
Eye problems/disorders: Cataract	6.8	7.9	10.7	-2.2	3.3
Mineral and other dietary supplements	6.7	9.0	13.3	3.6	-2.2
Allergy	6.6	15.1	26.6	-5.2	1.9
Supplements: Fish oil (including cod liver oil)	6.1	8.0	13.3	-3.6	1.6
Heart attack/myocardial infarction (self-reported)	6.0	7.7	15.3	-3.9	-0.4
Wheeze or whistling in the chest in last year	5.7	10.2	11.9	3.5	-2.9
Verbal and Numeric Reasoning (VNR)	5.5	13.3	21.4	-2.3	4.6
High blood pressure (mother)	5.4	7.6	9.2	-3.0	2.4
Sitting height	5.3	37.7	70.9	-2.1	8.4
Fluid intelligence score	4.9	10.2	18.7	-1.3	4.3
Commuting to job workplace: Public transport	4.9	5.9	11.7	-0.3	3.4
Number of operations (self-reported)	4.9	7.3	11.3	-1.8	3.4
Myopia	4.5	6.5	6.6	-2.6	2.5
Pulse rate	4.4	7.5	9.7	2.3	-3.1
Neuroticism (2016)	4.3	6.3	12.4	-3.5	0.4
High blood pressure (siblings)	4.3	6.1	9.9	-1.5	3.1
Average weekly champagne plus white wine intake	4.3	5.9	11.2	-0.8	3.4
Blood Platelet Count	4.1	47.3	56.4	-7.5	-6.2
Impedance of arm (right)	4.0	18.5	35.5	-1.2	6.0
Had major operations	4.0	4.6	8.2	-1.0	2.9
Vitamin and mineral supplements	3.9	5.3	9.0	3.0	-1.2
Chronotype (morning person)	3.8	8.8	11.8	-2.4	-3.4
Medication: Levothyroxine sodium	3.8	6.5	12.8	0.3	3.6
Qualifications: A levels/AS levels or equivalent	3.7	8.1	13.4	-1.7	3.7
Mouth/teeth dental problems: Loose teeth	3.6	4.3	6.2	2.5	-1.5
Mean Putamen Volume	3.4	3.9	5.8	-1.4	2.4
Ever used hormone-replacement therapy (HRT)	3.4	4.4	6.7	2.6	1.4
Medication: Ibuprofen (e.g. Nurofen)	3.4	4.4	8.4	-2.9	-0.6
Medication: Cholesterol lowering	3.4	5.3	10.6	-3.2	-0.2
Qualifications: College or University degree	3.4	10.9	17.5	-2.1	4.2
Body Mass Index (BMI) (2010)	3.3	4.5	8.6	2.9	0.6
Primary Biliary Cirrhosis	3.3	4.8	8.5	-1.0	2.9
Ulcerative Colitis	3.3	4.7	8.6	2.9	0.9
Medication: Ventolin 100micrograms inhaler	3.3	4.2	5.4	2.3	-1.8
Impedance of arm (left)	3.1	14.5	28.0	-1.0	5.3
Crohns Disease (2012)	3.0	4.8	9.6	0.2	3.1
Taking other prescription medications	3.0	4.6	7.8	2.8	-1.1
Comparative body size at age 10	3.0	8.3	12.3	2.0	-3.5
Medication for pain relief, constipation, heartburn	3.0	5.1	8.9	3.0	1.1
Exposure to tobacco smoke outside home	2.9	3.9	4.9	-1.7	-2.2
Medication: Seretide 50 evohaler	2.9	3.3	4.3	2.1	1.5
Crohns Disease (2017)	2.8	6.2	11.8	0.7	3.4
Ovarian Cancer	2.8	3.7	7.3	-0.2	-2.7
Relative age of first facial hair	2.8	5.8	11.2	-0.7	-3.4
Supplements: Zinc	2.8	3.0	5.0	-2.2	1.0
Tinnitus: Yes, but not now, but have in the past	2.8	2.9	5.8	-2.4	-0.4
Hayfever, allergic rhinitis or eczema	2.8	6.0	10.5	3.2	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.8	3.6	6.1	1.1	2.5
High cholesterol (Self-reported)	2.8	4.9	9.1	-3.0	-0.9
Sensitivity / hurt feelings	2.7	4.7	8.5	-0.9	2.9
Mouth/teeth dental problems	2.7	4.1	5.3	-2.3	1.7
Irritable Bowel Disease (IBD)	2.6	6.2	9.1	1.8	3.0
LDL Cholesterol	2.6	4.1	8.2	-2.9	0.0
Height	2.6	50.3	100.5	0.4	10.0
Pulse wave Arterial Stiffness index	2.6	3.0	3.8	1.9	1.5
Medication: Aspirin	2.6	3.4	6.6	-2.6	-0.5
Smoking status: Previous	2.6	3.8	6.4	2.5	1.1
Cholesterol lowering medication	2.6	3.9	7.7	-2.8	-0.0
Chronic bronchitis/emphysema (father)	2.5	3.0	4.7	2.2	-1.1
Exposure to tobacco smoke at home	2.5	2.9	5.2	0.7	-2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.5	3.0	5.8	-0.5	-2.4
Impedance of whole body	2.5	12.6	23.0	-1.5	4.8
Rheumatoid Arthritis	2.4	3.2	5.0	1.2	2.2
Hypothyroidism (self reported)	2.4	5.6	11.0	0.4	3.3
Diabetes (mother)	2.4	3.0	4.1	-2.0	1.4
Illnesses of mother	2.4	3.0	4.7	2.2	-1.1
Pulse wave peak to peak time	2.4	2.8	4.2	-2.1	-1.1
Overall health rating	2.4	5.1	10.0	3.2	-0.4
Medication: Gliclazide	2.4	2.7	2.8	1.7	-1.6
Medication: Simvastatin	2.3	3.3	6.7	-2.6	0.1
Noisy workplace	2.3	2.8	5.3	-0.5	-2.3
Medication: Aspirin	2.3	3.0	5.9	-2.4	0.1
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	4.2	2.1	1.3
Past tobacco smoking	2.2	4.0	7.5	-2.7	0.7
Pulse wave reflection index	2.2	2.7	5.2	-0.3	2.3
Hypothyroidism/myxoedema (self-reported)	2.2	4.4	7.3	1.2	2.7
Age at first live birth	2.2	3.9	4.7	-1.8	2.2
Health satisfaction	2.2	2.9	5.6	2.4	-0.4
Long-standing illness, disability or infirmity	2.2	3.4	5.9	2.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.7	9.4	-0.1	-3.1
Commuting to job workplace: Cycle	2.2	2.7	4.2	-2.0	-1.1
Allergy or Eczema	2.1	5.6	9.4	3.1	-1.3
Systolic blood pressure, automated reading	2.1	6.1	6.8	-2.6	2.3
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	2.5	1.6	-1.4
Angina	2.1	2.7	4.6	-0.9	-2.1
Multivitamins +/- minerals	2.1	2.7	3.3	-1.8	1.4
Suffer from ‘nerves’	2.1	3.3	6.3	2.5	0.6
Medication: Bendroflumethiazide	2.1	3.1	5.1	2.3	-1.1
Bipolar Disorder or Schizophrenia	2.0	4.9	9.7	3.1	-0.4
Depression (Nagel 2018)	2.0	2.9	4.9	-1.0	2.2
Blood Red Count	2.0	18.9	23.6	4.9	3.8
BMI	2.0	11.4	13.2	3.6	-3.1
Frequency of depressed mood in last 2 weeks	2.0	2.8	3.0	-1.7	1.6
Angina (self-reported)	2.0	2.6	4.4	-0.8	-2.1
Medication: Ibuprofen	2.0	2.4	4.8	-2.2	-0.3
Pulse rate, automated reading	2.0	6.6	8.8	3.0	-2.1
Ever had bowel cancer screening	2.0	2.4	3.8	-1.0	2.0
Alcohol intake versus 10 years previously	1.9	2.9	3.1	-1.8	-1.6
Medication: Atorvastatin	1.9	2.4	3.8	-2.0	-1.0
Lung FEV1/FVC ratio	1.8	9.4	11.4	3.4	-2.7
Severe depression (siblings)	1.8	2.1	3.2	0.9	1.8
Medication: Atenolol	1.8	2.3	3.6	-1.9	-1.0
Standing height	1.8	18.0	35.6	0.7	6.0
Ever taken oral contraceptive pill	1.8	2.0	3.3	0.8	1.8
Alzheimer’s Disease (in father)	1.7	1.8	3.4	1.8	-0.5
Ever had hysterectomy (womb removed)	1.7	1.9	3.8	1.9	-0.2
Hair/balding pattern: Pattern 4	1.7	4.2	6.8	-2.6	1.2
Irritability	1.7	2.8	5.0	-0.8	-2.2
Ever had prostate specific antigen (PSA) test	1.7	2.0	2.6	-1.6	1.1
Lupus	1.6	2.4	3.2	-1.2	1.8
Lung FVC	1.6	8.0	15.1	-1.0	-3.9
Impedance of leg (right)	1.6	7.9	8.1	-2.9	2.8
Supplements: Glucosamine	1.6	2.1	2.9	-1.7	1.2
Prospective memory result	1.6	2.0	3.9	-0.1	-2.0
Average weekly beer plus cider intake	1.6	2.2	2.8	1.7	-1.3
Schizophrenia (2018)	1.5	3.1	6.2	2.5	0.1
Maternal smoking around birth	1.5	2.2	4.3	2.1	-0.3
Illnesses of siblings	1.5	2.1	4.0	0.6	-2.0
Emphysema/chronic bronchitis	1.5	1.7	3.2	1.8	-0.4
Chest pain or discomfort	1.5	2.2	2.9	1.7	-1.2
Illnesses of father: Heart disease	1.5	2.1	4.0	-2.0	-0.4
Bipolar Disorder (2018)	1.4	2.1	3.6	1.9	-0.9
Neuroticism	1.4	3.4	4.8	-2.2	1.4
Average weekly spirits intake	1.4	1.7	2.6	-0.9	-1.6
Pack years adult smoking proportion	1.4	2.2	4.0	0.6	-2.0
Waist circumference	1.4	5.0	10.0	3.2	-0.2
Supplements: Vitamin C	1.4	1.7	2.4	-1.5	1.0
Smoking status: Current	1.4	2.2	4.3	-0.1	-2.1
Miserableness	1.4	2.4	4.7	-2.2	-0.4
Wears glasses or contact lenses	1.4	1.6	3.0	1.7	-0.5
Fractured/broken bones in last 5 years	1.4	1.9	2.3	1.2	-1.5
Depressed Affect (Nagel 2018)	1.3	2.7	4.4	-2.1	1.0
HbA1C	1.3	1.4	1.9	-0.9	1.4
Systolic Blood Pressure	1.3	6.5	10.5	-3.2	1.6
Serious illness, injury or assault to yourself	1.3	1.5	3.1	-0.0	1.8
Number of full brothers	1.3	1.7	3.3	1.8	-0.3
Shortness of breath walking on level ground	1.3	1.5	3.0	1.7	-0.3
Osteoarthritis (self-reported)	1.3	1.6	3.2	1.8	-0.3
Ulcerative Colitis (UC)	1.2	2.3	2.7	1.6	1.4
Trunk fat mass	1.2	5.0	5.5	2.3	2.1
Financial difficulties in last 2 years	1.2	1.7	2.6	0.8	-1.6
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.0	1.7	0.6
Number of live births	1.2	1.6	3.1	1.8	0.4
Heart disease (mother)	1.2	1.5	1.9	-1.4	1.1
Knee pain experienced in last month	1.2	1.9	3.6	0.5	-1.9
Breast cancer (self-reported)	1.2	1.4	2.5	1.6	0.6
Illnesses of father: High blood pressure	1.2	1.5	2.2	-0.8	1.5
Ever smoked	1.2	2.1	4.2	2.0	-0.1
Basal cell carcinoma (self-reported)	1.2	1.4	1.5	-1.2	1.1
Pack years of smoking	1.2	1.8	3.2	0.6	-1.8
Schizophrenia (2014)	1.1	2.3	4.6	2.2	0.2
Smoking Status	1.1	2.7	5.3	2.3	-0.4
Trunk fat percentage	1.1	4.3	4.5	2.0	2.1
Body mass index (BMI)	1.1	4.7	5.2	2.3	-2.1
Alcohol usually taken with meals	1.1	1.7	2.0	-1.4	1.2
Hip circumference	1.1	4.8	9.5	3.1	0.2
Worrier / anxious feelings	1.1	2.0	3.9	0.3	2.0
Tense / ‘highly strung’	1.1	1.8	3.6	1.9	0.1
Eye problems/disorders: Glaucoma	1.1	1.4	1.4	-1.2	1.1
Schizophrenia vs Biploar Disorder	1.0	1.3	2.6	0.1	1.6
Blood White Count	1.0	7.2	14.1	-3.8	0.6
Cardiovascular Disease	1.0	3.3	4.0	-1.6	-2.0
Medication for hormone replacement therapy	1.0	1.1	1.4	0.9	1.2
Current tobacco smoking	1.0	1.6	3.3	0.1	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	3.9	0.7	2.0
Impedance of leg (left)	1.0	5.0	7.0	-1.7	2.6
Qualifications: None of the above	1.0	2.2	4.1	0.5	-2.0
Pain all over the body in last month	1.0	1.1	2.0	1.4	-0.4
Medication: Lansoprazole	1.0	1.1	1.7	1.3	0.8
Birth weight	1.0	2.2	3.4	-1.0	1.9
Comparative height size at age 10	1.0	5.6	10.9	-0.6	3.3
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.3	1.5	-0.1
Commuting to job workplace: Walk	1.0	1.1	1.7	-0.6	-1.3
Pain type(s) experienced in last month: Hip pain	1.0	1.2	2.2	0.5	-1.5
Worry (Nagel 2018)	0.9	2.0	2.4	1.3	1.6
Bipolar Disorder (2011)	0.9	0.8	1.1	0.7	-1.1
Fasting Glucose	0.9	1.0	2.0	-0.3	1.4
Number of treatments/medications taken	0.9	1.6	3.1	-1.8	-0.3
Fed-up feelings	0.9	1.6	3.0	-1.7	0.2
Father’s age at death	0.9	1.2	2.1	0.6	1.5
Happiness	0.9	1.1	2.1	-1.4	-0.3
Length of working week for main job	0.9	1.0	1.6	-1.2	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	2.4	0.6	1.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	1.7	0.8	-1.3
Illnesses of siblings: Diabetes	0.9	1.1	2.1	-0.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	2.1	-1.3	1.5
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.6	1.3	0.8
Hearing aid user	0.9	1.0	2.0	-0.2	1.4
Medication: Paracetamol	0.9	1.3	2.3	-1.5	0.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.6	1.3	-0.8
Coronary Artery Disease (CAD)	0.8	1.0	1.1	0.9	-1.1
Hearing difficulty/problems: Yes	0.8	1.3	2.0	0.7	1.4
Townsend deprivation index at recruitment	0.8	1.1	2.0	1.4	0.5
Neuroticism score	0.8	1.6	2.2	-1.5	1.0
Weight	0.8	3.9	7.4	2.7	0.6
Falls in the last year	0.8	1.1	1.3	0.9	1.2
Headache pain in last month	0.8	1.4	2.7	-1.6	0.3
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	2.6	1.6	-0.0
Glaucoma (self-reported)	0.8	0.9	1.2	-0.8	1.1
Whole body fat mass	0.8	3.3	5.0	2.2	1.3
Back pain experienced in last month	0.8	1.2	2.1	0.6	1.4
Medication: Blood pressure	0.8	1.6	2.7	0.7	-1.6
Leg fat mass (left)	0.8	3.3	6.4	2.5	-0.3
Alzheimer’s Disease (including proxy)	0.7	1.0	1.4	1.2	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.5	-1.2	0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.5	0.0	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.1	1.8	0.4
Arm fat mass (right)	0.7	2.8	5.5	2.3	0.3
Peak expiratory flow (PEF)	0.7	1.7	3.0	1.7	-0.7
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	1.7	-1.3	0.8
Age at last live birth	0.7	1.0	1.4	-1.2	0.8
Number of self-reported non-cancer illnesses	0.7	1.2	1.3	1.2	1.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	0.8	-0.9	-0.9
Vascular/heart problems diagnosed by doctor	0.7	1.9	2.1	1.5	1.3
Neuroticism (Nagel 2018)	0.6	1.3	1.7	-1.0	1.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.3	0.2	1.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.0	1.0	0.6
Qualifications: CSEs or equivalent	0.6	0.9	1.1	0.8	-1.0
Number of incorrect matches in round	0.6	1.0	2.0	1.4	0.1
Mouth/teeth dental problems: Dentures	0.6	0.9	1.1	0.9	-1.0
Body fat percentage	0.6	2.5	3.9	2.0	1.1
Leg fat mass (right)	0.6	2.4	4.6	2.1	-0.4
Leg fat-free mass (right)	0.6	3.4	6.6	2.6	0.4
Mood swings	0.6	1.0	1.4	-1.2	-0.8
Leg predicted mass (right)	0.6	3.3	6.4	2.5	0.4
Medication: Lisinopril	0.6	0.8	1.0	-0.7	-1.0
Leg fat percentage (left)	0.6	2.3	3.7	1.9	-1.0
Risk taking	0.6	0.9	1.6	-0.5	-1.3
Ever depressed for a whole week	0.6	0.7	1.4	-1.2	-0.2
Heart disease (siblings)	0.6	0.7	0.8	0.9	-0.7
Heel T-Score	0.5	3.7	4.1	2.0	1.8
Hair Pigment	0.5	14.2	27.4	5.2	1.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	0.1	1.1
Nervous feelings	0.5	0.9	1.2	1.1	0.8
Had menopause	0.5	0.6	0.9	0.5	1.0
Time employed in main current job	0.5	0.6	1.2	1.1	0.0
Depression (self-reported)	0.5	0.6	0.8	0.7	0.9
Medication: Paracetamol	0.5	0.8	1.6	-1.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.8	0.9	-0.6
Alcohol intake frequency.	0.5	1.3	2.5	-1.6	-0.2
Number of full sisters	0.5	0.6	0.6	-0.8	0.8
Arm fat percentage (left)	0.5	1.9	3.8	2.0	0.1
Loneliness, isolation	0.5	0.7	1.1	-1.1	0.5
Arm fat mass (left)	0.5	2.1	4.2	2.1	0.2
Guilty feelings	0.5	0.8	1.5	-0.4	1.2
Financial situation satisfaction	0.5	0.6	1.3	0.2	-1.1
Unable to work because of sickness or disability	0.5	0.7	0.9	0.9	0.7
Major Depression (MDD)	0.4	0.5	0.9	0.1	0.9
Blood Eosinophil Count	0.4	2.9	4.4	2.1	-1.2
Medication: Metformin	0.4	0.5	0.9	0.9	-0.4
Leg fat-free mass (left)	0.4	2.4	4.4	2.1	0.6
Hand grip strength (right)	0.4	1.0	1.5	-0.7	1.2
Leg predicted mass (left)	0.4	2.0	3.7	1.9	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.2	1.1	-0.0
Arm fat percentage (right)	0.4	1.8	3.4	1.9	0.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	-1.0	0.3
Loud music exposure frequency	0.4	0.4	0.8	0.9	-0.1
Leg fat percentage (right)	0.4	1.4	1.7	1.3	-1.0
Worry too long after embarrassment	0.4	0.7	0.9	-1.0	0.7
Medication: Omeprazole	0.4	0.4	0.9	0.9	0.1
Arm predicted mass (right)	0.4	1.8	3.1	1.8	-0.8
Family relationship satisfaction	0.4	0.4	0.8	-0.9	-0.3
Osteoporosis (self-reported)	0.4	0.5	0.6	0.8	-0.7
Alcohol drinker status: Never	0.4	0.5	0.6	0.7	0.8
Basal metabolic rate	0.4	2.2	4.2	2.1	0.4
Arm fat-free mass (left)	0.4	2.1	4.2	2.0	-0.3
Age at First Birth	0.3	0.4	0.7	0.2	0.9
Tanning	0.3	3.8	4.8	2.2	-1.7
High blood pressure	0.3	0.8	1.4	-0.4	-1.2
Diabetes (self-reported)	0.3	0.4	0.8	0.9	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.1	1.0	-0.8
Arm fat-free mass (right)	0.3	1.7	2.6	1.6	-0.8
Neck or shoulder pain in last month	0.3	0.4	0.7	0.9	-0.3
Medication: Blood pressure	0.3	0.5	0.9	-0.9	-0.2
Hypertension (Self-reported)	0.3	0.7	1.4	-0.3	-1.2
Whole body fat-free mass	0.3	1.6	3.1	1.8	0.3
Friendships satisfaction	0.3	0.4	0.5	0.5	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.5	0.7	-0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	0.5	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.5	0.7	-0.5
Whole body water mass	0.3	1.6	3.1	1.8	0.2
Diastolic blood pressure, automated reading	0.3	0.8	1.4	-0.5	1.2
Arm predicted mass (left)	0.3	1.7	3.2	1.8	-0.5
Reaction Time	0.2	0.4	0.6	0.5	-0.7
Waist Hip Ratio (WHR)	0.2	1.0	1.2	1.1	0.9
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.8	-0.2	0.9
Medication: Co-codamol	0.2	0.2	0.4	0.2	-0.6
Diabetes (father)	0.2	0.2	0.3	0.5	0.4
Relative age voice broke	0.2	0.3	0.5	0.7	-0.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.4	-0.6	-0.2
Medication: Ramipril	0.2	0.2	0.4	0.7	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.6	0.8	0.3
Birth weight of first child	0.2	0.3	0.5	-0.7	0.3
Blood clot in the leg (DVT)	0.2	0.3	0.5	0.3	-0.7
Medication: Amlodipine	0.2	0.3	0.7	0.1	-0.8
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.3	0.4	-0.6
Average weekly red wine intake	0.2	0.3	0.4	0.6	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	0.6	-0.1
Qualifications: nursing, teaching	0.2	0.3	0.7	-0.0	0.8
Pain experienced in last month	0.2	0.3	0.7	0.8	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	0.6	-0.0	-0.8
Hand grip strength (left)	0.1	0.2	0.3	0.6	0.4
Average weekly fortified wine intake	0.1	0.2	0.3	-0.1	-0.5
Age when periods started (menarche)	0.1	0.2	0.2	0.4	-0.5
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.4	-0.2
Hearing difficulty/problems with background noise	0.1	0.1	0.1	0.3	0.3
Had other major operations	0.1	0.1	0.3	-0.0	0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.3	-0.6	0.1
Trunk fat-free mass	0.1	0.8	1.5	1.2	0.3
Trunk predicted mass	0.1	0.7	1.2	1.1	0.3
Breastfed as a baby	0.1	0.2	0.3	-0.5	0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.1	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.3	0.4
Forced vital capacity (FVC), Best measure	0.1	0.5	0.7	-0.9	0.6
Number of children fathered	0.1	0.1	0.1	-0.3	-0.3
Leg pain on walking	0.1	0.1	0.1	0.2	0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	-0.2	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	-0.4	-0.0
Mother’s age at death	0.1	0.1	0.2	-0.1	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.1	-0.4	-0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Forced vital capacity (FVC)	0.0	0.1	0.1	0.2	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	0.0	0.1
Lung cancer (father)	0.0	0.0	0.0	0.1	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.0	-0.0	-0.2
Migraine (self-reported)	0.0	0.0	0.1	-0.2	-0.1
Mean time to correctly identify matches	0.0	0.1	0.2	0.1	0.4
Diabetes diagnosed by doctor	0.0	0.1	0.1	0.3	-0.2
Medication for cholesterol	0.0	0.1	0.1	0.4	-0.1
Age started oral contraceptive pill	0.0	0.0	0.1	0.0	0.3
Supplements: Calcium	0.0	0.0	0.0	-0.1	-0.1

Hub : Genes

KIF5A

Models

Trait associations