[Hub]/) : Traits : Intelligence (Savage-Jansen 2018) :

chr16:52,772,129-54,235,440

Best TWAS P=8.15e-17 · Best GWAS P=1.75e-14 conditioned to 0.747

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex AKTIP 0.12 0.09 enet 10 0.08 1.9e-10 6.91 -6.5 7.0e-11 -0.64 0.39 0.61 FALSE
2 CommonMind Brain Pre-frontal Cortex RBL2 0.22 0.24 enet 15 0.26 1.8e-31 6.97 -7.7 1.1e-14 -0.87 0.32 0.68 FALSE
3 GTEx Adipose Subcutaneous RBL2 0.34 0.28 enet 18 0.30 1.0e-24 6.88 -7.4 1.0e-13 -0.76 0.34 0.66 FALSE
4 GTEx Adipose Visceral Omentum RBL2 0.30 0.27 lasso 2 0.27 4.3e-14 6.88 -6.9 5.9e-12 -0.71 0.39 0.61 FALSE
5 GTEx Adrenal Gland RBL2 0.35 0.27 enet 22 0.25 2.3e-09 6.88 -6.6 3.2e-11 -0.70 0.35 0.65 FALSE
6 GTEx Artery Aorta RBL2 0.27 0.21 enet 14 0.19 1.5e-10 6.89 -6.9 4.2e-12 -0.72 0.38 0.62 FALSE
7 GTEx Artery Coronary RBL2 0.36 0.33 enet 14 0.27 1.4e-09 6.86 -6.7 1.7e-11 -0.69 0.40 0.60 FALSE
8 GTEx Artery Tibial RBL2 0.16 0.17 enet 11 0.20 2.1e-15 7.06 -7.6 2.1e-14 -0.84 0.24 0.76 FALSE
9 GTEx Brain Cerebellar Hemisphere RBL2 0.55 0.55 enet 20 0.46 2.1e-13 6.88 -7.2 4.5e-13 -0.72 0.37 0.63 FALSE
10 GTEx Brain Cerebellum RBL2 0.66 0.72 enet 16 0.70 5.7e-28 6.86 -7.1 1.3e-12 -0.73 0.40 0.60 FALSE
11 GTEx Brain Cortex RBL2 0.51 0.45 enet 12 0.46 3.5e-14 6.63 -7.7 1.0e-14 -0.81 0.14 0.86 FALSE
12 GTEx Breast Mammary Tissue RBL2 0.36 0.35 lasso 3 0.36 3.0e-19 6.95 -6.9 6.4e-12 -0.71 0.33 0.67 FALSE
13 GTEx Breast Mammary Tissue (Male) RBL2 0.40 0.29 lasso 2 0.25 1.4e-06 6.95 -7.0 3.7e-12 -0.70 0.25 0.59 FALSE
14 GTEx Breast Mammary Tissue (Female) RBL2 0.47 0.27 lasso 7 0.20 1.1e-06 6.63 -6.8 1.1e-11 -0.70 0.30 0.69 FALSE
15 GTEx Cells EBV-transformed lymphocytes RBL2 0.33 0.12 lasso 6 0.08 1.1e-03 6.63 -5.9 4.5e-09 -0.58 0.19 0.33 FALSE
16 GTEx Cells Transformed fibroblasts RBL2 0.13 0.05 enet 9 0.02 8.9e-03 6.88 -5.8 9.1e-09 -0.66 0.25 0.56 FALSE
17 GTEx Colon Sigmoid RBL2 0.38 0.37 lasso 12 0.29 8.4e-11 6.88 -7.4 1.5e-13 -0.80 0.32 0.68 FALSE
18 GTEx Colon Transverse RBL2 0.59 0.44 enet 13 0.52 4.4e-28 6.88 -7.0 2.3e-12 -0.76 0.34 0.66 FALSE
19 GTEx Esophagus Gastroesophageal Junction RBL2 0.38 0.40 enet 17 0.38 1.1e-14 6.86 -6.7 1.5e-11 -0.70 0.40 0.60 FALSE
20 GTEx Esophagus Mucosa RBL2 0.36 0.36 enet 37 0.37 2.9e-26 6.88 -7.4 1.6e-13 -0.79 0.41 0.59 FALSE
21 GTEx Esophagus Muscularis RBL2 0.36 0.38 enet 10 0.41 6.8e-27 6.91 -6.9 5.9e-12 -0.70 0.41 0.59 FALSE
22 GTEx Heart Atrial Appendage RBL2 0.28 0.14 enet 25 0.23 8.6e-11 6.97 -6.7 2.2e-11 -0.77 0.10 0.90 FALSE
23 GTEx Heart Left Ventricle RBL2 0.12 0.11 enet 12 0.08 3.3e-05 6.89 -6.5 7.3e-11 -0.62 0.31 0.68 FALSE
24 GTEx Liver RBL2 0.38 0.22 enet 21 0.20 4.0e-06 6.56 -5.2 2.1e-07 -0.58 0.11 0.83 FALSE
25 GTEx Lung RBL2 0.29 0.37 enet 16 0.35 9.1e-28 6.88 -7.3 3.3e-13 -0.75 0.37 0.63 FALSE
26 GTEx Muscle Skeletal RBL2 0.11 0.00 lasso 5 0.00 2.9e-01 7.51 -8.1 6.5e-16 -0.90 0.01 0.96 FALSE
27 GTEx Nerve Tibial RBL2 0.46 0.52 enet 19 0.53 1.6e-43 6.97 -7.2 5.8e-13 -0.76 0.31 0.69 FALSE
28 GTEx Ovary RBL2 0.41 0.26 enet 29 0.18 3.2e-05 6.86 -7.4 1.4e-13 -0.74 0.06 0.92 FALSE
29 GTEx Pancreas RBL2 0.36 0.36 enet 26 0.36 5.9e-16 6.91 -7.2 5.3e-13 -0.79 0.38 0.62 FALSE
30 GTEx Pituitary RBL2 0.36 0.39 lasso 6 0.40 4.5e-11 6.86 6.7 2.9e-11 0.70 0.34 0.65 FALSE
31 GTEx Prostate RBL2 0.55 0.45 lasso 4 0.45 1.0e-12 6.88 -6.5 6.5e-11 -0.71 0.40 0.60 FALSE
32 GTEx Skin Not Sun Exposed Suprapubic RBL2 0.35 0.33 enet 16 0.34 2.6e-19 6.88 -7.3 3.7e-13 -0.75 0.39 0.61 FALSE
33 GTEx Skin Sun Exposed Lower leg RBL2 0.35 0.39 enet 25 0.37 2.9e-32 6.88 -7.1 1.5e-12 -0.74 0.41 0.59 FALSE
34 GTEx Spleen RBL2 0.59 0.47 enet 51 0.46 3.2e-13 6.86 -6.1 9.9e-10 -0.66 0.30 0.70 FALSE
35 GTEx Stomach RBL2 0.33 0.26 enet 20 0.26 8.7e-13 6.88 -6.2 6.1e-10 -0.64 0.37 0.63 FALSE
36 GTEx Thyroid RBL2 0.34 0.47 lasso 4 0.45 3.6e-38 6.88 -7.0 2.5e-12 -0.72 0.42 0.58 FALSE
37 GTEx Vagina RBL2 0.41 0.37 enet 13 0.34 1.6e-08 6.82 -7.2 8.8e-13 -0.76 0.20 0.78 FALSE
38 NTR Blood RBL2 0.09 0.11 bslmm 419 0.11 1.1e-33 6.88 -6.9 6.5e-12 -0.70 0.38 0.62 FALSE
39 YFS Blood AKTIP 0.19 0.27 lasso 13 0.30 3.3e-99 7.57 8.2 1.9e-16 0.92 0.00 1.00 FALSE
40 YFS Blood RBL2 0.18 0.26 bslmm 381 0.27 6.9e-90 6.86 -6.0 2.7e-09 -0.65 0.38 0.62 FALSE
41 The Cancer Genome Atlas Esophageal Carcinoma RBL2 0.08 0.04 lasso 3 0.03 4.4e-02 7.57 7.1 1.5e-12 0.84 0.01 0.76 FALSE
42 The Cancer Genome Atlas Brain Lower Grade Glioma AKTIP 0.04 0.03 blup 42 0.05 1.9e-06 6.88 -6.7 1.8e-11 -0.69 0.35 0.65 FALSE
43 The Cancer Genome Atlas Brain Lower Grade Glioma RBL2 0.03 0.06 enet 5 0.05 8.2e-07 6.63 -7.3 3.0e-13 -0.82 0.23 0.77 FALSE
44 The Cancer Genome Atlas Pancreatic Adenocarcinoma RBL2 0.11 0.08 blup 44 0.06 1.5e-03 7.67 -8.3 8.2e-17 -0.93 0.00 0.86 TRUE
45 The Cancer Genome Atlas Testicular Germ Cell Tumors AKTIP 0.18 -0.01 enet 10 0.08 6.9e-04 -0.62 -5.2 2.2e-07 -0.50 0.01 0.24 FALSE