Best TWAS P=2.08e-09 · Best GWAS P=3.51e-08 conditioned to 0.778
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | PLA2G15 | 0.11 | 0.03 | lasso | 7 | 0.07 | 1.4e-04 | -4.3 | 5.2 | 1.6e-07 | -0.72 | 0.10 | 0.74 | FALSE |
| 2 | GTEx | Brain Cerebellum | PSMB10 | 0.11 | 0.03 | lasso | 4 | 0.05 | 1.6e-02 | -4.1 | 5.5 | 4.9e-08 | -0.58 | 0.06 | 0.39 | FALSE |
| 3 | METSIM | Adipose | PLA2G15 | 0.03 | 0.01 | blup | 287 | 0.01 | 4.8e-03 | 4.5 | 5.4 | 6.5e-08 | -0.55 | 0.05 | 0.76 | FALSE |
| 4 | NTR | Blood | ESRP2 | 0.03 | 0.03 | lasso | 5 | 0.02 | 7.7e-08 | -5.2 | 6.0 | 2.1e-09 | -0.90 | 0.02 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PRMT7 | 0.07 | 0.00 | enet | 9 | 0.02 | 1.5e-02 | -4.5 | -5.6 | 2.7e-08 | 0.61 | 0.01 | 0.17 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PRMT7 | 0.19 | 0.14 | enet | 5 | 0.15 | 6.9e-17 | -4.6 | -5.2 | 1.9e-07 | 0.93 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SMPD3 | 0.09 | 0.04 | enet | 14 | 0.06 | 1.4e-06 | 4.2 | -5.2 | 2.2e-07 | 0.34 | 0.16 | 0.63 | FALSE |