Best TWAS P=4.11e-09 · Best GWAS P=6.66e-10 conditioned to 0.0542
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | HAUS6 | 0.14 | 0.13 | lasso | 4 | 0.12 | 2.3e-10 | 5.3 | -5.9 | 4.1e-09 | -0.93 | 0.01 | 0.99 | TRUE |
2 | GTEx | Adipose Visceral Omentum | HAUS6 | 0.15 | 0.02 | lasso | 5 | 0.05 | 1.4e-03 | 6.2 | -5.1 | 2.7e-07 | -0.79 | 0.01 | 0.92 | FALSE |
3 | GTEx | Artery Aorta | HAUS6 | 0.14 | 0.05 | lasso | 5 | 0.07 | 8.7e-05 | 5.3 | -5.5 | 2.9e-08 | -0.84 | 0.02 | 0.97 | FALSE |
4 | GTEx | Artery Tibial | HAUS6 | 0.14 | 0.14 | lasso | 1 | 0.14 | 3.7e-11 | 5.3 | -5.3 | 9.7e-08 | -0.86 | 0.14 | 0.86 | FALSE |
5 | GTEx | Breast Mammary Tissue | HAUS6 | 0.12 | 0.06 | lasso | 2 | 0.05 | 1.7e-03 | 5.5 | -5.7 | 1.4e-08 | -0.96 | 0.02 | 0.97 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | HAUS6 | 0.28 | 0.17 | lasso | 8 | 0.20 | 1.4e-14 | 5.8 | -5.5 | 4.7e-08 | -0.93 | 0.01 | 0.99 | FALSE |
7 | GTEx | Thyroid | HAUS6 | 0.12 | 0.05 | lasso | 3 | 0.02 | 5.3e-03 | 5.3 | -5.5 | 3.1e-08 | -0.91 | 0.01 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HAUS6 | 0.04 | 0.03 | blup | 87 | 0.05 | 4.1e-10 | 6.2 | -5.6 | 1.7e-08 | -0.90 | 0.00 | 1.00 | FALSE |
9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HAUS6 | 0.04 | 0.06 | lasso | 2 | 0.05 | 9.1e-07 | 5.6 | -5.6 | 2.7e-08 | -0.86 | 0.04 | 0.96 | FALSE |
10 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | FAM154A | 0.06 | 0.00 | blup | 174 | 0.01 | 1.3e-01 | 5.5 | -5.3 | 9.0e-08 | -0.88 | 0.02 | 0.90 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HAUS6 | 0.12 | 0.09 | blup | 87 | 0.10 | 1.4e-10 | 5.5 | -5.2 | 1.8e-07 | -0.83 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | HAUS6 | 0.07 | 0.11 | blup | 87 | 0.11 | 6.8e-11 | 5.5 | -5.1 | 2.7e-07 | -0.90 | 0.03 | 0.97 | FALSE |