Best TWAS P=3.24e-13 · Best GWAS P=3.15e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | VPS53 | 0.09 | 0.05 | enet | 10 | 0.08 | 5.9e-10 | 5.5 | -5.4 | 7.7e-08 | -0.81 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Brain Cortex | VPS53 | 0.31 | 0.16 | enet | 22 | 0.07 | 6.3e-03 | 5.9 | -5.2 | 2.0e-07 | -0.81 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Male) | RP11-1260E13.4 | 0.22 | 0.08 | lasso | 3 | 0.05 | 2.6e-02 | 4.6 | 5.8 | 5.1e-09 | 0.90 | 0.02 | 0.48 | FALSE |
| 4 | GTEx | Colon Transverse | FAM57A | 0.31 | 0.27 | lasso | 3 | 0.27 | 2.3e-13 | 6.9 | -6.7 | 1.9e-11 | -0.97 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Colon Transverse | GEMIN4 | 0.12 | 0.06 | enet | 7 | 0.02 | 2.3e-02 | 5.1 | -6.1 | 8.7e-10 | -0.92 | 0.01 | 0.96 | FALSE |
| 6 | GTEx | Pancreas | FAM57A | 0.12 | 0.04 | lasso | 4 | 0.05 | 3.5e-03 | 4.3 | -5.7 | 9.2e-09 | -0.88 | 0.01 | 0.94 | FALSE |
| 7 | GTEx | Testis | RNMTL1 | 0.39 | 0.31 | enet | 24 | 0.34 | 1.5e-15 | 6.0 | -5.7 | 1.6e-08 | -0.54 | 0.34 | 0.66 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | VPS53 | 0.29 | 0.17 | lasso | 6 | 0.28 | 9.0e-37 | 1.6 | -5.2 | 1.7e-07 | -0.66 | 0.08 | 0.92 | FALSE |
| 9 | The Cancer Genome Atlas | Glioblastoma Multiforme | FAM57A | 0.23 | 0.11 | blup | 50 | 0.09 | 1.3e-03 | 2.9 | 5.3 | 1.0e-07 | 0.45 | 0.03 | 0.26 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | VPS53 | 0.03 | 0.04 | lasso | 1 | 0.03 | 1.1e-04 | 7.0 | -7.0 | 3.2e-12 | -1.00 | 0.00 | 0.99 | FALSE |
| 11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | VPS53 | 0.09 | 0.06 | blup | 110 | 0.04 | 1.5e-05 | 5.1 | -5.9 | 3.9e-09 | -0.82 | 0.02 | 0.98 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Adenocarcinoma | VPS53 | 0.10 | 0.03 | blup | 113 | 0.06 | 1.9e-07 | 7.0 | -5.9 | 4.3e-09 | -0.71 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FAM57A | 0.17 | 0.16 | enet | 8 | 0.20 | 8.6e-21 | 7.0 | -6.7 | 2.7e-11 | -0.94 | 0.00 | 1.00 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GEMIN4 | 0.05 | 0.06 | lasso | 4 | 0.05 | 3.6e-06 | 7.0 | -7.3 | 3.2e-13 | -0.99 | 0.00 | 1.00 | TRUE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VPS53 | 0.13 | 0.15 | lasso | 4 | 0.15 | 7.2e-16 | 6.9 | -6.9 | 5.2e-12 | -0.99 | 0.00 | 1.00 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | RNMTL1 | 0.09 | 0.02 | enet | 18 | 0.04 | 9.3e-05 | 6.0 | 5.3 | 1.2e-07 | 0.46 | 0.00 | 0.99 | FALSE |