Hub : Genes

RNMTL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.3890	0.0690	1.4e-08	0.309	NA	0.335	NA	0.315	2.9e-14	NA	1.5e-15	NA	1.5e-14
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0405	0.0189	2.6e-03	0.003	-0.001	0.000	NA	-0.001	1.4e-01	0.51000	3.6e-01	NA	4.3e-01
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1190	0.0630	6.8e-03	0.018	0.037	0.018	NA	0.012	3.0e-02	0.00350	3.0e-02	NA	6.4e-02
4	TCGA	Brain Lower Grade Glioma	0.0461	0.0198	1.4e-04	0.025	0.024	0.019	NA	0.024	7.0e-04	0.00090	2.5e-03	NA	9.3e-04
5	TCGA	Lung Squamous Cell Carcinoma	0.0521	0.0228	9.1e-04	0.018	0.014	0.007	NA	0.009	3.3e-03	0.00790	5.2e-02	NA	3.2e-02
6	TCGA	Pheochromocytoma and Paraganglioma	0.1240	0.0590	6.0e-03	0.070	0.059	0.033	NA	0.028	9.4e-04	0.00230	1.8e-02	NA	2.8e-02
7	TCGA	Thyroid Carcinoma	0.0870	0.0370	2.8e-04	0.020	0.036	0.039	NA	0.029	4.3e-03	0.00019	9.3e-05	NA	7.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.2	1.8	4.4	0.0	1.4	1.7	1.6	0.7	2.1	0.7
Bipolar Disorder or Schizophrenia	0.8	1.9	5.2	-2.3	-0.1	0.7	1.5	-0.4	1.6	1.7
Depressed Affect (Nagel 2018)	0.2	0.4	1.2	-0.1	0.5	-1.1	-0.3	-0.2	0.7	0.8
Depression (Nagel 2018)	0.2	0.3	0.9	1.0	0.5	-0.6	0.1	-0.3	-0.3	-0.1
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.6	-1.2	1.0	-0.2	0.3	1.3	1.2	0.8
Neuroticism (Nagel 2018)	0.6	1.3	4.9	1.1	-0.2	-1.6	-2.2	0.2	0.6	-0.7
Schizophrenia (2018)	0.5	1.0	2.7	-1.0	-1.2	-0.4	0.6	-1.0	0.3	1.6
Schizophrenia vs Biploar Disorder	3.5	4.6	7.8	0.0	-2.2	-2.8	-1.2	-2.3	-2.6	-2.3
Worry (Nagel 2018)	1.2	2.5	6.6	1.9	-0.9	-1.1	-2.6	1.0	0.6	-2.0
Alzheimer’s Disease (in mother)	2.1	2.5	9.1	-0.9	1.6	1.0	-0.1	1.7	3.0	1.0
Alzheimer’s Disease (in father)	0.3	0.3	1.2	0.3	1.1	-0.9	-0.0	-0.2	-0.1	0.2
Alzheimer’s Disease (including proxy)	1.6	2.3	7.2	-0.5	2.1	0.9	0.2	1.4	2.7	1.0
Crohns Disease (2017)	0.1	0.3	0.6	-0.6	0.3	0.6	0.7	0.1	0.1	-0.8
Irritable Bowel Disease (IBD)	0.4	0.9	3.5	0.4	-0.0	-0.0	1.1	-1.2	-1.9	-0.6
Ulcerative Colitis (UC)	0.9	1.8	6.5	1.1	-0.4	-0.8	0.7	-1.8	-2.5	-0.2
Major Depression (MDD)	0.4	0.5	2.1	0.0	-0.4	-1.5	-0.6	-0.7	0.3	0.4
Reaction Time	0.7	1.4	2.9	1.0	-1.3	-0.6	-1.4	-1.1	-1.0	-1.7
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.0	0.2	0.8	-1.0	-0.8	0.2	0.3	-0.2
Breast Cancer	0.5	1.1	3.1	-1.3	-0.4	1.1	0.2	0.6	1.8	1.1
Ovarian Cancer	1.1	1.4	4.5	-1.1	-2.1	1.0	0.4	-1.3	0.1	1.2
Prostate Cancer	8.6	12.1	31.9	-5.7	-2.0	2.7	2.7	-2.4	0.4	5.3
Age at First Birth	0.4	0.6	1.3	0.8	0.0	-0.3	-0.9	0.6	1.0	-1.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.7	2.3	7.9	1.7	2.8	-0.1	-0.6	1.8	1.0	-1.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.2	0.3	0.9	-0.7	-0.1	-1.0	-0.6	-0.3	0.3	-0.6
Mean Putamen Volume	1.3	1.5	2.7	1.6	1.2	-1.3	-0.9	1.4	0.4	-1.1
Fasting Glucose	0.1	0.1	0.4	-0.1	0.5	-0.4	-0.2	-0.0	0.0	0.6
HbA1C	0.4	0.4	0.9	0.1	0.7	0.9	0.6	-0.5	-0.3	0.8
HDL Cholesterol	0.2	0.4	1.5	-0.2	-1.2	-0.4	-0.9	-0.4	0.4	0.2
LDL Cholesterol	0.3	0.4	1.1	-0.4	-0.5	-0.8	0.6	-0.6	0.2	1.0
Lupus	0.2	0.3	0.8	0.0	0.9	-0.8	-0.0	0.1	0.1	0.6
Neuroticism (2016)	0.3	0.5	2.2	0.0	1.5	-0.8	-0.6	0.5	0.1	-0.0
Primary Biliary Cirrhosis	1.5	2.1	3.5	-1.5	1.8	1.6	1.9	0.5	1.0	1.3
Rheumatoid Arthritis	0.3	0.5	1.5	0.8	-0.3	-0.8	-0.4	0.1	-0.4	-1.2
Schizophrenia (2014)	0.4	1.0	2.8	-0.7	-1.1	-0.6	1.0	-1.7	-0.2	1.0
Triglycerides	0.4	0.6	1.0	1.0	-0.4	0.8	1.0	0.0	-0.9	0.8
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.9	0.0	-1.0	0.0	0.5	0.0	-0.6	-0.3
Ulcerative Colitis	0.8	1.1	3.1	1.2	0.2	-1.3	-0.6	-0.6	-1.8	-1.0
Blood Eosinophil Count	1.2	9.4	24.2	4.0	1.5	-1.8	-3.5	2.6	1.2	-4.9
Blood Platelet Count	0.2	2.5	5.9	-1.8	-2.4	0.2	1.2	-1.9	-1.0	1.5
Blood Red Count	0.0	0.1	0.7	0.1	0.1	0.4	-0.4	0.8	0.1	0.3
Blood White Count	0.0	0.2	0.7	-0.6	-0.0	-0.6	-0.1	0.2	0.2	-0.8
Heel T-Score	0.2	1.6	3.1	-0.2	-1.7	0.8	0.8	-1.6	-1.8	1.0
BMI	0.2	1.2	4.0	-1.0	-0.4	-1.2	0.3	-1.2	-0.1	2.0
Height	0.5	9.0	20.9	4.3	0.8	-2.7	-4.6	0.4	-0.1	-3.9
Waist Hip Ratio (WHR)	0.2	1.0	3.5	-0.2	0.2	-1.8	-0.3	-0.3	-0.4	-1.9
Systolic Blood Pressure	0.5	2.3	5.6	-0.3	0.3	2.2	2.4	1.0	-1.1	1.8
Smoking Status	0.3	0.8	3.1	-1.8	-0.9	-0.2	0.9	-0.6	0.3	0.4
Allergy or Eczema	0.6	1.7	7.0	2.6	0.5	-1.4	-0.7	0.1	-0.4	-1.3
Cardiovascular Disease	0.3	0.9	1.9	-0.5	-0.6	1.1	1.3	0.2	-1.1	1.4
Hypothyroidism (self reported)	1.2	2.7	8.6	-2.4	-0.6	1.1	1.4	-1.0	0.2	2.9
Respiratory disease	0.2	0.5	1.5	-0.9	0.9	0.4	0.4	0.5	1.2	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	0.1	-0.8	0.7	-0.2	0.5	-0.7	0.3
Lung FEV1/FVC ratio	0.2	1.0	2.3	-0.4	-0.7	-1.0	-0.2	-1.5	-1.4	0.9
Lung FVC	0.4	2.1	4.5	1.4	-0.1	-1.4	-2.1	1.6	-0.7	-1.8
Neuroticism	1.4	3.3	7.7	2.0	0.9	-2.3	-2.8	0.6	0.7	-2.1
Chronotype (morning person)	0.5	1.2	3.2	-0.9	-1.8	0.0	-0.2	-1.7	-0.9	1.1
Hair Pigment	0.1	2.6	5.2	-1.5	-1.6	2.1	2.3	-1.2	-0.7	1.4
Tanning	0.1	1.2	4.2	-0.8	0.3	1.6	0.7	-0.2	-0.3	2.0
Hand grip strength (left)	0.4	0.9	2.4	1.2	0.8	-1.6	-1.2	0.4	-0.1	-0.7
Number of treatments/medications taken	0.8	1.4	3.6	-1.0	0.5	1.4	1.9	0.4	0.5	1.6
Average weekly spirits intake	0.8	1.0	2.2	-1.4	-0.0	0.3	0.6	-0.6	1.5	1.4
Sensitivity / hurt feelings	0.4	0.7	1.7	1.0	-0.7	0.4	-1.1	0.1	-0.3	-1.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.5	0.0	-0.7	-0.7	-0.2	-0.8	-1.2	0.7
Hearing difficulty/problems: Yes	1.6	2.5	6.5	0.1	-2.5	-1.4	-0.5	-1.6	-2.1	-1.4
Relative age of first facial hair	0.7	1.4	4.6	1.4	-0.9	-0.9	-0.8	-0.7	-2.1	-0.7
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	3.4	-0.2	1.5	0.5	0.9	1.5	1.4	1.8
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.5	0.1	0.7	1.6	1.5	0.2	-0.4	-0.1
Ever had hysterectomy (womb removed)	0.5	0.5	1.2	-0.8	-1.1	-0.2	-0.2	-0.9	-0.9	-0.3
Systolic blood pressure, automated reading	0.5	1.4	4.1	-0.2	-0.7	1.3	2.0	-0.9	-1.5	0.8
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	5.2	1.1	-1.0	-0.7	-0.8	-1.1	-2.3	-1.4
Angina	3.5	4.6	11.4	-2.0	-3.4	-1.8	-0.3	-3.2	-1.8	0.3
Medication for hormone replacement therapy	0.8	0.9	3.5	0.5	0.8	1.0	1.9	0.2	-0.7	0.4
Vitamin and mineral supplements	0.5	0.7	2.9	-0.4	-0.4	-1.0	-1.7	-0.6	-0.0	-0.4
Supplements: Zinc	2.4	2.6	7.7	2.8	1.1	-0.2	-0.9	1.7	-0.2	-2.3
Medication: Co-codamol	0.2	0.2	0.6	-0.1	0.3	-0.5	0.8	-0.1	0.7	0.4
Medication: Metformin	0.1	0.2	0.5	0.7	0.2	0.2	-0.0	0.6	-0.3	-0.4
Diabetes (father)	0.7	0.9	2.2	0.4	-1.2	0.2	-0.5	0.1	-1.5	-1.4
Diabetes (mother)	0.4	0.5	1.1	0.8	0.4	-0.8	-0.4	1.1	-0.6	-0.4
Severe depression (siblings)	2.3	2.6	5.9	0.2	2.0	1.6	0.2	2.2	2.4	0.7
Pack years adult smoking proportion	0.2	0.3	0.6	-0.7	-0.8	-0.6	0.1	-0.6	0.4	0.4
Impedance of leg (right)	0.6	2.7	6.2	-0.8	2.5	1.4	1.2	1.9	2.3	-0.2
Leg fat-free mass (left)	0.3	1.8	5.3	1.7	-0.7	-1.6	-2.3	-0.7	-0.6	-0.6
Trunk fat percentage	0.3	1.1	2.3	0.7	1.4	-1.1	-1.1	0.7	1.5	-0.6
Hand grip strength (right)	0.4	1.0	1.8	1.2	-0.1	-1.3	-0.3	-1.0	-1.4	-1.0
Townsend deprivation index at recruitment	0.2	0.3	0.6	-0.4	-0.8	-0.1	0.1	-0.6	-0.6	0.6
Current tobacco smoking	0.4	0.6	1.3	-1.1	-1.0	-0.7	-0.4	-1.1	-0.3	0.2
Average weekly fortified wine intake	1.0	1.1	2.8	-1.2	0.2	0.4	1.3	-0.2	1.3	1.7
Maternal smoking around birth	0.8	1.1	2.5	-0.6	1.0	-0.6	-0.7	0.9	1.5	1.6
Fed-up feelings	0.7	1.3	3.3	1.2	-0.4	-1.7	-1.8	-0.3	-0.4	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.6	-0.1	-0.8	-0.9	-0.3	-0.0	-0.3
Relative age voice broke	1.5	2.3	7.5	2.7	-0.9	-0.5	-2.1	0.3	-1.3	-1.3
Taking other prescription medications	0.1	0.2	0.6	-0.8	0.2	0.1	0.5	0.3	0.3	0.5
Age when periods started (menarche)	0.8	1.8	4.0	1.0	-0.9	-1.9	-1.8	-0.2	-0.1	-2.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.8	-0.1	0.9	-0.8	-1.1	0.1	-0.1	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.7	-0.6	0.3	0.4	0.6	-0.9	-0.5	1.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.0	-1.4	-0.6	0.7	0.3	-0.3	0.1	1.2
Qualifications: CSEs or equivalent	1.1	1.5	3.2	1.8	-0.1	-1.3	-0.7	-0.0	-1.3	-1.8
Serious illness, injury or assault to yourself	0.6	0.7	1.6	0.0	-1.1	0.4	1.0	-0.9	-1.2	0.5
High blood pressure	0.3	0.8	2.5	-0.2	-0.4	0.9	1.6	0.5	-0.6	1.2
Hayfever, allergic rhinitis or eczema	0.7	1.6	6.9	2.6	1.4	-0.9	-0.4	0.5	-0.4	-0.9
Multivitamins +/- minerals	1.0	1.3	5.8	0.2	0.2	1.6	2.4	0.1	-0.4	0.6
Stomach or abdominal pain in last month	0.7	0.8	2.0	0.4	-0.6	-0.9	-0.6	-1.4	-1.4	0.5
Supplements: Glucosamine	0.4	0.5	2.8	-0.1	0.4	-0.4	1.7	-0.2	-0.2	0.5
Diverticular disease/diverticulitis (self-reported)	2.1	2.5	5.7	1.6	-0.3	-1.7	-2.1	-0.3	-1.5	-2.4
Medication: Atenolol	0.3	0.4	1.2	-0.6	0.9	-0.3	0.3	1.1	0.7	0.1
Medication: Levothyroxine sodium	0.8	1.4	5.9	-2.4	-0.5	0.4	0.7	-0.2	0.7	1.6
Sitting height	0.5	3.5	12.1	2.2	0.8	-2.3	-3.5	0.5	0.7	-0.8
Chronic bronchitis/emphysema (father)	0.3	0.4	1.9	-0.1	-0.1	-1.4	-0.6	-0.3	0.1	-0.4
High blood pressure (mother)	0.3	0.4	1.2	1.1	0.2	0.4	0.6	0.3	-0.8	-0.2
Body mass index (BMI)	0.2	0.7	1.7	-0.6	-1.0	-0.9	-0.2	-1.3	-0.3	1.1
Impedance of leg (left)	0.6	3.0	8.7	0.3	3.0	0.9	0.3	2.3	2.4	-0.8
Leg predicted mass (left)	0.3	1.8	5.2	1.8	-0.7	-1.6	-2.3	-0.8	-0.7	-0.6
Trunk fat mass	0.2	1.0	2.4	0.9	0.8	-1.3	-1.5	0.2	1.1	-0.5
Waist circumference	0.3	1.3	3.8	0.3	0.0	-2.0	-1.9	-0.3	1.0	-0.4
Number of incorrect matches in round	0.5	0.8	2.2	-1.5	-0.5	0.3	1.1	-1.1	-0.2	0.9
Past tobacco smoking	0.3	0.6	1.4	0.6	-0.9	-0.5	-0.5	-0.9	-1.2	0.2
Alcohol usually taken with meals	0.2	0.4	0.7	0.6	0.3	0.7	-0.9	0.6	0.5	0.6
Nervous feelings	1.3	2.4	5.6	2.4	-0.4	-1.6	-1.7	0.7	-0.5	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.4	0.3	-0.1	0.6	0.1	-0.0	0.4	0.5
Hearing difficulty/problems with background noise	0.8	1.3	3.7	1.7	-0.5	-0.7	-0.2	0.0	-1.2	-1.9
Hair/balding pattern: Pattern 2	0.9	1.2	2.9	1.6	0.1	-1.7	-0.7	-0.3	-1.1	-0.8
Had menopause	0.9	1.1	3.2	-0.1	0.9	1.2	1.8	0.1	0.9	1.1
Had other major operations	0.6	0.7	1.3	-0.1	-1.1	-0.9	0.1	-1.1	-1.1	0.6
Forced vital capacity (FVC)	1.2	4.5	9.1	3.0	0.7	-1.2	-2.9	1.9	0.3	-3.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.2	-0.6	-0.4	0.5	0.1	-0.9	-1.1	0.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	4.1	0.4	-0.8	-2.0	-1.8	0.1	-0.5	-1.1
Qualifications: None of the above	1.8	3.9	9.6	-1.2	-2.8	-1.9	-1.0	-3.1	-1.9	-0.2
Financial difficulties in last 2 years	1.2	1.6	5.4	-0.9	-1.5	-0.7	-0.5	-2.3	-1.4	0.3
Mouth/teeth dental problems	0.2	0.3	0.7	0.5	-0.7	0.4	0.3	-0.5	-0.9	-0.1
Heart attack	1.4	1.7	4.1	-2.0	-1.6	1.4	1.4	-0.4	0.6	1.0
Allergy	0.4	1.0	4.1	-2.0	-1.2	0.0	-0.0	-0.5	0.3	1.1
Pain all over the body in last month	0.2	0.2	0.6	-0.1	-0.7	-0.4	-0.8	-0.3	0.2	-0.6
Diabetes (self-reported)	0.2	0.3	0.9	0.9	-0.2	-0.3	-0.9	0.4	-0.4	0.0
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.9	0.2	1.3	-1.4	-0.3	0.8	1.0	-0.3
Medication: Ramipril	0.4	0.5	1.4	-0.5	0.1	1.2	0.2	1.0	0.5	0.6
Medication: Simvastatin	1.2	1.8	4.0	-1.4	-2.0	0.3	1.0	-1.4	-1.1	1.6
Fluid intelligence score	0.1	0.2	0.5	-0.4	-0.1	-0.5	0.4	-0.5	-0.0	0.7
Illnesses of siblings	1.2	1.6	3.7	0.6	-1.2	-0.8	-1.3	-1.4	-1.9	-1.2
Neuroticism score	1.5	3.1	7.1	2.3	0.6	-1.3	-2.7	1.4	0.8	-2.3
Weight	0.2	1.1	3.5	1.0	-0.3	-1.6	-1.9	-0.7	0.1	-0.0
Impedance of arm (right)	0.8	3.7	9.1	0.8	3.0	0.4	-0.3	2.8	2.3	-1.7
Arm fat percentage (right)	0.0	0.2	0.5	-0.4	0.1	-0.7	-0.4	-0.3	0.5	0.3
Trunk fat-free mass	0.3	1.8	4.8	1.6	-1.0	-1.3	-2.2	-1.1	-1.1	-0.3
Hip circumference	0.8	3.5	7.3	2.3	1.7	-1.2	-2.7	1.3	2.4	-0.8
Time employed in main current job	1.1	1.3	3.0	1.2	1.0	0.2	-1.7	1.3	0.5	-1.2
Alcohol intake versus 10 years previously	0.7	1.1	3.6	-1.2	-1.9	-0.5	-1.4	-0.6	0.2	0.4
Father’s age at death	0.3	0.4	1.0	-0.2	0.2	0.2	0.7	1.0	0.4	-0.9
Worrier / anxious feelings	1.3	2.4	5.2	2.3	0.6	-0.9	-2.1	1.4	0.2	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.1	0.5	1.1	-0.5	0.1	0.8	0.8	0.5
Falls in the last year	1.7	2.3	5.6	-1.8	-0.4	2.4	0.8	-0.6	1.1	2.2
Hair/balding pattern: Pattern 3	0.3	0.4	1.7	-1.3	-0.5	0.3	0.4	-0.3	0.4	0.8
Number of live births	0.6	0.8	1.8	-1.4	-1.0	0.4	1.0	-1.1	-0.7	0.2
Forced expiratory volume in 1-second (FEV1)	1.5	5.0	10.8	3.1	0.6	-1.8	-3.3	1.3	-0.5	-3.0
Pulse rate	0.3	0.6	2.1	0.5	1.4	-0.1	0.3	0.7	0.8	-0.6
Happiness	0.4	0.5	1.2	-1.1	0.3	-0.9	0.5	-0.7	0.1	0.8
Noisy workplace	0.3	0.4	1.0	-1.0	-0.6	-0.5	-0.4	-0.6	-0.8	0.5
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.7	1.1	1.9	0.1	0.5	1.5	0.0	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.1	0.6	0.6	1.0	1.5	0.1	-0.7	0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	2.2	-1.5	0.1	0.5	0.9	-0.5	0.5	0.1
Asthma	0.5	0.9	2.3	0.9	1.5	0.6	-0.2	0.9	0.8	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	4.4	0.7	2.1	1.0	-0.2	1.7	1.6	-0.4
Medication: Cholesterol lowering	0.3	0.4	1.6	0.0	-1.3	-0.5	-0.2	-0.1	-0.9	0.2
Depression (self-reported)	0.2	0.2	0.6	-0.3	0.1	-0.6	0.1	0.4	0.8	0.6
Medication: Lansoprazole	0.8	0.9	1.9	-0.2	-1.4	-0.6	-0.1	-1.3	-1.2	-0.9
Prospective memory result	1.7	2.1	4.4	-2.1	-0.9	-0.0	1.1	-2.1	-1.2	1.6
Lung cancer (father)	0.7	0.9	2.3	-1.5	0.4	0.6	-0.2	-0.4	1.3	1.2
Illnesses of mother	0.6	0.7	1.9	-1.4	-0.8	0.5	0.6	-1.1	-0.5	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.1	3.5	8.6	2.9	0.7	-1.2	-2.7	1.3	-0.5	-2.2
Pulse wave Arterial Stiffness index	0.6	0.7	2.5	-0.1	-1.3	0.1	-0.5	-0.8	-1.6	0.1
Impedance of arm (left)	1.0	4.5	12.7	0.9	3.6	0.7	0.0	2.9	2.6	-1.6
Arm fat mass (right)	0.1	0.3	0.7	0.0	-0.3	-0.8	-0.8	-0.7	0.0	0.5
Trunk predicted mass	0.3	1.7	4.6	1.5	-1.0	-1.2	-2.1	-1.1	-1.1	-0.3
Standing height	0.6	5.5	13.2	3.6	1.7	-1.5	-3.6	1.3	0.8	-2.3
Length of working week for main job	6.0	6.6	18.8	-3.3	-0.7	2.4	2.7	-1.1	1.4	4.3
Exposure to tobacco smoke at home	0.6	0.7	2.4	-1.4	0.1	0.5	0.5	-0.0	0.3	1.5
Breastfed as a baby	0.4	0.5	1.3	0.7	-0.2	-0.3	-1.1	0.5	0.0	-1.1
Tense / ‘highly strung’	0.2	0.4	0.7	-0.1	-0.8	0.9	-0.0	0.5	0.9	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.3	0.6	-0.5	0.1	0.3	0.7	-0.0
Hair/balding pattern: Pattern 4	0.4	0.9	4.0	-0.7	1.0	0.1	0.8	-0.1	0.1	2.0
Birth weight of first child	1.9	3.5	7.6	1.7	0.0	-2.5	-2.6	-0.1	-1.2	-2.8
Peak expiratory flow (PEF)	1.7	4.0	9.0	2.9	0.9	-1.2	-2.6	1.1	-0.4	-3.0
Pulse wave reflection index	0.3	0.3	1.3	-0.2	-0.6	0.0	-0.7	-0.2	-1.2	0.2
Ever highly irritable/argumentative for 2 days	1.3	1.6	5.5	2.3	0.9	-1.2	-1.3	0.4	-0.7	-1.0
Loud music exposure frequency	0.9	0.9	3.8	-1.1	-0.6	0.3	0.6	-0.7	-0.6	1.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	1.5	0.7	1.2	-0.4	-0.7	1.2	0.5	-0.9
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.5	0.2	1.2	-0.1	0.7	0.1	0.3	0.6
Blood clot in the leg (DVT)	1.6	2.0	5.3	-0.6	-2.3	0.3	0.7	-2.2	-1.7	0.0
Medication: Paracetamol	0.4	0.6	1.4	0.7	1.2	-0.2	-1.0	-0.1	0.7	-0.9
Headache pain in last month	0.2	0.3	1.0	-0.2	-0.6	1.0	-0.3	-0.1	0.4	0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.9	0.0	1.7	-0.1	-0.2	-0.0	1.4	-0.1
Glaucoma (self-reported)	1.8	2.1	7.4	0.1	-1.8	-0.3	0.0	-1.7	-2.7	-1.1
Gout (self-reported)	0.8	1.0	1.9	0.4	0.9	-1.1	-0.9	1.4	1.1	-1.1
Hypothyroidism/myxoedema (self-reported)	1.0	2.0	5.5	-2.3	-0.9	0.3	1.2	-0.7	0.3	2.4
Medication: Amlodipine	0.3	0.4	1.7	-1.3	-0.2	0.0	0.2	-0.3	-0.3	0.7
Medication: Ventolin 100micrograms inhaler	1.8	2.4	6.7	2.1	-0.2	-0.8	-0.4	-0.7	-2.0	-2.6
Birth weight	0.4	0.9	2.2	1.5	0.3	-1.2	-0.8	-0.4	-1.2	-0.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.0	0.7	-0.0	-1.3	-1.4	-0.3	-0.0	-0.4
High blood pressure (siblings)	1.0	1.4	2.7	-1.1	0.5	0.9	1.6	0.5	1.4	1.6
Forced vital capacity (FVC), Best measure	0.9	3.3	8.3	2.9	1.1	-0.8	-2.2	1.8	0.1	-2.2
Body fat percentage	0.2	0.7	2.0	0.1	1.0	-1.1	-0.8	0.3	1.4	-0.1
Leg fat percentage (right)	0.2	0.8	2.5	-1.6	0.1	-0.7	0.2	-0.8	1.1	1.0
Arm fat-free mass (right)	0.3	1.6	3.3	1.6	-1.1	-1.0	-1.8	-1.3	-1.1	-0.3
Exposure to tobacco smoke outside home	2.0	2.7	5.8	-2.1	0.9	0.9	0.6	0.9	2.4	2.4
Comparative body size at age 10	0.6	1.6	4.8	-1.5	-0.5	-0.3	1.5	-1.2	-0.7	2.2
Number of full brothers	1.5	1.9	3.8	-1.9	0.2	1.4	1.1	0.7	1.8	1.5
Worry too long after embarrassment	1.0	1.8	4.3	1.6	-0.0	-1.0	-1.9	0.1	-0.9	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.6	-0.7	0.7	1.0	1.9	0.1	0.4	1.1
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	-1.0	-0.6	-0.5	0.0	-0.7	-0.1	0.8
Number of children fathered	0.4	0.5	2.6	-0.5	-0.2	-0.1	0.6	-0.2	-0.2	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	0.6	0.9	-0.4	0.8	0.1	-0.5	-0.1
Age at first live birth	2.3	4.0	11.5	2.8	-0.4	-1.7	-2.2	0.4	-0.6	-3.4
Pulse wave peak to peak time	0.8	0.9	2.7	0.5	1.5	-0.1	0.3	1.1	1.6	-0.5
Health satisfaction	0.1	0.2	0.6	0.1	-0.8	-0.1	-0.3	0.5	0.1	-0.3
Shortness of breath walking on level ground	1.6	1.9	6.9	-2.6	0.3	0.6	1.1	0.2	1.5	1.5
Qualifications: College or University degree	0.2	0.6	1.1	1.0	-0.2	0.9	1.0	0.3	-0.9	0.3
Eye problems/disorders: None of the above	0.1	0.1	0.3	-0.5	0.1	0.2	0.5	-0.2	0.1	0.0
Mouth/teeth dental problems: Loose teeth	0.8	0.9	2.6	0.6	1.6	-0.0	0.5	1.4	1.0	0.2
Emphysema/chronic bronchitis	0.8	0.9	1.5	-0.8	0.8	1.2	1.2	0.9	1.2	0.0
Medication for pain relief, constipation, heartburn	0.4	0.7	2.2	0.4	-1.5	-0.9	-0.5	-1.0	-0.8	-0.1
Neck or shoulder pain in last month	0.2	0.2	1.1	-0.2	0.1	-0.0	-1.0	0.4	0.5	-0.2
Medication: Blood pressure	0.3	0.5	1.4	-0.2	-1.2	0.6	0.2	0.6	-1.0	0.7
Angina (self-reported)	3.5	4.6	10.8	-1.9	-3.3	-1.9	-0.3	-3.2	-2.0	0.4
Migraine (self-reported)	0.3	0.4	1.0	0.1	0.9	0.6	0.5	0.3	1.0	0.2
Medication: Ibuprofen	1.0	1.2	2.4	0.7	1.5	0.6	-1.1	1.4	1.4	-0.2
Medication: Allopurinol	0.5	0.7	2.3	0.4	0.7	-1.5	-0.4	0.7	0.9	-0.5
Medication: Omeprazole	0.4	0.5	1.3	-0.2	0.9	0.3	-0.4	1.0	1.1	-0.5
Medication: Seretide 50 evohaler	1.1	1.2	2.6	0.8	1.6	-0.7	-0.4	1.5	1.2	-1.1
Mean time to correctly identify matches	0.7	1.4	3.1	-0.3	-1.8	-1.1	-0.9	-1.7	-1.0	-0.9
Heart disease (mother)	0.7	0.9	3.0	-1.3	-0.4	0.9	0.1	0.3	1.7	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.8	0.7	-0.3	-0.7	-1.3	0.1	-0.6	-1.1
Whole body fat mass	0.2	0.9	2.3	0.5	0.6	-1.3	-1.5	0.0	1.3	-0.1
Leg fat mass (right)	0.1	0.6	1.2	-0.5	-0.2	-1.1	-0.8	-0.9	0.6	0.7
Arm predicted mass (right)	0.4	1.8	4.3	1.7	-1.0	-1.2	-2.1	-1.3	-1.1	-0.3
Pulse rate, automated reading	0.2	0.7	1.8	-0.6	1.0	0.8	0.6	0.4	1.4	0.5
Alcohol intake frequency.	0.8	1.9	4.4	-2.1	-1.7	-1.3	0.3	-1.8	0.4	0.7
Comparative height size at age 10	0.3	1.7	4.8	2.2	1.7	0.4	-1.2	1.0	1.0	-1.0
Number of full sisters	1.5	1.8	8.1	-2.8	-0.1	0.4	1.5	-0.4	0.1	1.3
Suffer from ‘nerves’	1.4	2.1	5.3	1.3	0.3	-1.2	-2.3	1.7	1.4	-1.2
Overall health rating	0.1	0.3	0.9	-0.8	-0.0	-0.2	-0.3	0.4	0.9	0.1
Chest pain or discomfort	0.3	0.4	1.3	-1.0	-0.5	0.1	0.2	0.4	1.1	0.6
Had major operations	1.0	1.2	3.3	0.4	-1.4	0.8	0.9	-1.1	-1.8	0.3
Age at last live birth	1.4	2.0	5.0	1.3	-1.2	-1.5	-1.2	-0.6	-1.2	-2.2
Family relationship satisfaction	1.2	1.4	2.6	-1.1	-0.6	1.4	1.6	-0.8	-1.3	1.4
Leg pain on walking	1.2	1.5	4.0	2.0	0.6	-0.9	-1.0	0.6	-0.8	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.9	-1.3	0.2	1.4	0.7	-0.2	1.0	0.7
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.7	-1.0	0.1	1.2	0.9	0.6	1.3	0.2
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	6.6	0.1	1.3	0.7	-0.3	2.5	2.6	-0.9
Medication: Aspirin	2.3	3.0	8.2	-2.9	-0.5	1.7	2.0	-0.1	0.3	2.3
Supplements: Vitamin C	1.2	1.4	6.0	2.4	1.2	-0.1	-0.5	1.0	-0.0	-1.1
Knee pain experienced in last month	0.1	0.2	0.7	0.6	0.2	-0.8	0.0	-0.4	-0.5	-0.2
Hypertension (Self-reported)	0.5	1.3	3.8	-0.4	-0.2	1.6	1.9	0.8	-0.3	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.1	3.7	0.5	0.1	-1.8	-0.8	0.3	0.2	-1.9
Illnesses of father: Heart disease	0.6	0.8	1.5	0.5	-1.2	-1.2	-0.2	-0.6	-1.0	-1.0
Illnesses of siblings: Diabetes	2.3	2.8	6.3	-1.2	1.4	1.8	-0.2	1.9	2.5	1.8
Smoking status: Previous	0.2	0.3	0.7	-0.1	0.6	0.4	0.1	0.8	0.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	2.4	4.9	12.3	3.5	1.5	-1.5	-3.2	1.2	-0.5	-2.3
Whole body fat-free mass	0.4	2.1	5.7	1.7	-1.0	-1.5	-2.4	-1.1	-1.0	-0.5
Leg fat-free mass (right)	0.5	2.8	8.2	2.3	-0.5	-2.0	-2.9	-0.6	-0.8	-0.9
Arm fat percentage (left)	0.0	0.2	0.4	-0.3	0.3	-0.5	-0.2	-0.2	0.7	0.3
Average weekly red wine intake	1.4	2.1	6.1	1.7	0.6	-1.5	-2.5	0.7	0.2	-1.5
Handedness (chirality/laterality): Left-handed	0.6	0.7	2.4	-1.3	-0.8	-0.3	-0.3	-0.2	0.2	1.6
Mood swings	1.2	2.1	4.6	0.9	2.2	-0.1	-1.1	2.0	2.1	0.1
Loneliness, isolation	0.1	0.1	0.2	0.0	-0.0	-0.4	0.3	-0.4	-0.3	-0.1
Long-standing illness, disability or infirmity	1.4	2.2	5.2	-2.3	-1.2	0.1	1.4	-1.4	-0.4	2.1
Ever had bowel cancer screening	0.5	0.6	1.9	0.0	0.9	-0.3	-0.5	0.9	1.4	-0.2
Diabetes diagnosed by doctor	0.6	0.9	2.1	1.5	-0.9	-0.7	-1.3	0.3	-1.0	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	6.9	-0.3	-0.8	-1.3	-2.6	0.3	0.4	-1.0
Friendships satisfaction	0.3	0.4	1.1	-0.3	-1.0	-0.2	0.6	-0.3	-0.8	0.7
Qualifications: nursing, teaching	0.7	1.0	3.5	0.5	1.9	0.3	1.1	1.3	0.7	0.4
Commuting to job workplace: Walk	0.6	0.6	1.7	1.1	0.4	-1.3	-0.3	-0.4	-1.1	-0.2
Eye problems/disorders: Cataract	0.2	0.2	0.6	-0.1	-0.8	-0.5	-0.6	0.3	0.5	0.1
Mouth/teeth dental problems: Mouth ulcers	2.0	3.2	9.2	1.1	0.7	-2.7	-3.0	1.2	0.3	-1.7
Medication for cholesterol	0.2	0.4	1.0	0.2	-0.5	-0.3	-1.0	0.5	0.5	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	1.8	-1.0	0.3	1.2	1.3	0.1	0.7	1.4
Back pain experienced in last month	0.5	0.7	2.4	0.5	1.5	0.7	-0.2	0.9	1.1	0.4
Mineral and other dietary supplements	0.3	0.4	1.5	-1.2	-0.5	-0.0	-0.7	-0.7	0.2	0.7
Breast cancer (self-reported)	0.1	0.1	0.5	-0.0	-0.1	0.7	0.3	0.3	0.1	-0.6
Asthma (self-reported)	0.5	0.9	2.4	0.3	1.6	0.9	0.0	1.1	1.3	-0.7
Osteoporosis (self-reported)	0.8	1.0	2.4	1.1	0.4	1.3	0.8	1.6	0.6	-0.8
Osteoarthritis (self-reported)	0.2	0.3	0.7	0.6	0.8	-0.4	0.2	0.6	0.4	0.6
Medication: Aspirin	2.2	2.8	7.2	-2.7	-0.2	1.4	2.1	-0.4	0.2	2.4
Medication: Gliclazide	0.7	0.8	2.0	1.2	0.6	0.1	-0.1	1.2	0.3	-1.4
Illnesses of father: None of the above (group 1)	0.5	0.6	1.7	-0.7	-0.1	0.9	-0.8	0.0	1.3	0.4
Smoking status: Current	0.4	0.7	1.9	-1.0	-0.7	-1.0	-0.2	-1.4	-0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.7	0.6	0.9	-0.5	0.1	0.7	0.0	-0.3
Whole body water mass	0.3	1.9	5.5	1.6	-0.9	-1.4	-2.3	-1.0	-0.9	-0.4
Leg predicted mass (right)	0.5	2.8	8.4	2.4	-0.5	-2.0	-2.9	-0.4	-0.7	-0.9
Arm fat mass (left)	0.1	0.3	0.6	-0.1	-0.2	-0.7	-0.6	-0.7	0.3	0.6
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	-0.1	-0.5	0.3	0.4	0.4	0.3	-0.2
Average weekly champagne plus white wine intake	0.3	0.4	1.2	0.3	-0.5	-0.4	0.1	-0.7	-1.1	0.8
Miserableness	0.2	0.3	0.7	0.5	0.5	-0.1	0.8	0.1	-0.7	0.4
Guilty feelings	2.0	3.0	12.2	0.9	-0.6	-2.4	-3.5	-0.1	0.5	-1.3
Wears glasses or contact lenses	0.7	0.8	2.6	-0.0	0.1	1.5	1.6	0.6	0.2	0.4
Ever taken oral contraceptive pill	2.1	2.4	6.1	2.0	1.1	-0.4	-1.4	1.7	-0.1	-2.5
Hearing aid user	0.1	0.1	0.3	-0.3	-0.1	0.0	0.5	-0.3	0.0	0.6
Mother’s age at death	0.5	0.6	2.0	0.7	-0.8	-0.8	-1.4	-0.4	0.5	-0.7
Financial situation satisfaction	0.1	0.1	0.3	-0.6	0.2	0.3	-0.3	0.1	-0.1	-0.5
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.7	0.1	0.0	-0.6	-0.2	0.0	-0.8	-0.3
Commuting to job workplace: Public transport	1.5	1.8	4.0	2.0	1.2	-1.5	-1.3	0.3	-0.8	-1.7
Eye problems/disorders: Glaucoma	0.9	1.1	4.1	-0.4	-1.0	-0.0	0.4	-1.3	-2.0	-0.6
Medication: Blood pressure	0.4	0.8	1.9	-1.4	0.6	0.1	1.2	-0.4	0.6	1.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.8	-0.8	-0.1	0.3	-0.4	0.4	1.3	0.9
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.6	0.9	0.5	-0.1	0.3	0.8	0.1	-1.3
High cholesterol (Self-reported)	0.3	0.6	1.4	-0.6	-1.1	1.2	0.8	-0.5	-0.1	0.6
Medication: Bendroflumethiazide	0.6	0.8	2.2	-0.7	1.5	-0.9	1.5	0.4	0.3	-0.2
Medication: Paracetamol	0.3	0.5	1.1	0.7	0.6	0.1	-1.0	-0.2	0.5	-1.0
Medication: Lisinopril	0.1	0.2	0.5	0.7	-0.2	0.1	0.5	0.2	-0.5	0.1
Medication: Atorvastatin	1.1	1.4	4.8	1.0	-0.1	-0.9	-1.6	0.5	0.3	-2.2
Illnesses of father: High blood pressure	1.1	1.3	2.3	0.1	1.1	1.5	1.5	1.3	0.7	1.1
Alcohol drinker status: Never	1.6	1.9	5.8	-1.4	0.8	-0.3	1.0	0.6	2.4	1.9
Ever smoked	0.5	0.9	2.1	-0.1	1.1	0.1	-0.5	0.9	1.4	-1.3
Basal metabolic rate	0.4	2.0	6.0	1.7	-0.8	-1.7	-2.4	-1.0	-0.8	-0.4
Leg fat percentage (left)	0.2	0.7	1.7	-0.9	0.5	-1.0	-0.3	-0.5	1.3	0.8
Arm fat-free mass (left)	0.3	1.8	4.7	1.5	-1.1	-1.4	-2.2	-1.1	-1.0	-0.1
Number of operations (self-reported)	1.0	1.5	4.9	0.5	-0.9	-0.9	-0.1	-1.6	-2.2	0.9
Average weekly beer plus cider intake	1.0	1.4	3.0	1.3	1.7	-0.4	-0.6	1.5	1.4	-0.6
Irritability	0.7	1.1	4.9	0.3	0.7	-0.3	-0.9	0.9	2.2	0.8
Risk taking	0.6	0.8	3.9	-0.7	-0.1	-0.1	0.8	-0.8	-0.5	2.0
Ever had prostate specific antigen (PSA) test	1.1	1.3	4.5	0.4	2.1	0.9	1.4	1.0	0.5	0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.2	0.5	0.6	0.3	0.5	0.1	-0.3
Age started oral contraceptive pill	0.2	0.3	0.8	0.4	0.2	-0.4	-0.9	0.2	0.4	-0.6
Diastolic blood pressure, automated reading	0.4	1.4	4.2	0.3	0.3	2.0	1.9	-0.8	-0.9	0.7
Ever depressed for a whole week	1.1	1.3	3.1	-0.8	-1.5	-1.3	-0.6	-1.8	-0.8	0.5
Unable to work because of sickness or disability	2.6	3.3	9.1	-2.7	0.3	1.0	1.3	0.5	2.0	3.0
Commuting to job workplace: Cycle	0.6	0.8	3.0	-0.6	-1.0	0.2	0.4	-0.8	-1.7	0.5
Myopia	0.2	0.3	1.3	-0.2	0.6	0.4	1.1	0.2	-0.5	0.0
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.5	1.2	1.1	-0.8	-1.6	0.1	0.4	-1.5
Cholesterol lowering medication	0.8	1.2	3.0	-0.3	-1.7	-0.5	-0.5	-1.7	-1.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	-0.8	0.8	0.8	-0.2	0.9	1.1	0.5
Pain experienced in last month	0.4	0.7	1.8	-1.4	-1.0	-0.2	0.6	-1.1	-0.6	0.2
Supplements: Calcium	1.3	1.4	4.0	0.7	1.0	1.2	-0.3	2.0	1.5	-0.7
Basal cell carcinoma (self-reported)	1.1	1.3	2.4	0.6	1.2	-1.2	-1.5	0.9	1.1	-1.3
Heart attack/myocardial infarction (self-reported)	1.1	1.4	3.1	-1.8	-1.7	1.1	1.2	-0.6	0.2	0.6
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	4.6	-0.4	-2.1	0.3	0.7	-1.9	-1.7	0.0
Heart disease (siblings)	1.0	1.3	3.4	-0.7	1.2	-0.3	0.7	1.7	1.9	0.2
Alcohol drinker status: Previous	0.8	0.9	1.7	-1.2	0.7	0.5	1.0	0.3	1.3	1.3
Pack years of smoking	0.4	0.5	1.0	-1.0	-0.7	-0.9	0.0	-0.7	0.8	0.6
Impedance of whole body	0.8	4.3	11.6	0.8	3.4	0.8	0.1	2.8	2.8	-1.3
Leg fat mass (left)	0.1	0.6	1.5	-0.1	0.0	-1.2	-1.1	-0.7	0.7	0.6
Arm predicted mass (left)	0.2	1.1	3.4	1.1	-0.9	-1.1	-1.9	-1.0	-0.7	0.1