Best TWAS P=4.97e-34 · Best GWAS P=3.18e-43 conditioned to 8.42e-30
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MCAT | 0.16 | 0.09 | bslmm | 552 | 0.09 | 3.9e-11 | -7.8 | 7.9 | 2.9e-15 | -0.21 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adrenal Gland | TSPO | 0.38 | 0.11 | lasso | 7 | 0.17 | 1.3e-06 | 6.0 | -6.1 | 1.2e-09 | 0.18 | 0.88 | 0.01 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | TTLL12 | 0.34 | 0.06 | enet | 21 | 0.10 | 1.6e-03 | 5.9 | 5.3 | 1.4e-07 | -0.41 | 0.07 | 0.25 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | TTLL12 | 0.29 | -0.01 | lasso | 7 | 0.02 | 8.3e-02 | -10.8 | 9.1 | 6.6e-20 | -0.41 | 0.08 | 0.07 | FALSE |
| 5 | GTEx | Nerve Tibial | TSPO | 0.33 | 0.26 | lasso | 6 | 0.28 | 8.4e-20 | -4.9 | -5.2 | 2.4e-07 | 0.05 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Testis | TTLL12 | 0.38 | 0.20 | enet | 31 | 0.28 | 6.3e-13 | -4.3 | 5.4 | 8.5e-08 | -0.10 | 1.00 | 0.00 | FALSE |
| 7 | YFS | Blood | TSPO | 0.22 | 0.08 | bslmm | 550 | 0.11 | 2.5e-34 | 6.3 | 6.5 | 8.8e-11 | -0.30 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | MCAT | 0.06 | 0.05 | lasso | 2 | 0.05 | 2.3e-05 | -7.6 | 5.6 | 1.9e-08 | -0.09 | 0.59 | 0.03 | FALSE |
| 9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MCAT | 0.02 | 0.02 | lasso | 2 | 0.02 | 7.6e-05 | -7.8 | 7.8 | 5.0e-15 | -0.11 | 0.35 | 0.02 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | BIK | 0.05 | 0.02 | blup | 72 | 0.05 | 4.2e-06 | -7.6 | -6.3 | 2.7e-10 | 0.20 | 0.33 | 0.02 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TTLL1 | 0.05 | 0.00 | blup | 75 | 0.01 | 1.7e-02 | -2.1 | -8.2 | 2.9e-16 | 0.44 | 0.01 | 0.07 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | MCAT | 0.15 | 0.09 | lasso | 2 | 0.11 | 6.6e-07 | -11.9 | 11.4 | 5.3e-30 | -0.16 | 0.92 | 0.00 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | BIK | 0.05 | 0.01 | lasso | 2 | 0.01 | 4.9e-02 | -7.8 | -7.7 | 1.3e-14 | 0.10 | 0.03 | 0.09 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MCAT | 0.12 | 0.09 | blup | 65 | 0.09 | 1.8e-10 | -7.6 | 8.2 | 3.8e-16 | -0.21 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TTLL12 | 0.07 | 0.02 | blup | 83 | 0.05 | 9.9e-06 | -4.3 | 6.4 | 1.9e-10 | -0.06 | 0.15 | 0.43 | FALSE |
| 16 | The Cancer Genome Atlas | Thyroid Carcinoma | BIK | 0.11 | 0.07 | lasso | 5 | 0.08 | 2.8e-08 | -12.0 | 12.2 | 5.0e-34 | -0.22 | 0.99 | 0.00 | TRUE |