Hub : Genes

TTLL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1280	0.0330	5.0e-07	0.085	0.051	0.093	0.082	0.116	1.8e-10	8.2e-07	2.2e-11	3.5e-10	5.3e-14
2	GTEx	Brain Cortex	0.2320	0.0940	7.2e-03	0.285	NA	0.193	NA	0.241	1.6e-08	NA	5.2e-06	NA	2.6e-07
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0509	0.0240	2.8e-03	-0.002	0.011	0.006	NA	-0.002	9.1e-01	1.7e-02	6.5e-02	NA	6.0e-01
4	TCGA	Brain Lower Grade Glioma	0.1190	0.0392	1.4e-09	0.108	0.091	0.105	NA	0.117	3.3e-12	1.6e-10	6.0e-12	NA	3.6e-13
5	TCGA	Thyroid Carcinoma	0.0500	0.0240	6.2e-03	0.038	0.011	0.015	NA	0.028	1.3e-04	2.9e-02	1.3e-02	NA	8.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.7	2.6	4.9	1.7	-1.2	-1.8	-0.7	2.2
Bipolar Disorder or Schizophrenia	3.2	7.7	18.1	4.3	-3.6	-1.9	-1.7	0.8
Depressed Affect (Nagel 2018)	0.4	0.9	2.5	-0.1	0.5	0.9	1.0	1.6
Depression (Nagel 2018)	0.2	0.2	0.9	-0.2	0.4	-0.0	0.9	0.3
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.9	1.4	-0.2	1.1	1.1	0.8
Neuroticism (Nagel 2018)	1.1	2.6	4.6	-0.7	1.4	1.6	2.1	1.9
Schizophrenia (2018)	3.3	7.0	17.0	4.1	-3.7	-1.0	-1.6	-0.7
Schizophrenia vs Biploar Disorder	0.9	1.2	2.9	-0.4	1.1	1.3	1.7	-0.3
Worry (Nagel 2018)	0.8	1.7	4.1	0.1	0.9	1.0	1.6	2.0
Alzheimer’s Disease (in mother)	1.2	1.4	3.3	-1.5	0.3	-0.5	-1.1	-1.8
Alzheimer’s Disease (in father)	0.9	0.9	2.4	-0.3	0.6	1.2	1.5	-0.6
Alzheimer’s Disease (including proxy)	0.7	1.0	4.0	-0.9	0.1	-0.0	-0.4	-2.0
Crohns Disease (2017)	0.2	0.5	0.9	-0.8	0.9	0.3	0.4	0.8
Irritable Bowel Disease (IBD)	0.3	0.8	1.8	-0.6	0.7	-1.1	0.2	1.4
Ulcerative Colitis (UC)	0.4	0.8	2.0	-0.5	0.4	-1.4	-0.2	1.3
Major Depression (MDD)	0.1	0.1	0.2	0.1	0.4	0.3	0.4	0.2
Reaction Time	0.4	0.8	1.9	0.4	-0.9	1.2	-0.1	-1.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.1	1.1	-0.2	0.6	-0.0	-0.3
Breast Cancer	2.5	6.1	13.2	-2.6	3.2	-3.6	0.2	-0.4
Ovarian Cancer	2.5	3.3	8.3	-1.8	2.9	-0.1	1.7	1.5
Prostate Cancer	12.9	18.2	66.9	1.6	-2.1	-8.2	-3.8	-1.6
Age at First Birth	0.7	1.0	2.5	1.5	-1.6	0.3	-0.4	0.2
Bipolar Disorder (2011)	3.7	3.5	7.5	1.8	-2.2	-1.2	-2.7	0.7
Body Mass Index (BMI) (2010)	0.0	0.1	0.1	0.2	-0.2	-0.3	0.0	-0.3
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.1	0.5	-0.4	0.5	0.2
Crohns Disease (2012)	0.3	0.4	1.6	1.3	-0.7	-0.2	-0.0	0.1
Mean Putamen Volume	0.1	0.1	0.2	0.4	-0.2	0.5	0.3	-0.1
Fasting Glucose	0.2	0.3	0.6	-0.4	0.4	0.7	0.8	0.4
HbA1C	1.2	1.3	2.7	1.6	-1.4	0.6	0.6	1.0
HDL Cholesterol	1.7	2.8	5.4	-1.0	1.9	1.2	2.3	1.5
LDL Cholesterol	0.5	0.8	1.2	-0.7	0.9	-1.0	-1.1	-0.7
Lupus	1.9	2.8	7.1	0.2	-1.5	-1.4	-2.7	-1.7
Neuroticism (2016)	0.9	1.3	2.4	0.1	0.5	1.3	1.6	1.5
Primary Biliary Cirrhosis	0.1	0.1	0.6	-0.0	0.2	-0.8	-0.1	0.3
Rheumatoid Arthritis	0.2	0.3	1.0	-0.5	1.0	0.2	0.6	0.1
Schizophrenia (2014)	2.9	6.5	17.4	4.2	-3.4	-1.3	-0.9	-0.8
Triglycerides	1.0	1.6	4.3	0.2	-1.2	-0.6	-2.1	-1.3
Type 2 Diabetes (T2D) (2012)	1.0	1.2	4.1	-0.0	-0.5	-2.0	-1.3	-0.1
Ulcerative Colitis	0.7	1.1	3.9	0.6	-0.6	-2.0	-0.8	0.1
Blood Eosinophil Count	0.1	0.7	1.6	-1.3	1.1	0.2	0.0	-0.8
Blood Platelet Count	5.6	65.3	110.2	-10.5	10.1	7.6	7.1	2.5
Blood Red Count	0.5	5.3	13.8	3.7	-2.9	-1.4	-1.4	0.5
Blood White Count	0.6	4.5	17.6	1.2	-0.7	-4.2	-1.6	-0.4
Heel T-Score	0.3	2.4	8.2	0.5	-0.1	2.9	1.8	0.8
BMI	0.3	1.8	2.5	1.3	-1.6	-1.6	-0.5	1.5
Height	0.5	9.7	18.8	-1.3	1.8	4.3	4.3	2.5
Waist Hip Ratio (WHR)	0.7	3.1	6.8	0.6	-0.9	-2.2	-2.6	-1.5
Systolic Blood Pressure	0.6	2.9	6.5	2.2	-2.6	0.4	-1.6	-0.6
Smoking Status	1.0	2.5	5.4	-2.3	2.1	-1.2	0.6	0.9
Allergy or Eczema	0.1	0.2	0.4	-0.6	0.1	0.6	0.4	-0.3
Cardiovascular Disease	1.3	4.3	7.7	2.8	-2.7	-1.5	-1.9	-0.9
Hypothyroidism (self reported)	0.1	0.2	0.4	0.6	-0.6	-0.4	0.0	-0.1
Respiratory disease	0.4	0.8	2.7	-0.7	1.0	0.1	1.6	0.3
Type 2 Diabetes (T2D) (2018)	0.7	1.4	3.2	1.8	-1.1	-1.5	-0.2	0.3
Lung FEV1/FVC ratio	0.8	4.0	7.1	2.7	-2.6	0.3	-2.4	0.4
Lung FVC	0.1	0.4	0.7	-0.8	0.5	0.9	0.3	-0.4
Neuroticism	0.7	1.6	2.9	-0.7	1.4	0.9	1.7	1.4
Chronotype (morning person)	0.3	0.7	1.4	0.9	-0.5	-0.9	-1.2	-0.1
Hair Pigment	0.0	0.4	0.8	-0.6	0.4	0.9	0.7	0.0
Tanning	0.0	0.2	0.7	-0.1	-0.0	-0.5	-0.3	-0.8
Hand grip strength (left)	0.2	0.6	2.4	0.1	0.2	1.5	0.4	0.5
Number of treatments/medications taken	0.1	0.2	0.3	0.5	-0.1	-0.3	0.4	0.5
Average weekly spirits intake	0.4	0.5	1.1	1.0	-0.9	0.1	-0.7	-0.4
Sensitivity / hurt feelings	0.5	0.8	1.5	-1.1	1.2	0.2	1.0	0.2
Frequency of depressed mood in last 2 weeks	1.0	1.4	1.8	-1.3	1.3	0.6	1.4	1.2
Hearing difficulty/problems: Yes	1.4	2.1	4.3	-1.8	2.1	0.4	1.4	-0.9
Relative age of first facial hair	1.1	2.3	4.9	-2.2	1.8	-0.4	-0.8	-1.6
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	3.3	0.2	0.9	1.8	1.8	1.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.6	-0.2	0.1	0.5	1.0	1.6
Ever had hysterectomy (womb removed)	0.4	0.5	0.7	0.8	-0.7	0.7	0.2	0.8
Systolic blood pressure, automated reading	0.9	2.5	4.0	1.9	-2.0	1.7	-1.0	1.0
Eye problems/disorders: Diabetes related eye disease	1.2	1.3	2.4	1.3	-1.5	0.3	-0.5	1.5
Angina	0.7	1.0	2.7	-1.6	0.9	0.6	0.0	-1.0
Medication for hormone replacement therapy	0.4	0.4	1.6	0.1	-0.2	1.2	0.7	0.1
Vitamin and mineral supplements	0.8	1.1	4.3	0.8	-0.0	-0.5	0.3	2.1
Supplements: Zinc	0.3	0.3	0.5	0.5	-0.7	0.7	-0.3	0.6
Medication: Co-codamol	0.1	0.2	0.3	0.5	-0.4	-0.2	-0.5	0.4
Medication: Metformin	0.2	0.2	0.6	0.8	-0.2	-0.4	0.4	0.3
Diabetes (father)	0.8	1.0	2.0	-0.0	0.9	-0.3	1.4	1.4
Diabetes (mother)	0.3	0.4	1.0	1.0	-0.5	-0.1	0.4	-0.6
Severe depression (siblings)	0.5	0.6	0.9	-0.9	0.8	-0.9	-0.7	-0.3
Pack years adult smoking proportion	0.3	0.5	1.5	-0.7	0.3	-0.7	-1.2	-0.3
Impedance of leg (right)	0.3	1.3	2.7	-1.6	1.6	0.9	0.0	0.6
Leg fat-free mass (left)	0.1	0.5	1.7	0.3	-0.4	-0.0	1.3	0.7
Trunk fat percentage	0.4	1.7	5.1	-0.5	0.8	-0.6	1.4	2.3
Hand grip strength (right)	0.1	0.2	0.8	-0.2	0.2	0.5	-0.1	0.9
Townsend deprivation index at recruitment	0.3	0.4	0.8	-0.9	0.8	0.3	0.6	0.1
Current tobacco smoking	0.9	1.4	3.9	-0.8	1.4	-2.0	0.5	0.6
Average weekly fortified wine intake	0.1	0.2	0.6	0.0	-0.2	0.2	-0.8	0.3
Maternal smoking around birth	1.0	1.5	4.9	-0.3	-0.4	1.5	0.0	2.2
Fed-up feelings	1.2	2.2	4.4	-0.9	1.4	1.0	1.6	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.7	-0.3	0.7	0.2	1.3	0.4
Relative age voice broke	0.9	1.4	3.5	-1.3	0.2	0.8	-1.9	-1.0
Taking other prescription medications	0.6	0.9	3.9	-0.2	0.6	-2.0	0.3	0.3
Age when periods started (menarche)	1.7	4.1	10.1	-3.2	2.9	0.7	0.9	0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.3	-0.2	-0.0	0.4	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.0	-1.0	0.6	0.4	0.4	-0.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.4	0.4	-0.2	0.5	0.6	0.7
Qualifications: CSEs or equivalent	0.8	1.0	2.0	-0.8	0.8	-1.3	-0.6	-1.4
Serious illness, injury or assault to yourself	1.7	2.0	5.2	2.3	-2.1	0.2	-0.2	0.7
High blood pressure	1.8	5.0	10.3	2.9	-3.2	-1.0	-2.3	-0.5
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.7	-0.5	0.2	-0.3	0.6	-0.8
Multivitamins +/- minerals	0.7	0.8	2.7	-0.9	-0.1	-0.1	-0.8	-1.7
Stomach or abdominal pain in last month	1.3	1.6	5.1	-0.1	1.1	-0.5	1.2	2.3
Supplements: Glucosamine	1.0	1.2	3.4	0.3	-0.8	1.4	0.0	1.8
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	-1.1	1.2	-0.3	0.7	-0.1
Medication: Atenolol	1.1	1.3	3.7	0.3	-0.6	-0.9	-1.4	-1.9
Medication: Levothyroxine sodium	0.6	0.9	1.8	1.2	-1.3	-0.5	-1.1	0.2
Sitting height	0.2	1.3	2.6	-1.6	1.0	1.0	1.3	0.1
Chronic bronchitis/emphysema (father)	2.0	2.3	5.6	-0.2	0.0	-2.4	-1.4	-2.0
High blood pressure (mother)	0.8	1.2	2.9	1.7	-1.3	-0.8	-0.6	0.5
Body mass index (BMI)	0.2	1.0	2.5	0.9	-0.6	-1.0	0.6	1.6
Impedance of leg (left)	0.4	1.9	3.8	-1.9	1.9	1.2	0.4	0.6
Leg predicted mass (left)	0.1	0.5	1.6	0.3	-0.5	0.0	1.3	0.7
Trunk fat mass	0.4	1.8	5.0	-0.3	0.7	-0.4	1.8	2.2
Waist circumference	0.2	0.8	1.4	1.2	-1.0	-0.8	-0.0	1.0
Number of incorrect matches in round	0.7	1.2	3.3	1.8	-1.4	-0.7	-0.1	0.3
Past tobacco smoking	0.1	0.2	0.5	0.7	-0.4	0.4	0.1	-0.7
Alcohol usually taken with meals	0.4	0.6	1.7	-1.3	0.3	0.9	-0.4	-0.6
Nervous feelings	0.1	0.2	0.8	0.4	-0.2	0.9	-0.1	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.2	-0.5	1.3	-1.5	0.9	0.4
Hearing difficulty/problems with background noise	2.3	3.7	8.6	-2.9	2.6	0.7	1.6	-0.3
Hair/balding pattern: Pattern 2	0.3	0.3	0.8	-0.4	-0.2	0.7	-0.4	0.9
Had menopause	1.2	1.5	3.0	1.2	-1.7	-0.4	-1.6	-0.7
Had other major operations	0.3	0.4	1.0	0.4	-0.8	-1.0	-0.4	-0.2
Forced vital capacity (FVC)	0.3	1.1	3.9	-0.5	0.3	2.0	1.0	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	4.8	-2.2	2.1	1.3	1.6	0.4
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	3.5	1.5	-1.9	-1.7	-1.4	-1.5
Qualifications: None of the above	0.4	0.8	3.0	0.4	-0.2	0.7	0.4	1.7
Financial difficulties in last 2 years	0.3	0.4	0.8	0.2	0.5	-0.4	0.9	0.8
Mouth/teeth dental problems	0.6	0.9	2.0	-1.4	1.0	0.6	0.8	-0.8
Heart attack	0.4	0.5	2.0	-0.5	0.0	0.1	-0.5	-1.4
Allergy	0.1	0.2	0.6	0.3	0.1	0.1	-0.7	0.7
Pain all over the body in last month	0.2	0.2	0.7	-0.3	0.4	0.8	0.3	-0.4
Diabetes (self-reported)	1.2	1.8	4.8	2.2	-1.6	-1.1	-0.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	-0.5	-0.1	-0.5	-0.1	-0.4
Medication: Ramipril	0.2	0.3	1.2	0.2	-0.4	0.0	-1.1	-0.3
Medication: Simvastatin	1.0	1.5	3.2	1.8	-1.4	-0.7	-1.3	0.6
Fluid intelligence score	0.1	0.2	0.4	0.7	0.2	0.4	-0.3	-0.1
Illnesses of siblings	0.3	0.4	0.9	0.5	-0.9	-0.1	-0.7	-0.5
Neuroticism score	0.3	0.6	1.2	-0.7	1.0	0.2	1.1	0.8
Weight	0.3	1.3	3.2	0.3	-0.0	0.1	1.8	1.7
Impedance of arm (right)	0.2	0.7	2.2	-1.5	0.9	-0.1	-0.8	-0.0
Arm fat percentage (right)	0.2	0.9	2.6	0.2	-0.3	-1.6	0.2	1.4
Trunk fat-free mass	0.1	0.8	1.7	0.9	-0.8	0.7	1.3	0.3
Hip circumference	0.2	0.9	2.0	0.9	-0.8	-0.3	0.9	1.4
Time employed in main current job	0.2	0.2	0.6	0.7	-0.8	0.3	-0.1	-0.1
Alcohol intake versus 10 years previously	1.0	1.5	3.4	-0.7	-0.4	-1.9	-1.8	-0.7
Father’s age at death	0.8	1.1	2.0	1.2	-1.4	0.6	-1.0	-0.6
Worrier / anxious feelings	0.1	0.1	0.4	0.4	0.1	0.1	0.6	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	1.8	-1.0	0.2	-1.3	-1.1	-1.3
Falls in the last year	0.0	0.1	0.2	0.5	-0.1	-0.2	0.1	0.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.6	-0.8	0.2	-0.6	-0.3
Number of live births	0.1	0.1	0.3	-0.6	-0.2	0.2	-0.3	-0.4
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	4.2	0.4	-0.3	2.1	0.5	0.4
Pulse rate	1.3	2.2	5.5	1.1	-1.2	1.7	-0.2	2.3
Happiness	1.4	1.6	3.5	0.3	0.3	1.5	1.5	1.9
Noisy workplace	1.3	1.6	4.4	-0.3	0.6	1.1	1.4	2.1
Qualifications: A levels/AS levels or equivalent	0.5	1.1	1.6	-1.3	1.2	0.9	1.0	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.8	-0.2	0.1	1.3	-0.4	-0.6
Mouth/teeth dental problems: Dentures	0.2	0.4	1.3	1.1	-0.5	-0.1	0.0	0.7
Asthma	0.2	0.3	0.9	0.0	0.1	0.8	1.0	0.4
Medication: Ibuprofen (e.g. Nurofen)	4.0	5.0	9.1	-1.5	1.5	3.0	2.3	2.5
Medication: Cholesterol lowering	0.2	0.3	0.5	0.6	-0.7	0.1	-0.7	0.5
Depression (self-reported)	0.9	1.1	3.6	0.4	-0.4	-1.9	-0.2	1.2
Medication: Lansoprazole	2.1	2.4	4.8	-1.9	2.2	0.1	1.8	0.8
Prospective memory result	1.3	1.7	2.9	1.7	-1.6	0.4	-0.2	1.6
Lung cancer (father)	0.6	0.7	1.7	0.1	1.0	-0.8	1.3	-0.1
Illnesses of mother	0.4	0.5	1.6	-1.3	0.9	0.4	0.3	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	6.3	0.0	-0.1	2.5	1.3	1.2
Pulse wave Arterial Stiffness index	0.8	0.9	1.4	1.2	-0.9	1.1	0.7	0.9
Impedance of arm (left)	0.2	0.8	2.2	-1.5	1.1	0.6	0.1	0.6
Arm fat mass (right)	0.2	0.9	2.5	0.4	-0.3	-1.1	0.9	1.6
Trunk predicted mass	0.1	0.8	1.8	0.9	-0.7	0.8	1.4	0.3
Standing height	0.3	3.5	7.8	-1.2	1.2	2.4	2.8	1.0
Length of working week for main job	0.3	0.3	0.8	-0.1	-0.6	-0.3	-0.9	-0.2
Exposure to tobacco smoke at home	0.8	0.9	1.8	-0.9	1.4	-0.3	0.7	1.2
Breastfed as a baby	0.8	1.0	2.2	0.4	-0.9	-0.2	-1.3	-1.5
Tense / ‘highly strung’	1.0	1.7	3.1	-1.5	1.8	0.5	0.9	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	4.0	0.2	-0.0	-2.0	-0.2	-0.5
Hair/balding pattern: Pattern 4	1.1	2.6	5.9	-1.9	2.4	-0.5	1.6	-0.7
Birth weight of first child	0.6	1.2	3.4	-0.2	0.3	1.9	1.1	1.0
Peak expiratory flow (PEF)	0.1	0.3	0.6	0.2	-0.1	0.8	0.5	-0.7
Pulse wave reflection index	0.6	0.8	3.0	-0.1	-0.1	-0.8	-0.4	-1.7
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.1	-0.2	0.2	-1.4	0.3	1.1
Loud music exposure frequency	1.7	1.8	4.4	-2.1	1.7	-1.4	0.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	-0.4	0.1	-0.2	-0.1	-0.6
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	1.9	1.2	-1.4	0.9	-1.3	0.8
Blood clot in the leg (DVT)	0.6	0.8	1.6	-0.5	0.6	-1.3	0.6	1.1
Medication: Paracetamol	1.1	1.9	4.1	-1.8	2.0	-0.3	1.4	0.6
Headache pain in last month	0.4	0.6	2.5	-0.4	0.1	-1.6	-0.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.6	2.8	-1.6	1.7	-0.7	1.4	-0.4
Glaucoma (self-reported)	1.5	1.8	4.5	0.5	-1.1	-1.7	-2.1	-0.6
Gout (self-reported)	2.2	3.1	4.3	-2.0	2.1	1.7	1.4	1.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	0.1	-0.3	-0.9	-0.3	-0.9
Medication: Amlodipine	1.9	2.7	4.6	1.8	-2.2	-0.2	-1.8	-1.6
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.1	-0.4	0.9	1.5	1.3	0.1
Birth weight	0.2	0.5	1.0	-0.4	0.8	-1.0	0.1	-0.7
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.5	-0.0	0.2	-1.2	0.1	-0.3
High blood pressure (siblings)	0.7	1.0	2.5	-1.5	1.6	-0.6	0.2	-0.0
Forced vital capacity (FVC), Best measure	0.6	2.2	6.8	-0.8	0.5	2.6	1.7	0.7
Body fat percentage	0.4	1.4	4.6	-0.4	0.6	-0.9	1.1	2.1
Leg fat percentage (right)	0.4	1.4	5.2	-0.2	0.5	-0.8	0.9	2.3
Arm fat-free mass (right)	0.2	1.2	3.5	0.7	-0.4	0.6	1.9	1.1
Exposure to tobacco smoke outside home	1.3	1.7	3.8	-0.5	-0.5	-1.7	-2.0	-1.2
Comparative body size at age 10	0.5	1.4	3.3	1.8	-1.3	-1.4	0.1	0.3
Number of full brothers	0.5	0.6	2.4	-1.6	0.2	0.1	-0.2	-0.5
Worry too long after embarrassment	0.6	1.1	2.9	-1.1	0.7	-0.3	0.8	-1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	4.7	0.4	-0.7	-2.2	-1.0	0.4
Wheeze or whistling in the chest in last year	0.3	0.5	0.8	-0.9	0.8	0.4	0.6	0.7
Number of children fathered	1.0	1.1	3.3	-0.4	1.3	-0.4	1.8	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.8	0.9	-0.8	0.1	-0.7	-0.2
Age at first live birth	0.3	0.6	1.6	0.6	-0.9	1.3	-0.4	-0.4
Pulse wave peak to peak time	0.6	0.7	1.2	-1.1	0.8	-0.8	-0.4	-0.8
Health satisfaction	0.8	1.1	2.3	1.5	-0.8	0.9	0.7	1.1
Shortness of breath walking on level ground	0.2	0.2	0.3	0.6	-0.1	0.1	0.6	0.5
Qualifications: College or University degree	0.3	0.8	3.1	0.2	-0.6	1.8	0.7	0.1
Eye problems/disorders: None of the above	0.5	0.6	1.7	-0.8	-0.4	1.3	-0.6	-0.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.2	1.5	-1.4	-0.1	-0.7	0.5
Emphysema/chronic bronchitis	3.1	3.5	11.2	-0.0	-0.1	-3.4	-1.3	-2.1
Medication for pain relief, constipation, heartburn	2.3	3.9	7.2	1.7	-2.4	-0.8	-2.7	-1.7
Neck or shoulder pain in last month	0.3	0.4	1.1	0.7	-0.6	-1.1	-0.3	0.3
Medication: Blood pressure	1.1	1.9	3.4	1.6	-1.9	0.7	-1.7	-0.1
Angina (self-reported)	0.7	0.9	2.3	-1.5	1.0	1.1	0.4	-0.2
Migraine (self-reported)	0.3	0.4	1.3	-0.5	-0.4	-1.1	-0.6	0.2
Medication: Ibuprofen	4.7	5.6	9.7	-1.8	1.7	3.1	2.4	2.6
Medication: Allopurinol	0.0	0.0	0.1	-0.1	0.1	-0.1	0.3	0.2
Medication: Omeprazole	0.8	0.9	2.8	1.0	-0.2	0.2	1.7	0.9
Medication: Seretide 50 evohaler	0.6	0.7	1.4	-1.2	0.3	-0.7	-0.9	-0.6
Mean time to correctly identify matches	1.1	2.2	4.0	1.7	-2.0	1.5	-0.5	-1.2
Heart disease (mother)	0.3	0.3	0.6	0.6	0.1	0.7	0.8	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.4	3.2	0.3	-1.1	-0.8	-1.3	-1.8
Whole body fat mass	0.4	1.5	4.5	-0.1	0.5	-0.6	1.6	2.1
Leg fat mass (right)	0.4	1.4	4.7	0.1	0.1	-0.7	1.3	2.2
Arm predicted mass (right)	0.3	1.4	4.2	0.9	-0.5	0.8	2.0	1.1
Pulse rate, automated reading	0.5	1.8	6.1	0.8	0.3	0.4	1.4	2.5
Alcohol intake frequency.	1.2	2.7	7.2	0.4	-0.8	-2.7	-2.2	-0.7
Comparative height size at age 10	0.1	0.6	0.9	0.9	-0.9	0.2	0.9	0.7
Number of full sisters	2.1	2.6	5.3	-1.2	1.5	2.3	1.5	1.3
Suffer from ‘nerves’	0.2	0.3	0.6	0.0	0.5	-0.2	0.7	0.8
Overall health rating	0.2	0.4	1.0	0.9	-0.4	-0.3	0.1	1.0
Chest pain or discomfort	0.7	1.0	2.3	-1.0	1.2	0.1	0.5	1.5
Had major operations	0.2	0.3	0.6	0.6	-0.8	-0.6	-0.3	0.4
Age at last live birth	0.8	1.1	4.0	-0.4	-0.3	-0.2	-1.1	-2.0
Family relationship satisfaction	0.5	0.7	1.2	-0.5	0.1	1.1	0.9	1.0
Leg pain on walking	1.0	1.3	4.3	0.2	0.9	0.1	1.1	2.1
Qualifications: NVQ or HND or HNC or equivalent	3.3	4.0	10.4	-1.6	0.9	-1.8	-1.8	-3.2
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	1.1	-0.4	0.9	0.5	0.4
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	2.0	-1.4	1.2	1.0	1.1	0.9
Medication: Aspirin	0.1	0.1	0.2	0.1	0.3	-0.4	0.3	-0.5
Supplements: Vitamin C	1.1	1.3	3.7	-0.3	0.6	1.1	1.9	0.9
Knee pain experienced in last month	0.1	0.1	0.3	0.3	-0.1	-0.5	0.3	-0.6
Hypertension (Self-reported)	1.9	5.3	11.1	2.8	-3.3	-0.9	-2.5	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.5	0.6	-0.3	0.6	1.2	0.1
Illnesses of father: Heart disease	1.7	2.3	5.4	-2.0	2.3	-0.0	0.9	1.2
Illnesses of siblings: Diabetes	0.6	0.7	2.0	1.1	-0.3	-0.2	0.2	1.4
Smoking status: Previous	0.2	0.3	0.7	-0.0	-0.3	0.8	0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.5	-0.0	-0.6	0.1	0.0	-0.7
Whole body fat-free mass	0.1	0.7	2.1	0.6	-0.6	0.5	1.5	0.4
Leg fat-free mass (right)	0.1	0.5	2.0	0.3	-0.3	0.1	1.4	0.6
Arm fat percentage (left)	0.3	1.0	2.9	0.1	0.0	-1.3	0.7	1.7
Average weekly red wine intake	0.4	0.5	1.5	-0.5	0.1	1.2	0.9	0.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.9	-0.3	0.6	2.2	0.6	0.4
Mood swings	0.8	1.4	4.0	-2.0	1.6	0.3	0.6	0.0
Loneliness, isolation	0.8	1.1	1.7	1.3	-1.1	0.8	0.2	1.3
Long-standing illness, disability or infirmity	0.6	0.9	3.1	0.4	0.7	-0.1	1.8	1.0
Ever had bowel cancer screening	0.8	1.0	2.2	1.5	-0.9	1.2	0.6	0.4
Diabetes diagnosed by doctor	0.7	1.1	2.9	1.7	-1.2	-0.9	-0.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.6	-1.3	0.2	0.5	-0.6	-0.8
Friendships satisfaction	0.3	0.4	1.1	-0.4	0.8	0.4	0.3	1.0
Qualifications: nursing, teaching	0.6	0.9	2.0	1.2	-1.4	0.5	-0.4	-0.9
Commuting to job workplace: Walk	2.1	2.2	5.8	-1.8	1.4	-2.4	-0.2	-0.4
Eye problems/disorders: Cataract	0.7	0.8	2.6	0.0	1.1	-1.6	0.5	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.3	-0.4	1.3	-0.1	1.5	0.9
Medication for cholesterol	1.5	2.3	4.5	-2.1	2.1	0.9	1.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.4	0.5	-0.2	1.5	0.7	1.3
Back pain experienced in last month	0.5	0.7	2.5	-0.4	0.6	-1.6	-0.6	0.2
Mineral and other dietary supplements	0.6	0.8	3.2	0.8	-0.0	-1.8	0.0	-0.5
Breast cancer (self-reported)	0.4	0.5	1.0	-1.0	0.8	0.8	0.0	0.3
Asthma (self-reported)	0.1	0.2	0.7	0.0	0.0	0.3	0.8	0.3
Osteoporosis (self-reported)	1.4	1.7	5.0	0.2	-0.3	-1.5	-1.2	-2.2
Osteoarthritis (self-reported)	0.2	0.2	0.5	0.0	-0.7	-0.7	-0.4	-0.1
Medication: Aspirin	0.2	0.3	0.9	0.5	-0.1	-1.0	-0.3	-0.5
Medication: Gliclazide	0.4	0.5	1.4	0.7	-0.4	-1.2	0.3	-0.3
Illnesses of father: None of the above (group 1)	0.2	0.2	0.5	-0.2	0.1	0.3	0.7	0.7
Smoking status: Current	1.2	1.9	5.2	-1.2	1.5	-2.3	0.3	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.0	0.8	-0.9	1.7	-0.0	1.4
Whole body water mass	0.1	0.6	1.9	0.7	-0.6	0.4	1.4	0.4
Leg predicted mass (right)	0.1	0.6	2.2	0.2	-0.3	0.2	1.5	0.6
Arm fat mass (left)	0.3	1.1	3.0	0.4	-0.1	-1.0	1.2	1.7
Number of self-reported non-cancer illnesses	0.4	0.7	2.0	0.2	-0.1	-1.4	0.1	1.1
Average weekly champagne plus white wine intake	0.7	1.0	3.0	-0.1	-0.9	-0.4	-0.9	-1.7
Miserableness	1.1	1.9	2.9	-1.1	1.0	1.7	1.7	1.1
Guilty feelings	0.8	1.2	2.1	-0.5	0.5	1.4	1.4	1.1
Wears glasses or contact lenses	0.2	0.2	0.6	0.4	-0.3	0.7	0.6	0.2
Ever taken oral contraceptive pill	1.0	1.1	2.5	0.2	-0.4	-1.6	-1.0	-1.4
Hearing aid user	0.3	0.4	0.9	0.3	-0.2	0.9	0.3	-0.9
Mother’s age at death	2.6	3.3	8.0	-0.6	0.9	2.8	2.3	1.5
Financial situation satisfaction	1.7	2.1	3.1	-1.8	1.7	0.6	1.4	1.4
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	-0.3	0.4	0.8	0.4	1.2
Commuting to job workplace: Public transport	1.6	1.9	6.0	-0.6	0.3	-2.5	-1.4	-1.2
Eye problems/disorders: Glaucoma	0.9	1.1	2.6	0.4	-0.7	-1.5	-1.6	-0.4
Medication: Blood pressure	2.1	3.9	6.7	1.9	-2.5	-1.2	-2.6	-1.3
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.4	-0.8	1.0	-1.1	0.4	2.1
Supplements: Fish oil (including cod liver oil)	0.6	0.7	3.3	-0.3	-0.4	1.8	0.1	0.4
High cholesterol (Self-reported)	0.1	0.3	0.7	0.4	-0.1	-0.8	-0.3	0.6
Medication: Bendroflumethiazide	2.0	3.0	8.4	0.7	-1.6	-1.6	-2.9	-0.8
Medication: Paracetamol	0.8	1.3	1.9	-1.3	1.4	0.5	1.4	0.8
Medication: Lisinopril	1.5	1.9	3.2	1.5	-1.8	-1.3	-1.5	-0.1
Medication: Atorvastatin	0.4	0.5	1.4	0.3	-0.8	-0.8	-1.2	-0.1
Illnesses of father: High blood pressure	0.1	0.2	0.4	0.5	-0.5	-0.1	-0.6	-0.0
Alcohol drinker status: Never	1.3	1.6	2.8	1.7	-1.6	-0.9	-1.1	-0.6
Ever smoked	0.1	0.1	0.2	-0.5	0.5	-0.1	0.2	0.3
Basal metabolic rate	0.1	0.8	2.6	0.5	-0.4	0.4	1.6	0.8
Leg fat percentage (left)	0.4	1.3	4.8	-0.2	0.6	-0.8	0.9	2.2
Arm fat-free mass (left)	0.1	0.7	2.3	0.6	-0.3	0.3	1.5	0.8
Number of operations (self-reported)	1.3	2.0	5.1	1.7	-2.3	-1.2	-0.7	-0.1
Average weekly beer plus cider intake	0.1	0.2	0.4	0.3	0.1	0.6	0.5	-0.3
Irritability	0.7	1.1	2.2	-1.5	1.4	-0.8	0.8	0.3
Risk taking	0.1	0.1	0.4	-0.1	0.2	0.0	0.1	0.6
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.9	1.4	-0.5	-0.1	1.0	1.3
Fractured/broken bones in last 5 years	1.0	1.2	2.5	1.5	-1.6	0.3	-0.7	-1.0
Age started oral contraceptive pill	0.1	0.1	0.3	0.6	-0.3	0.2	-0.1	0.1
Diastolic blood pressure, automated reading	0.7	2.0	3.2	1.8	-1.7	1.1	-0.4	1.6
Ever depressed for a whole week	1.9	2.3	5.2	2.3	-1.9	-0.7	-1.4	-0.7
Unable to work because of sickness or disability	1.1	1.5	3.9	0.5	-1.0	-2.0	-1.4	0.4
Commuting to job workplace: Cycle	0.6	0.7	1.3	0.7	-0.8	0.7	-0.7	1.1
Myopia	0.7	1.0	2.9	-1.2	0.4	-0.5	-0.1	-1.7
Vascular/heart problems diagnosed by doctor	1.2	3.2	5.8	-2.0	2.4	1.0	2.0	0.9
Cholesterol lowering medication	0.6	0.9	3.0	1.7	-1.0	-0.8	-0.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.2	0.6	0.1	-0.5	1.1	1.0
Pain experienced in last month	0.2	0.3	1.5	-0.1	0.1	1.2	-0.1	-0.2
Supplements: Calcium	0.1	0.1	0.2	-0.5	0.4	0.1	0.0	-0.4
Basal cell carcinoma (self-reported)	0.3	0.3	1.1	0.3	0.2	1.0	0.6	-0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	-0.6	0.2	-0.1	-0.4	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.4	-0.7	0.9	-1.2	0.8	0.7
Heart disease (siblings)	0.5	0.6	1.4	-1.2	0.9	0.6	0.4	0.8
Alcohol drinker status: Previous	0.8	0.9	2.4	0.7	-0.8	-0.9	-1.5	-0.0
Pack years of smoking	0.5	0.8	1.6	-1.1	0.4	-0.7	-1.3	-0.6
Impedance of whole body	0.3	1.7	3.4	-1.8	1.8	0.9	0.5	0.9
Leg fat mass (left)	0.3	1.4	4.4	0.1	0.2	-0.7	1.4	2.1
Arm predicted mass (left)	0.1	0.5	1.6	0.6	-0.5	0.1	1.3	0.6