Hub : Genes

BIK

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0142 0.0075 8.8e-03 0.000 0.007 0.001 NA 0.000 3.8e-01 1.1e-02 2.0e-01 NA 4.0e-01
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0505 0.0219 3.0e-04 0.019 0.048 0.025 NA 0.028 2.6e-03 4.2e-06 7.1e-04 NA 3.7e-04
3 TCGA Brain Lower Grade Glioma 0.0462 0.0238 9.3e-03 0.006 0.005 0.002 NA 0.007 6.5e-02 7.0e-02 1.6e-01 NA 4.9e-02
4 TCGA Thyroid Carcinoma 0.1150 0.0370 5.4e-07 0.072 0.066 0.073 NA 0.081 1.5e-07 5.1e-07 1.4e-07 NA 2.8e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.8 2.8 6.2 -1.4 -2.5 -1.8 0.3
Bipolar Disorder or Schizophrenia 1.3 3.1 8.1 -2.9 -1.8 -1.0 -0.4
Depressed Affect (Nagel 2018) 0.1 0.3 0.4 0.2 0.5 0.6 -0.5
Depression (Nagel 2018) 0.2 0.2 0.6 -0.2 -0.4 -0.4 -0.8
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.6 -0.0 0.5 -0.9 1.3
Neuroticism (Nagel 2018) 0.2 0.5 0.9 0.9 0.5 0.6 -0.6
Schizophrenia (2018) 0.9 1.8 6.6 -2.6 -0.3 0.2 -0.8
Schizophrenia vs Biploar Disorder 1.2 1.6 4.1 0.9 2.0 1.0 0.6
Worry (Nagel 2018) 0.1 0.1 0.3 0.4 -0.5 -0.3 0.3
Alzheimer’s Disease (in mother) 0.7 0.8 2.4 1.6 0.2 0.0 0.8
Alzheimer’s Disease (in father) 0.9 1.0 2.4 -0.7 0.5 0.8 -1.6
Alzheimer’s Disease (including proxy) 0.3 0.5 0.9 0.8 0.6 0.9 -0.0
Crohns Disease (2017) 0.1 0.3 0.5 -0.7 -0.7 0.5 -0.4
Irritable Bowel Disease (IBD) 1.4 3.3 7.6 -2.2 -2.8 -0.9 -0.1
Ulcerative Colitis (UC) 2.1 3.9 8.4 -2.5 -2.9 -0.9 -0.3
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.9 3.6 5.5 -0.1 1.8 2.3 -2.3
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.2 0.2 1.1 -0.5 0.6
Breast Cancer 3.8 9.2 16.4 1.8 -3.0 -2.8 4.0
Ovarian Cancer 2.8 3.7 5.0 2.0 -2.2 -1.9 1.4
Prostate Cancer 44.2 62.1 148.8 0.6 -6.3 -7.7 12.2
Age at First Birth 1.4 2.0 5.7 -2.4 -0.7 -0.1 -1.3
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.3 1.7 3.9 -1.7 -2.0 -0.4 -0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 1.3 2.0 6.3 -2.5 -0.5 1.0 -0.7
Mean Putamen Volume 0.2 0.2 0.4 -0.2 -0.6 -0.1 -0.5
Fasting Glucose 0.3 0.4 0.9 -0.7 -0.1 1.0 -0.5
HbA1C 1.6 1.7 3.0 -1.5 0.1 1.2 -1.7
HDL Cholesterol 0.1 0.1 0.3 -0.2 -0.4 -0.6 -0.2
LDL Cholesterol 0.1 0.1 0.5 -0.1 -0.2 0.7 0.3
Lupus 0.8 1.2 2.6 -0.3 1.4 1.6 0.2
Neuroticism (2016) 0.8 1.2 3.0 0.9 1.7 0.9 -0.2
Primary Biliary Cirrhosis 0.6 0.9 1.5 0.6 -1.0 -1.0 1.2
Rheumatoid Arthritis 0.7 1.0 1.9 -0.2 1.2 1.4 -0.8
Schizophrenia (2014) 1.1 2.5 8.9 -3.0 -0.5 -0.7 -0.4
Triglycerides 0.2 0.3 0.8 -0.1 0.2 0.7 0.9
Type 2 Diabetes (T2D) (2012) 5.1 5.9 11.2 -1.8 -3.3 -2.4 1.8
Ulcerative Colitis 1.9 2.7 6.1 -2.5 -2.1 -0.7 0.2
Blood Eosinophil Count 0.2 1.3 3.2 -0.9 -1.8 0.5 0.9
Blood Platelet Count 1.9 21.6 39.4 6.1 -1.1 -2.9 6.3
Blood Red Count 1.2 11.2 20.2 -4.5 -4.5 -2.1 0.6
Blood White Count 0.6 4.8 12.2 0.2 -2.3 -1.2 3.5
Heel T-Score 1.0 7.8 12.4 -0.1 2.7 3.4 -3.5
BMI 0.6 3.4 6.8 -2.6 -2.1 -1.5 0.2
Height 0.3 6.0 8.5 2.8 -0.9 -2.9 2.6
Waist Hip Ratio (WHR) 0.4 1.9 3.1 1.7 1.3 1.8 0.2
Systolic Blood Pressure 0.6 3.1 7.3 -0.3 1.4 1.8 -2.7
Smoking Status 2.0 4.8 6.7 2.2 -1.5 -2.6 2.3
Allergy or Eczema 0.4 1.1 2.8 -1.7 -1.1 -0.6 -0.3
Cardiovascular Disease 0.3 0.9 3.0 -1.7 -0.8 -0.0 -0.2
Hypothyroidism (self reported) 2.0 4.5 8.7 -1.7 -2.9 -2.6 0.4
Respiratory disease 0.5 1.2 2.9 0.4 -1.2 -1.7 0.5
Type 2 Diabetes (T2D) (2018) 1.0 1.9 4.0 -0.3 -1.4 -2.0 1.2
Lung FEV1/FVC ratio 2.1 10.5 17.3 -3.2 1.8 3.3 -4.2
Lung FVC 0.1 0.6 1.0 1.0 -0.8 -0.6 0.6
Neuroticism 0.1 0.2 0.7 0.8 0.1 0.3 0.3
Chronotype (morning person) 0.5 1.2 2.8 0.3 0.3 1.7 -1.4
Hair Pigment 0.0 0.3 1.1 -0.0 0.2 0.1 -1.0
Tanning 0.0 0.2 0.3 -0.4 0.3 0.5 0.6
Hand grip strength (left) 0.2 0.4 1.3 -0.4 0.1 0.4 -1.1
Number of treatments/medications taken 0.9 1.6 2.5 -1.1 -1.6 -1.5 0.5
Average weekly spirits intake 0.4 0.4 0.9 -0.2 -0.2 -0.9 0.9
Sensitivity / hurt feelings 0.3 0.5 1.8 1.4 0.3 0.0 0.1
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.6 0.6 -0.2 -0.2 -0.8
Hearing difficulty/problems: Yes 0.3 0.4 0.9 0.8 0.2 0.2 -0.9
Relative age of first facial hair 0.0 0.1 0.3 -0.0 -0.6 0.1 0.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.5 1.2 -0.5 0.4 0.4 -1.1
Ever used hormone-replacement therapy (HRT) 0.9 1.1 3.0 -0.2 -1.1 -1.7 0.7
Ever had hysterectomy (womb removed) 1.1 1.3 3.8 -1.0 0.3 0.5 -2.0
Systolic blood pressure, automated reading 1.1 3.1 6.6 -0.9 1.2 2.0 -2.6
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 0.6 0.1 -0.7 -0.8 0.6
Angina 0.3 0.4 1.1 1.1 0.5 0.6 -0.2
Medication for hormone replacement therapy 1.1 1.2 2.5 -1.6 0.0 -0.3 -1.5
Vitamin and mineral supplements 1.2 1.6 4.3 0.0 -2.1 -1.4 -0.1
Supplements: Zinc 0.8 0.9 1.8 -1.4 -0.6 -0.4 -1.0
Medication: Co-codamol 0.5 0.5 1.3 0.4 0.8 1.1 -0.2
Medication: Metformin 0.4 0.6 1.2 -0.1 -0.3 -1.1 1.1
Diabetes (father) 0.1 0.2 0.5 0.3 0.0 -0.3 -0.7
Diabetes (mother) 0.7 0.9 1.4 -0.7 1.0 1.2 -0.8
Severe depression (siblings) 0.2 0.3 0.6 0.8 -0.4 0.1 -0.5
Pack years adult smoking proportion 0.8 1.2 2.6 -0.2 0.1 1.5 -1.6
Impedance of leg (right) 0.2 0.9 2.1 1.4 -0.2 0.5 -1.1
Leg fat-free mass (left) 0.6 3.3 7.7 -0.5 -1.5 -2.8 1.7
Trunk fat percentage 1.2 5.0 10.9 -0.7 -2.6 -3.3 1.3
Hand grip strength (right) 0.1 0.4 0.9 -0.3 -1.0 -0.7 0.2
Townsend deprivation index at recruitment 0.2 0.3 1.0 1.0 -0.2 -0.1 0.6
Current tobacco smoking 1.1 1.9 3.3 1.1 -1.8 -1.4 1.0
Average weekly fortified wine intake 0.5 0.6 1.4 0.2 1.2 0.7 -0.8
Maternal smoking around birth 0.3 0.4 1.3 0.0 -0.3 -0.1 -1.2
Fed-up feelings 0.2 0.4 1.3 1.1 0.1 0.3 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.5 0.5 -0.7 -0.7 -0.4
Relative age voice broke 1.6 2.4 4.6 0.8 2.1 2.1 -0.4
Taking other prescription medications 1.3 1.9 3.2 0.5 -1.5 -1.8 1.4
Age when periods started (menarche) 0.5 1.1 4.3 2.1 0.1 0.1 0.0
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 2.1 -0.3 -0.7 -1.2 1.4
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 2.1 0.5 1.4 1.2 -1.4
Tinnitus: Yes, but not now, but have in the past 1.3 1.4 2.3 -1.5 -1.4 -0.9 -0.8
Qualifications: CSEs or equivalent 0.5 0.6 1.5 0.2 1.2 1.0 0.1
Serious illness, injury or assault to yourself 1.2 1.5 4.2 -2.0 -0.6 -0.2 -1.1
High blood pressure 0.9 2.4 4.7 -2.2 -0.3 0.5 -2.1
Hayfever, allergic rhinitis or eczema 1.5 3.3 4.1 -2.0 -2.0 -1.6 1.6
Multivitamins +/- minerals 0.6 0.8 1.6 0.3 1.3 1.2 0.0
Stomach or abdominal pain in last month 1.1 1.3 3.7 0.4 -1.9 -1.2 -0.2
Supplements: Glucosamine 0.2 0.3 0.6 -0.0 0.6 0.8 -0.3
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 0.9 0.9 0.3 -0.5 0.5
Medication: Atenolol 0.3 0.3 0.6 -0.4 0.7 0.7 -0.2
Medication: Levothyroxine sodium 1.3 2.3 3.2 -1.7 -1.8 -1.7 -0.4
Sitting height 0.7 5.2 9.5 1.9 -0.8 -3.1 2.7
Chronic bronchitis/emphysema (father) 0.4 0.5 1.4 -1.2 -0.3 -0.3 -0.6
High blood pressure (mother) 0.1 0.1 0.2 -0.2 -0.5 -0.1 0.3
Body mass index (BMI) 0.4 1.8 2.7 -1.5 -1.4 -1.6 0.7
Impedance of leg (left) 0.2 1.0 2.8 1.7 0.2 0.5 -0.9
Leg predicted mass (left) 0.6 3.1 7.3 -0.5 -1.4 -2.7 1.7
Trunk fat mass 1.3 5.4 12.3 -0.6 -2.5 -3.5 1.7
Waist circumference 0.2 0.7 1.2 -1.1 -0.7 -0.7 0.8
Number of incorrect matches in round 1.1 1.8 5.0 -2.2 -0.4 0.5 -1.3
Past tobacco smoking 1.2 2.2 5.2 -1.4 0.2 1.4 -2.3
Alcohol usually taken with meals 0.4 0.6 1.0 0.8 1.0 0.8 -0.2
Nervous feelings 0.5 0.9 2.0 -1.4 -0.4 1.0 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 1.7 0.5 -0.9 -1.3 0.5
Hearing difficulty/problems with background noise 0.4 0.7 2.0 1.4 -0.1 0.1 -0.8
Hair/balding pattern: Pattern 2 0.2 0.3 0.8 -0.9 -0.2 0.6 0.0
Had menopause 1.6 2.0 6.0 -2.5 -0.6 0.4 -1.1
Had other major operations 0.2 0.2 0.4 -0.6 -0.5 -0.4 -0.1
Forced vital capacity (FVC) 0.3 1.3 2.5 1.6 -0.3 -1.5 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.2 3.6 1.9 1.7 1.0 -1.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.3 -0.5 0.5 -0.6 0.0
Qualifications: None of the above 0.1 0.3 0.5 -0.7 -0.6 0.4 -0.4
Financial difficulties in last 2 years 0.4 0.5 1.3 -0.5 -0.2 0.6 -1.1
Mouth/teeth dental problems 0.4 0.6 1.3 0.8 -0.2 -0.8 1.1
Heart attack 0.4 0.5 0.9 -0.9 0.3 0.6 -0.8
Allergy 1.1 2.5 4.7 2.2 1.6 1.3 -1.1
Pain all over the body in last month 1.7 1.8 3.1 -0.3 1.1 1.6 -1.8
Diabetes (self-reported) 1.0 1.6 2.1 -1.1 -0.9 -1.5 1.5
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 2.9 -0.2 -1.0 -1.6 1.7
Medication: Ramipril 0.4 0.6 1.0 -0.7 -1.0 -0.6 -0.6
Medication: Simvastatin 0.9 1.3 2.4 -0.7 -1.5 -0.7 1.4
Fluid intelligence score 0.4 0.8 1.7 0.4 1.3 0.6 0.9
Illnesses of siblings 0.8 1.1 2.5 0.8 1.2 -0.1 1.6
Neuroticism score 0.2 0.4 1.0 0.8 -0.3 -0.1 1.0
Weight 0.7 3.3 7.6 -0.6 -1.7 -2.8 1.6
Impedance of arm (right) 0.1 0.6 1.1 0.8 -0.8 -1.0 0.2
Arm fat percentage (right) 0.8 3.1 6.5 -1.0 -1.9 -2.5 1.1
Trunk fat-free mass 0.1 0.8 1.9 -0.0 -0.1 -1.4 1.1
Hip circumference 0.8 3.2 4.9 -1.8 -1.9 -2.2 1.1
Time employed in main current job 0.6 0.7 1.7 -1.3 -0.7 0.7 -0.3
Alcohol intake versus 10 years previously 0.0 0.0 0.1 0.4 0.1 0.0 0.2
Father’s age at death 0.9 1.2 1.4 -0.9 1.2 1.1 -1.2
Worrier / anxious feelings 0.4 0.7 1.5 0.2 -0.8 -0.9 1.2
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.3 0.4 -0.0 -0.6 -0.2
Falls in the last year 1.2 1.6 3.4 -1.8 -1.4 -0.3 -0.9
Hair/balding pattern: Pattern 3 0.5 0.7 1.7 -0.1 1.0 1.3 -0.5
Number of live births 0.8 1.1 1.8 0.7 0.9 1.3 -1.1
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.9 0.3 0.2 -0.5 -0.9
Pulse rate 0.4 0.8 1.1 -0.9 -0.2 1.1 -1.1
Happiness 0.5 0.6 0.8 0.9 0.9 0.8 -0.6
Noisy workplace 0.5 0.6 2.3 0.1 -0.5 0.2 -1.5
Qualifications: A levels/AS levels or equivalent 1.2 2.6 7.2 2.7 1.6 0.9 0.1
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.3 0.4 1.8 1.4 -0.7
Mouth/teeth dental problems: Dentures 0.1 0.2 0.5 -0.4 -0.1 0.7 -0.4
Asthma 0.1 0.3 0.7 -0.8 -0.3 -0.0 0.6
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.8 1.7 0.5 0.0 -0.4
Medication: Cholesterol lowering 0.5 0.8 2.1 0.8 -0.7 -0.3 1.4
Depression (self-reported) 1.4 1.7 3.7 -0.2 -1.9 -1.1 1.4
Medication: Lansoprazole 2.0 2.3 4.3 2.1 -0.4 -1.6 1.4
Prospective memory result 0.4 0.5 0.9 -0.9 -0.9 -0.2 0.6
Lung cancer (father) 0.9 1.0 1.9 0.1 -0.8 -1.4 1.2
Illnesses of mother 0.2 0.2 0.3 0.5 0.5 0.4 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.3 0.5 -0.2 -0.4 -0.4
Pulse wave Arterial Stiffness index 0.8 1.0 2.2 -1.2 -0.2 -0.5 -1.5
Impedance of arm (left) 0.2 0.9 1.7 0.6 -1.3 -1.3 -0.1
Arm fat mass (right) 0.8 3.5 7.5 -1.0 -2.0 -2.7 1.2
Trunk predicted mass 0.1 0.8 2.0 0.1 0.0 -1.4 1.1
Standing height 0.5 4.9 9.5 1.8 -1.2 -3.1 2.3
Length of working week for main job 1.2 1.4 2.3 -1.5 -1.0 -0.4 -1.4
Exposure to tobacco smoke at home 0.4 0.4 1.0 1.0 -0.6 -0.4 -0.4
Breastfed as a baby 0.3 0.4 0.7 -0.4 0.8 0.8 -0.2
Tense / ‘highly strung’ 1.3 2.1 3.4 1.7 -1.0 -1.1 1.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.4 0.3 -0.4 -1.2 0.1
Hair/balding pattern: Pattern 4 1.0 2.4 8.4 2.9 0.2 -0.9 0.6
Birth weight of first child 0.6 1.1 4.4 -0.3 -0.0 0.2 -2.1
Peak expiratory flow (PEF) 0.1 0.3 0.6 -0.8 -0.2 -0.5 -0.6
Pulse wave reflection index 0.9 1.1 2.8 0.1 1.2 0.5 -1.7
Ever highly irritable/argumentative for 2 days 2.1 2.5 5.6 0.6 -1.9 -2.4 0.6
Loud music exposure frequency 3.2 3.5 6.6 2.6 -0.9 -1.8 1.8
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 1.8 1.4 1.2 0.1 1.1
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 3.7 -1.1 1.1 1.9 -1.1
Blood clot in the leg (DVT) 0.9 1.2 3.6 0.8 -0.5 -0.7 1.9
Medication: Paracetamol 0.7 1.1 1.7 1.2 -1.1 -1.3 0.2
Headache pain in last month 0.3 0.6 1.6 0.0 -1.3 -0.8 0.4
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.1 -0.3 0.1 -0.1 -0.4
Glaucoma (self-reported) 0.1 0.1 0.2 -0.5 0.3 0.5 0.0
Gout (self-reported) 3.1 4.3 7.2 2.7 2.6 1.6 -1.0
Hypothyroidism/myxoedema (self-reported) 1.4 2.8 5.6 -0.8 -2.1 -2.4 0.9
Medication: Amlodipine 1.7 2.4 3.9 -2.0 0.9 1.2 -1.8
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.0 0.3 1.7 1.1 -1.0
Birth weight 0.3 0.6 1.5 1.2 0.3 -0.1 0.8
Chronic bronchitis/emphysema (mother) 0.7 0.9 2.1 0.3 -0.6 -1.5 0.9
High blood pressure (siblings) 0.3 0.4 0.6 0.8 -0.3 0.8 -0.6
Forced vital capacity (FVC), Best measure 0.3 1.0 3.1 1.8 0.0 -0.9 0.4
Body fat percentage 1.1 4.4 9.3 -0.7 -2.5 -3.0 1.1
Leg fat percentage (right) 0.5 1.7 3.6 -0.5 -1.7 -1.9 0.4
Arm fat-free mass (right) 0.3 1.6 3.8 -0.1 -0.8 -2.0 1.3
Exposure to tobacco smoke outside home 0.4 0.5 1.0 0.3 -0.9 -1.0 0.4
Comparative body size at age 10 0.1 0.3 0.9 -1.0 -0.1 -0.3 0.2
Number of full brothers 0.6 0.7 1.4 0.0 0.3 1.1 -1.2
Worry too long after embarrassment 0.1 0.1 0.3 0.1 0.6 0.2 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.6 -0.1 -0.8 -0.1 0.1
Wheeze or whistling in the chest in last year 0.0 0.0 0.2 0.0 -0.0 0.2 -0.4
Number of children fathered 1.7 2.0 5.4 0.7 -1.1 -2.3 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.7 0.6 1.3 0.6 -0.1
Age at first live birth 0.2 0.4 0.6 -0.7 0.7 0.8 -0.1
Pulse wave peak to peak time 0.9 1.1 3.0 1.2 0.0 0.1 1.7
Health satisfaction 0.3 0.4 0.7 -0.9 -0.3 -0.8 -0.3
Shortness of breath walking on level ground 0.6 0.7 1.3 -0.9 -1.1 -0.8 -0.3
Qualifications: College or University degree 0.1 0.2 0.5 0.7 0.3 -0.3 -0.3
Eye problems/disorders: None of the above 3.3 3.8 8.0 -0.4 1.5 2.8 -2.2
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.2 -1.5 0.1 0.9 -1.1
Emphysema/chronic bronchitis 2.1 2.3 4.0 -1.2 -1.7 -2.0 1.0
Medication for pain relief, constipation, heartburn 1.4 2.3 4.5 -1.4 1.5 2.1 -0.8
Neck or shoulder pain in last month 0.7 1.0 2.3 -1.5 -1.0 -0.8 0.6
Medication: Blood pressure 0.3 0.5 1.3 -0.7 0.0 0.7 -1.1
Angina (self-reported) 0.2 0.3 0.8 0.9 0.3 0.5 -0.3
Migraine (self-reported) 1.0 1.3 2.3 -0.8 -1.5 -1.3 0.5
Medication: Ibuprofen 0.8 1.0 2.9 1.7 0.9 0.1 -0.4
Medication: Allopurinol 0.4 0.5 1.3 1.1 0.7 0.5 0.3
Medication: Omeprazole 0.8 1.0 2.7 -1.6 -0.3 -1.0 -0.2
Medication: Seretide 50 evohaler 0.4 0.4 1.0 1.0 -0.2 -0.7 0.4
Mean time to correctly identify matches 1.4 2.6 4.7 -0.8 1.4 2.2 -1.8
Heart disease (mother) 0.1 0.1 0.3 -0.5 -0.1 -0.3 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 1.6 -0.4 1.3 0.2 0.4
Whole body fat mass 1.3 5.3 11.9 -0.7 -2.5 -3.5 1.6
Leg fat mass (right) 0.9 3.5 7.5 -0.8 -2.1 -2.7 1.1
Arm predicted mass (right) 0.3 1.5 3.8 -0.2 -0.6 -1.9 1.4
Pulse rate, automated reading 0.1 0.3 0.9 -0.5 -1.0 0.1 0.2
Alcohol intake frequency. 0.2 0.5 1.2 -1.1 -0.7 0.4 -0.2
Comparative height size at age 10 0.5 3.0 5.5 1.2 -0.6 -2.2 2.4
Number of full sisters 0.4 0.5 1.6 -0.3 -0.6 0.2 -1.3
Suffer from ‘nerves’ 0.3 0.4 0.8 -0.2 -0.9 -0.7 0.5
Overall health rating 0.7 1.5 2.8 -1.4 -1.7 -1.0 -0.5
Chest pain or discomfort 1.8 2.5 4.8 0.5 -2.2 -1.6 1.6
Had major operations 0.7 0.8 1.6 -0.6 -1.3 -0.5 -1.0
Age at last live birth 0.2 0.3 0.6 0.1 0.6 0.7 0.8
Family relationship satisfaction 0.9 1.1 2.6 0.4 0.9 1.6 -1.0
Leg pain on walking 1.6 2.0 5.0 -0.9 -2.2 -1.4 -0.4
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.6 1.6 1.2 0.7 0.3
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.4 -1.6 0.3 0.4 -0.2
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.1 1.1 -0.8 -0.8 1.4
Medication: Aspirin 0.6 0.8 1.7 0.4 -0.6 -1.0 1.3
Supplements: Vitamin C 0.1 0.1 0.2 -0.4 0.5 0.2 0.4
Knee pain experienced in last month 0.2 0.4 1.1 -1.0 -0.5 0.1 -0.5
Hypertension (Self-reported) 0.7 1.8 3.8 -1.9 -0.4 0.5 -1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.5 -0.6 1.2 -0.1 0.2
Illnesses of father: Heart disease 2.3 3.2 6.8 1.1 -2.6 -2.1 0.8
Illnesses of siblings: Diabetes 0.1 0.1 0.4 -0.3 -0.6 -0.2 0.1
Smoking status: Previous 0.6 0.9 2.0 0.8 0.2 -1.0 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.3 0.7 -0.4 -1.5 0.3
Whole body fat-free mass 0.3 1.6 4.0 -0.2 -0.6 -2.0 1.5
Leg fat-free mass (right) 0.6 3.3 7.6 -0.3 -1.2 -2.8 2.0
Arm fat percentage (left) 0.9 3.5 7.2 -1.1 -2.1 -2.7 1.1
Average weekly red wine intake 0.2 0.3 0.8 0.0 -0.7 -0.9 0.2
Handedness (chirality/laterality): Left-handed 5.4 6.5 9.6 1.3 3.1 2.3 -3.1
Mood swings 1.3 2.3 3.9 2.0 1.9 1.2 -0.5
Loneliness, isolation 0.0 0.0 0.1 -0.3 -0.1 0.0 -0.2
Long-standing illness, disability or infirmity 1.5 2.3 5.0 -0.9 -2.2 -1.8 -0.1
Ever had bowel cancer screening 1.0 1.2 3.4 -1.9 -0.3 0.8 -0.8
Diabetes diagnosed by doctor 0.3 0.6 1.1 -0.6 -0.2 -0.9 1.1
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 2.9 1.3 1.4 1.7 0.3
Friendships satisfaction 0.5 0.7 1.0 0.2 0.8 0.9 -1.0
Qualifications: nursing, teaching 0.6 0.9 1.7 -1.3 0.9 0.8 -0.8
Commuting to job workplace: Walk 1.7 1.9 2.6 1.6 -1.4 -1.2 1.2
Eye problems/disorders: Cataract 2.1 2.4 5.2 0.4 -1.1 -2.3 1.8
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.7 -0.0 -1.3 -0.7 1.0
Medication for cholesterol 1.4 2.1 5.7 2.4 1.1 1.2 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.1 -0.4 0.5 1.1 -0.6
Back pain experienced in last month 0.4 0.5 1.4 -0.4 -0.7 -1.2 0.3
Mineral and other dietary supplements 0.4 0.6 1.1 -0.2 -1.1 -1.1 0.4
Breast cancer (self-reported) 2.8 3.4 6.8 0.5 1.8 2.6 -1.8
Asthma (self-reported) 0.2 0.3 0.4 -0.6 -0.6 -0.4 0.6
Osteoporosis (self-reported) 0.5 0.6 1.6 0.1 -0.0 -0.8 1.3
Osteoarthritis (self-reported) 0.2 0.3 0.6 0.8 0.2 -0.6 0.3
Medication: Aspirin 0.7 0.9 2.2 0.5 -0.6 -0.9 1.5
Medication: Gliclazide 0.7 0.8 1.8 -0.5 -0.7 -1.3 0.9
Illnesses of father: None of the above (group 1) 2.1 2.6 8.1 1.3 0.2 -0.9 2.9
Smoking status: Current 1.5 2.4 3.5 1.3 -1.9 -1.5 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.9 -0.8 -0.0 0.5 -1.0
Whole body water mass 0.3 1.9 4.6 -0.2 -0.8 -2.1 1.5
Leg predicted mass (right) 0.6 3.2 7.4 -0.3 -1.2 -2.7 2.0
Arm fat mass (left) 1.1 4.4 9.8 -0.9 -2.2 -3.1 1.5
Number of self-reported non-cancer illnesses 1.2 2.1 4.9 -1.0 -2.2 -1.5 0.4
Average weekly champagne plus white wine intake 0.3 0.4 1.2 -0.6 0.1 0.3 1.1
Miserableness 1.4 2.4 5.1 1.1 2.3 1.8 -0.2
Guilty feelings 0.1 0.2 0.3 0.5 -0.6 -0.3 0.3
Wears glasses or contact lenses 0.4 0.5 1.1 0.0 -0.3 -1.1 0.9
Ever taken oral contraceptive pill 0.2 0.2 0.7 -0.8 -0.3 0.1 0.1
Hearing aid user 1.5 1.7 3.8 -1.7 0.2 0.5 -1.9
Mother’s age at death 0.1 0.2 0.5 -0.2 0.7 0.0 -0.4
Financial situation satisfaction 0.8 0.9 3.2 1.8 0.4 0.1 0.7
Tinnitus: Yes, now most or all of the time 0.1 0.2 0.3 0.0 -0.3 0.5 0.5
Commuting to job workplace: Public transport 1.0 1.2 3.7 1.9 -0.0 -0.0 1.1
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 -0.2 0.1 0.2 0.4
Medication: Blood pressure 0.8 1.6 3.0 -1.4 0.8 0.8 -1.7
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.8 0.0 -1.7 -1.6 0.4
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.4 -0.6 0.1 -0.0 0.4
High cholesterol (Self-reported) 1.5 2.6 5.3 0.6 -2.0 -1.0 2.3
Medication: Bendroflumethiazide 0.2 0.3 0.6 0.8 0.4 0.3 -0.7
Medication: Paracetamol 0.5 0.8 1.3 1.1 -0.8 -1.2 -0.1
Medication: Lisinopril 0.2 0.2 0.5 0.4 0.1 0.7 -0.4
Medication: Atorvastatin 0.2 0.3 1.0 0.5 -0.0 -0.2 1.0
Illnesses of father: High blood pressure 0.4 0.5 1.4 -0.3 -0.6 -0.3 -1.2
Alcohol drinker status: Never 1.4 1.6 4.9 -2.2 -1.2 -0.3 0.2
Ever smoked 0.2 0.4 0.8 0.5 0.2 -0.7 0.9
Basal metabolic rate 0.4 2.1 5.4 -0.2 -0.9 -2.3 1.5
Leg fat percentage (left) 0.4 1.6 3.5 -0.4 -1.5 -1.9 0.6
Arm fat-free mass (left) 0.2 1.0 2.7 0.1 -0.4 -1.6 1.2
Number of operations (self-reported) 1.6 2.3 4.7 -2.2 -1.8 -0.9 -0.8
Average weekly beer plus cider intake 0.3 0.5 1.3 0.0 1.2 -0.7 -0.2
Irritability 1.1 1.8 2.7 1.1 -1.4 -1.1 1.7
Risk taking 0.4 0.6 1.6 -0.3 -1.3 -0.8 0.1
Ever had prostate specific antigen (PSA) test 1.3 1.5 3.5 0.1 -0.9 -1.2 1.9
Fractured/broken bones in last 5 years 1.9 2.4 5.6 -1.9 -0.0 0.7 -2.4
Age started oral contraceptive pill 0.2 0.3 0.6 -0.8 -0.5 -0.3 0.4
Diastolic blood pressure, automated reading 0.4 1.3 3.9 -0.9 -0.2 0.5 -2.0
Ever depressed for a whole week 1.7 2.1 4.4 -0.9 2.1 1.2 -1.3
Unable to work because of sickness or disability 0.7 1.0 2.8 -0.9 -1.7 0.1 -0.5
Commuting to job workplace: Cycle 0.1 0.1 0.2 -0.3 -0.4 0.2 0.4
Myopia 1.2 1.7 4.1 1.4 0.3 -0.9 2.0
Vascular/heart problems diagnosed by doctor 0.5 1.5 2.9 1.7 0.1 -0.4 1.7
Cholesterol lowering medication 0.8 1.2 2.5 -1.6 -0.9 -0.6 1.0
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.9 -0.9 -0.8 -1.4 0.4
Pain experienced in last month 1.3 2.1 3.3 1.6 1.8 1.5 -0.4
Supplements: Calcium 0.2 0.2 0.4 -0.5 -0.0 -0.2 0.7
Basal cell carcinoma (self-reported) 1.0 1.1 3.2 0.2 1.8 1.0 -0.6
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 -0.9 0.3 0.4 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 3.3 0.9 -0.1 -0.5 1.8
Heart disease (siblings) 1.0 1.2 2.6 -0.8 -1.6 -0.6 -1.0
Alcohol drinker status: Previous 2.4 2.7 4.8 -2.2 -1.8 -0.7 -1.6
Pack years of smoking 0.9 1.3 2.6 -0.1 0.2 1.6 -1.6
Impedance of whole body 0.1 0.6 1.1 1.1 -0.9 -0.7 -0.3
Leg fat mass (left) 0.8 3.3 7.3 -0.7 -2.0 -2.7 1.2
Arm predicted mass (left) 0.3 1.3 3.3 0.1 -0.5 -1.8 1.3