Hub : Genes

BIK

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0142	0.0075	8.8e-03	0.000	0.007	0.001	NA	0.000	3.8e-01	1.1e-02	2.0e-01	NA	4.0e-01
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0505	0.0219	3.0e-04	0.019	0.048	0.025	NA	0.028	2.6e-03	4.2e-06	7.1e-04	NA	3.7e-04
3	TCGA	Brain Lower Grade Glioma	0.0462	0.0238	9.3e-03	0.006	0.005	0.002	NA	0.007	6.5e-02	7.0e-02	1.6e-01	NA	4.9e-02
4	TCGA	Thyroid Carcinoma	0.1150	0.0370	5.4e-07	0.072	0.066	0.073	NA	0.081	1.5e-07	5.1e-07	1.4e-07	NA	2.8e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.8	2.8	6.2	-1.4	-2.5	-1.8	0.3
Bipolar Disorder or Schizophrenia	1.3	3.1	8.1	-2.9	-1.8	-1.0	-0.4
Depressed Affect (Nagel 2018)	0.1	0.3	0.4	0.2	0.5	0.6	-0.5
Depression (Nagel 2018)	0.2	0.2	0.6	-0.2	-0.4	-0.4	-0.8
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.6	-0.0	0.5	-0.9	1.3
Neuroticism (Nagel 2018)	0.2	0.5	0.9	0.9	0.5	0.6	-0.6
Schizophrenia (2018)	0.9	1.8	6.6	-2.6	-0.3	0.2	-0.8
Schizophrenia vs Biploar Disorder	1.2	1.6	4.1	0.9	2.0	1.0	0.6
Worry (Nagel 2018)	0.1	0.1	0.3	0.4	-0.5	-0.3	0.3
Alzheimer’s Disease (in mother)	0.7	0.8	2.4	1.6	0.2	0.0	0.8
Alzheimer’s Disease (in father)	0.9	1.0	2.4	-0.7	0.5	0.8	-1.6
Alzheimer’s Disease (including proxy)	0.3	0.5	0.9	0.8	0.6	0.9	-0.0
Crohns Disease (2017)	0.1	0.3	0.5	-0.7	-0.7	0.5	-0.4
Irritable Bowel Disease (IBD)	1.4	3.3	7.6	-2.2	-2.8	-0.9	-0.1
Ulcerative Colitis (UC)	2.1	3.9	8.4	-2.5	-2.9	-0.9	-0.3
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.9	3.6	5.5	-0.1	1.8	2.3	-2.3
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.2	0.2	1.1	-0.5	0.6
Breast Cancer	3.8	9.2	16.4	1.8	-3.0	-2.8	4.0
Ovarian Cancer	2.8	3.7	5.0	2.0	-2.2	-1.9	1.4
Prostate Cancer	44.2	62.1	148.8	0.6	-6.3	-7.7	12.2
Age at First Birth	1.4	2.0	5.7	-2.4	-0.7	-0.1	-1.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.3	1.7	3.9	-1.7	-2.0	-0.4	-0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	1.3	2.0	6.3	-2.5	-0.5	1.0	-0.7
Mean Putamen Volume	0.2	0.2	0.4	-0.2	-0.6	-0.1	-0.5
Fasting Glucose	0.3	0.4	0.9	-0.7	-0.1	1.0	-0.5
HbA1C	1.6	1.7	3.0	-1.5	0.1	1.2	-1.7
HDL Cholesterol	0.1	0.1	0.3	-0.2	-0.4	-0.6	-0.2
LDL Cholesterol	0.1	0.1	0.5	-0.1	-0.2	0.7	0.3
Lupus	0.8	1.2	2.6	-0.3	1.4	1.6	0.2
Neuroticism (2016)	0.8	1.2	3.0	0.9	1.7	0.9	-0.2
Primary Biliary Cirrhosis	0.6	0.9	1.5	0.6	-1.0	-1.0	1.2
Rheumatoid Arthritis	0.7	1.0	1.9	-0.2	1.2	1.4	-0.8
Schizophrenia (2014)	1.1	2.5	8.9	-3.0	-0.5	-0.7	-0.4
Triglycerides	0.2	0.3	0.8	-0.1	0.2	0.7	0.9
Type 2 Diabetes (T2D) (2012)	5.1	5.9	11.2	-1.8	-3.3	-2.4	1.8
Ulcerative Colitis	1.9	2.7	6.1	-2.5	-2.1	-0.7	0.2
Blood Eosinophil Count	0.2	1.3	3.2	-0.9	-1.8	0.5	0.9
Blood Platelet Count	1.9	21.6	39.4	6.1	-1.1	-2.9	6.3
Blood Red Count	1.2	11.2	20.2	-4.5	-4.5	-2.1	0.6
Blood White Count	0.6	4.8	12.2	0.2	-2.3	-1.2	3.5
Heel T-Score	1.0	7.8	12.4	-0.1	2.7	3.4	-3.5
BMI	0.6	3.4	6.8	-2.6	-2.1	-1.5	0.2
Height	0.3	6.0	8.5	2.8	-0.9	-2.9	2.6
Waist Hip Ratio (WHR)	0.4	1.9	3.1	1.7	1.3	1.8	0.2
Systolic Blood Pressure	0.6	3.1	7.3	-0.3	1.4	1.8	-2.7
Smoking Status	2.0	4.8	6.7	2.2	-1.5	-2.6	2.3
Allergy or Eczema	0.4	1.1	2.8	-1.7	-1.1	-0.6	-0.3
Cardiovascular Disease	0.3	0.9	3.0	-1.7	-0.8	-0.0	-0.2
Hypothyroidism (self reported)	2.0	4.5	8.7	-1.7	-2.9	-2.6	0.4
Respiratory disease	0.5	1.2	2.9	0.4	-1.2	-1.7	0.5
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.0	-0.3	-1.4	-2.0	1.2
Lung FEV1/FVC ratio	2.1	10.5	17.3	-3.2	1.8	3.3	-4.2
Lung FVC	0.1	0.6	1.0	1.0	-0.8	-0.6	0.6
Neuroticism	0.1	0.2	0.7	0.8	0.1	0.3	0.3
Chronotype (morning person)	0.5	1.2	2.8	0.3	0.3	1.7	-1.4
Hair Pigment	0.0	0.3	1.1	-0.0	0.2	0.1	-1.0
Tanning	0.0	0.2	0.3	-0.4	0.3	0.5	0.6
Hand grip strength (left)	0.2	0.4	1.3	-0.4	0.1	0.4	-1.1
Number of treatments/medications taken	0.9	1.6	2.5	-1.1	-1.6	-1.5	0.5
Average weekly spirits intake	0.4	0.4	0.9	-0.2	-0.2	-0.9	0.9
Sensitivity / hurt feelings	0.3	0.5	1.8	1.4	0.3	0.0	0.1
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.6	0.6	-0.2	-0.2	-0.8
Hearing difficulty/problems: Yes	0.3	0.4	0.9	0.8	0.2	0.2	-0.9
Relative age of first facial hair	0.0	0.1	0.3	-0.0	-0.6	0.1	0.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.5	1.2	-0.5	0.4	0.4	-1.1
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.0	-0.2	-1.1	-1.7	0.7
Ever had hysterectomy (womb removed)	1.1	1.3	3.8	-1.0	0.3	0.5	-2.0
Systolic blood pressure, automated reading	1.1	3.1	6.6	-0.9	1.2	2.0	-2.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.6	0.1	-0.7	-0.8	0.6
Angina	0.3	0.4	1.1	1.1	0.5	0.6	-0.2
Medication for hormone replacement therapy	1.1	1.2	2.5	-1.6	0.0	-0.3	-1.5
Vitamin and mineral supplements	1.2	1.6	4.3	0.0	-2.1	-1.4	-0.1
Supplements: Zinc	0.8	0.9	1.8	-1.4	-0.6	-0.4	-1.0
Medication: Co-codamol	0.5	0.5	1.3	0.4	0.8	1.1	-0.2
Medication: Metformin	0.4	0.6	1.2	-0.1	-0.3	-1.1	1.1
Diabetes (father)	0.1	0.2	0.5	0.3	0.0	-0.3	-0.7
Diabetes (mother)	0.7	0.9	1.4	-0.7	1.0	1.2	-0.8
Severe depression (siblings)	0.2	0.3	0.6	0.8	-0.4	0.1	-0.5
Pack years adult smoking proportion	0.8	1.2	2.6	-0.2	0.1	1.5	-1.6
Impedance of leg (right)	0.2	0.9	2.1	1.4	-0.2	0.5	-1.1
Leg fat-free mass (left)	0.6	3.3	7.7	-0.5	-1.5	-2.8	1.7
Trunk fat percentage	1.2	5.0	10.9	-0.7	-2.6	-3.3	1.3
Hand grip strength (right)	0.1	0.4	0.9	-0.3	-1.0	-0.7	0.2
Townsend deprivation index at recruitment	0.2	0.3	1.0	1.0	-0.2	-0.1	0.6
Current tobacco smoking	1.1	1.9	3.3	1.1	-1.8	-1.4	1.0
Average weekly fortified wine intake	0.5	0.6	1.4	0.2	1.2	0.7	-0.8
Maternal smoking around birth	0.3	0.4	1.3	0.0	-0.3	-0.1	-1.2
Fed-up feelings	0.2	0.4	1.3	1.1	0.1	0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.5	0.5	-0.7	-0.7	-0.4
Relative age voice broke	1.6	2.4	4.6	0.8	2.1	2.1	-0.4
Taking other prescription medications	1.3	1.9	3.2	0.5	-1.5	-1.8	1.4
Age when periods started (menarche)	0.5	1.1	4.3	2.1	0.1	0.1	0.0
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.1	-0.3	-0.7	-1.2	1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.1	0.5	1.4	1.2	-1.4
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	2.3	-1.5	-1.4	-0.9	-0.8
Qualifications: CSEs or equivalent	0.5	0.6	1.5	0.2	1.2	1.0	0.1
Serious illness, injury or assault to yourself	1.2	1.5	4.2	-2.0	-0.6	-0.2	-1.1
High blood pressure	0.9	2.4	4.7	-2.2	-0.3	0.5	-2.1
Hayfever, allergic rhinitis or eczema	1.5	3.3	4.1	-2.0	-2.0	-1.6	1.6
Multivitamins +/- minerals	0.6	0.8	1.6	0.3	1.3	1.2	0.0
Stomach or abdominal pain in last month	1.1	1.3	3.7	0.4	-1.9	-1.2	-0.2
Supplements: Glucosamine	0.2	0.3	0.6	-0.0	0.6	0.8	-0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	0.9	0.3	-0.5	0.5
Medication: Atenolol	0.3	0.3	0.6	-0.4	0.7	0.7	-0.2
Medication: Levothyroxine sodium	1.3	2.3	3.2	-1.7	-1.8	-1.7	-0.4
Sitting height	0.7	5.2	9.5	1.9	-0.8	-3.1	2.7
Chronic bronchitis/emphysema (father)	0.4	0.5	1.4	-1.2	-0.3	-0.3	-0.6
High blood pressure (mother)	0.1	0.1	0.2	-0.2	-0.5	-0.1	0.3
Body mass index (BMI)	0.4	1.8	2.7	-1.5	-1.4	-1.6	0.7
Impedance of leg (left)	0.2	1.0	2.8	1.7	0.2	0.5	-0.9
Leg predicted mass (left)	0.6	3.1	7.3	-0.5	-1.4	-2.7	1.7
Trunk fat mass	1.3	5.4	12.3	-0.6	-2.5	-3.5	1.7
Waist circumference	0.2	0.7	1.2	-1.1	-0.7	-0.7	0.8
Number of incorrect matches in round	1.1	1.8	5.0	-2.2	-0.4	0.5	-1.3
Past tobacco smoking	1.2	2.2	5.2	-1.4	0.2	1.4	-2.3
Alcohol usually taken with meals	0.4	0.6	1.0	0.8	1.0	0.8	-0.2
Nervous feelings	0.5	0.9	2.0	-1.4	-0.4	1.0	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.7	0.5	-0.9	-1.3	0.5
Hearing difficulty/problems with background noise	0.4	0.7	2.0	1.4	-0.1	0.1	-0.8
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.9	-0.2	0.6	0.0
Had menopause	1.6	2.0	6.0	-2.5	-0.6	0.4	-1.1
Had other major operations	0.2	0.2	0.4	-0.6	-0.5	-0.4	-0.1
Forced vital capacity (FVC)	0.3	1.3	2.5	1.6	-0.3	-1.5	0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.2	3.6	1.9	1.7	1.0	-1.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	-0.5	0.5	-0.6	0.0
Qualifications: None of the above	0.1	0.3	0.5	-0.7	-0.6	0.4	-0.4
Financial difficulties in last 2 years	0.4	0.5	1.3	-0.5	-0.2	0.6	-1.1
Mouth/teeth dental problems	0.4	0.6	1.3	0.8	-0.2	-0.8	1.1
Heart attack	0.4	0.5	0.9	-0.9	0.3	0.6	-0.8
Allergy	1.1	2.5	4.7	2.2	1.6	1.3	-1.1
Pain all over the body in last month	1.7	1.8	3.1	-0.3	1.1	1.6	-1.8
Diabetes (self-reported)	1.0	1.6	2.1	-1.1	-0.9	-1.5	1.5
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	2.9	-0.2	-1.0	-1.6	1.7
Medication: Ramipril	0.4	0.6	1.0	-0.7	-1.0	-0.6	-0.6
Medication: Simvastatin	0.9	1.3	2.4	-0.7	-1.5	-0.7	1.4
Fluid intelligence score	0.4	0.8	1.7	0.4	1.3	0.6	0.9
Illnesses of siblings	0.8	1.1	2.5	0.8	1.2	-0.1	1.6
Neuroticism score	0.2	0.4	1.0	0.8	-0.3	-0.1	1.0
Weight	0.7	3.3	7.6	-0.6	-1.7	-2.8	1.6
Impedance of arm (right)	0.1	0.6	1.1	0.8	-0.8	-1.0	0.2
Arm fat percentage (right)	0.8	3.1	6.5	-1.0	-1.9	-2.5	1.1
Trunk fat-free mass	0.1	0.8	1.9	-0.0	-0.1	-1.4	1.1
Hip circumference	0.8	3.2	4.9	-1.8	-1.9	-2.2	1.1
Time employed in main current job	0.6	0.7	1.7	-1.3	-0.7	0.7	-0.3
Alcohol intake versus 10 years previously	0.0	0.0	0.1	0.4	0.1	0.0	0.2
Father’s age at death	0.9	1.2	1.4	-0.9	1.2	1.1	-1.2
Worrier / anxious feelings	0.4	0.7	1.5	0.2	-0.8	-0.9	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.4	-0.0	-0.6	-0.2
Falls in the last year	1.2	1.6	3.4	-1.8	-1.4	-0.3	-0.9
Hair/balding pattern: Pattern 3	0.5	0.7	1.7	-0.1	1.0	1.3	-0.5
Number of live births	0.8	1.1	1.8	0.7	0.9	1.3	-1.1
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.9	0.3	0.2	-0.5	-0.9
Pulse rate	0.4	0.8	1.1	-0.9	-0.2	1.1	-1.1
Happiness	0.5	0.6	0.8	0.9	0.9	0.8	-0.6
Noisy workplace	0.5	0.6	2.3	0.1	-0.5	0.2	-1.5
Qualifications: A levels/AS levels or equivalent	1.2	2.6	7.2	2.7	1.6	0.9	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.3	0.4	1.8	1.4	-0.7
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.4	-0.1	0.7	-0.4
Asthma	0.1	0.3	0.7	-0.8	-0.3	-0.0	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.8	1.7	0.5	0.0	-0.4
Medication: Cholesterol lowering	0.5	0.8	2.1	0.8	-0.7	-0.3	1.4
Depression (self-reported)	1.4	1.7	3.7	-0.2	-1.9	-1.1	1.4
Medication: Lansoprazole	2.0	2.3	4.3	2.1	-0.4	-1.6	1.4
Prospective memory result	0.4	0.5	0.9	-0.9	-0.9	-0.2	0.6
Lung cancer (father)	0.9	1.0	1.9	0.1	-0.8	-1.4	1.2
Illnesses of mother	0.2	0.2	0.3	0.5	0.5	0.4	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.3	0.5	-0.2	-0.4	-0.4
Pulse wave Arterial Stiffness index	0.8	1.0	2.2	-1.2	-0.2	-0.5	-1.5
Impedance of arm (left)	0.2	0.9	1.7	0.6	-1.3	-1.3	-0.1
Arm fat mass (right)	0.8	3.5	7.5	-1.0	-2.0	-2.7	1.2
Trunk predicted mass	0.1	0.8	2.0	0.1	0.0	-1.4	1.1
Standing height	0.5	4.9	9.5	1.8	-1.2	-3.1	2.3
Length of working week for main job	1.2	1.4	2.3	-1.5	-1.0	-0.4	-1.4
Exposure to tobacco smoke at home	0.4	0.4	1.0	1.0	-0.6	-0.4	-0.4
Breastfed as a baby	0.3	0.4	0.7	-0.4	0.8	0.8	-0.2
Tense / ‘highly strung’	1.3	2.1	3.4	1.7	-1.0	-1.1	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.4	0.3	-0.4	-1.2	0.1
Hair/balding pattern: Pattern 4	1.0	2.4	8.4	2.9	0.2	-0.9	0.6
Birth weight of first child	0.6	1.1	4.4	-0.3	-0.0	0.2	-2.1
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.8	-0.2	-0.5	-0.6
Pulse wave reflection index	0.9	1.1	2.8	0.1	1.2	0.5	-1.7
Ever highly irritable/argumentative for 2 days	2.1	2.5	5.6	0.6	-1.9	-2.4	0.6
Loud music exposure frequency	3.2	3.5	6.6	2.6	-0.9	-1.8	1.8
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	1.8	1.4	1.2	0.1	1.1
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.7	-1.1	1.1	1.9	-1.1
Blood clot in the leg (DVT)	0.9	1.2	3.6	0.8	-0.5	-0.7	1.9
Medication: Paracetamol	0.7	1.1	1.7	1.2	-1.1	-1.3	0.2
Headache pain in last month	0.3	0.6	1.6	0.0	-1.3	-0.8	0.4
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	-0.3	0.1	-0.1	-0.4
Glaucoma (self-reported)	0.1	0.1	0.2	-0.5	0.3	0.5	0.0
Gout (self-reported)	3.1	4.3	7.2	2.7	2.6	1.6	-1.0
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	5.6	-0.8	-2.1	-2.4	0.9
Medication: Amlodipine	1.7	2.4	3.9	-2.0	0.9	1.2	-1.8
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.0	0.3	1.7	1.1	-1.0
Birth weight	0.3	0.6	1.5	1.2	0.3	-0.1	0.8
Chronic bronchitis/emphysema (mother)	0.7	0.9	2.1	0.3	-0.6	-1.5	0.9
High blood pressure (siblings)	0.3	0.4	0.6	0.8	-0.3	0.8	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.0	3.1	1.8	0.0	-0.9	0.4
Body fat percentage	1.1	4.4	9.3	-0.7	-2.5	-3.0	1.1
Leg fat percentage (right)	0.5	1.7	3.6	-0.5	-1.7	-1.9	0.4
Arm fat-free mass (right)	0.3	1.6	3.8	-0.1	-0.8	-2.0	1.3
Exposure to tobacco smoke outside home	0.4	0.5	1.0	0.3	-0.9	-1.0	0.4
Comparative body size at age 10	0.1	0.3	0.9	-1.0	-0.1	-0.3	0.2
Number of full brothers	0.6	0.7	1.4	0.0	0.3	1.1	-1.2
Worry too long after embarrassment	0.1	0.1	0.3	0.1	0.6	0.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.6	-0.1	-0.8	-0.1	0.1
Wheeze or whistling in the chest in last year	0.0	0.0	0.2	0.0	-0.0	0.2	-0.4
Number of children fathered	1.7	2.0	5.4	0.7	-1.1	-2.3	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	0.6	1.3	0.6	-0.1
Age at first live birth	0.2	0.4	0.6	-0.7	0.7	0.8	-0.1
Pulse wave peak to peak time	0.9	1.1	3.0	1.2	0.0	0.1	1.7
Health satisfaction	0.3	0.4	0.7	-0.9	-0.3	-0.8	-0.3
Shortness of breath walking on level ground	0.6	0.7	1.3	-0.9	-1.1	-0.8	-0.3
Qualifications: College or University degree	0.1	0.2	0.5	0.7	0.3	-0.3	-0.3
Eye problems/disorders: None of the above	3.3	3.8	8.0	-0.4	1.5	2.8	-2.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.2	-1.5	0.1	0.9	-1.1
Emphysema/chronic bronchitis	2.1	2.3	4.0	-1.2	-1.7	-2.0	1.0
Medication for pain relief, constipation, heartburn	1.4	2.3	4.5	-1.4	1.5	2.1	-0.8
Neck or shoulder pain in last month	0.7	1.0	2.3	-1.5	-1.0	-0.8	0.6
Medication: Blood pressure	0.3	0.5	1.3	-0.7	0.0	0.7	-1.1
Angina (self-reported)	0.2	0.3	0.8	0.9	0.3	0.5	-0.3
Migraine (self-reported)	1.0	1.3	2.3	-0.8	-1.5	-1.3	0.5
Medication: Ibuprofen	0.8	1.0	2.9	1.7	0.9	0.1	-0.4
Medication: Allopurinol	0.4	0.5	1.3	1.1	0.7	0.5	0.3
Medication: Omeprazole	0.8	1.0	2.7	-1.6	-0.3	-1.0	-0.2
Medication: Seretide 50 evohaler	0.4	0.4	1.0	1.0	-0.2	-0.7	0.4
Mean time to correctly identify matches	1.4	2.6	4.7	-0.8	1.4	2.2	-1.8
Heart disease (mother)	0.1	0.1	0.3	-0.5	-0.1	-0.3	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.6	-0.4	1.3	0.2	0.4
Whole body fat mass	1.3	5.3	11.9	-0.7	-2.5	-3.5	1.6
Leg fat mass (right)	0.9	3.5	7.5	-0.8	-2.1	-2.7	1.1
Arm predicted mass (right)	0.3	1.5	3.8	-0.2	-0.6	-1.9	1.4
Pulse rate, automated reading	0.1	0.3	0.9	-0.5	-1.0	0.1	0.2
Alcohol intake frequency.	0.2	0.5	1.2	-1.1	-0.7	0.4	-0.2
Comparative height size at age 10	0.5	3.0	5.5	1.2	-0.6	-2.2	2.4
Number of full sisters	0.4	0.5	1.6	-0.3	-0.6	0.2	-1.3
Suffer from ‘nerves’	0.3	0.4	0.8	-0.2	-0.9	-0.7	0.5
Overall health rating	0.7	1.5	2.8	-1.4	-1.7	-1.0	-0.5
Chest pain or discomfort	1.8	2.5	4.8	0.5	-2.2	-1.6	1.6
Had major operations	0.7	0.8	1.6	-0.6	-1.3	-0.5	-1.0
Age at last live birth	0.2	0.3	0.6	0.1	0.6	0.7	0.8
Family relationship satisfaction	0.9	1.1	2.6	0.4	0.9	1.6	-1.0
Leg pain on walking	1.6	2.0	5.0	-0.9	-2.2	-1.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.6	1.6	1.2	0.7	0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.4	-1.6	0.3	0.4	-0.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.1	1.1	-0.8	-0.8	1.4
Medication: Aspirin	0.6	0.8	1.7	0.4	-0.6	-1.0	1.3
Supplements: Vitamin C	0.1	0.1	0.2	-0.4	0.5	0.2	0.4
Knee pain experienced in last month	0.2	0.4	1.1	-1.0	-0.5	0.1	-0.5
Hypertension (Self-reported)	0.7	1.8	3.8	-1.9	-0.4	0.5	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.5	-0.6	1.2	-0.1	0.2
Illnesses of father: Heart disease	2.3	3.2	6.8	1.1	-2.6	-2.1	0.8
Illnesses of siblings: Diabetes	0.1	0.1	0.4	-0.3	-0.6	-0.2	0.1
Smoking status: Previous	0.6	0.9	2.0	0.8	0.2	-1.0	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.3	0.7	-0.4	-1.5	0.3
Whole body fat-free mass	0.3	1.6	4.0	-0.2	-0.6	-2.0	1.5
Leg fat-free mass (right)	0.6	3.3	7.6	-0.3	-1.2	-2.8	2.0
Arm fat percentage (left)	0.9	3.5	7.2	-1.1	-2.1	-2.7	1.1
Average weekly red wine intake	0.2	0.3	0.8	0.0	-0.7	-0.9	0.2
Handedness (chirality/laterality): Left-handed	5.4	6.5	9.6	1.3	3.1	2.3	-3.1
Mood swings	1.3	2.3	3.9	2.0	1.9	1.2	-0.5
Loneliness, isolation	0.0	0.0	0.1	-0.3	-0.1	0.0	-0.2
Long-standing illness, disability or infirmity	1.5	2.3	5.0	-0.9	-2.2	-1.8	-0.1
Ever had bowel cancer screening	1.0	1.2	3.4	-1.9	-0.3	0.8	-0.8
Diabetes diagnosed by doctor	0.3	0.6	1.1	-0.6	-0.2	-0.9	1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	2.9	1.3	1.4	1.7	0.3
Friendships satisfaction	0.5	0.7	1.0	0.2	0.8	0.9	-1.0
Qualifications: nursing, teaching	0.6	0.9	1.7	-1.3	0.9	0.8	-0.8
Commuting to job workplace: Walk	1.7	1.9	2.6	1.6	-1.4	-1.2	1.2
Eye problems/disorders: Cataract	2.1	2.4	5.2	0.4	-1.1	-2.3	1.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.7	-0.0	-1.3	-0.7	1.0
Medication for cholesterol	1.4	2.1	5.7	2.4	1.1	1.2	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.1	-0.4	0.5	1.1	-0.6
Back pain experienced in last month	0.4	0.5	1.4	-0.4	-0.7	-1.2	0.3
Mineral and other dietary supplements	0.4	0.6	1.1	-0.2	-1.1	-1.1	0.4
Breast cancer (self-reported)	2.8	3.4	6.8	0.5	1.8	2.6	-1.8
Asthma (self-reported)	0.2	0.3	0.4	-0.6	-0.6	-0.4	0.6
Osteoporosis (self-reported)	0.5	0.6	1.6	0.1	-0.0	-0.8	1.3
Osteoarthritis (self-reported)	0.2	0.3	0.6	0.8	0.2	-0.6	0.3
Medication: Aspirin	0.7	0.9	2.2	0.5	-0.6	-0.9	1.5
Medication: Gliclazide	0.7	0.8	1.8	-0.5	-0.7	-1.3	0.9
Illnesses of father: None of the above (group 1)	2.1	2.6	8.1	1.3	0.2	-0.9	2.9
Smoking status: Current	1.5	2.4	3.5	1.3	-1.9	-1.5	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	-0.8	-0.0	0.5	-1.0
Whole body water mass	0.3	1.9	4.6	-0.2	-0.8	-2.1	1.5
Leg predicted mass (right)	0.6	3.2	7.4	-0.3	-1.2	-2.7	2.0
Arm fat mass (left)	1.1	4.4	9.8	-0.9	-2.2	-3.1	1.5
Number of self-reported non-cancer illnesses	1.2	2.1	4.9	-1.0	-2.2	-1.5	0.4
Average weekly champagne plus white wine intake	0.3	0.4	1.2	-0.6	0.1	0.3	1.1
Miserableness	1.4	2.4	5.1	1.1	2.3	1.8	-0.2
Guilty feelings	0.1	0.2	0.3	0.5	-0.6	-0.3	0.3
Wears glasses or contact lenses	0.4	0.5	1.1	0.0	-0.3	-1.1	0.9
Ever taken oral contraceptive pill	0.2	0.2	0.7	-0.8	-0.3	0.1	0.1
Hearing aid user	1.5	1.7	3.8	-1.7	0.2	0.5	-1.9
Mother’s age at death	0.1	0.2	0.5	-0.2	0.7	0.0	-0.4
Financial situation satisfaction	0.8	0.9	3.2	1.8	0.4	0.1	0.7
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	0.0	-0.3	0.5	0.5
Commuting to job workplace: Public transport	1.0	1.2	3.7	1.9	-0.0	-0.0	1.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.2	0.1	0.2	0.4
Medication: Blood pressure	0.8	1.6	3.0	-1.4	0.8	0.8	-1.7
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.8	0.0	-1.7	-1.6	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.4	-0.6	0.1	-0.0	0.4
High cholesterol (Self-reported)	1.5	2.6	5.3	0.6	-2.0	-1.0	2.3
Medication: Bendroflumethiazide	0.2	0.3	0.6	0.8	0.4	0.3	-0.7
Medication: Paracetamol	0.5	0.8	1.3	1.1	-0.8	-1.2	-0.1
Medication: Lisinopril	0.2	0.2	0.5	0.4	0.1	0.7	-0.4
Medication: Atorvastatin	0.2	0.3	1.0	0.5	-0.0	-0.2	1.0
Illnesses of father: High blood pressure	0.4	0.5	1.4	-0.3	-0.6	-0.3	-1.2
Alcohol drinker status: Never	1.4	1.6	4.9	-2.2	-1.2	-0.3	0.2
Ever smoked	0.2	0.4	0.8	0.5	0.2	-0.7	0.9
Basal metabolic rate	0.4	2.1	5.4	-0.2	-0.9	-2.3	1.5
Leg fat percentage (left)	0.4	1.6	3.5	-0.4	-1.5	-1.9	0.6
Arm fat-free mass (left)	0.2	1.0	2.7	0.1	-0.4	-1.6	1.2
Number of operations (self-reported)	1.6	2.3	4.7	-2.2	-1.8	-0.9	-0.8
Average weekly beer plus cider intake	0.3	0.5	1.3	0.0	1.2	-0.7	-0.2
Irritability	1.1	1.8	2.7	1.1	-1.4	-1.1	1.7
Risk taking	0.4	0.6	1.6	-0.3	-1.3	-0.8	0.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.5	0.1	-0.9	-1.2	1.9
Fractured/broken bones in last 5 years	1.9	2.4	5.6	-1.9	-0.0	0.7	-2.4
Age started oral contraceptive pill	0.2	0.3	0.6	-0.8	-0.5	-0.3	0.4
Diastolic blood pressure, automated reading	0.4	1.3	3.9	-0.9	-0.2	0.5	-2.0
Ever depressed for a whole week	1.7	2.1	4.4	-0.9	2.1	1.2	-1.3
Unable to work because of sickness or disability	0.7	1.0	2.8	-0.9	-1.7	0.1	-0.5
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.3	-0.4	0.2	0.4
Myopia	1.2	1.7	4.1	1.4	0.3	-0.9	2.0
Vascular/heart problems diagnosed by doctor	0.5	1.5	2.9	1.7	0.1	-0.4	1.7
Cholesterol lowering medication	0.8	1.2	2.5	-1.6	-0.9	-0.6	1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.9	-0.9	-0.8	-1.4	0.4
Pain experienced in last month	1.3	2.1	3.3	1.6	1.8	1.5	-0.4
Supplements: Calcium	0.2	0.2	0.4	-0.5	-0.0	-0.2	0.7
Basal cell carcinoma (self-reported)	1.0	1.1	3.2	0.2	1.8	1.0	-0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.9	0.3	0.4	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.3	0.9	-0.1	-0.5	1.8
Heart disease (siblings)	1.0	1.2	2.6	-0.8	-1.6	-0.6	-1.0
Alcohol drinker status: Previous	2.4	2.7	4.8	-2.2	-1.8	-0.7	-1.6
Pack years of smoking	0.9	1.3	2.6	-0.1	0.2	1.6	-1.6
Impedance of whole body	0.1	0.6	1.1	1.1	-0.9	-0.7	-0.3
Leg fat mass (left)	0.8	3.3	7.3	-0.7	-2.0	-2.7	1.2
Arm predicted mass (left)	0.3	1.3	3.3	0.1	-0.5	-1.8	1.3