TWAS
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Models
Genes
Traits
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Traits
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Blood Red Count
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chr5:87,006,055-88,875,673
Best TWAS P=1.99e-22 · Best GWAS P=7.32e-36 conditioned to 1.23e-15
87M
87.5M
88M
88.5M
0
10
20
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
ROSMAP
Brain Pre-frontal Cortex
LINC00461
0.10
0.07
lasso
2
0.05
4.5e-07
9.7
9.7
2.0e-22
-0.18
1.00
0.00
TRUE
2
ROSMAP
Brain Pre-frontal Cortex
CTC-498M16.2
0.11
0.13
lasso
6
0.12
1.2e-14
-7.5
-7.6
3.5e-14
0.41
1.00
0.00
TRUE
3
YFS
Blood
MEF2C
0.16
0.09
enet
28
0.12
5.1e-36
-9.8
7.4
1.4e-13
-0.83
1.00
0.00
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
TMEM161B
0.03
0.01
blup
48
0.01
4.6e-02
-5.8
-5.2
1.5e-07
0.28
0.02
0.34
FALSE