Best TWAS P=1.21e-12 · Best GWAS P=4.07e-14 conditioned to 0.00125
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RAB23 | 0.04 | 0.01 | blup | 202 | 0.02 | 1.3e-03 | 1.8 | 6.4 | 1.7e-10 | 0.46 | 0.07 | 0.18 | FALSE |
| 2 | GTEx | Brain Hypothalamus | ZNF451 | 0.17 | 0.18 | lasso | 2 | 0.14 | 3.1e-04 | 7.1 | 7.1 | 1.2e-12 | 0.78 | 0.05 | 0.82 | TRUE |
| 3 | GTEx | Heart Atrial Appendage | DST | 0.15 | 0.01 | lasso | 1 | 0.02 | 4.8e-02 | 5.5 | 5.5 | 3.3e-08 | 0.90 | 0.02 | 0.92 | FALSE |
| 4 | GTEx | Pancreas | PRIM2 | 0.18 | 0.04 | lasso | 5 | 0.04 | 9.4e-03 | 7.0 | -6.9 | 5.7e-12 | -0.68 | 0.02 | 0.66 | FALSE |
| 5 | GTEx | Testis | DST | 0.17 | 0.12 | lasso | 7 | 0.12 | 4.9e-06 | 7.1 | -6.9 | 5.0e-12 | -0.78 | 0.09 | 0.90 | FALSE |
| 6 | METSIM | Adipose | RAB23 | 0.03 | 0.00 | bslmm | 197 | 0.01 | 2.3e-02 | 6.5 | 7.1 | 1.6e-12 | 0.51 | 0.10 | 0.31 | FALSE |