TWAS hub - PRIM2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.116	0.0359	8.1e-07	0.080	NA	0.068	NA	0.066	3.1e-08	NA	3.2e-07	NA	4.8e-07
2	GTEx	Pancreas	0.176	0.0750	2.3e-03	0.040	NA	0.030	NA	0.039	8.8e-03	NA	2.0e-02	NA	9.4e-03
3	TCGA	Prostate Adenocarcinoma	0.110	0.0415	2.3e-07	0.073	0.068	0.079	NA	0.071	4.3e-08	1.1e-07	1.2e-08	NA	6.9e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Comparative body size at age 10	4.1	11.4	15.0	3.1	-3.1	3.9
Friendships satisfaction	3.7	4.6	8.8	2.0	-3.0	-1.0
Current tobacco smoking	3.4	5.6	15.8	-0.7	-4.0	-0.6
Lung cancer (father)	3.3	3.8	8.5	2.9	0.1	1.8
Smoking status: Current	3.3	5.2	15.3	-0.2	-3.9	-0.6
Relative age voice broke	3.2	4.9	10.3	-3.2	1.8	-1.0
Chronotype (morning person)	3.1	7.2	16.0	-0.6	4.0	2.3
Hair/balding pattern: Pattern 2	3.1	4.0	8.4	-1.8	2.9	0.7
Lung FEV1/FVC ratio	3.0	15.1	30.6	0.7	-5.5	-3.8
Eye problems/disorders: Cataract	3.0	3.5	6.0	-2.5	0.6	-2.0
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	5.3	-2.3	-0.7	-1.9
Tinnitus: Yes, now most or all of the time	2.9	3.4	9.1	-3.0	-0.0	-1.1
Deep venous thrombosis (DVT) (self-reported)	2.8	3.7	8.4	-1.4	-0.8	-2.9
Frequency of tiredness / lethargy in last 2 weeks	2.6	4.3	12.0	3.5	0.7	-0.6
Ever depressed for a whole week	2.6	3.2	6.7	-0.2	1.7	-2.6
Diabetes (father)	2.5	3.1	4.7	-2.2	-1.2	-1.8
Number of live births	2.5	3.5	8.2	1.4	0.3	2.9
Pulse wave peak to peak time	2.5	2.9	4.5	-2.1	2.1	-0.1
Supplements: Vitamin C	2.5	3.0	4.5	-1.7	-1.2	-2.1
Knee pain experienced in last month	2.5	3.8	4.8	1.7	2.2	1.9
Asthma	2.4	4.6	13.7	3.7	0.1	0.5
Prospective memory result	2.4	2.9	3.9	-1.3	-1.8	-2.0
Asthma (self-reported)	2.4	4.7	13.6	3.7	0.1	0.8
Relative age of first facial hair	2.3	4.8	11.7	-3.4	1.6	-0.2
Fed-up feelings	2.3	4.2	9.4	3.1	-1.6	-0.6
Irritability	2.3	3.9	7.8	2.8	-1.6	-1.3
Exposure to tobacco smoke at home	2.2	2.4	3.8	1.8	0.5	1.9
Blood clot in the leg (DVT)	2.2	2.8	6.4	-1.1	-0.9	-2.5
Glaucoma (self-reported)	2.2	2.6	6.7	-0.2	1.1	2.6
Diastolic blood pressure, automated reading	2.2	6.9	18.9	-0.8	-4.3	-1.0
Bipolar Disorder or Schizophrenia	2.1	5.2	11.4	-0.4	3.4	-2.0
HbA1C	2.1	2.3	3.3	-0.7	1.8	-1.8
Respiratory disease	2.1	4.7	12.8	3.6	0.8	0.9
Happiness	2.1	2.6	5.8	1.0	-2.4	-1.0
Pulse wave Arterial Stiffness index	2.1	2.4	3.6	1.9	-1.9	0.2
Leg fat percentage (right)	2.1	7.7	21.0	1.4	-4.6	-0.2
Commuting to job workplace: Public transport	2.1	2.5	3.5	-0.7	1.9	-1.8
Schizophrenia (2018)	2.0	4.1	6.8	-0.6	2.2	-2.6
Qualifications: None of the above	2.0	4.3	11.7	0.5	-3.4	1.0
Blood Red Count	1.9	18.1	47.5	-0.3	-6.9	-2.6
Heel T-Score	1.9	15.2	34.8	-3.3	-0.1	-5.9
Sensitivity / hurt feelings	1.9	3.2	6.0	1.2	-1.5	-2.5
Average weekly fortified wine intake	1.9	2.2	4.5	-0.7	1.3	-2.1
Peak expiratory flow (PEF)	1.9	4.3	11.1	-1.2	-0.6	-3.3
Overall health rating	1.9	4.1	11.7	3.4	-0.5	0.5
Qualifications: nursing, teaching	1.9	2.9	7.7	0.3	2.8	0.9
Leg fat percentage (left)	1.9	6.9	18.4	1.5	-4.3	-0.2
Alzheimer’s Disease (including proxy)	1.8	2.6	3.9	0.5	1.9	2.0
Schizophrenia (2014)	1.8	3.9	7.7	0.2	2.8	-2.0
Hand grip strength (left)	1.8	4.8	7.1	-2.4	-1.3	-2.7
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	4.0	-1.6	2.0	-0.7
Maternal smoking around birth	1.8	2.6	5.3	1.5	0.4	2.3
Mouth/teeth dental problems: Dentures	1.8	3.1	7.7	-2.8	-1.1	0.6
Commuting to job workplace: Walk	1.8	2.0	4.5	0.4	2.1	-1.1
Bipolar Disorder (2011)	1.7	1.6	4.0	-0.5	0.8	-2.0
HDL Cholesterol	1.7	2.8	5.3	-1.7	2.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	5.7	2.4	-1.1	0.4
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	4.0	1.5	-0.8	2.0
Family relationship satisfaction	1.7	2.1	4.7	2.2	-1.3	-0.3
Smoking Status	1.6	3.9	6.5	-0.0	-2.3	-2.5
Systolic blood pressure, automated reading	1.6	4.8	5.4	-2.3	-2.1	-2.1
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.4	6.6	2.6	0.1	0.8
Mouth/teeth dental problems: Bleeding gums	1.6	2.0	5.9	0.4	-0.2	2.4
Gout (self-reported)	1.6	2.2	5.3	-0.8	-2.3	-0.8
Body fat percentage	1.6	6.4	16.5	1.6	-4.1	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.8	5.0	-0.2	2.2	0.7
Medication: Allopurinol	1.6	2.1	4.2	-1.3	-2.0	-0.7
Long-standing illness, disability or infirmity	1.6	2.4	4.6	2.1	0.2	-1.6
Breast cancer (self-reported)	1.6	1.9	4.9	0.7	-2.2	-0.7
Mother’s age at death	1.6	1.9	3.0	-1.7	1.6	0.3
Lung FVC	1.5	7.8	11.1	-2.9	2.0	-3.3
Taking other prescription medications	1.5	2.4	5.6	2.4	1.2	0.4
Medication: Cholesterol lowering	1.5	2.4	5.1	-1.2	-0.8	-2.2
Ever highly irritable/argumentative for 2 days	1.5	1.9	2.4	1.3	-1.2	-1.6
Number of children fathered	1.5	1.7	2.1	1.4	-1.5	0.9
Migraine (self-reported)	1.5	1.8	4.3	0.6	0.9	2.1
Leg fat mass (right)	1.5	5.7	12.9	1.8	-3.6	0.9
Pulse rate, automated reading	1.5	4.9	12.8	1.4	-3.6	-0.4
Alcohol drinker status: Previous	1.5	1.7	1.9	1.3	1.4	1.3
Bipolar Disorder (2018)	1.4	2.3	6.8	0.1	2.6	0.1
Fasting Glucose	1.4	1.7	3.8	-0.2	1.0	-2.0
Supplements: Zinc	1.4	1.5	3.9	0.2	2.0	-0.7
Trunk fat percentage	1.4	5.5	13.5	1.7	-3.7	0.3
Mouth/teeth dental problems	1.4	2.1	3.6	1.3	1.0	-1.9
Neuroticism score	1.4	3.0	7.3	2.7	0.6	-1.1
Arm fat percentage (right)	1.4	5.3	11.2	2.0	-3.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	4.1	-1.4	2.0	-0.6
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	3.7	-1.4	1.0	-1.9
Exposure to tobacco smoke outside home	1.4	1.8	3.1	1.5	-0.1	1.8
Arm fat percentage (left)	1.4	5.6	11.9	2.0	-3.5	0.9
Alzheimer’s Disease (in father)	1.3	1.4	2.0	1.0	1.1	1.4
Age when periods started (menarche)	1.3	3.1	7.1	-2.7	1.4	0.4
Supplements: Glucosamine	1.3	1.7	4.4	-0.4	2.1	0.7
Breastfed as a baby	1.3	1.6	4.2	0.7	2.0	0.1
Wheeze or whistling in the chest in last year	1.3	2.4	6.8	2.6	0.5	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	4.5	-1.9	-0.6	-2.1
Pack years of smoking	1.3	1.9	3.5	-1.2	-1.9	0.9
Leg fat mass (left)	1.3	4.9	11.0	1.7	-3.3	0.9
Alzheimer’s Disease (in mother)	1.2	1.4	2.9	0.8	0.8	1.7
Ovarian Cancer	1.2	1.6	3.4	0.0	1.1	1.9
Pack years adult smoking proportion	1.2	1.9	3.0	-1.0	-1.7	1.2
Noisy workplace	1.2	1.5	2.6	-1.1	-1.6	-0.9
Pulse wave reflection index	1.2	1.4	3.1	1.8	0.4	1.0
Medication for cholesterol, blood pressure or diabetes	1.2	2.1	4.0	1.4	-0.5	2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.3	1.0	1.8	0.2
Whole body fat mass	1.2	5.0	11.7	1.6	-3.4	0.9
Illnesses of siblings: Diabetes	1.2	1.5	3.0	-1.7	-0.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.5	1.6	1.3	-1.1	-1.2
Systolic Blood Pressure	1.1	5.6	5.9	-2.4	-2.3	-2.4
Ever used hormone-replacement therapy (HRT)	1.1	1.4	2.7	0.9	0.7	1.7
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.5	0.2	1.6	-1.2
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.1	-0.4	1.4	1.3
Medication: Bendroflumethiazide	1.1	1.7	4.1	0.6	-2.0	-0.8
Number of operations (self-reported)	1.1	1.7	2.2	0.9	1.4	1.5
Unable to work because of sickness or disability	1.1	1.5	2.6	1.0	-0.9	-1.6
Neuroticism (2016)	1.0	1.4	4.1	0.2	0.2	-2.0
Triglycerides	1.0	1.7	4.6	0.3	-2.1	-0.7
Neuroticism	1.0	2.4	4.7	2.2	1.3	-0.9
Hand grip strength (right)	1.0	2.7	3.4	-1.8	-1.5	-1.6
Trunk fat mass	1.0	4.3	9.4	1.7	-3.1	0.8
Nervous feelings	1.0	1.9	3.0	1.7	1.6	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	3.6	-1.4	-1.1	-1.9
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	6.9	-1.7	0.3	-2.6
Depression (self-reported)	1.0	1.2	2.0	-0.9	0.9	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.1	7.1	-1.5	0.2	-2.7
Arm fat mass (right)	1.0	4.1	6.8	1.9	-2.6	1.4
Loud music exposure frequency	1.0	1.1	1.6	0.3	-1.2	-1.3
Birth weight	1.0	2.2	2.9	-1.1	1.7	1.6
Medication: Omeprazole	1.0	1.2	1.8	1.4	-1.1	0.7
Chest pain or discomfort	1.0	1.4	3.9	2.0	0.1	0.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.7	-1.0	1.0	-1.3
Smoking status: Previous	1.0	1.5	2.5	0.8	1.6	-1.2
Ever had bowel cancer screening	1.0	1.1	2.1	-1.5	-0.2	1.1
Illnesses of father: None of the above (group 1)	1.0	1.2	2.5	1.6	-0.4	1.0
Arm fat mass (left)	1.0	4.1	7.1	1.8	-2.7	1.4
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.3	-0.3	1.5	-1.2
Myopia	1.0	1.5	4.3	-0.1	2.1	-0.3
Medication: Atenolol	0.9	1.1	3.0	-1.7	-0.3	-0.5
Heart attack	0.9	1.1	3.1	-0.3	1.7	0.4
Fluid intelligence score	0.9	1.9	3.3	0.7	1.8	-1.4
Time employed in main current job	0.9	1.1	2.4	1.6	-0.8	-0.2
Falls in the last year	0.9	1.3	1.9	0.3	1.3	-1.4
Qualifications: A levels/AS levels or equivalent	0.9	2.1	5.5	-0.8	2.4	0.3
Birth weight of first child	0.9	1.6	2.8	-0.7	1.3	1.7
Headache pain in last month	0.9	1.6	3.3	-1.8	0.2	-1.2
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.6	1.6	0.3	0.9
Qualifications: College or University degree	0.9	2.7	4.7	1.8	2.2	-0.4
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.6	0.6	0.5	1.6
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.4	-1.0	-1.0	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.7	1.6	-0.2	-0.5
Illnesses of father: Heart disease	0.9	1.2	2.7	-0.5	1.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.4	1.0	1.2	0.8
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.4	-0.7	0.5	1.6
Pain experienced in last month	0.9	1.5	2.3	-0.0	-1.5	1.5
Coronary Artery Disease (CAD)	0.8	1.0	3.0	-0.1	-0.1	-1.7
BMI	0.8	4.8	10.0	2.0	-3.2	0.5
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.8	1.7	0.4	0.6
Angina	0.8	1.1	1.6	-1.2	0.4	-1.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.2	-0.8	-1.1	-0.8
Body mass index (BMI)	0.8	3.4	5.2	2.0	-2.3	1.0
Waist circumference	0.8	3.0	4.8	1.8	-2.2	1.0
Number of incorrect matches in round	0.8	1.3	3.2	0.7	0.5	-1.8
Alcohol usually taken with meals	0.8	1.3	2.5	-1.1	1.6	-0.4
Had menopause	0.8	1.1	1.9	0.8	0.8	1.4
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.7	0.8	0.8	-1.3
Length of working week for main job	0.8	0.9	1.3	-0.5	-1.0	1.1
Medication: Paracetamol	0.8	1.4	3.6	-1.9	0.8	0.2
Leg pain on walking	0.8	1.0	2.6	1.6	0.4	0.5
Hypertension (Self-reported)	0.8	2.3	3.1	-1.8	-1.2	-1.5
Mineral and other dietary supplements	0.8	1.1	1.5	1.2	-1.0	0.9
Vascular/heart problems diagnosed by doctor	0.8	2.3	3.4	1.9	1.1	1.5
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.1	0.5	-1.4	0.7
Depressed Affect (Nagel 2018)	0.7	1.4	2.6	1.6	-1.0	-0.7
Ulcerative Colitis (UC)	0.7	1.3	3.7	-0.4	1.9	0.2
Major Depression (MDD)	0.7	0.9	2.6	0.1	-0.0	1.6
Lupus	0.7	1.1	1.7	1.2	1.3	0.3
Ulcerative Colitis	0.7	1.0	1.5	1.2	1.2	0.3
Type 2 Diabetes (T2D) (2018)	0.7	1.3	2.7	0.8	-0.8	-1.6
Vitamin and mineral supplements	0.7	0.9	2.4	0.6	0.0	1.6
Severe depression (siblings)	0.7	0.8	1.4	0.9	0.2	1.2
Impedance of leg (right)	0.7	3.3	6.8	-1.0	-2.6	-1.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.8	1.4	0.1	0.8
High blood pressure	0.7	1.9	3.2	-1.8	-1.2	-1.1
High blood pressure (mother)	0.7	1.0	3.0	-1.7	0.4	-0.2
Medication: Ramipril	0.7	0.8	1.1	-0.8	-0.9	-1.1
Medication: Lansoprazole	0.7	0.8	2.1	0.6	-1.4	0.1
Hair/balding pattern: Pattern 4	0.7	1.8	2.2	1.5	-1.4	-1.1
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	2.7	-1.1	-0.6	1.6
Worry too long after embarrassment	0.7	1.1	1.7	1.2	1.3	0.1
Health satisfaction	0.7	0.9	2.6	1.6	0.1	-0.3
Emphysema/chronic bronchitis	0.7	0.8	1.3	-0.0	1.1	1.0
Angina (self-reported)	0.7	0.9	1.6	-1.2	0.3	-1.0
Medication: Ibuprofen	0.7	0.9	1.6	0.6	1.3	-0.8
Mean time to correctly identify matches	0.7	1.4	3.1	-1.0	0.3	-1.8
Heart disease (mother)	0.7	0.8	1.3	-0.5	1.0	-1.1
Commuting to job workplace: Car/motor vehicle	0.7	0.9	2.2	-0.6	-1.5	-0.2
Medication: Aspirin	0.7	0.9	1.5	-1.2	0.7	-0.8
Miserableness	0.7	1.2	3.0	1.7	-0.8	-0.2
Guilty feelings	0.7	1.1	2.5	0.0	1.6	0.8
Supplements: Calcium	0.7	0.8	1.7	0.2	1.3	-0.8
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.6	-0.2	1.6	0.4
Primary Biliary Cirrhosis	0.6	0.9	1.9	0.8	-0.3	-1.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.8	-0.3	1.4	-0.1
Cardiovascular Disease	0.6	2.1	3.2	-1.4	-1.1	-1.8
Average weekly spirits intake	0.6	0.8	2.2	-0.4	-0.2	-1.5
Medication for hormone replacement therapy	0.6	0.7	2.0	1.4	-0.4	0.3
Medication: Co-codamol	0.6	0.7	1.8	-0.2	-1.4	-0.4
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.3	0.6	1.0	1.5
Multivitamins +/- minerals	0.6	0.8	1.7	0.1	1.3	-0.8
Medication: Levothyroxine sodium	0.6	1.0	1.3	-1.1	-0.8	1.1
Impedance of leg (left)	0.6	3.1	5.6	-1.0	-2.4	-1.7
Forced vital capacity (FVC)	0.6	2.4	3.8	-2.0	1.4	-1.2
Worrier / anxious feelings	0.6	1.1	1.9	0.7	1.4	1.0
Illnesses of mother	0.6	0.7	1.0	0.9	-0.6	-1.0
Age at first live birth	0.6	1.1	1.5	0.6	1.2	-1.2
Shortness of breath walking on level ground	0.6	0.8	2.1	-0.1	1.4	-0.4
Medication: Aspirin	0.6	0.8	1.6	-0.7	1.3	-0.6
Average weekly red wine intake	0.6	0.9	1.4	1.1	1.2	0.1
Mood swings	0.6	1.1	1.6	1.2	-0.4	-1.3
Osteoporosis (self-reported)	0.6	0.8	1.8	-0.7	-1.4	0.2
Eye problems/disorders: Glaucoma	0.6	0.7	1.8	0.4	0.3	1.4
Average weekly beer plus cider intake	0.6	0.9	2.2	0.4	-0.6	1.5
Commuting to job workplace: Cycle	0.6	0.7	1.7	-0.5	1.3	-0.4
Crohns Disease (2017)	0.5	1.2	3.2	-0.5	0.0	-1.8
Waist Hip Ratio (WHR)	0.5	2.0	4.5	1.1	-2.1	-0.7
Financial difficulties in last 2 years	0.5	0.7	1.3	0.4	1.1	0.8
Medication: Simvastatin	0.5	0.7	0.9	-0.9	-0.7	-0.9
Weight	0.5	2.4	3.3	1.6	-1.1	1.8
Tense / ‘highly strung’	0.5	0.9	2.0	0.2	1.4	-0.7
Forced vital capacity (FVC), Best measure	0.5	1.9	2.2	-1.5	1.4	-1.3
Eye problems/disorders: None of the above	0.5	0.6	1.3	1.1	-0.5	0.4
Neck or shoulder pain in last month	0.5	0.7	1.7	0.6	0.1	-1.3
Medication: Blood pressure	0.5	0.9	1.6	-0.9	0.5	-1.3
Alcohol intake frequency.	0.5	1.3	3.0	0.8	1.7	0.4
Had major operations	0.5	0.6	0.8	0.9	0.0	0.9
Age at last live birth	0.5	0.7	1.6	1.3	0.1	-0.6
Back pain experienced in last month	0.5	0.7	2.0	1.4	-0.1	-0.4
Medication: Gliclazide	0.5	0.6	0.8	0.9	0.7	-0.6
Average weekly champagne plus white wine intake	0.5	0.7	2.0	0.3	1.4	-0.2
Medication: Paracetamol	0.5	0.7	1.9	-1.4	0.4	0.3
Ever smoked	0.5	0.8	1.8	0.3	-0.8	-1.3
Age started oral contraceptive pill	0.5	0.6	1.7	-1.3	-0.2	0.1
Heart disease (siblings)	0.5	0.6	1.5	0.3	-1.2	-0.5
Depression (Nagel 2018)	0.4	0.7	1.5	1.2	-0.6	0.3
Neuroticism (Nagel 2018)	0.4	1.0	2.5	1.6	0.3	-0.6
Worry (Nagel 2018)	0.4	0.9	2.4	0.4	1.6	0.2
Irritable Bowel Disease (IBD)	0.4	0.9	1.9	-0.2	1.4	-0.9
Crohns Disease (2012)	0.4	0.6	1.1	-0.4	-0.6	-1.1
Mean Putamen Volume	0.4	0.4	1.1	1.1	0.4	0.2
LDL Cholesterol	0.4	0.6	1.4	-1.2	-0.7	0.3
Ever had hysterectomy (womb removed)	0.4	0.4	0.5	0.6	0.6	0.7
Townsend deprivation index at recruitment	0.4	0.6	1.5	-1.2	0.0	0.5
Qualifications: CSEs or equivalent	0.4	0.5	1.1	-0.7	-0.2	-1.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.3	0.2	-1.1	0.4
Past tobacco smoking	0.4	0.8	1.4	-1.2	-0.2	1.0
Allergy	0.4	0.9	1.5	-1.2	-0.8	-0.8
Trunk fat-free mass	0.4	2.1	3.6	0.1	1.7	1.9
Alcohol intake versus 10 years previously	0.4	0.7	0.9	0.7	-0.8	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	0.8	0.9	-0.2	0.9
Trunk predicted mass	0.4	2.2	3.8	0.2	1.7	1.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.8	-0.0	-0.9	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	-1.0	0.7	0.5
Arm predicted mass (right)	0.4	2.0	5.2	0.6	0.7	2.3
Leg fat-free mass (right)	0.4	2.1	4.2	0.9	1.2	2.1
Loneliness, isolation	0.4	0.5	0.9	1.0	-0.7	-0.5
Diabetes diagnosed by doctor	0.4	0.6	0.8	0.6	-0.9	-0.8
Osteoarthritis (self-reported)	0.4	0.5	1.2	-0.6	1.1	0.0
Whole body water mass	0.4	2.1	4.6	0.4	1.2	2.1
Leg predicted mass (right)	0.4	2.2	4.2	1.0	1.1	2.1
Ever taken oral contraceptive pill	0.4	0.4	0.6	0.8	-0.5	0.7
Hearing aid user	0.4	0.5	0.7	0.8	-0.7	0.6
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-0.7	0.3	-1.0
Arm predicted mass (left)	0.4	1.9	4.8	0.8	0.6	2.2
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.4	-0.4	1.2	-0.9
Reaction Time	0.3	0.6	1.1	-1.0	0.4	-0.7
Medication: Metformin	0.3	0.4	0.6	0.8	0.3	-0.7
Diabetes (mother)	0.3	0.4	1.0	1.0	-0.2	-0.5
Leg fat-free mass (left)	0.3	1.8	4.2	1.0	0.5	2.0
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.1	-0.5	-0.2	-1.4
Leg predicted mass (left)	0.3	1.8	4.2	0.9	0.6	2.1
Hearing difficulty/problems with background noise	0.3	0.5	0.9	-0.4	1.0	-0.6
Had other major operations	0.3	0.4	0.9	0.2	-1.0	0.3
Diabetes (self-reported)	0.3	0.5	0.5	0.7	-0.7	-0.7
Hip circumference	0.3	1.2	1.8	0.7	-1.1	1.3
Standing height	0.3	3.3	6.2	-0.5	2.5	1.9
Arm fat-free mass (right)	0.3	1.6	3.4	0.6	1.0	1.9
Medication for pain relief, constipation, heartburn	0.3	0.6	1.0	1.0	-0.8	0.3
Suffer from ‘nerves’	0.3	0.4	0.6	0.6	-0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	1.0	0.5	0.6	1.0
Whole body fat-free mass	0.3	1.9	4.2	0.4	1.2	2.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	1.1	0.2	-0.2	1.1
Medication for cholesterol	0.3	0.5	0.9	-0.2	0.9	0.8
Alcohol drinker status: Never	0.3	0.3	0.9	0.2	1.0	0.1
Basal metabolic rate	0.3	1.7	4.2	0.8	0.5	2.0
Arm fat-free mass (left)	0.3	1.7	4.3	0.8	0.4	2.1
Risk taking	0.3	0.5	0.9	-0.9	0.4	0.6
Cholesterol lowering medication	0.3	0.4	0.8	-0.6	0.9	-0.0
Impedance of whole body	0.3	1.4	2.8	-0.3	-1.7	-1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.4	0.2	1.2	-0.3
Breast Cancer	0.2	0.5	1.1	0.1	-0.5	-1.1
Age at First Birth	0.2	0.3	0.7	0.5	0.4	0.8
Body Mass Index (BMI) (2010)	0.2	0.3	0.8	0.1	-0.9	-0.0
Blood White Count	0.2	1.3	2.9	-1.7	-1.0	-0.1
Hypothyroidism (self reported)	0.2	0.5	0.9	-0.7	-0.4	1.0
Stomach or abdominal pain in last month	0.2	0.2	0.6	0.2	0.8	-0.1
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	-0.8	-0.4	0.3
Pain all over the body in last month	0.2	0.2	0.4	0.1	-0.5	-0.6
Illnesses of siblings	0.2	0.3	0.5	0.4	0.7	-0.5
Father’s age at death	0.2	0.2	0.5	0.3	0.7	0.3
Pulse rate	0.2	0.4	0.5	0.5	-0.7	-0.7
High blood pressure (siblings)	0.2	0.3	0.7	-0.9	0.0	0.5
Comparative height size at age 10	0.2	1.0	2.2	1.5	0.5	0.8
Number of full sisters	0.2	0.2	0.4	-0.6	-0.2	0.5
Number of self-reported non-cancer illnesses	0.2	0.4	0.6	-0.7	0.8	-0.2
Wears glasses or contact lenses	0.2	0.2	0.4	-0.3	0.7	0.3
Medication: Blood pressure	0.2	0.4	0.9	-0.5	-0.1	-1.0
Medication: Lisinopril	0.2	0.3	0.3	-0.6	0.6	-0.5
Medication: Atorvastatin	0.2	0.2	0.5	-0.4	0.1	-0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.3	-0.0	0.8
Schizophrenia vs Biploar Disorder	0.1	0.1	0.1	-0.4	-0.4	-0.2
Rheumatoid Arthritis	0.1	0.1	0.3	0.2	-0.3	0.6
Blood Eosinophil Count	0.1	1.0	1.5	0.7	-1.2	1.0
Blood Platelet Count	0.1	1.0	1.6	-0.9	1.3	-0.7
Height	0.1	2.6	5.6	-1.5	2.4	0.1
Hair Pigment	0.1	1.7	3.2	-0.9	0.9	1.8
Tanning	0.1	1.8	4.8	2.2	-0.6	0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.2	-0.5	0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.3	0.5	-0.2
Impedance of arm (right)	0.1	0.5	1.2	0.2	-1.1	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.2	0.4	0.1
Impedance of arm (left)	0.1	0.5	1.0	-0.3	-1.0	-0.6
Medication: Amlodipine	0.1	0.1	0.2	0.1	0.2	-0.5
Number of full brothers	0.1	0.1	0.2	-0.5	0.2	-0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.1	-0.3	-0.4
High cholesterol (Self-reported)	0.1	0.2	0.6	0.0	-0.8	-0.3
Illnesses of father: High blood pressure	0.1	0.1	0.4	-0.6	0.0	-0.2
Fractured/broken bones in last 5 years	0.1	0.2	0.4	-0.6	0.3	-0.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Allergy or Eczema	0.0	0.1	0.1	0.4	0.2	-0.1
Number of treatments/medications taken	0.0	0.0	0.1	-0.2	0.1	-0.3
Sitting height	0.0	0.2	0.5	-0.7	-0.0	0.1
Financial situation satisfaction	0.0	0.1	0.1	0.2	0.1	-0.3

Hub : Genes

PRIM2

Models

Trait associations