TWAS hub - ZNF451

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.184	0.072	0.0010	0.091	NA	0.058	NA	0.052	0.00250	NA	0.01300	NA	0.01800
2	GTEx	Brain Hypothalamus	0.168	0.074	0.0027	0.177	NA	0.128	NA	0.143	0.00006	NA	0.00066	NA	0.00031
3	GTEx	Skin Not Sun Exposed Suprapubic	0.088	0.046	0.0059	-0.003	NA	-0.002	NA	-0.003	0.54000	NA	0.41000	NA	0.50000

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Leg fat percentage (right)	6.1	22.0	27.5	5.2	4.5	4.2
Ever depressed for a whole week	5.5	6.8	9.0	3.0	-1.6	3.0
Current tobacco smoking	5.2	8.6	17.5	2.4	4.2	1.6
Leg fat percentage (left)	5.2	18.7	23.5	4.8	4.1	3.9
Smoking status: Current	5.1	8.1	16.9	2.3	4.1	1.4
Had other major operations	4.8	5.9	10.3	2.6	1.0	3.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.8	5.8	8.8	-2.8	-0.7	-3.0
Diverticular disease/diverticulitis (self-reported)	4.6	5.5	8.5	2.4	1.4	2.9
Body fat percentage	4.4	17.4	19.8	4.5	3.9	4.2
Supplements: Glucosamine	4.3	5.7	7.5	-2.5	-1.7	-2.7
Qualifications: nursing, teaching	4.0	6.2	7.2	-2.7	-2.2	-2.6
Breast cancer (self-reported)	3.8	4.6	5.0	2.2	2.0	2.2
Bipolar Disorder or Schizophrenia	3.6	8.9	24.8	-0.8	-5.0	-1.1
Arm fat percentage (right)	3.6	14.0	16.7	4.1	3.2	3.9
Hair/balding pattern: Pattern 2	3.5	4.5	6.7	-2.0	-2.6	-1.7
Arm fat percentage (left)	3.5	14.2	16.7	4.1	3.3	3.8
Sensitivity / hurt feelings	3.4	5.8	10.6	3.2	0.7	2.5
Trunk fat percentage	3.4	13.6	14.7	3.8	3.5	3.7
Relative age voice broke	3.4	5.2	8.5	-2.9	-2.0	-1.7
Financial difficulties in last 2 years	3.3	4.4	6.3	2.5	-1.3	2.3
Commuting to job workplace: Cycle	3.3	4.0	5.7	2.2	-1.3	2.4
Schizophrenia (2018)	3.2	6.7	13.7	-1.2	-3.7	-2.2
Leg fat mass (right)	3.2	12.3	14.8	3.9	3.0	3.6
Blood Red Count	3.1	30.3	50.4	5.1	7.1	3.9
Bipolar Disorder (2011)	2.9	2.9	3.5	1.6	-1.9	1.6
HDL Cholesterol	2.7	4.5	8.4	-1.5	-2.9	-1.7
Schizophrenia (2014)	2.7	5.9	14.7	-0.8	-3.8	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	6.0	-1.2	-2.4	-1.4
Whole body fat mass	2.7	11.4	13.6	3.7	2.8	3.5
Bipolar Disorder (2018)	2.6	4.1	11.2	0.2	-3.3	1.1
Lung FEV1/FVC ratio	2.6	13.1	29.9	3.0	5.5	-0.4
Chronotype (morning person)	2.6	6.0	15.8	-1.4	-4.0	0.4
Illnesses of father: Heart disease	2.6	3.6	4.9	-2.0	-1.4	-2.2
Leg fat mass (left)	2.6	10.2	12.0	3.5	2.7	3.4
Medication: Lansoprazole	2.5	2.9	4.5	2.1	1.1	1.7
BMI	2.4	14.0	19.3	4.4	2.2	4.2
Number of operations (self-reported)	2.4	3.6	4.4	2.1	-1.5	2.1
Type 2 Diabetes (T2D) (2018)	2.3	4.3	7.1	2.7	1.7	1.7
Other serious medical condition/disability diagnosed by doctor	2.3	2.9	8.8	0.2	-3.0	-0.1
Exposure to tobacco smoke at home	2.3	2.6	5.2	-2.3	-1.2	-1.0
Coronary Artery Disease (CAD)	2.2	2.7	6.0	-2.4	-0.3	-1.4
Primary Biliary Cirrhosis	2.2	3.2	6.4	2.5	-0.4	1.7
Supplements: Zinc	2.2	2.4	3.4	-1.4	-1.8	-1.3
Smoking Status	2.1	5.1	9.2	2.1	3.0	1.2
Stomach or abdominal pain in last month	2.1	2.6	2.9	1.4	-1.7	1.7
Trunk fat mass	2.1	9.1	11.0	3.3	2.5	3.2
Mouth/teeth dental problems: Dentures	2.1	3.6	7.4	1.6	0.9	2.7
Depression (self-reported)	2.1	2.5	3.6	-1.3	-1.5	-1.9
Loud music exposure frequency	2.1	2.3	5.2	0.6	2.3	1.2
Pulse wave peak to peak time	2.1	2.5	3.8	-1.6	-1.0	-2.0
Friendships satisfaction	2.1	2.6	7.7	-0.1	2.8	0.2
Body mass index (BMI)	2.0	8.3	12.6	3.5	1.7	3.1
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.6	9.3	3.0	0.5	2.1
Mouth/teeth dental problems	2.0	3.1	8.2	-0.6	-0.8	-2.9
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	7.2	0.4	-2.7	0.4
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	3.9	-1.8	0.6	-2.0
Guilty feelings	2.0	3.0	4.6	1.1	-1.8	2.2
Relative age of first facial hair	1.9	3.9	5.8	-2.4	-2.2	-1.0
Qualifications: CSEs or equivalent	1.9	2.5	4.2	2.0	0.2	1.8
Arm fat mass (right)	1.9	8.0	10.6	3.3	1.9	3.1
Medication for cholesterol	1.9	2.9	6.9	-2.6	-0.2	-1.4
Arm fat mass (left)	1.9	7.8	9.9	3.1	2.1	3.0
Miserableness	1.9	3.3	5.5	2.3	1.6	1.4
Pulse wave Arterial Stiffness index	1.8	2.1	3.8	1.4	0.8	1.9
Pulse rate, automated reading	1.8	5.8	12.5	1.6	3.5	1.5
Diabetes diagnosed by doctor	1.8	3.0	5.3	1.7	2.3	0.9
Diabetes (father)	1.7	2.0	4.5	2.1	0.5	1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	8.1	2.8	0.2	1.9
Happiness	1.7	2.0	6.0	0.1	2.4	0.3
Qualifications: A levels/AS levels or equivalent	1.7	3.8	5.0	-2.1	-1.4	-2.2
Illnesses of mother	1.7	2.1	4.5	-1.1	2.1	-0.8
Comparative body size at age 10	1.7	4.8	11.8	0.9	3.4	1.4
Commuting to job workplace: Car/motor vehicle	1.7	1.9	3.3	-0.3	1.8	-1.6
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	2.6	1.2	1.4	1.6
Depressed Affect (Nagel 2018)	1.6	3.4	7.0	2.6	1.1	1.4
Ulcerative Colitis (UC)	1.6	3.0	8.0	0.8	-2.8	0.4
Age at first live birth	1.6	2.8	5.7	-1.4	-0.8	-2.4
Average weekly champagne plus white wine intake	1.6	2.2	6.0	-0.3	-2.5	-0.7
Fed-up feelings	1.5	2.7	2.9	1.6	1.7	1.6
Age when periods started (menarche)	1.5	3.6	5.3	-2.0	-2.3	-1.2
Waist circumference	1.5	5.6	9.2	3.0	1.5	2.4
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.8	1.9	-0.6	1.1
Gout (self-reported)	1.5	2.1	3.9	1.0	2.0	1.2
Birth weight	1.5	3.2	7.9	-0.5	-2.8	-1.1
Medication: Ibuprofen	1.5	1.8	4.8	0.6	-2.2	0.6
Heart disease (siblings)	1.5	1.9	2.4	1.3	1.5	1.2
Ovarian Cancer	1.4	1.8	2.5	1.0	-1.4	1.6
Mean Putamen Volume	1.4	1.5	3.3	-1.0	-0.6	-1.8
HbA1C	1.4	1.5	2.7	1.0	-1.6	0.9
Hearing difficulty/problems with background noise	1.4	2.2	4.6	-1.2	-2.1	-0.8
Mother’s age at death	1.4	1.7	4.5	-0.8	-2.1	-0.2
Myopia	1.4	2.0	3.5	-1.4	-1.9	-0.6
Frequency of depressed mood in last 2 weeks	1.3	1.9	3.0	1.6	-0.0	1.7
High blood pressure	1.3	3.7	8.3	2.9	-0.0	1.7
Diabetes (self-reported)	1.3	2.0	4.7	0.9	2.2	0.7
Prospective memory result	1.3	1.7	4.6	0.3	2.1	-0.5
Length of working week for main job	1.3	1.4	1.9	1.4	1.1	1.1
Qualifications: College or University degree	1.3	4.0	5.4	-1.7	-1.9	-2.3
Age at last live birth	1.3	1.9	3.7	-1.4	0.3	-1.9
Knee pain experienced in last month	1.3	2.0	5.6	-0.1	-2.4	0.7
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.2	0.2	-1.8	1.2
Osteoarthritis (self-reported)	1.3	1.6	3.3	-0.8	-1.8	-1.0
Commuting to job workplace: Public transport	1.3	1.5	4.3	0.2	-2.1	0.5
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.0	-0.8	-2.0	-0.4
Alzheimer’s Disease (in mother)	1.2	1.4	3.6	0.6	-1.9	0.4
Body Mass Index (BMI) (2010)	1.2	1.7	2.5	1.5	0.5	1.6
Medication: Co-codamol	1.2	1.4	2.6	1.6	0.6	1.1
Pack years adult smoking proportion	1.2	1.9	4.7	0.1	2.2	1.0
Standing height	1.2	11.4	15.3	-3.9	-3.6	-2.5
Breastfed as a baby	1.2	1.5	3.4	0.5	-1.8	-0.9
Medication: Paracetamol	1.2	1.9	2.6	1.6	-1.1	1.4
Migraine (self-reported)	1.2	1.5	3.2	-1.8	0.0	-1.1
Medication: Omeprazole	1.2	1.4	1.7	1.2	1.3	1.1
Commuting to job workplace: Walk	1.2	1.3	2.8	0.4	-1.7	0.9
Mineral and other dietary supplements	1.2	1.6	2.4	0.4	1.5	1.6
Diastolic blood pressure, automated reading	1.2	3.7	10.8	0.4	3.3	0.2
Unable to work because of sickness or disability	1.2	1.6	3.1	0.9	0.9	1.7
Pack years of smoking	1.2	1.8	4.5	0.1	2.1	0.9
Depression (Nagel 2018)	1.1	1.7	3.1	1.8	0.8	1.2
Neuroticism (2016)	1.1	1.6	4.0	2.0	-0.2	0.9
Height	1.1	20.7	26.0	-5.1	-3.9	-4.5
High blood pressure (mother)	1.1	1.6	4.1	0.3	-2.0	0.7
Had menopause	1.1	1.4	2.4	-1.5	-0.7	-1.1
Qualifications: None of the above	1.1	2.4	4.9	1.1	2.2	1.0
Blood clot in the leg (DVT)	1.1	1.4	2.1	1.0	1.1	1.5
Overall health rating	1.1	2.4	3.4	1.6	1.1	1.9
Hypertension (Self-reported)	1.1	2.9	6.4	2.5	-0.0	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.9	-0.2	2.0	-0.1
Neuroticism (Nagel 2018)	1.0	2.4	5.2	2.3	0.1	1.4
Fasting Glucose	1.0	1.2	2.6	0.0	-1.0	-1.6
Triglycerides	1.0	1.7	2.3	1.2	1.5	1.2
Medication for hormone replacement therapy	1.0	1.1	2.0	1.4	-0.2	1.1
Fluid intelligence score	1.0	2.0	3.3	-1.3	-1.8	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.2	0.4	-1.8	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.6	0.9	-0.6	1.6
Medication for pain relief, constipation, heartburn	1.0	1.7	2.5	-1.6	0.8	-1.4
Heart disease (mother)	1.0	1.2	2.1	-0.8	-1.0	-1.5
Comparative height size at age 10	1.0	5.5	11.5	-3.4	-1.4	-1.7
Mood swings	1.0	1.9	3.0	1.7	0.4	1.6
Medication: Atorvastatin	1.0	1.2	2.4	1.5	-0.4	1.0
Irritability	1.0	1.8	4.3	-0.1	2.1	-1.0
Vascular/heart problems diagnosed by doctor	1.0	2.8	6.3	-2.5	-0.2	-1.4
Alzheimer’s Disease (including proxy)	0.9	1.3	4.0	-0.0	-2.0	0.1
Crohns Disease (2017)	0.9	1.9	4.7	1.0	0.2	2.2
Impedance of leg (right)	0.9	4.4	12.4	0.7	3.5	0.6
Pulse wave reflection index	0.9	1.1	2.2	0.1	-1.5	1.0
Supplements: Vitamin C	0.9	1.1	2.2	-0.5	0.9	-1.5
Back pain experienced in last month	0.9	1.3	2.3	1.5	0.4	1.1
Illnesses of father: None of the above (group 1)	0.9	1.1	2.1	1.5	0.0	1.1
Medication: Bendroflumethiazide	0.9	1.3	2.2	1.0	1.5	-0.9
Ulcerative Colitis	0.8	1.2	3.2	0.6	-1.8	0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.7	1.3	-1.0	0.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.4	0.2	0.5	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.3	1.1	1.1	0.7
Serious illness, injury or assault to yourself	0.8	1.0	2.0	1.4	-0.5	0.8
Worrier / anxious feelings	0.8	1.5	1.7	1.1	-1.3	1.3
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.2	1.5	0.7	0.5
Health satisfaction	0.8	1.1	1.3	1.1	1.1	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.0	1.0	-0.9	0.9
Supplements: Calcium	0.8	0.9	2.6	-0.0	-1.6	-0.2
Basal cell carcinoma (self-reported)	0.8	1.0	1.2	0.8	-1.0	1.1
Intelligence (Savage-Jansen 2018)	0.7	2.0	3.2	-1.2	-1.8	-1.2
Irritable Bowel Disease (IBD)	0.7	1.7	3.1	0.9	-1.7	1.2
Crohns Disease (2012)	0.7	1.1	2.8	0.8	0.2	1.7
LDL Cholesterol	0.7	1.1	2.0	-1.4	-0.1	-1.2
Lupus	0.7	1.1	3.3	-0.0	-1.8	0.2
Multivitamins +/- minerals	0.7	0.9	1.9	0.8	-1.4	0.3
Impedance of leg (left)	0.7	3.5	10.4	0.0	3.2	0.3
Trunk fat-free mass	0.7	4.0	9.9	-1.2	-3.1	-0.9
Hip circumference	0.7	3.0	5.2	1.9	0.5	2.3
Trunk predicted mass	0.7	4.1	10.2	-1.2	-3.2	-0.8
Forced vital capacity (FVC), Best measure	0.7	2.5	4.2	-1.6	-2.0	-1.0
Worry too long after embarrassment	0.7	1.2	2.5	0.9	-0.6	1.6
Medication: Blood pressure	0.7	1.2	2.1	1.2	-0.4	1.4
Had major operations	0.7	0.8	1.2	1.1	0.4	1.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.2	0.1	0.1	1.8
Medication: Paracetamol	0.7	1.1	1.6	1.2	-0.8	1.1
Ever smoked	0.7	1.3	2.5	0.5	1.6	1.0
Age started oral contraceptive pill	0.7	0.9	2.3	-0.6	-0.3	-1.5
Cholesterol lowering medication	0.7	1.0	1.7	1.3	-0.2	1.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.6	0.7	0.8	1.3
Alzheimer’s Disease (in father)	0.6	0.6	1.5	0.0	-1.2	0.6
Blood Eosinophil Count	0.6	4.4	4.7	2.1	2.2	2.0
Blood White Count	0.6	4.4	7.0	2.5	-0.0	2.6
Waist Hip Ratio (WHR)	0.6	2.8	5.7	1.6	2.4	0.3
Number of treatments/medications taken	0.6	1.1	3.0	1.7	0.2	0.5
Average weekly spirits intake	0.6	0.8	1.5	0.9	-0.0	1.2
Severe depression (siblings)	0.6	0.7	1.5	0.0	-1.2	0.7
Heart attack	0.6	0.7	1.4	-0.8	-1.2	0.0
Neuroticism score	0.6	1.2	2.2	1.5	-0.2	1.1
Falls in the last year	0.6	0.8	1.1	0.9	-1.1	0.8
Hair/balding pattern: Pattern 4	0.6	1.4	2.2	1.3	0.5	1.5
High blood pressure (siblings)	0.6	0.9	1.2	1.1	-0.9	0.9
Number of children fathered	0.6	0.7	1.0	0.0	1.0	1.0
Alcohol intake frequency.	0.6	1.3	3.4	0.1	-1.9	0.7
Number of self-reported non-cancer illnesses	0.6	1.0	1.3	0.9	-1.0	1.1
Impedance of whole body	0.6	3.2	9.5	-0.4	3.1	0.2
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.6	-1.0	-1.3	-0.8
Taking other prescription medications	0.5	0.7	1.3	1.1	-0.6	0.7
Alcohol usually taken with meals	0.5	0.8	2.3	0.3	-1.5	-0.1
Illnesses of siblings	0.5	0.7	1.4	-1.2	0.4	-0.8
Impedance of arm (left)	0.5	2.1	5.8	-0.8	2.4	-0.0
Tense / ‘highly strung’	0.5	0.8	2.2	0.2	-1.5	-0.4
Peak expiratory flow (PEF)	0.5	1.1	1.7	0.2	1.3	-1.2
Shortness of breath walking on level ground	0.5	0.6	1.3	0.1	-1.2	0.6
Medication: Allopurinol	0.5	0.6	1.7	0.4	1.3	0.3
Suffer from ‘nerves’	0.5	0.8	1.5	1.2	0.2	0.9
Family relationship satisfaction	0.5	0.6	1.3	-0.1	1.1	-0.6
Illnesses of siblings: Diabetes	0.5	0.6	1.0	1.0	-0.3	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	0.7	-0.8	-0.8	0.6
Medication: Lisinopril	0.5	0.7	1.3	-0.7	1.1	-0.4
Alcohol drinker status: Never	0.5	0.6	0.9	0.9	-0.9	0.4
Risk taking	0.5	0.7	1.8	-0.2	-0.4	1.4
Alcohol drinker status: Previous	0.5	0.5	0.9	0.1	-0.8	0.9
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	-0.5	0.1	-1.2
Worry (Nagel 2018)	0.4	0.9	2.1	0.8	-1.5	0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.3	-0.4	-1.1	0.2
Heel T-Score	0.4	2.9	8.2	2.9	-0.1	0.6
Neuroticism	0.4	0.9	1.7	1.3	-0.8	0.5
Ever had hysterectomy (womb removed)	0.4	0.5	1.1	1.1	0.3	0.4
Systolic blood pressure, automated reading	0.4	1.2	2.0	1.2	1.4	0.1
Average weekly fortified wine intake	0.4	0.5	1.0	0.6	-1.0	0.4
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.8	0.9	0.2	0.6
Medication: Atenolol	0.4	0.4	0.8	0.6	0.9	0.4
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	-0.9	0.3	-0.6
Past tobacco smoking	0.4	0.7	1.0	-0.6	-0.9	-1.0
Nervous feelings	0.4	0.7	2.0	0.2	-1.4	0.2
Forced vital capacity (FVC)	0.4	1.5	2.2	-1.5	-1.5	-0.5
Pain all over the body in last month	0.4	0.4	0.8	-0.6	-0.2	-0.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.9	0.7	-0.3
Weight	0.4	2.2	3.8	1.6	0.1	2.0
Impedance of arm (right)	0.4	2.0	5.7	-0.2	2.4	0.6
Alcohol intake versus 10 years previously	0.4	0.6	1.7	1.3	0.1	-0.1
Pulse rate	0.4	0.6	0.9	0.9	1.0	0.3
Noisy workplace	0.4	0.5	1.0	0.2	0.8	1.0
Glaucoma (self-reported)	0.4	0.5	1.4	0.0	-1.2	-0.2
Arm fat-free mass (right)	0.4	2.3	5.8	-0.9	-2.4	-0.5
Eye problems/disorders: None of the above	0.4	0.5	1.4	-0.1	0.1	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.4	0.1	-1.2	0.3
Emphysema/chronic bronchitis	0.4	0.4	0.8	-0.6	-0.9	0.4
Leg pain on walking	0.4	0.5	1.1	0.5	-1.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.2	-1.1	-0.8	-0.7
Whole body fat-free mass	0.4	2.5	6.7	-0.9	-2.6	-0.3
Leg fat-free mass (right)	0.4	2.0	5.3	-0.9	-2.3	0.1
Whole body water mass	0.4	2.5	6.8	-0.8	-2.6	-0.2
Leg predicted mass (right)	0.4	1.9	5.0	-0.8	-2.2	0.1
Wears glasses or contact lenses	0.4	0.5	1.1	-0.4	-1.1	-0.5
Financial situation satisfaction	0.4	0.5	0.9	0.9	-0.4	0.6
High cholesterol (Self-reported)	0.4	0.6	1.1	1.0	-0.3	0.9
Pain experienced in last month	0.4	0.7	1.9	0.3	1.4	-0.0
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.1	-0.7	-1.1	0.2
Age at First Birth	0.3	0.4	0.8	-0.5	-0.3	-0.9
Lung FVC	0.3	1.6	4.7	0.1	-2.2	-0.3
Hearing difficulty/problems: Yes	0.3	0.4	1.1	-1.0	-0.1	0.5
Medication: Metformin	0.3	0.4	0.9	0.0	0.9	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	0.5	0.1	1.0
Medication: Ramipril	0.3	0.4	0.9	-0.5	0.2	-1.0
Medication: Simvastatin	0.3	0.4	0.5	0.6	0.7	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.6	0.8	-0.6	0.8
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.5	-1.1	-0.4	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.1	-1.0	-0.7	-1.0
Birth weight of first child	0.3	0.6	1.1	-1.0	-0.9	0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.1	0.3	-1.1	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.5	-0.7	0.7	-0.7
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.4	-0.8	0.5
Number of full brothers	0.3	0.3	0.8	-0.5	0.1	-0.9
Arm predicted mass (right)	0.3	1.7	4.6	-0.7	-2.1	0.1
Smoking status: Previous	0.3	0.4	0.9	0.1	-1.0	0.6
Eye problems/disorders: Cataract	0.3	0.3	0.9	0.2	-0.2	-1.0
Osteoporosis (self-reported)	0.3	0.4	0.8	-0.4	0.5	-0.9
Hearing aid user	0.3	0.3	0.5	0.4	0.5	0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	0.5	-0.8	-0.3
Arm fat-free mass (left)	0.3	1.3	3.6	-0.1	-1.9	0.4
Average weekly beer plus cider intake	0.3	0.5	0.9	-0.9	0.1	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	0.7	-0.2	0.5
Arm predicted mass (left)	0.3	1.4	4.0	-0.3	-2.0	0.4
Breast Cancer	0.2	0.4	0.9	1.0	0.2	0.5
Rheumatoid Arthritis	0.2	0.3	0.5	0.2	0.5	-0.7
Systolic Blood Pressure	0.2	1.0	2.7	0.5	1.6	-0.1
Cardiovascular Disease	0.2	0.6	1.1	1.1	-0.3	0.8
Tanning	0.2	2.6	4.2	1.9	-0.2	2.0
Vitamin and mineral supplements	0.2	0.3	0.8	-0.9	0.2	0.3
Leg fat-free mass (left)	0.2	0.9	2.4	-0.2	-1.5	0.6
Hand grip strength (right)	0.2	0.6	1.4	0.0	0.6	1.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.5	0.1	-0.5
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.9	-0.3	-1.0	-0.1
Leg predicted mass (left)	0.2	1.0	2.6	-0.1	-1.6	0.6
Number of incorrect matches in round	0.2	0.3	0.8	-0.9	-0.3	-0.1
Allergy	0.2	0.5	0.7	0.8	0.8	0.5
Time employed in main current job	0.2	0.3	0.8	0.0	0.1	-0.9
Father’s age at death	0.2	0.3	0.6	-0.8	-0.1	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.1	-0.7	0.3
Lung cancer (father)	0.2	0.2	0.5	0.0	0.3	-0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.3	-0.5	0.5	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.2	0.4	0.8
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	0.3	-0.7	0.5
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.7	-0.6	0.0
Number of full sisters	0.2	0.2	0.3	-0.4	0.6	-0.4
Average weekly red wine intake	0.2	0.3	0.4	0.6	-0.6	-0.5
Basal metabolic rate	0.2	1.2	3.4	-0.2	-1.9	0.3
Fractured/broken bones in last 5 years	0.2	0.3	0.9	0.1	0.2	-1.0
Major Depression (MDD)	0.1	0.1	0.3	0.1	0.6	0.3
Blood Platelet Count	0.1	1.7	4.7	0.6	-2.2	-0.2
Allergy or Eczema	0.1	0.2	0.4	-0.4	-0.6	-0.5
Hypothyroidism (self reported)	0.1	0.2	0.5	-0.7	0.5	0.0
Respiratory disease	0.1	0.3	0.5	-0.0	-0.7	-0.6
Hair Pigment	0.1	2.5	4.2	-1.2	-1.4	-2.0
Angina	0.1	0.1	0.3	0.2	-0.5	0.2
Diabetes (mother)	0.1	0.2	0.3	0.5	-0.4	-0.2
Townsend deprivation index at recruitment	0.1	0.2	0.6	-0.1	-0.1	0.8
Maternal smoking around birth	0.1	0.1	0.2	-0.1	0.5	-0.1
Medication: Levothyroxine sodium	0.1	0.1	0.1	-0.2	-0.4	0.3
Sitting height	0.1	0.7	1.5	-1.2	-0.6	-0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.1	0.2	0.7
Number of live births	0.1	0.1	0.2	-0.4	0.3	0.3
Asthma	0.1	0.2	0.4	0.4	-0.6	-0.3
Medication: Cholesterol lowering	0.1	0.1	0.2	0.3	0.4	-0.1
Headache pain in last month	0.1	0.2	0.5	0.0	-0.7	-0.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	-0.3	0.0	0.5
Medication: Amlodipine	0.1	0.2	0.6	0.7	-0.0	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	0.7	-0.0	0.1
Angina (self-reported)	0.1	0.1	0.2	0.2	-0.4	0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	-0.1	-0.5
Mean time to correctly identify matches	0.1	0.2	0.4	0.1	-0.6	-0.6
Chest pain or discomfort	0.1	0.2	0.4	-0.3	-0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.0	0.1	0.6
Medication: Aspirin	0.1	0.1	0.3	0.0	-0.5	-0.1
Loneliness, isolation	0.1	0.2	0.4	0.3	0.4	0.6
Long-standing illness, disability or infirmity	0.1	0.1	0.3	0.5	-0.0	0.2
Ever had bowel cancer screening	0.1	0.1	0.2	-0.3	0.1	-0.4
Asthma (self-reported)	0.1	0.3	0.5	0.7	-0.6	-0.1
Medication: Aspirin	0.1	0.1	0.2	0.5	-0.3	0.1
Medication: Gliclazide	0.1	0.1	0.3	0.5	-0.1	-0.3
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.5	0.3	-0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.4	0.3	-0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.1	-0.3	-0.5
Medication: Blood pressure	0.1	0.2	0.3	0.5	0.2	-0.6
Illnesses of father: High blood pressure	0.1	0.1	0.4	-0.0	0.6	0.2
Reaction Time	0.0	0.1	0.1	0.2	-0.2	0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Hand grip strength (left)	0.0	0.1	0.2	-0.5	0.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.2	0.2	-0.3

Hub : Genes

ZNF451

Models

Trait associations