Hub : Genes

ZNF451

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellar Hemisphere	0.184	0.072	0.0010	0.091	NA	0.058	NA	0.052	0.00250	NA	0.01300	NA	0.01800
2	GTEx	Brain Hypothalamus	0.168	0.074	0.0027	0.177	NA	0.128	NA	0.143	0.00006	NA	0.00066	NA	0.00031
3	GTEx	Skin Not Sun Exposed Suprapubic	0.088	0.046	0.0059	-0.003	NA	-0.002	NA	-0.003	0.54000	NA	0.41000	NA	0.50000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	2.6	4.1	11.2	0.2	-3.3	1.1
Bipolar Disorder or Schizophrenia	3.6	8.9	24.8	-0.8	-5.0	-1.1
Depressed Affect (Nagel 2018)	1.6	3.4	7.0	2.6	1.1	1.4
Depression (Nagel 2018)	1.1	1.7	3.1	1.8	0.8	1.2
Intelligence (Savage-Jansen 2018)	0.7	2.0	3.2	-1.2	-1.8	-1.2
Neuroticism (Nagel 2018)	1.0	2.4	5.2	2.3	0.1	1.4
Schizophrenia (2018)	3.2	6.7	13.7	-1.2	-3.7	-2.2
Schizophrenia vs Biploar Disorder	0.4	0.5	1.3	-0.5	0.1	-1.2
Worry (Nagel 2018)	0.4	0.9	2.1	0.8	-1.5	0.0
Alzheimer’s Disease (in mother)	1.2	1.4	3.6	0.6	-1.9	0.4
Alzheimer’s Disease (in father)	0.6	0.6	1.5	0.0	-1.2	0.6
Alzheimer’s Disease (including proxy)	0.9	1.3	4.0	-0.0	-2.0	0.1
Crohns Disease (2017)	0.9	1.9	4.7	1.0	0.2	2.2
Irritable Bowel Disease (IBD)	0.7	1.7	3.1	0.9	-1.7	1.2
Ulcerative Colitis (UC)	1.6	3.0	8.0	0.8	-2.8	0.4
Major Depression (MDD)	0.1	0.1	0.3	0.1	0.6	0.3
Reaction Time	0.0	0.1	0.1	0.2	-0.2	0.2
Verbal and Numeric Reasoning (VNR)	0.5	1.1	1.6	-1.0	-1.3	-0.8
Breast Cancer	0.2	0.4	0.9	1.0	0.2	0.5
Ovarian Cancer	1.4	1.8	2.5	1.0	-1.4	1.6
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.3	0.4	0.8	-0.5	-0.3	-0.9
Bipolar Disorder (2011)	2.9	2.9	3.5	1.6	-1.9	1.6
Body Mass Index (BMI) (2010)	1.2	1.7	2.5	1.5	0.5	1.6
Coronary Artery Disease (CAD)	2.2	2.7	6.0	-2.4	-0.3	-1.4
Crohns Disease (2012)	0.7	1.1	2.8	0.8	0.2	1.7
Mean Putamen Volume	1.4	1.5	3.3	-1.0	-0.6	-1.8
Fasting Glucose	1.0	1.2	2.6	0.0	-1.0	-1.6
HbA1C	1.4	1.5	2.7	1.0	-1.6	0.9
HDL Cholesterol	2.7	4.5	8.4	-1.5	-2.9	-1.7
LDL Cholesterol	0.7	1.1	2.0	-1.4	-0.1	-1.2
Lupus	0.7	1.1	3.3	-0.0	-1.8	0.2
Neuroticism (2016)	1.1	1.6	4.0	2.0	-0.2	0.9
Primary Biliary Cirrhosis	2.2	3.2	6.4	2.5	-0.4	1.7
Rheumatoid Arthritis	0.2	0.3	0.5	0.2	0.5	-0.7
Schizophrenia (2014)	2.7	5.9	14.7	-0.8	-3.8	-1.5
Triglycerides	1.0	1.7	2.3	1.2	1.5	1.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.3	-0.4	-1.1	0.2
Ulcerative Colitis	0.8	1.2	3.2	0.6	-1.8	0.2
Blood Eosinophil Count	0.6	4.4	4.7	2.1	2.2	2.0
Blood Platelet Count	0.1	1.7	4.7	0.6	-2.2	-0.2
Blood Red Count	3.1	30.3	50.4	5.1	7.1	3.9
Blood White Count	0.6	4.4	7.0	2.5	-0.0	2.6
Heel T-Score	0.4	2.9	8.2	2.9	-0.1	0.6
BMI	2.4	14.0	19.3	4.4	2.2	4.2
Height	1.1	20.7	26.0	-5.1	-3.9	-4.5
Waist Hip Ratio (WHR)	0.6	2.8	5.7	1.6	2.4	0.3
Systolic Blood Pressure	0.2	1.0	2.7	0.5	1.6	-0.1
Smoking Status	2.1	5.1	9.2	2.1	3.0	1.2
Allergy or Eczema	0.1	0.2	0.4	-0.4	-0.6	-0.5
Cardiovascular Disease	0.2	0.6	1.1	1.1	-0.3	0.8
Hypothyroidism (self reported)	0.1	0.2	0.5	-0.7	0.5	0.0
Respiratory disease	0.1	0.3	0.5	-0.0	-0.7	-0.6
Type 2 Diabetes (T2D) (2018)	2.3	4.3	7.1	2.7	1.7	1.7
Lung FEV1/FVC ratio	2.6	13.1	29.9	3.0	5.5	-0.4
Lung FVC	0.3	1.6	4.7	0.1	-2.2	-0.3
Neuroticism	0.4	0.9	1.7	1.3	-0.8	0.5
Chronotype (morning person)	2.6	6.0	15.8	-1.4	-4.0	0.4
Hair Pigment	0.1	2.5	4.2	-1.2	-1.4	-2.0
Tanning	0.2	2.6	4.2	1.9	-0.2	2.0
Hand grip strength (left)	0.0	0.1	0.2	-0.5	0.2	0.1
Number of treatments/medications taken	0.6	1.1	3.0	1.7	0.2	0.5
Average weekly spirits intake	0.6	0.8	1.5	0.9	-0.0	1.2
Sensitivity / hurt feelings	3.4	5.8	10.6	3.2	0.7	2.5
Frequency of depressed mood in last 2 weeks	1.3	1.9	3.0	1.6	-0.0	1.7
Hearing difficulty/problems: Yes	0.3	0.4	1.1	-1.0	-0.1	0.5
Relative age of first facial hair	1.9	3.9	5.8	-2.4	-2.2	-1.0
Other serious medical condition/disability diagnosed by doctor	2.3	2.9	8.8	0.2	-3.0	-0.1
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.7	1.3	-1.0	0.6
Ever had hysterectomy (womb removed)	0.4	0.5	1.1	1.1	0.3	0.4
Systolic blood pressure, automated reading	0.4	1.2	2.0	1.2	1.4	0.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.4	0.2	0.5	-1.6
Angina	0.1	0.1	0.3	0.2	-0.5	0.2
Medication for hormone replacement therapy	1.0	1.1	2.0	1.4	-0.2	1.1
Vitamin and mineral supplements	0.2	0.3	0.8	-0.9	0.2	0.3
Supplements: Zinc	2.2	2.4	3.4	-1.4	-1.8	-1.3
Medication: Co-codamol	1.2	1.4	2.6	1.6	0.6	1.1
Medication: Metformin	0.3	0.4	0.9	0.0	0.9	-0.6
Diabetes (father)	1.7	2.0	4.5	2.1	0.5	1.2
Diabetes (mother)	0.1	0.2	0.3	0.5	-0.4	-0.2
Severe depression (siblings)	0.6	0.7	1.5	0.0	-1.2	0.7
Pack years adult smoking proportion	1.2	1.9	4.7	0.1	2.2	1.0
Impedance of leg (right)	0.9	4.4	12.4	0.7	3.5	0.6
Leg fat-free mass (left)	0.2	0.9	2.4	-0.2	-1.5	0.6
Trunk fat percentage	3.4	13.6	14.7	3.8	3.5	3.7
Hand grip strength (right)	0.2	0.6	1.4	0.0	0.6	1.2
Townsend deprivation index at recruitment	0.1	0.2	0.6	-0.1	-0.1	0.8
Current tobacco smoking	5.2	8.6	17.5	2.4	4.2	1.6
Average weekly fortified wine intake	0.4	0.5	1.0	0.6	-1.0	0.4
Maternal smoking around birth	0.1	0.1	0.2	-0.1	0.5	-0.1
Fed-up feelings	1.5	2.7	2.9	1.6	1.7	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.3	1.1	1.1	0.7
Relative age voice broke	3.4	5.2	8.5	-2.9	-2.0	-1.7
Taking other prescription medications	0.5	0.7	1.3	1.1	-0.6	0.7
Age when periods started (menarche)	1.5	3.6	5.3	-2.0	-2.3	-1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.8	0.9	0.2	0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	8.1	2.8	0.2	1.9
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.5	0.1	-0.5
Qualifications: CSEs or equivalent	1.9	2.5	4.2	2.0	0.2	1.8
Serious illness, injury or assault to yourself	0.8	1.0	2.0	1.4	-0.5	0.8
High blood pressure	1.3	3.7	8.3	2.9	-0.0	1.7
Hayfever, allergic rhinitis or eczema	0.2	0.3	0.9	-0.3	-1.0	-0.1
Multivitamins +/- minerals	0.7	0.9	1.9	0.8	-1.4	0.3
Stomach or abdominal pain in last month	2.1	2.6	2.9	1.4	-1.7	1.7
Supplements: Glucosamine	4.3	5.7	7.5	-2.5	-1.7	-2.7
Diverticular disease/diverticulitis (self-reported)	4.6	5.5	8.5	2.4	1.4	2.9
Medication: Atenolol	0.4	0.4	0.8	0.6	0.9	0.4
Medication: Levothyroxine sodium	0.1	0.1	0.1	-0.2	-0.4	0.3
Sitting height	0.1	0.7	1.5	-1.2	-0.6	-0.4
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	-0.9	0.3	-0.6
High blood pressure (mother)	1.1	1.6	4.1	0.3	-2.0	0.7
Body mass index (BMI)	2.0	8.3	12.6	3.5	1.7	3.1
Impedance of leg (left)	0.7	3.5	10.4	0.0	3.2	0.3
Leg predicted mass (left)	0.2	1.0	2.6	-0.1	-1.6	0.6
Trunk fat mass	2.1	9.1	11.0	3.3	2.5	3.2
Waist circumference	1.5	5.6	9.2	3.0	1.5	2.4
Number of incorrect matches in round	0.2	0.3	0.8	-0.9	-0.3	-0.1
Past tobacco smoking	0.4	0.7	1.0	-0.6	-0.9	-1.0
Alcohol usually taken with meals	0.5	0.8	2.3	0.3	-1.5	-0.1
Nervous feelings	0.4	0.7	2.0	0.2	-1.4	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.0	0.5	0.1	1.0
Hearing difficulty/problems with background noise	1.4	2.2	4.6	-1.2	-2.1	-0.8
Hair/balding pattern: Pattern 2	3.5	4.5	6.7	-2.0	-2.6	-1.7
Had menopause	1.1	1.4	2.4	-1.5	-0.7	-1.1
Had other major operations	4.8	5.9	10.3	2.6	1.0	3.2
Forced vital capacity (FVC)	0.4	1.5	2.2	-1.5	-1.5	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.6	9.3	3.0	0.5	2.1
Ever unenthusiastic/disinterested for a whole week	1.5	1.8	3.8	1.9	-0.6	1.1
Qualifications: None of the above	1.1	2.4	4.9	1.1	2.2	1.0
Financial difficulties in last 2 years	3.3	4.4	6.3	2.5	-1.3	2.3
Mouth/teeth dental problems	2.0	3.1	8.2	-0.6	-0.8	-2.9
Heart attack	0.6	0.7	1.4	-0.8	-1.2	0.0
Allergy	0.2	0.5	0.7	0.8	0.8	0.5
Pain all over the body in last month	0.4	0.4	0.8	-0.6	-0.2	-0.9
Diabetes (self-reported)	1.3	2.0	4.7	0.9	2.2	0.7
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	0.9	-0.9	0.7	-0.3
Medication: Ramipril	0.3	0.4	0.9	-0.5	0.2	-1.0
Medication: Simvastatin	0.3	0.4	0.5	0.6	0.7	0.6
Fluid intelligence score	1.0	2.0	3.3	-1.3	-1.8	-1.0
Illnesses of siblings	0.5	0.7	1.4	-1.2	0.4	-0.8
Neuroticism score	0.6	1.2	2.2	1.5	-0.2	1.1
Weight	0.4	2.2	3.8	1.6	0.1	2.0
Impedance of arm (right)	0.4	2.0	5.7	-0.2	2.4	0.6
Arm fat percentage (right)	3.6	14.0	16.7	4.1	3.2	3.9
Trunk fat-free mass	0.7	4.0	9.9	-1.2	-3.1	-0.9
Hip circumference	0.7	3.0	5.2	1.9	0.5	2.3
Time employed in main current job	0.2	0.3	0.8	0.0	0.1	-0.9
Alcohol intake versus 10 years previously	0.4	0.6	1.7	1.3	0.1	-0.1
Father’s age at death	0.2	0.3	0.6	-0.8	-0.1	-0.5
Worrier / anxious feelings	0.8	1.5	1.7	1.1	-1.3	1.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.6	0.8	-0.6	0.8
Falls in the last year	0.6	0.8	1.1	0.9	-1.1	0.8
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.1	0.2	0.7
Number of live births	0.1	0.1	0.2	-0.4	0.3	0.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.5	-1.1	-0.4	-1.2
Pulse rate	0.4	0.6	0.9	0.9	1.0	0.3
Happiness	1.7	2.0	6.0	0.1	2.4	0.3
Noisy workplace	0.4	0.5	1.0	0.2	0.8	1.0
Qualifications: A levels/AS levels or equivalent	1.7	3.8	5.0	-2.1	-1.4	-2.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.6	-0.1	-0.7	0.3
Mouth/teeth dental problems: Dentures	2.1	3.6	7.4	1.6	0.9	2.7
Asthma	0.1	0.2	0.4	0.4	-0.6	-0.3
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	7.2	0.4	-2.7	0.4
Medication: Cholesterol lowering	0.1	0.1	0.2	0.3	0.4	-0.1
Depression (self-reported)	2.1	2.5	3.6	-1.3	-1.5	-1.9
Medication: Lansoprazole	2.5	2.9	4.5	2.1	1.1	1.7
Prospective memory result	1.3	1.7	4.6	0.3	2.1	-0.5
Lung cancer (father)	0.2	0.2	0.5	0.0	0.3	-0.7
Illnesses of mother	1.7	2.1	4.5	-1.1	2.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.1	-1.0	-0.7	-1.0
Pulse wave Arterial Stiffness index	1.8	2.1	3.8	1.4	0.8	1.9
Impedance of arm (left)	0.5	2.1	5.8	-0.8	2.4	-0.0
Arm fat mass (right)	1.9	8.0	10.6	3.3	1.9	3.1
Trunk predicted mass	0.7	4.1	10.2	-1.2	-3.2	-0.8
Standing height	1.2	11.4	15.3	-3.9	-3.6	-2.5
Length of working week for main job	1.3	1.4	1.9	1.4	1.1	1.1
Exposure to tobacco smoke at home	2.3	2.6	5.2	-2.3	-1.2	-1.0
Breastfed as a baby	1.2	1.5	3.4	0.5	-1.8	-0.9
Tense / ‘highly strung’	0.5	0.8	2.2	0.2	-1.5	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.2	0.4	-1.8	1.0
Hair/balding pattern: Pattern 4	0.6	1.4	2.2	1.3	0.5	1.5
Birth weight of first child	0.3	0.6	1.1	-1.0	-0.9	0.0
Peak expiratory flow (PEF)	0.5	1.1	1.7	0.2	1.3	-1.2
Pulse wave reflection index	0.9	1.1	2.2	0.1	-1.5	1.0
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.2	1.5	0.7	0.5
Loud music exposure frequency	2.1	2.3	5.2	0.6	2.3	1.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.1	0.3	-1.1	-0.6
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.3	-0.5	0.5	0.6
Blood clot in the leg (DVT)	1.1	1.4	2.1	1.0	1.1	1.5
Medication: Paracetamol	1.2	1.9	2.6	1.6	-1.1	1.4
Headache pain in last month	0.1	0.2	0.5	0.0	-0.7	-0.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.5	-0.7	0.7	-0.7
Glaucoma (self-reported)	0.4	0.5	1.4	0.0	-1.2	-0.2
Gout (self-reported)	1.5	2.1	3.9	1.0	2.0	1.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	-0.3	0.0	0.5
Medication: Amlodipine	0.1	0.2	0.6	0.7	-0.0	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	0.7	-0.0	0.1
Birth weight	1.5	3.2	7.9	-0.5	-2.8	-1.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.2	0.4	0.8
High blood pressure (siblings)	0.6	0.9	1.2	1.1	-0.9	0.9
Forced vital capacity (FVC), Best measure	0.7	2.5	4.2	-1.6	-2.0	-1.0
Body fat percentage	4.4	17.4	19.8	4.5	3.9	4.2
Leg fat percentage (right)	6.1	22.0	27.5	5.2	4.5	4.2
Arm fat-free mass (right)	0.4	2.3	5.8	-0.9	-2.4	-0.5
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.4	-0.8	0.5
Comparative body size at age 10	1.7	4.8	11.8	0.9	3.4	1.4
Number of full brothers	0.3	0.3	0.8	-0.5	0.1	-0.9
Worry too long after embarrassment	0.7	1.2	2.5	0.9	-0.6	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.6	0.9	-0.6	1.6
Wheeze or whistling in the chest in last year	0.2	0.3	0.5	0.3	-0.7	0.5
Number of children fathered	0.6	0.7	1.0	0.0	1.0	1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	6.0	-1.2	-2.4	-1.4
Age at first live birth	1.6	2.8	5.7	-1.4	-0.8	-2.4
Pulse wave peak to peak time	2.1	2.5	3.8	-1.6	-1.0	-2.0
Health satisfaction	0.8	1.1	1.3	1.1	1.1	0.8
Shortness of breath walking on level ground	0.5	0.6	1.3	0.1	-1.2	0.6
Qualifications: College or University degree	1.3	4.0	5.4	-1.7	-1.9	-2.3
Eye problems/disorders: None of the above	0.4	0.5	1.4	-0.1	0.1	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.4	0.1	-1.2	0.3
Emphysema/chronic bronchitis	0.4	0.4	0.8	-0.6	-0.9	0.4
Medication for pain relief, constipation, heartburn	1.0	1.7	2.5	-1.6	0.8	-1.4
Neck or shoulder pain in last month	0.2	0.3	0.5	-0.7	-0.6	0.0
Medication: Blood pressure	0.7	1.2	2.1	1.2	-0.4	1.4
Angina (self-reported)	0.1	0.1	0.2	0.2	-0.4	0.3
Migraine (self-reported)	1.2	1.5	3.2	-1.8	0.0	-1.1
Medication: Ibuprofen	1.5	1.8	4.8	0.6	-2.2	0.6
Medication: Allopurinol	0.5	0.6	1.7	0.4	1.3	0.3
Medication: Omeprazole	1.2	1.4	1.7	1.2	1.3	1.1
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	-0.1	-0.5
Mean time to correctly identify matches	0.1	0.2	0.4	0.1	-0.6	-0.6
Heart disease (mother)	1.0	1.2	2.1	-0.8	-1.0	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.8	5.8	8.8	-2.8	-0.7	-3.0
Whole body fat mass	2.7	11.4	13.6	3.7	2.8	3.5
Leg fat mass (right)	3.2	12.3	14.8	3.9	3.0	3.6
Arm predicted mass (right)	0.3	1.7	4.6	-0.7	-2.1	0.1
Pulse rate, automated reading	1.8	5.8	12.5	1.6	3.5	1.5
Alcohol intake frequency.	0.6	1.3	3.4	0.1	-1.9	0.7
Comparative height size at age 10	1.0	5.5	11.5	-3.4	-1.4	-1.7
Number of full sisters	0.2	0.2	0.3	-0.4	0.6	-0.4
Suffer from ‘nerves’	0.5	0.8	1.5	1.2	0.2	0.9
Overall health rating	1.1	2.4	3.4	1.6	1.1	1.9
Chest pain or discomfort	0.1	0.2	0.4	-0.3	-0.2	0.7
Had major operations	0.7	0.8	1.2	1.1	0.4	1.1
Age at last live birth	1.3	1.9	3.7	-1.4	0.3	-1.9
Family relationship satisfaction	0.5	0.6	1.3	-0.1	1.1	-0.6
Leg pain on walking	0.4	0.5	1.1	0.5	-1.0	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.3	-0.0	0.1	0.6
Commuting to job workplace: Car/motor vehicle	1.7	1.9	3.3	-0.3	1.8	-1.6
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	3.9	-1.8	0.6	-2.0
Medication: Aspirin	0.1	0.1	0.3	0.0	-0.5	-0.1
Supplements: Vitamin C	0.9	1.1	2.2	-0.5	0.9	-1.5
Knee pain experienced in last month	1.3	2.0	5.6	-0.1	-2.4	0.7
Hypertension (Self-reported)	1.1	2.9	6.4	2.5	-0.0	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.0	1.0	-0.9	0.9
Illnesses of father: Heart disease	2.6	3.6	4.9	-2.0	-1.4	-2.2
Illnesses of siblings: Diabetes	0.5	0.6	1.0	1.0	-0.3	1.0
Smoking status: Previous	0.3	0.4	0.9	0.1	-1.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.2	-1.1	-0.8	-0.7
Whole body fat-free mass	0.4	2.5	6.7	-0.9	-2.6	-0.3
Leg fat-free mass (right)	0.4	2.0	5.3	-0.9	-2.3	0.1
Arm fat percentage (left)	3.5	14.2	16.7	4.1	3.3	3.8
Average weekly red wine intake	0.2	0.3	0.4	0.6	-0.6	-0.5
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.2	0.2	-1.8	1.2
Mood swings	1.0	1.9	3.0	1.7	0.4	1.6
Loneliness, isolation	0.1	0.2	0.4	0.3	0.4	0.6
Long-standing illness, disability or infirmity	0.1	0.1	0.3	0.5	-0.0	0.2
Ever had bowel cancer screening	0.1	0.1	0.2	-0.3	0.1	-0.4
Diabetes diagnosed by doctor	1.8	3.0	5.3	1.7	2.3	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	0.7	-0.8	-0.8	0.6
Friendships satisfaction	2.1	2.6	7.7	-0.1	2.8	0.2
Qualifications: nursing, teaching	4.0	6.2	7.2	-2.7	-2.2	-2.6
Commuting to job workplace: Walk	1.2	1.3	2.8	0.4	-1.7	0.9
Eye problems/disorders: Cataract	0.3	0.3	0.9	0.2	-0.2	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.2	0.1	0.1	1.8
Medication for cholesterol	1.9	2.9	6.9	-2.6	-0.2	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.9	-0.2	2.0	-0.1
Back pain experienced in last month	0.9	1.3	2.3	1.5	0.4	1.1
Mineral and other dietary supplements	1.2	1.6	2.4	0.4	1.5	1.6
Breast cancer (self-reported)	3.8	4.6	5.0	2.2	2.0	2.2
Asthma (self-reported)	0.1	0.3	0.5	0.7	-0.6	-0.1
Osteoporosis (self-reported)	0.3	0.4	0.8	-0.4	0.5	-0.9
Osteoarthritis (self-reported)	1.3	1.6	3.3	-0.8	-1.8	-1.0
Medication: Aspirin	0.1	0.1	0.2	0.5	-0.3	0.1
Medication: Gliclazide	0.1	0.1	0.3	0.5	-0.1	-0.3
Illnesses of father: None of the above (group 1)	0.9	1.1	2.1	1.5	0.0	1.1
Smoking status: Current	5.1	8.1	16.9	2.3	4.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	-0.2	0.2	-0.3
Whole body water mass	0.4	2.5	6.8	-0.8	-2.6	-0.2
Leg predicted mass (right)	0.4	1.9	5.0	-0.8	-2.2	0.1
Arm fat mass (left)	1.9	7.8	9.9	3.1	2.1	3.0
Number of self-reported non-cancer illnesses	0.6	1.0	1.3	0.9	-1.0	1.1
Average weekly champagne plus white wine intake	1.6	2.2	6.0	-0.3	-2.5	-0.7
Miserableness	1.9	3.3	5.5	2.3	1.6	1.4
Guilty feelings	2.0	3.0	4.6	1.1	-1.8	2.2
Wears glasses or contact lenses	0.4	0.5	1.1	-0.4	-1.1	-0.5
Ever taken oral contraceptive pill	0.1	0.1	0.2	-0.5	0.3	-0.3
Hearing aid user	0.3	0.3	0.5	0.4	0.5	0.7
Mother’s age at death	1.4	1.7	4.5	-0.8	-2.1	-0.2
Financial situation satisfaction	0.4	0.5	0.9	0.9	-0.4	0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.4	0.3	-0.2
Commuting to job workplace: Public transport	1.3	1.5	4.3	0.2	-2.1	0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.1	-0.3	-0.5
Medication: Blood pressure	0.1	0.2	0.3	0.5	0.2	-0.6
Pain type(s) experienced in last month: Hip pain	1.3	1.6	4.0	-0.8	-2.0	-0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	0.5	-0.8	-0.3
High cholesterol (Self-reported)	0.4	0.6	1.1	1.0	-0.3	0.9
Medication: Bendroflumethiazide	0.9	1.3	2.2	1.0	1.5	-0.9
Medication: Paracetamol	0.7	1.1	1.6	1.2	-0.8	1.1
Medication: Lisinopril	0.5	0.7	1.3	-0.7	1.1	-0.4
Medication: Atorvastatin	1.0	1.2	2.4	1.5	-0.4	1.0
Illnesses of father: High blood pressure	0.1	0.1	0.4	-0.0	0.6	0.2
Alcohol drinker status: Never	0.5	0.6	0.9	0.9	-0.9	0.4
Ever smoked	0.7	1.3	2.5	0.5	1.6	1.0
Basal metabolic rate	0.2	1.2	3.4	-0.2	-1.9	0.3
Leg fat percentage (left)	5.2	18.7	23.5	4.8	4.1	3.9
Arm fat-free mass (left)	0.3	1.3	3.6	-0.1	-1.9	0.4
Number of operations (self-reported)	2.4	3.6	4.4	2.1	-1.5	2.1
Average weekly beer plus cider intake	0.3	0.5	0.9	-0.9	0.1	-0.7
Irritability	1.0	1.8	4.3	-0.1	2.1	-1.0
Risk taking	0.5	0.7	1.8	-0.2	-0.4	1.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	0.7	-0.2	0.5
Fractured/broken bones in last 5 years	0.2	0.3	0.9	0.1	0.2	-1.0
Age started oral contraceptive pill	0.7	0.9	2.3	-0.6	-0.3	-1.5
Diastolic blood pressure, automated reading	1.2	3.7	10.8	0.4	3.3	0.2
Ever depressed for a whole week	5.5	6.8	9.0	3.0	-1.6	3.0
Unable to work because of sickness or disability	1.2	1.6	3.1	0.9	0.9	1.7
Commuting to job workplace: Cycle	3.3	4.0	5.7	2.2	-1.3	2.4
Myopia	1.4	2.0	3.5	-1.4	-1.9	-0.6
Vascular/heart problems diagnosed by doctor	1.0	2.8	6.3	-2.5	-0.2	-1.4
Cholesterol lowering medication	0.7	1.0	1.7	1.3	-0.2	1.1
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	2.6	1.2	1.4	1.6
Pain experienced in last month	0.4	0.7	1.9	0.3	1.4	-0.0
Supplements: Calcium	0.8	0.9	2.6	-0.0	-1.6	-0.2
Basal cell carcinoma (self-reported)	0.8	1.0	1.2	0.8	-1.0	1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.1	-0.7	-1.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.6	0.7	0.8	1.3
Heart disease (siblings)	1.5	1.9	2.4	1.3	1.5	1.2
Alcohol drinker status: Previous	0.5	0.5	0.9	0.1	-0.8	0.9
Pack years of smoking	1.2	1.8	4.5	0.1	2.1	0.9
Impedance of whole body	0.6	3.2	9.5	-0.4	3.1	0.2
Leg fat mass (left)	2.6	10.2	12.0	3.5	2.7	3.4
Arm predicted mass (left)	0.3	1.4	4.0	-0.3	-2.0	0.4