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chr7:43,821,453-45,801,046

Best TWAS P=2.38e-56 · Best GWAS P=5.67e-54 conditioned to 0.923

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Testis	H2AFV	0.22	0.06	lasso	4	0.05	3.2e-03	-15.2	-15.8	2.4e-56	0.91	0.02	0.94	TRUE
14	YFS	Blood	DDX56	0.04	0.03	enet	38	0.04	1.6e-12	-3.8	-5.7	1.0e-08	0.18	1.00	0.00	TRUE
1	CommonMind	Brain Pre-frontal Cortex	H2AFV	0.14	0.08	lasso	8	0.08	1.8e-10	-15.2	15.5	1.7e-54	-0.92	0.01	0.99	FALSE
12	NTR	Blood	ZMIZ2	0.08	0.06	enet	17	0.06	1.5e-18	15.0	-14.7	8.9e-49	0.72	0.91	0.09	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	ZMIZ2	0.06	0.03	blup	35	0.03	3.8e-04	10.8	14.2	5.2e-46	-0.87	0.00	0.99	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	H2AFV	0.15	0.14	lasso	3	0.14	1.3e-13	13.1	13.9	6.7e-44	-0.80	0.86	0.14	FALSE
2	GTEx	Artery Aorta	H2AFV	0.10	0.08	lasso	2	0.06	1.9e-04	13.1	13.1	5.3e-39	-0.73	0.42	0.08	FALSE
17	The Cancer Genome Atlas	Prostate Adenocarcinoma	H2AFV	0.08	0.03	enet	11	0.06	1.9e-06	13.0	12.6	3.8e-36	-0.67	0.04	0.75	FALSE
11	GTEx	Thyroid	H2AFV	0.15	0.04	lasso	6	0.08	1.8e-06	13.1	12.0	2.1e-33	-0.67	0.06	0.88	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	H2AFV	0.05	0.04	blup	40	0.04	4.5e-08	13.0	11.2	6.0e-29	-0.63	0.68	0.32	FALSE
7	GTEx	Lung	DDX56	0.15	0.03	enet	17	0.08	1.6e-06	-4.1	-11.0	3.0e-28	0.52	0.15	0.79	FALSE
9	GTEx	Stomach	SNORA5C	0.14	0.00	enet	21	0.02	2.5e-02	-15.2	-10.4	1.6e-25	0.67	0.02	0.76	FALSE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	PPIA	0.05	0.02	enet	5	0.03	7.7e-05	-12.1	-9.1	8.7e-20	0.61	0.03	0.48	FALSE
8	GTEx	Nerve Tibial	ZMIZ2	0.12	0.06	lasso	5	0.06	5.1e-05	-6.0	9.0	2.5e-19	-0.40	0.70	0.02	FALSE
13	ROSMAP	Brain Pre-frontal Cortex	ZMIZ2	0.10	0.06	enet	15	0.07	1.3e-09	12.8	8.7	4.4e-18	-0.39	1.00	0.00	FALSE
4	GTEx	Brain Hypothalamus	AC004453.8	0.54	0.13	lasso	7	0.16	1.8e-04	-1.9	-8.5	2.5e-17	0.52	0.05	0.19	FALSE
5	GTEx	Brain Hypothalamus	TMED4	0.37	-0.01	enet	36	-0.01	6.3e-01	-14.5	7.9	2.0e-15	-0.45	0.03	0.27	FALSE
3	GTEx	Brain Cortex	ZMIZ2	0.49	0.07	enet	58	0.02	7.1e-02	10.8	7.6	3.1e-14	-0.34	0.05	0.40	FALSE
6	GTEx	Cells Transformed fibroblasts	ZMIZ2	0.12	0.09	lasso	4	0.06	2.3e-05	-8.3	-7.6	3.2e-14	0.40	0.61	0.29	FALSE