Best TWAS P=2.38e-56 · Best GWAS P=5.67e-54 conditioned to 0.923
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | H2AFV | 0.14 | 0.08 | lasso | 8 | 0.08 | 1.8e-10 | -15.2 | 15.5 | 1.7e-54 | -0.92 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Artery Aorta | H2AFV | 0.10 | 0.08 | lasso | 2 | 0.06 | 1.9e-04 | 13.1 | 13.1 | 5.3e-39 | -0.73 | 0.42 | 0.08 | FALSE |
| 3 | GTEx | Brain Cortex | ZMIZ2 | 0.49 | 0.07 | enet | 58 | 0.02 | 7.1e-02 | 10.8 | 7.6 | 3.1e-14 | -0.34 | 0.05 | 0.40 | FALSE |
| 4 | GTEx | Brain Hypothalamus | AC004453.8 | 0.54 | 0.13 | lasso | 7 | 0.16 | 1.8e-04 | -1.9 | -8.5 | 2.5e-17 | 0.52 | 0.05 | 0.19 | FALSE |
| 5 | GTEx | Brain Hypothalamus | TMED4 | 0.37 | -0.01 | enet | 36 | -0.01 | 6.3e-01 | -14.5 | 7.9 | 2.0e-15 | -0.45 | 0.03 | 0.27 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | ZMIZ2 | 0.12 | 0.09 | lasso | 4 | 0.06 | 2.3e-05 | -8.3 | -7.6 | 3.2e-14 | 0.40 | 0.61 | 0.29 | FALSE |
| 7 | GTEx | Lung | DDX56 | 0.15 | 0.03 | enet | 17 | 0.08 | 1.6e-06 | -4.1 | -11.0 | 3.0e-28 | 0.52 | 0.15 | 0.79 | FALSE |
| 8 | GTEx | Nerve Tibial | ZMIZ2 | 0.12 | 0.06 | lasso | 5 | 0.06 | 5.1e-05 | -6.0 | 9.0 | 2.5e-19 | -0.40 | 0.70 | 0.02 | FALSE |
| 9 | GTEx | Stomach | SNORA5C | 0.14 | 0.00 | enet | 21 | 0.02 | 2.5e-02 | -15.2 | -10.4 | 1.6e-25 | 0.67 | 0.02 | 0.76 | FALSE |
| 10 | GTEx | Testis | H2AFV | 0.22 | 0.06 | lasso | 4 | 0.05 | 3.2e-03 | -15.2 | -15.8 | 2.4e-56 | 0.91 | 0.02 | 0.94 | TRUE |
| 11 | GTEx | Thyroid | H2AFV | 0.15 | 0.04 | lasso | 6 | 0.08 | 1.8e-06 | 13.1 | 12.0 | 2.1e-33 | -0.67 | 0.06 | 0.88 | FALSE |
| 12 | NTR | Blood | ZMIZ2 | 0.08 | 0.06 | enet | 17 | 0.06 | 1.5e-18 | 15.0 | -14.7 | 8.9e-49 | 0.72 | 0.91 | 0.09 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | ZMIZ2 | 0.10 | 0.06 | enet | 15 | 0.07 | 1.3e-09 | 12.8 | 8.7 | 4.4e-18 | -0.39 | 1.00 | 0.00 | FALSE |
| 14 | YFS | Blood | DDX56 | 0.04 | 0.03 | enet | 38 | 0.04 | 1.6e-12 | -3.8 | -5.7 | 1.0e-08 | 0.18 | 1.00 | 0.00 | TRUE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | H2AFV | 0.05 | 0.04 | blup | 40 | 0.04 | 4.5e-08 | 13.0 | 11.2 | 6.0e-29 | -0.63 | 0.68 | 0.32 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PPIA | 0.05 | 0.02 | enet | 5 | 0.03 | 7.7e-05 | -12.1 | -9.1 | 8.7e-20 | 0.61 | 0.03 | 0.48 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | H2AFV | 0.08 | 0.03 | enet | 11 | 0.06 | 1.9e-06 | 13.0 | 12.6 | 3.8e-36 | -0.67 | 0.04 | 0.75 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | H2AFV | 0.15 | 0.14 | lasso | 3 | 0.14 | 1.3e-13 | 13.1 | 13.9 | 6.7e-44 | -0.80 | 0.86 | 0.14 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | ZMIZ2 | 0.06 | 0.03 | blup | 35 | 0.03 | 3.8e-04 | 10.8 | 14.2 | 5.2e-46 | -0.87 | 0.00 | 0.99 | FALSE |