Hub : Genes

IKZF1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0734 0.0225 6.7e-06 0.032 0.021 0.039 0.035 0.036 1.4e-10 1.6e-07 1.3e-12 1.6e-11 7.6e-12
2 TCGA Bladder Urothelial Carcinoma 0.1460 0.0550 1.2e-03 0.009 0.026 0.005 NA 0.002 5.3e-02 2.8e-03 1.1e-01 NA 2.2e-01
3 TCGA Lung Squamous Cell Carcinoma 0.0308 0.0157 9.8e-03 -0.002 0.008 0.004 NA -0.002 7.6e-01 3.7e-02 1.0e-01 NA 6.4e-01
4 TCGA Skin Cutaneous Melanoma 0.1590 0.0770 8.7e-03 0.027 0.018 0.059 NA 0.041 6.4e-02 1.0e-01 1.1e-02 NA 3.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.2 2.0 4.6 -2.1 1.3 0.8 -1.0
Bipolar Disorder or Schizophrenia 0.7 1.6 4.8 -2.2 0.5 -1.1 0.4
Depressed Affect (Nagel 2018) 0.4 0.8 2.1 -0.8 0.7 1.4 0.1
Depression (Nagel 2018) 0.6 0.8 1.3 0.8 0.8 1.2 0.9
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.6 0.8 1.3 0.9 -0.3
Neuroticism (Nagel 2018) 0.1 0.3 0.6 -0.4 -0.2 -0.8 0.7
Schizophrenia (2018) 0.9 2.0 4.3 -1.2 -0.5 -2.1 1.3
Schizophrenia vs Biploar Disorder 0.7 0.9 2.5 -1.6 -0.0 -0.9 0.7
Worry (Nagel 2018) 1.1 2.4 4.7 1.1 -0.7 -2.2 1.7
Alzheimer’s Disease (in mother) 0.5 0.6 1.9 -0.1 0.6 -1.4 0.1
Alzheimer’s Disease (in father) 0.2 0.2 0.6 0.4 0.4 0.1 0.8
Alzheimer’s Disease (including proxy) 0.4 0.5 1.9 0.1 1.4 -0.1 0.2
Crohns Disease (2017) 3.3 7.3 20.7 1.1 2.2 4.6 1.5
Irritable Bowel Disease (IBD) 2.5 5.9 13.9 -0.3 3.0 3.7 0.7
Ulcerative Colitis (UC) 1.3 2.4 6.7 -1.2 2.6 1.2 -0.3
Major Depression (MDD) 0.6 0.7 2.5 0.5 -0.2 0.2 1.6
Reaction Time 1.2 2.3 4.8 2.2 -0.1 2.1 -0.1
Verbal and Numeric Reasoning (VNR) 0.5 1.2 4.4 0.2 2.1 0.7 -0.0
Breast Cancer 0.2 0.5 1.3 -0.0 0.4 -0.7 -1.1
Ovarian Cancer 1.0 1.4 4.2 0.3 -0.6 -1.0 2.0
Prostate Cancer 0.6 0.9 3.4 1.8 -0.3 0.1 -0.2
Age at First Birth 0.5 0.8 1.4 0.1 1.2 -0.8 1.0
Bipolar Disorder (2011) 0.8 0.8 2.5 -0.5 1.6 0.2 -0.6
Body Mass Index (BMI) (2010) 0.7 0.9 2.3 0.8 0.8 1.5 -0.1
Coronary Artery Disease (CAD) 2.6 3.1 12.5 0.0 -0.2 -3.5 0.2
Crohns Disease (2012) 1.8 2.8 4.4 -0.3 2.1 1.7 2.0
Mean Putamen Volume 1.3 1.5 2.6 -1.6 -0.8 1.6 0.4
Fasting Glucose 1.1 1.3 3.5 -0.4 1.2 -0.2 -1.9
HbA1C 0.1 0.1 0.3 0.4 0.6 0.1 -0.3
HDL Cholesterol 0.2 0.3 0.7 0.0 -0.0 -0.9 -0.6
LDL Cholesterol 0.6 0.9 1.9 0.4 1.2 0.5 1.4
Lupus 0.8 1.2 2.4 1.4 -0.4 -0.4 1.6
Neuroticism (2016) 0.3 0.4 0.8 -0.6 -0.6 -0.3 0.9
Primary Biliary Cirrhosis 1.5 2.1 3.7 -1.2 1.9 0.7 1.7
Rheumatoid Arthritis 1.6 2.2 8.0 0.3 0.4 2.8 -0.8
Schizophrenia (2014) 0.8 1.8 3.1 -1.8 0.5 -1.7 1.1
Triglycerides 0.3 0.5 1.2 0.0 0.6 1.1 0.6
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.4 1.2 0.8 0.1 0.6
Ulcerative Colitis 1.1 1.6 4.4 -2.1 0.3 0.7 -1.2
Blood Eosinophil Count 1.1 8.8 19.8 -1.8 -3.5 -0.0 -4.5
Blood Platelet Count 0.5 5.4 14.6 -3.8 -0.5 -1.0 -2.4
Blood Red Count 1.9 18.4 37.2 4.8 0.4 6.1 -3.6
Blood White Count 0.4 2.9 10.0 1.0 -0.3 3.2 0.7
Heel T-Score 0.4 3.2 9.1 -0.8 -1.7 -3.0 -0.4
BMI 0.4 2.4 8.6 -0.8 -0.4 0.5 -2.9
Height 0.4 7.1 11.6 -3.4 0.2 -2.5 -3.3
Waist Hip Ratio (WHR) 1.1 5.2 9.8 2.3 1.7 1.6 3.1
Systolic Blood Pressure 0.3 1.4 5.6 -2.4 0.2 -0.2 -0.2
Smoking Status 0.4 1.0 2.0 -0.5 -1.2 1.4 -0.7
Allergy or Eczema 0.9 2.3 6.7 1.3 0.5 0.8 2.6
Cardiovascular Disease 0.6 1.9 3.6 -1.9 1.6 -0.1 1.2
Hypothyroidism (self reported) 0.1 0.3 0.7 0.4 -0.9 0.4 -0.2
Respiratory disease 0.3 0.8 3.0 0.2 -1.7 -0.1 -0.1
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.1 -1.3 -0.4 -0.7 -1.4
Lung FEV1/FVC ratio 0.2 1.1 2.7 0.9 -1.6 -0.7 -0.5
Lung FVC 0.6 3.0 9.8 1.2 -0.8 -3.1 -0.3
Neuroticism 0.1 0.3 1.1 -0.3 0.1 -0.3 1.0
Chronotype (morning person) 1.5 3.5 7.3 1.1 -2.7 -2.2 0.7
Hair Pigment 0.0 0.2 0.8 0.2 -0.9 0.3 -0.1
Tanning 0.1 1.1 2.0 -1.4 -0.5 -0.6 -1.4
Hand grip strength (left) 1.3 3.5 5.5 -2.3 -0.5 -2.3 -1.7
Number of treatments/medications taken 1.0 1.8 5.1 1.1 -2.3 0.6 -0.6
Average weekly spirits intake 0.5 0.7 2.0 0.0 -0.7 -0.4 -1.4
Sensitivity / hurt feelings 1.4 2.4 5.3 -1.9 -0.7 -2.3 -0.4
Frequency of depressed mood in last 2 weeks 0.5 0.7 2.0 1.4 -0.7 0.2 -0.6
Hearing difficulty/problems: Yes 2.3 3.5 7.4 2.7 -1.1 1.1 2.1
Relative age of first facial hair 0.4 0.9 1.8 -1.3 0.2 -1.3 0.0
Other serious medical condition/disability diagnosed by doctor 1.9 2.4 5.3 0.8 -1.2 2.3 -1.5
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.5 0.7 -0.6 0.5 0.7
Ever had hysterectomy (womb removed) 0.7 0.8 1.8 1.3 0.8 0.7 0.2
Systolic blood pressure, automated reading 0.1 0.3 0.6 -0.8 0.5 0.3 0.2
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.8 0.6 -0.1 0.9 -0.5
Angina 0.4 0.5 1.4 -0.1 -0.6 -0.3 1.2
Medication for hormone replacement therapy 1.4 1.6 4.0 0.8 -2.0 0.7 -1.1
Vitamin and mineral supplements 0.2 0.3 1.0 1.0 0.2 0.4 -0.2
Supplements: Zinc 1.8 1.9 5.7 -0.2 -1.3 -2.4 -0.5
Medication: Co-codamol 0.8 1.0 3.3 0.6 -0.1 1.8 -0.5
Medication: Metformin 1.4 1.9 4.3 -1.1 -0.8 -1.3 -2.1
Diabetes (father) 0.6 0.7 1.8 -0.4 -0.8 -1.3 0.6
Diabetes (mother) 0.5 0.6 2.1 1.4 -0.7 -0.1 0.2
Severe depression (siblings) 1.4 1.5 4.3 0.2 -1.0 -0.9 2.1
Pack years adult smoking proportion 0.3 0.5 1.3 -0.2 -0.6 1.2 0.6
Impedance of leg (right) 0.2 1.1 3.2 1.0 -0.1 -0.3 1.8
Leg fat-free mass (left) 1.3 6.8 16.8 -3.2 -0.1 -0.5 -4.1
Trunk fat percentage 0.5 2.0 5.2 -1.2 0.8 0.8 -2.3
Hand grip strength (right) 0.8 2.2 3.8 -1.9 -0.3 -1.9 -1.2
Townsend deprivation index at recruitment 0.2 0.4 1.1 1.0 -0.4 0.1 0.4
Current tobacco smoking 0.8 1.2 2.2 1.5 -1.0 1.2 -0.5
Average weekly fortified wine intake 1.5 1.8 2.9 1.4 0.9 -1.2 1.7
Maternal smoking around birth 0.7 1.0 2.0 1.3 0.7 -0.3 1.4
Fed-up feelings 0.1 0.3 0.7 -0.4 0.4 0.8 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.1 0.2 0.1 0.2 0.1 0.4
Relative age voice broke 0.4 0.6 0.8 0.9 0.1 -0.9 0.9
Taking other prescription medications 1.5 2.2 6.0 1.3 -1.0 2.5 0.2
Age when periods started (menarche) 0.4 0.9 2.2 -1.5 1.0 0.0 0.6
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.5 1.2 0.0 0.5 -0.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.6 0.8 0.6 0.5 -0.7
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 2.2 0.4 -0.7 -1.5 -0.0
Qualifications: CSEs or equivalent 0.4 0.5 1.0 -1.0 0.5 -0.9 -0.1
Serious illness, injury or assault to yourself 0.3 0.4 1.1 0.6 1.1 -0.2 0.3
High blood pressure 0.5 1.3 2.8 -1.5 0.3 -0.6 1.7
Hayfever, allergic rhinitis or eczema 0.7 1.5 4.8 1.0 0.4 0.4 2.2
Multivitamins +/- minerals 0.4 0.5 1.1 -1.1 -0.8 -0.1 -0.4
Stomach or abdominal pain in last month 1.0 1.3 1.8 -1.3 -1.3 -0.5 -1.2
Supplements: Glucosamine 0.2 0.2 0.7 -0.1 0.8 0.4 -0.1
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.1 -1.0 -0.2 0.9 0.1
Medication: Atenolol 1.5 1.9 5.0 -2.2 0.9 -0.9 -1.0
Medication: Levothyroxine sodium 0.1 0.2 0.3 -0.5 0.5 -0.3 0.0
Sitting height 1.0 7.3 16.7 -3.2 -0.8 -1.3 -4.1
Chronic bronchitis/emphysema (father) 0.9 1.1 2.0 1.4 0.8 1.3 0.1
High blood pressure (mother) 0.6 0.8 2.4 -0.7 -0.6 -1.6 -0.2
Body mass index (BMI) 0.6 2.4 5.8 -1.9 0.2 0.5 -2.4
Impedance of leg (left) 0.4 1.9 6.2 0.9 0.8 -0.4 2.5
Leg predicted mass (left) 1.2 6.5 15.9 -3.1 -0.1 -0.5 -4.0
Trunk fat mass 0.9 3.8 10.6 -2.0 0.6 0.5 -3.2
Waist circumference 0.6 2.1 5.5 -1.1 0.8 0.9 -2.4
Number of incorrect matches in round 0.5 0.8 1.6 0.1 0.6 -1.1 1.3
Past tobacco smoking 0.5 0.9 1.6 1.0 0.9 -1.2 0.2
Alcohol usually taken with meals 0.3 0.5 1.4 -1.2 0.7 -0.4 0.2
Nervous feelings 1.4 2.6 8.5 -0.2 -1.4 -2.9 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.6 1.3 0.1 -0.3 0.1
Hearing difficulty/problems with background noise 1.2 1.9 2.4 1.5 -1.2 1.3 1.6
Hair/balding pattern: Pattern 2 1.4 1.8 5.4 -2.3 0.0 -0.5 -1.2
Had menopause 1.0 1.3 2.8 1.7 1.3 0.4 0.6
Had other major operations 4.8 5.8 16.6 2.1 0.5 4.1 1.5
Forced vital capacity (FVC) 0.8 3.0 8.4 -1.2 -0.3 -2.9 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 0.6 0.8 0.6 0.5 -0.7
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.8 -0.0 -0.5 -0.9 -0.8
Qualifications: None of the above 0.1 0.2 0.4 -0.1 -0.5 0.5 0.7
Financial difficulties in last 2 years 0.5 0.7 2.3 0.0 -0.6 1.5 -0.3
Mouth/teeth dental problems 1.9 3.0 4.7 1.2 -2.0 -2.2 -1.4
Heart attack 1.7 2.1 3.1 -0.4 1.7 -1.8 1.6
Allergy 0.6 1.4 3.8 -1.2 0.4 -0.3 -1.9
Pain all over the body in last month 4.1 4.4 6.4 2.1 2.5 0.8 2.5
Diabetes (self-reported) 0.4 0.6 1.1 -1.1 -0.7 0.3 -0.9
Hayfever/allergic rhinitis (self-reported) 1.2 1.5 3.6 -0.2 0.2 1.9 1.6
Medication: Ramipril 0.8 1.0 2.3 -1.5 0.9 -0.9 0.3
Medication: Simvastatin 0.0 0.1 0.1 0.0 -0.3 0.4 0.2
Fluid intelligence score 0.5 1.0 3.4 0.1 1.8 0.5 -0.6
Illnesses of siblings 0.1 0.1 0.3 -0.1 0.3 -0.6 0.2
Neuroticism score 0.3 0.7 1.8 0.2 -0.4 -1.0 1.4
Weight 1.1 5.6 14.3 -2.8 0.2 -0.4 -3.8
Impedance of arm (right) 0.1 0.6 2.4 1.6 -0.1 0.2 0.4
Arm fat percentage (right) 0.6 2.2 6.2 -1.4 0.2 0.7 -2.5
Trunk fat-free mass 1.2 7.0 14.0 -3.5 -0.4 -1.3 -3.7
Hip circumference 1.7 7.3 21.6 -2.6 0.5 0.5 -4.7
Time employed in main current job 1.0 1.2 4.3 -0.3 2.1 0.5 0.2
Alcohol intake versus 10 years previously 0.0 0.0 0.1 -0.1 -0.0 0.2 0.2
Father’s age at death 0.4 0.6 1.1 1.0 -0.8 0.6 -0.5
Worrier / anxious feelings 0.7 1.2 2.2 0.9 -1.4 -1.5 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.0 1.0 -0.3 -0.3 0.7
Falls in the last year 0.6 0.9 1.6 0.7 0.4 1.1 1.3
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 0.8 0.5 -0.1 0.6
Number of live births 1.0 1.5 2.9 0.1 0.9 1.4 1.7
Forced expiratory volume in 1-second (FEV1) 0.9 3.1 10.2 -0.5 -0.5 -3.2 -1.3
Pulse rate 0.6 1.1 3.8 -0.3 1.9 -0.5 0.3
Happiness 0.5 0.6 1.3 -1.1 1.1 -0.0 -0.3
Noisy workplace 0.3 0.4 1.0 0.1 0.0 1.0 0.6
Qualifications: A levels/AS levels or equivalent 1.5 3.4 5.2 -1.2 -1.8 -2.3 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.9 0.5 0.9 -0.2 -1.4
Mouth/teeth dental problems: Dentures 0.7 1.1 3.1 -1.8 1.2 0.2 0.2
Asthma 0.4 0.8 2.4 0.1 -1.6 0.8 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 2.0 -0.3 -1.4 -0.2 -1.0
Medication: Cholesterol lowering 0.7 1.1 1.7 -1.3 -0.9 -1.3 0.3
Depression (self-reported) 0.5 0.5 1.2 0.2 1.1 0.4 -0.9
Medication: Lansoprazole 0.9 1.1 2.9 -0.6 -1.7 -0.3 -1.0
Prospective memory result 0.8 1.0 1.8 0.9 -1.4 0.0 1.1
Lung cancer (father) 1.1 1.3 3.2 0.1 1.8 1.0 0.9
Illnesses of mother 2.1 2.6 4.6 1.5 1.2 2.1 1.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 5.6 0.0 -0.4 -2.4 -0.8
Pulse wave Arterial Stiffness index 0.9 1.1 2.7 0.2 1.1 1.6 -0.6
Impedance of arm (left) 0.1 0.4 1.7 1.3 0.2 0.0 0.2
Arm fat mass (right) 1.0 4.0 10.0 -2.4 0.3 0.2 -3.2
Trunk predicted mass 1.3 7.2 14.4 -3.5 -0.5 -1.3 -3.8
Standing height 0.5 5.3 9.7 -2.7 0.2 -2.0 -3.1
Length of working week for main job 0.6 0.7 1.5 -1.2 0.7 -0.8 -0.2
Exposure to tobacco smoke at home 0.5 0.5 0.8 0.9 -0.4 0.8 0.7
Breastfed as a baby 1.4 1.8 4.6 1.4 0.5 0.6 2.1
Tense / ‘highly strung’ 0.7 1.2 2.9 0.1 0.5 -1.3 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 3.8 2.0 -0.7 0.6 0.3
Hair/balding pattern: Pattern 4 0.3 0.7 1.6 1.2 -0.9 -0.7 0.3
Birth weight of first child 0.2 0.3 0.7 0.1 -0.4 0.5 -0.8
Peak expiratory flow (PEF) 0.4 0.9 2.0 -0.2 -0.9 -1.4 -1.0
Pulse wave reflection index 0.2 0.3 0.8 0.3 -0.5 0.9 -0.1
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.3 0.0 -0.5 0.2 0.4
Loud music exposure frequency 0.8 0.9 2.8 -0.5 -0.7 -0.1 -1.7
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.8 -0.2 0.1 0.0 -0.9
Mouth/teeth dental problems: Bleeding gums 1.1 1.5 2.9 -1.7 1.7 0.1 -0.5
Blood clot in the leg (DVT) 0.6 0.7 1.5 0.7 -1.0 -0.2 1.2
Medication: Paracetamol 0.8 1.3 4.1 0.9 -0.2 2.0 0.5
Headache pain in last month 0.5 0.8 1.6 1.3 -1.1 -0.5 0.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 2.0 1.4 0.7 0.5 -0.8
Glaucoma (self-reported) 1.1 1.3 1.5 -1.1 -0.9 1.2 -1.2
Gout (self-reported) 2.3 3.1 8.0 0.3 -2.8 -0.4 -2.1
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.3 -0.1 -0.5 0.3 -0.5
Medication: Amlodipine 1.5 2.1 5.0 -2.2 1.1 0.3 1.4
Medication: Ventolin 100micrograms inhaler 0.6 0.8 2.9 0.3 0.2 1.7 0.5
Birth weight 0.4 0.9 1.7 -1.3 -0.5 0.7 -1.1
Chronic bronchitis/emphysema (mother) 0.2 0.3 1.0 0.1 -1.0 0.2 0.1
High blood pressure (siblings) 0.1 0.1 0.3 -0.5 0.2 0.0 0.4
Forced vital capacity (FVC), Best measure 0.4 1.5 4.9 -0.3 -0.4 -2.2 -0.9
Body fat percentage 0.5 2.0 4.4 -1.5 0.9 0.9 -2.1
Leg fat percentage (right) 0.5 1.8 4.6 -1.1 0.4 1.2 -2.2
Arm fat-free mass (right) 1.1 5.6 11.7 -3.4 0.5 -0.9 -3.1
Exposure to tobacco smoke outside home 0.1 0.1 0.3 -0.2 -0.2 -0.2 -0.5
Comparative body size at age 10 0.1 0.3 0.6 -0.4 0.4 -0.4 -0.8
Number of full brothers 0.4 0.5 1.1 -0.7 0.4 1.0 0.6
Worry too long after embarrassment 0.3 0.4 1.4 -0.1 -0.4 -1.2 0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 2.8 -0.1 -1.2 0.4 -1.7
Wheeze or whistling in the chest in last year 0.5 0.8 1.2 -0.8 -1.1 1.1 0.5
Number of children fathered 3.0 3.4 5.9 1.3 0.9 2.3 2.4
Reason for reducing amount of alcohol drunk: Health precaution 1.7 1.9 6.3 -2.5 0.6 0.3 1.0
Age at first live birth 1.4 2.6 4.2 -1.4 -1.5 -2.0 -1.4
Pulse wave peak to peak time 1.0 1.1 2.8 -0.4 -1.2 -1.7 0.2
Health satisfaction 0.8 1.1 3.6 0.7 0.5 0.4 1.9
Shortness of breath walking on level ground 1.1 1.3 2.5 1.1 -1.6 -0.1 1.3
Qualifications: College or University degree 0.4 1.3 2.9 -1.4 0.7 -1.7 -0.1
Eye problems/disorders: None of the above 0.1 0.1 0.2 0.3 0.0 -0.1 -0.4
Mouth/teeth dental problems: Loose teeth 1.3 1.6 2.5 1.6 1.0 1.4 0.9
Emphysema/chronic bronchitis 0.3 0.3 0.4 0.6 0.7 0.1 -0.6
Medication for pain relief, constipation, heartburn 0.2 0.3 0.7 -0.4 0.8 -0.1 -0.5
Neck or shoulder pain in last month 0.1 0.2 0.6 -0.8 -0.2 0.0 -0.3
Medication: Blood pressure 0.5 0.9 1.7 -1.3 -0.6 -0.6 1.1
Angina (self-reported) 0.5 0.7 1.6 -0.0 -0.8 -0.7 1.3
Migraine (self-reported) 0.8 1.0 3.8 0.1 0.5 -1.9 0.2
Medication: Ibuprofen 0.6 0.7 1.9 0.6 -1.4 0.1 -0.7
Medication: Allopurinol 1.8 2.5 5.9 0.1 -2.4 -0.5 -1.9
Medication: Omeprazole 0.7 0.8 1.6 -0.0 0.8 1.2 1.0
Medication: Seretide 50 evohaler 1.0 1.1 2.1 0.9 -0.4 1.5 1.1
Mean time to correctly identify matches 1.1 2.1 5.3 2.3 0.1 1.7 0.3
Heart disease (mother) 1.3 1.5 4.6 -0.0 -2.2 -0.1 -1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 4.5 0.9 -1.1 0.2 -2.1
Whole body fat mass 0.8 3.5 8.4 -2.3 0.7 0.3 -2.9
Leg fat mass (right) 0.8 3.1 9.0 -1.8 -0.0 0.4 -3.0
Arm predicted mass (right) 1.0 4.9 10.0 -3.0 0.2 -0.8 -3.2
Pulse rate, automated reading 0.5 1.6 4.4 2.1 0.6 1.0 -0.9
Alcohol intake frequency. 0.5 1.0 1.9 0.4 0.5 1.4 1.4
Comparative height size at age 10 0.6 3.0 6.5 -0.9 -0.2 -2.2 -2.5
Number of full sisters 3.7 4.6 6.7 0.3 2.4 2.6 2.3
Suffer from ‘nerves’ 0.9 1.5 3.5 1.5 0.2 -0.3 1.9
Overall health rating 1.0 2.1 3.6 1.3 0.2 1.8 1.9
Chest pain or discomfort 0.0 0.0 0.0 -0.2 -0.1 -0.1 -0.2
Had major operations 2.0 2.4 4.8 1.5 -0.2 2.2 1.6
Age at last live birth 1.0 1.5 4.1 -1.2 -0.7 -2.0 0.1
Family relationship satisfaction 0.6 0.7 1.2 -0.1 1.1 1.1 0.8
Leg pain on walking 1.2 1.5 3.3 -1.1 -1.1 -0.6 -1.8
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.4 0.7 -0.0 0.6 1.2
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.2 -1.1 -0.2 -0.3 0.4
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.5 0.2 -0.9 -1.2 -0.1
Medication: Aspirin 1.0 1.3 2.0 -1.4 -1.2 -1.3 0.1
Supplements: Vitamin C 1.7 2.0 6.6 0.1 -1.1 -2.6 -0.3
Knee pain experienced in last month 0.2 0.4 0.6 -0.5 0.5 0.7 0.8
Hypertension (Self-reported) 0.3 0.9 2.7 -0.8 0.0 -0.5 1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.0 1.0 -0.7 0.3 0.9
Illnesses of father: Heart disease 0.2 0.2 0.4 0.5 -0.5 -0.6 0.3
Illnesses of siblings: Diabetes 0.1 0.1 0.4 0.2 0.7 -0.3 -0.1
Smoking status: Previous 0.5 0.8 1.6 -1.3 -0.8 0.9 0.0
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.6 -0.4 0.4 0.0 -0.8
Whole body fat-free mass 1.2 7.1 14.9 -3.5 -0.1 -1.0 -3.9
Leg fat-free mass (right) 1.1 6.0 13.1 -3.2 0.4 -0.7 -3.6
Arm fat percentage (left) 0.6 2.5 6.9 -1.6 0.4 0.6 -2.6
Average weekly red wine intake 0.7 1.1 2.6 -0.9 -0.6 0.7 -1.6
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.6 -0.0 0.2 -1.3 -0.9
Mood swings 0.3 0.5 1.1 -0.2 0.2 1.1 0.8
Loneliness, isolation 0.2 0.2 0.8 0.2 -0.1 -0.9 -0.4
Long-standing illness, disability or infirmity 2.7 4.1 6.2 2.4 0.2 2.5 2.1
Ever had bowel cancer screening 1.2 1.4 2.4 -0.9 1.5 1.5 0.0
Diabetes diagnosed by doctor 0.1 0.2 0.7 -0.8 -0.1 -0.3 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 3.0 -0.9 1.7 0.4 1.6
Friendships satisfaction 0.3 0.3 0.8 -0.1 0.5 -0.5 0.9
Qualifications: nursing, teaching 0.9 1.4 4.3 -0.9 0.4 -2.1 0.5
Commuting to job workplace: Walk 1.0 1.1 2.1 0.4 1.4 0.6 1.4
Eye problems/disorders: Cataract 0.8 0.9 2.1 -0.6 1.0 -0.5 1.4
Mouth/teeth dental problems: Mouth ulcers 7.3 11.7 23.3 2.8 -0.3 4.8 3.9
Medication for cholesterol 0.6 0.9 2.3 0.5 1.5 0.7 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.4 1.2 -0.5 0.5 0.7
Back pain experienced in last month 0.8 1.2 4.2 -0.7 -2.0 0.0 -0.4
Mineral and other dietary supplements 0.3 0.5 1.3 -0.7 -0.1 0.3 1.2
Breast cancer (self-reported) 0.8 0.9 1.9 0.2 -1.1 -1.4 -0.8
Asthma (self-reported) 0.4 0.7 2.0 0.0 -1.4 0.8 0.5
Osteoporosis (self-reported) 1.2 1.5 3.0 -0.7 1.4 1.7 -0.6
Osteoarthritis (self-reported) 0.3 0.4 1.5 1.2 0.1 0.3 0.1
Medication: Aspirin 1.0 1.3 2.8 -1.7 -1.0 -1.3 0.0
Medication: Gliclazide 0.5 0.6 2.0 -0.1 0.5 -0.1 -1.4
Illnesses of father: None of the above (group 1) 0.1 0.1 0.2 0.4 -0.3 -0.2 -0.5
Smoking status: Current 0.5 0.8 1.5 0.9 -1.2 0.7 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.4 3.0 8.2 0.3 -1.5 -2.9 -1.2
Whole body water mass 1.2 6.8 13.7 -3.5 -0.0 -1.0 -3.7
Leg predicted mass (right) 1.1 6.1 13.3 -3.2 0.4 -0.6 -3.6
Arm fat mass (left) 1.0 4.2 9.5 -2.6 0.5 0.2 -3.1
Number of self-reported non-cancer illnesses 1.8 3.2 5.2 2.3 -0.2 1.8 2.1
Average weekly champagne plus white wine intake 1.1 1.4 4.0 -2.0 0.0 -0.5 -1.2
Miserableness 0.5 0.9 1.7 -0.9 1.0 0.1 1.3
Guilty feelings 0.6 0.9 1.7 0.3 -1.3 -1.2 0.5
Wears glasses or contact lenses 0.8 1.0 3.1 -0.6 -0.6 -1.8 -0.0
Ever taken oral contraceptive pill 0.9 1.0 4.0 -0.1 -2.0 -0.2 0.1
Hearing aid user 0.3 0.3 0.7 0.5 -0.1 0.4 0.8
Mother’s age at death 1.5 1.9 4.1 -0.9 2.0 1.5 0.6
Financial situation satisfaction 0.6 0.8 1.8 0.3 -0.7 -0.9 1.3
Tinnitus: Yes, now most or all of the time 1.6 1.8 3.8 2.0 0.2 1.6 1.0
Commuting to job workplace: Public transport 1.3 1.6 2.2 1.5 1.1 1.5 0.7
Eye problems/disorders: Glaucoma 1.5 1.8 2.9 -0.8 -1.7 1.2 -1.5
Medication: Blood pressure 0.3 0.6 1.3 -0.8 -0.2 -1.1 0.5
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.9 0.5 -0.6 0.6 -1.0
Supplements: Fish oil (including cod liver oil) 0.5 0.7 1.0 1.0 -0.9 -0.5 -0.7
High cholesterol (Self-reported) 0.3 0.5 1.1 0.2 1.0 -0.0 1.0
Medication: Bendroflumethiazide 0.4 0.6 1.5 -0.4 0.5 -0.8 1.2
Medication: Paracetamol 1.7 2.6 5.4 2.1 -0.4 2.3 0.7
Medication: Lisinopril 1.0 1.3 3.3 -0.4 -1.8 -1.2 -0.3
Medication: Atorvastatin 1.0 1.2 1.9 -0.1 1.1 -1.4 1.4
Illnesses of father: High blood pressure 1.7 2.1 5.7 -2.4 -0.8 -0.9 -1.2
Alcohol drinker status: Never 0.7 0.9 2.3 -0.8 0.6 -1.5 0.6
Ever smoked 0.5 0.9 1.4 -0.8 -1.2 0.8 -1.0
Basal metabolic rate 1.3 7.3 15.6 -3.6 0.1 -0.8 -4.0
Leg fat percentage (left) 0.6 2.0 3.8 -1.4 0.9 1.2 -1.9
Arm fat-free mass (left) 1.1 5.5 11.4 -3.4 0.3 -0.8 -3.2
Number of operations (self-reported) 5.2 7.7 16.3 3.1 -0.3 4.0 2.2
Average weekly beer plus cider intake 0.2 0.2 0.5 0.7 -0.0 -0.6 -0.4
Irritability 0.2 0.4 1.1 -1.1 -0.5 -0.2 0.2
Risk taking 0.1 0.1 0.3 0.1 0.4 -0.2 -0.6
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.4 0.6 -0.1 0.0 0.5
Fractured/broken bones in last 5 years 1.2 1.5 3.9 1.5 -0.1 -2.0 0.1
Age started oral contraceptive pill 1.5 1.8 3.6 1.6 -1.9 -0.9 -0.4
Diastolic blood pressure, automated reading 0.1 0.3 0.6 -0.2 0.7 0.6 0.3
Ever depressed for a whole week 0.2 0.2 0.6 0.3 -0.8 0.1 0.5
Unable to work because of sickness or disability 1.0 1.3 1.8 1.2 0.9 1.4 1.1
Commuting to job workplace: Cycle 0.5 0.6 1.0 -0.9 0.7 -0.1 -1.0
Myopia 0.4 0.6 1.8 0.5 1.3 0.3 -0.4
Vascular/heart problems diagnosed by doctor 0.6 1.6 3.3 1.7 -0.2 0.6 -1.8
Cholesterol lowering medication 0.1 0.2 0.5 0.2 0.7 0.2 -0.5
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 1.0 -0.6 0.2 1.0 0.8
Pain experienced in last month 0.1 0.2 0.8 0.3 0.2 -0.9 0.2
Supplements: Calcium 0.2 0.2 0.3 0.1 0.6 0.4 -0.4
Basal cell carcinoma (self-reported) 1.1 1.4 4.6 0.2 0.7 2.1 0.6
Heart attack/myocardial infarction (self-reported) 1.8 2.4 3.5 -0.1 1.6 -1.9 1.8
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.6 0.5 -0.9 -0.4 1.3
Heart disease (siblings) 1.8 2.2 4.9 2.2 -0.9 1.4 -1.1
Alcohol drinker status: Previous 2.5 2.8 5.2 2.2 -1.1 2.3 0.4
Pack years of smoking 0.3 0.4 1.1 -0.2 -0.3 1.0 0.7
Impedance of whole body 0.2 0.9 1.6 1.3 0.5 0.0 1.3
Leg fat mass (left) 0.8 3.0 7.4 -2.1 0.5 0.4 -2.7
Arm predicted mass (left) 1.1 5.4 10.6 -3.2 0.3 -0.8 -3.2