Hub : Genes

IKZF1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0734	0.0225	6.7e-06	0.032	0.021	0.039	0.035	0.036	1.4e-10	1.6e-07	1.3e-12	1.6e-11	7.6e-12
2	TCGA	Bladder Urothelial Carcinoma	0.1460	0.0550	1.2e-03	0.009	0.026	0.005	NA	0.002	5.3e-02	2.8e-03	1.1e-01	NA	2.2e-01
3	TCGA	Lung Squamous Cell Carcinoma	0.0308	0.0157	9.8e-03	-0.002	0.008	0.004	NA	-0.002	7.6e-01	3.7e-02	1.0e-01	NA	6.4e-01
4	TCGA	Skin Cutaneous Melanoma	0.1590	0.0770	8.7e-03	0.027	0.018	0.059	NA	0.041	6.4e-02	1.0e-01	1.1e-02	NA	3.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.2	2.0	4.6	-2.1	1.3	0.8	-1.0
Bipolar Disorder or Schizophrenia	0.7	1.6	4.8	-2.2	0.5	-1.1	0.4
Depressed Affect (Nagel 2018)	0.4	0.8	2.1	-0.8	0.7	1.4	0.1
Depression (Nagel 2018)	0.6	0.8	1.3	0.8	0.8	1.2	0.9
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.6	0.8	1.3	0.9	-0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.4	-0.2	-0.8	0.7
Schizophrenia (2018)	0.9	2.0	4.3	-1.2	-0.5	-2.1	1.3
Schizophrenia vs Biploar Disorder	0.7	0.9	2.5	-1.6	-0.0	-0.9	0.7
Worry (Nagel 2018)	1.1	2.4	4.7	1.1	-0.7	-2.2	1.7
Alzheimer’s Disease (in mother)	0.5	0.6	1.9	-0.1	0.6	-1.4	0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.4	0.4	0.1	0.8
Alzheimer’s Disease (including proxy)	0.4	0.5	1.9	0.1	1.4	-0.1	0.2
Crohns Disease (2017)	3.3	7.3	20.7	1.1	2.2	4.6	1.5
Irritable Bowel Disease (IBD)	2.5	5.9	13.9	-0.3	3.0	3.7	0.7
Ulcerative Colitis (UC)	1.3	2.4	6.7	-1.2	2.6	1.2	-0.3
Major Depression (MDD)	0.6	0.7	2.5	0.5	-0.2	0.2	1.6
Reaction Time	1.2	2.3	4.8	2.2	-0.1	2.1	-0.1
Verbal and Numeric Reasoning (VNR)	0.5	1.2	4.4	0.2	2.1	0.7	-0.0
Breast Cancer	0.2	0.5	1.3	-0.0	0.4	-0.7	-1.1
Ovarian Cancer	1.0	1.4	4.2	0.3	-0.6	-1.0	2.0
Prostate Cancer	0.6	0.9	3.4	1.8	-0.3	0.1	-0.2
Age at First Birth	0.5	0.8	1.4	0.1	1.2	-0.8	1.0
Bipolar Disorder (2011)	0.8	0.8	2.5	-0.5	1.6	0.2	-0.6
Body Mass Index (BMI) (2010)	0.7	0.9	2.3	0.8	0.8	1.5	-0.1
Coronary Artery Disease (CAD)	2.6	3.1	12.5	0.0	-0.2	-3.5	0.2
Crohns Disease (2012)	1.8	2.8	4.4	-0.3	2.1	1.7	2.0
Mean Putamen Volume	1.3	1.5	2.6	-1.6	-0.8	1.6	0.4
Fasting Glucose	1.1	1.3	3.5	-0.4	1.2	-0.2	-1.9
HbA1C	0.1	0.1	0.3	0.4	0.6	0.1	-0.3
HDL Cholesterol	0.2	0.3	0.7	0.0	-0.0	-0.9	-0.6
LDL Cholesterol	0.6	0.9	1.9	0.4	1.2	0.5	1.4
Lupus	0.8	1.2	2.4	1.4	-0.4	-0.4	1.6
Neuroticism (2016)	0.3	0.4	0.8	-0.6	-0.6	-0.3	0.9
Primary Biliary Cirrhosis	1.5	2.1	3.7	-1.2	1.9	0.7	1.7
Rheumatoid Arthritis	1.6	2.2	8.0	0.3	0.4	2.8	-0.8
Schizophrenia (2014)	0.8	1.8	3.1	-1.8	0.5	-1.7	1.1
Triglycerides	0.3	0.5	1.2	0.0	0.6	1.1	0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.4	1.2	0.8	0.1	0.6
Ulcerative Colitis	1.1	1.6	4.4	-2.1	0.3	0.7	-1.2
Blood Eosinophil Count	1.1	8.8	19.8	-1.8	-3.5	-0.0	-4.5
Blood Platelet Count	0.5	5.4	14.6	-3.8	-0.5	-1.0	-2.4
Blood Red Count	1.9	18.4	37.2	4.8	0.4	6.1	-3.6
Blood White Count	0.4	2.9	10.0	1.0	-0.3	3.2	0.7
Heel T-Score	0.4	3.2	9.1	-0.8	-1.7	-3.0	-0.4
BMI	0.4	2.4	8.6	-0.8	-0.4	0.5	-2.9
Height	0.4	7.1	11.6	-3.4	0.2	-2.5	-3.3
Waist Hip Ratio (WHR)	1.1	5.2	9.8	2.3	1.7	1.6	3.1
Systolic Blood Pressure	0.3	1.4	5.6	-2.4	0.2	-0.2	-0.2
Smoking Status	0.4	1.0	2.0	-0.5	-1.2	1.4	-0.7
Allergy or Eczema	0.9	2.3	6.7	1.3	0.5	0.8	2.6
Cardiovascular Disease	0.6	1.9	3.6	-1.9	1.6	-0.1	1.2
Hypothyroidism (self reported)	0.1	0.3	0.7	0.4	-0.9	0.4	-0.2
Respiratory disease	0.3	0.8	3.0	0.2	-1.7	-0.1	-0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.1	-1.3	-0.4	-0.7	-1.4
Lung FEV1/FVC ratio	0.2	1.1	2.7	0.9	-1.6	-0.7	-0.5
Lung FVC	0.6	3.0	9.8	1.2	-0.8	-3.1	-0.3
Neuroticism	0.1	0.3	1.1	-0.3	0.1	-0.3	1.0
Chronotype (morning person)	1.5	3.5	7.3	1.1	-2.7	-2.2	0.7
Hair Pigment	0.0	0.2	0.8	0.2	-0.9	0.3	-0.1
Tanning	0.1	1.1	2.0	-1.4	-0.5	-0.6	-1.4
Hand grip strength (left)	1.3	3.5	5.5	-2.3	-0.5	-2.3	-1.7
Number of treatments/medications taken	1.0	1.8	5.1	1.1	-2.3	0.6	-0.6
Average weekly spirits intake	0.5	0.7	2.0	0.0	-0.7	-0.4	-1.4
Sensitivity / hurt feelings	1.4	2.4	5.3	-1.9	-0.7	-2.3	-0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	1.4	-0.7	0.2	-0.6
Hearing difficulty/problems: Yes	2.3	3.5	7.4	2.7	-1.1	1.1	2.1
Relative age of first facial hair	0.4	0.9	1.8	-1.3	0.2	-1.3	0.0
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	5.3	0.8	-1.2	2.3	-1.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.5	0.7	-0.6	0.5	0.7
Ever had hysterectomy (womb removed)	0.7	0.8	1.8	1.3	0.8	0.7	0.2
Systolic blood pressure, automated reading	0.1	0.3	0.6	-0.8	0.5	0.3	0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	0.6	-0.1	0.9	-0.5
Angina	0.4	0.5	1.4	-0.1	-0.6	-0.3	1.2
Medication for hormone replacement therapy	1.4	1.6	4.0	0.8	-2.0	0.7	-1.1
Vitamin and mineral supplements	0.2	0.3	1.0	1.0	0.2	0.4	-0.2
Supplements: Zinc	1.8	1.9	5.7	-0.2	-1.3	-2.4	-0.5
Medication: Co-codamol	0.8	1.0	3.3	0.6	-0.1	1.8	-0.5
Medication: Metformin	1.4	1.9	4.3	-1.1	-0.8	-1.3	-2.1
Diabetes (father)	0.6	0.7	1.8	-0.4	-0.8	-1.3	0.6
Diabetes (mother)	0.5	0.6	2.1	1.4	-0.7	-0.1	0.2
Severe depression (siblings)	1.4	1.5	4.3	0.2	-1.0	-0.9	2.1
Pack years adult smoking proportion	0.3	0.5	1.3	-0.2	-0.6	1.2	0.6
Impedance of leg (right)	0.2	1.1	3.2	1.0	-0.1	-0.3	1.8
Leg fat-free mass (left)	1.3	6.8	16.8	-3.2	-0.1	-0.5	-4.1
Trunk fat percentage	0.5	2.0	5.2	-1.2	0.8	0.8	-2.3
Hand grip strength (right)	0.8	2.2	3.8	-1.9	-0.3	-1.9	-1.2
Townsend deprivation index at recruitment	0.2	0.4	1.1	1.0	-0.4	0.1	0.4
Current tobacco smoking	0.8	1.2	2.2	1.5	-1.0	1.2	-0.5
Average weekly fortified wine intake	1.5	1.8	2.9	1.4	0.9	-1.2	1.7
Maternal smoking around birth	0.7	1.0	2.0	1.3	0.7	-0.3	1.4
Fed-up feelings	0.1	0.3	0.7	-0.4	0.4	0.8	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.1	0.2	0.1	0.2	0.1	0.4
Relative age voice broke	0.4	0.6	0.8	0.9	0.1	-0.9	0.9
Taking other prescription medications	1.5	2.2	6.0	1.3	-1.0	2.5	0.2
Age when periods started (menarche)	0.4	0.9	2.2	-1.5	1.0	0.0	0.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.5	1.2	0.0	0.5	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	0.8	0.6	0.5	-0.7
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.2	0.4	-0.7	-1.5	-0.0
Qualifications: CSEs or equivalent	0.4	0.5	1.0	-1.0	0.5	-0.9	-0.1
Serious illness, injury or assault to yourself	0.3	0.4	1.1	0.6	1.1	-0.2	0.3
High blood pressure	0.5	1.3	2.8	-1.5	0.3	-0.6	1.7
Hayfever, allergic rhinitis or eczema	0.7	1.5	4.8	1.0	0.4	0.4	2.2
Multivitamins +/- minerals	0.4	0.5	1.1	-1.1	-0.8	-0.1	-0.4
Stomach or abdominal pain in last month	1.0	1.3	1.8	-1.3	-1.3	-0.5	-1.2
Supplements: Glucosamine	0.2	0.2	0.7	-0.1	0.8	0.4	-0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	-1.0	-0.2	0.9	0.1
Medication: Atenolol	1.5	1.9	5.0	-2.2	0.9	-0.9	-1.0
Medication: Levothyroxine sodium	0.1	0.2	0.3	-0.5	0.5	-0.3	0.0
Sitting height	1.0	7.3	16.7	-3.2	-0.8	-1.3	-4.1
Chronic bronchitis/emphysema (father)	0.9	1.1	2.0	1.4	0.8	1.3	0.1
High blood pressure (mother)	0.6	0.8	2.4	-0.7	-0.6	-1.6	-0.2
Body mass index (BMI)	0.6	2.4	5.8	-1.9	0.2	0.5	-2.4
Impedance of leg (left)	0.4	1.9	6.2	0.9	0.8	-0.4	2.5
Leg predicted mass (left)	1.2	6.5	15.9	-3.1	-0.1	-0.5	-4.0
Trunk fat mass	0.9	3.8	10.6	-2.0	0.6	0.5	-3.2
Waist circumference	0.6	2.1	5.5	-1.1	0.8	0.9	-2.4
Number of incorrect matches in round	0.5	0.8	1.6	0.1	0.6	-1.1	1.3
Past tobacco smoking	0.5	0.9	1.6	1.0	0.9	-1.2	0.2
Alcohol usually taken with meals	0.3	0.5	1.4	-1.2	0.7	-0.4	0.2
Nervous feelings	1.4	2.6	8.5	-0.2	-1.4	-2.9	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.6	1.3	0.1	-0.3	0.1
Hearing difficulty/problems with background noise	1.2	1.9	2.4	1.5	-1.2	1.3	1.6
Hair/balding pattern: Pattern 2	1.4	1.8	5.4	-2.3	0.0	-0.5	-1.2
Had menopause	1.0	1.3	2.8	1.7	1.3	0.4	0.6
Had other major operations	4.8	5.8	16.6	2.1	0.5	4.1	1.5
Forced vital capacity (FVC)	0.8	3.0	8.4	-1.2	-0.3	-2.9	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	0.6	0.8	0.6	0.5	-0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.8	-0.0	-0.5	-0.9	-0.8
Qualifications: None of the above	0.1	0.2	0.4	-0.1	-0.5	0.5	0.7
Financial difficulties in last 2 years	0.5	0.7	2.3	0.0	-0.6	1.5	-0.3
Mouth/teeth dental problems	1.9	3.0	4.7	1.2	-2.0	-2.2	-1.4
Heart attack	1.7	2.1	3.1	-0.4	1.7	-1.8	1.6
Allergy	0.6	1.4	3.8	-1.2	0.4	-0.3	-1.9
Pain all over the body in last month	4.1	4.4	6.4	2.1	2.5	0.8	2.5
Diabetes (self-reported)	0.4	0.6	1.1	-1.1	-0.7	0.3	-0.9
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	3.6	-0.2	0.2	1.9	1.6
Medication: Ramipril	0.8	1.0	2.3	-1.5	0.9	-0.9	0.3
Medication: Simvastatin	0.0	0.1	0.1	0.0	-0.3	0.4	0.2
Fluid intelligence score	0.5	1.0	3.4	0.1	1.8	0.5	-0.6
Illnesses of siblings	0.1	0.1	0.3	-0.1	0.3	-0.6	0.2
Neuroticism score	0.3	0.7	1.8	0.2	-0.4	-1.0	1.4
Weight	1.1	5.6	14.3	-2.8	0.2	-0.4	-3.8
Impedance of arm (right)	0.1	0.6	2.4	1.6	-0.1	0.2	0.4
Arm fat percentage (right)	0.6	2.2	6.2	-1.4	0.2	0.7	-2.5
Trunk fat-free mass	1.2	7.0	14.0	-3.5	-0.4	-1.3	-3.7
Hip circumference	1.7	7.3	21.6	-2.6	0.5	0.5	-4.7
Time employed in main current job	1.0	1.2	4.3	-0.3	2.1	0.5	0.2
Alcohol intake versus 10 years previously	0.0	0.0	0.1	-0.1	-0.0	0.2	0.2
Father’s age at death	0.4	0.6	1.1	1.0	-0.8	0.6	-0.5
Worrier / anxious feelings	0.7	1.2	2.2	0.9	-1.4	-1.5	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.0	1.0	-0.3	-0.3	0.7
Falls in the last year	0.6	0.9	1.6	0.7	0.4	1.1	1.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.8	0.5	-0.1	0.6
Number of live births	1.0	1.5	2.9	0.1	0.9	1.4	1.7
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	10.2	-0.5	-0.5	-3.2	-1.3
Pulse rate	0.6	1.1	3.8	-0.3	1.9	-0.5	0.3
Happiness	0.5	0.6	1.3	-1.1	1.1	-0.0	-0.3
Noisy workplace	0.3	0.4	1.0	0.1	0.0	1.0	0.6
Qualifications: A levels/AS levels or equivalent	1.5	3.4	5.2	-1.2	-1.8	-2.3	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.9	0.5	0.9	-0.2	-1.4
Mouth/teeth dental problems: Dentures	0.7	1.1	3.1	-1.8	1.2	0.2	0.2
Asthma	0.4	0.8	2.4	0.1	-1.6	0.8	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.0	-0.3	-1.4	-0.2	-1.0
Medication: Cholesterol lowering	0.7	1.1	1.7	-1.3	-0.9	-1.3	0.3
Depression (self-reported)	0.5	0.5	1.2	0.2	1.1	0.4	-0.9
Medication: Lansoprazole	0.9	1.1	2.9	-0.6	-1.7	-0.3	-1.0
Prospective memory result	0.8	1.0	1.8	0.9	-1.4	0.0	1.1
Lung cancer (father)	1.1	1.3	3.2	0.1	1.8	1.0	0.9
Illnesses of mother	2.1	2.6	4.6	1.5	1.2	2.1	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	5.6	0.0	-0.4	-2.4	-0.8
Pulse wave Arterial Stiffness index	0.9	1.1	2.7	0.2	1.1	1.6	-0.6
Impedance of arm (left)	0.1	0.4	1.7	1.3	0.2	0.0	0.2
Arm fat mass (right)	1.0	4.0	10.0	-2.4	0.3	0.2	-3.2
Trunk predicted mass	1.3	7.2	14.4	-3.5	-0.5	-1.3	-3.8
Standing height	0.5	5.3	9.7	-2.7	0.2	-2.0	-3.1
Length of working week for main job	0.6	0.7	1.5	-1.2	0.7	-0.8	-0.2
Exposure to tobacco smoke at home	0.5	0.5	0.8	0.9	-0.4	0.8	0.7
Breastfed as a baby	1.4	1.8	4.6	1.4	0.5	0.6	2.1
Tense / ‘highly strung’	0.7	1.2	2.9	0.1	0.5	-1.3	1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.8	2.0	-0.7	0.6	0.3
Hair/balding pattern: Pattern 4	0.3	0.7	1.6	1.2	-0.9	-0.7	0.3
Birth weight of first child	0.2	0.3	0.7	0.1	-0.4	0.5	-0.8
Peak expiratory flow (PEF)	0.4	0.9	2.0	-0.2	-0.9	-1.4	-1.0
Pulse wave reflection index	0.2	0.3	0.8	0.3	-0.5	0.9	-0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.3	0.0	-0.5	0.2	0.4
Loud music exposure frequency	0.8	0.9	2.8	-0.5	-0.7	-0.1	-1.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.8	-0.2	0.1	0.0	-0.9
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	2.9	-1.7	1.7	0.1	-0.5
Blood clot in the leg (DVT)	0.6	0.7	1.5	0.7	-1.0	-0.2	1.2
Medication: Paracetamol	0.8	1.3	4.1	0.9	-0.2	2.0	0.5
Headache pain in last month	0.5	0.8	1.6	1.3	-1.1	-0.5	0.2
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.0	1.4	0.7	0.5	-0.8
Glaucoma (self-reported)	1.1	1.3	1.5	-1.1	-0.9	1.2	-1.2
Gout (self-reported)	2.3	3.1	8.0	0.3	-2.8	-0.4	-2.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.1	-0.5	0.3	-0.5
Medication: Amlodipine	1.5	2.1	5.0	-2.2	1.1	0.3	1.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.9	0.3	0.2	1.7	0.5
Birth weight	0.4	0.9	1.7	-1.3	-0.5	0.7	-1.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.0	0.1	-1.0	0.2	0.1
High blood pressure (siblings)	0.1	0.1	0.3	-0.5	0.2	0.0	0.4
Forced vital capacity (FVC), Best measure	0.4	1.5	4.9	-0.3	-0.4	-2.2	-0.9
Body fat percentage	0.5	2.0	4.4	-1.5	0.9	0.9	-2.1
Leg fat percentage (right)	0.5	1.8	4.6	-1.1	0.4	1.2	-2.2
Arm fat-free mass (right)	1.1	5.6	11.7	-3.4	0.5	-0.9	-3.1
Exposure to tobacco smoke outside home	0.1	0.1	0.3	-0.2	-0.2	-0.2	-0.5
Comparative body size at age 10	0.1	0.3	0.6	-0.4	0.4	-0.4	-0.8
Number of full brothers	0.4	0.5	1.1	-0.7	0.4	1.0	0.6
Worry too long after embarrassment	0.3	0.4	1.4	-0.1	-0.4	-1.2	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.8	-0.1	-1.2	0.4	-1.7
Wheeze or whistling in the chest in last year	0.5	0.8	1.2	-0.8	-1.1	1.1	0.5
Number of children fathered	3.0	3.4	5.9	1.3	0.9	2.3	2.4
Reason for reducing amount of alcohol drunk: Health precaution	1.7	1.9	6.3	-2.5	0.6	0.3	1.0
Age at first live birth	1.4	2.6	4.2	-1.4	-1.5	-2.0	-1.4
Pulse wave peak to peak time	1.0	1.1	2.8	-0.4	-1.2	-1.7	0.2
Health satisfaction	0.8	1.1	3.6	0.7	0.5	0.4	1.9
Shortness of breath walking on level ground	1.1	1.3	2.5	1.1	-1.6	-0.1	1.3
Qualifications: College or University degree	0.4	1.3	2.9	-1.4	0.7	-1.7	-0.1
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.3	0.0	-0.1	-0.4
Mouth/teeth dental problems: Loose teeth	1.3	1.6	2.5	1.6	1.0	1.4	0.9
Emphysema/chronic bronchitis	0.3	0.3	0.4	0.6	0.7	0.1	-0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	-0.4	0.8	-0.1	-0.5
Neck or shoulder pain in last month	0.1	0.2	0.6	-0.8	-0.2	0.0	-0.3
Medication: Blood pressure	0.5	0.9	1.7	-1.3	-0.6	-0.6	1.1
Angina (self-reported)	0.5	0.7	1.6	-0.0	-0.8	-0.7	1.3
Migraine (self-reported)	0.8	1.0	3.8	0.1	0.5	-1.9	0.2
Medication: Ibuprofen	0.6	0.7	1.9	0.6	-1.4	0.1	-0.7
Medication: Allopurinol	1.8	2.5	5.9	0.1	-2.4	-0.5	-1.9
Medication: Omeprazole	0.7	0.8	1.6	-0.0	0.8	1.2	1.0
Medication: Seretide 50 evohaler	1.0	1.1	2.1	0.9	-0.4	1.5	1.1
Mean time to correctly identify matches	1.1	2.1	5.3	2.3	0.1	1.7	0.3
Heart disease (mother)	1.3	1.5	4.6	-0.0	-2.2	-0.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	4.5	0.9	-1.1	0.2	-2.1
Whole body fat mass	0.8	3.5	8.4	-2.3	0.7	0.3	-2.9
Leg fat mass (right)	0.8	3.1	9.0	-1.8	-0.0	0.4	-3.0
Arm predicted mass (right)	1.0	4.9	10.0	-3.0	0.2	-0.8	-3.2
Pulse rate, automated reading	0.5	1.6	4.4	2.1	0.6	1.0	-0.9
Alcohol intake frequency.	0.5	1.0	1.9	0.4	0.5	1.4	1.4
Comparative height size at age 10	0.6	3.0	6.5	-0.9	-0.2	-2.2	-2.5
Number of full sisters	3.7	4.6	6.7	0.3	2.4	2.6	2.3
Suffer from ‘nerves’	0.9	1.5	3.5	1.5	0.2	-0.3	1.9
Overall health rating	1.0	2.1	3.6	1.3	0.2	1.8	1.9
Chest pain or discomfort	0.0	0.0	0.0	-0.2	-0.1	-0.1	-0.2
Had major operations	2.0	2.4	4.8	1.5	-0.2	2.2	1.6
Age at last live birth	1.0	1.5	4.1	-1.2	-0.7	-2.0	0.1
Family relationship satisfaction	0.6	0.7	1.2	-0.1	1.1	1.1	0.8
Leg pain on walking	1.2	1.5	3.3	-1.1	-1.1	-0.6	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.4	0.7	-0.0	0.6	1.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.2	-1.1	-0.2	-0.3	0.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.5	0.2	-0.9	-1.2	-0.1
Medication: Aspirin	1.0	1.3	2.0	-1.4	-1.2	-1.3	0.1
Supplements: Vitamin C	1.7	2.0	6.6	0.1	-1.1	-2.6	-0.3
Knee pain experienced in last month	0.2	0.4	0.6	-0.5	0.5	0.7	0.8
Hypertension (Self-reported)	0.3	0.9	2.7	-0.8	0.0	-0.5	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.0	1.0	-0.7	0.3	0.9
Illnesses of father: Heart disease	0.2	0.2	0.4	0.5	-0.5	-0.6	0.3
Illnesses of siblings: Diabetes	0.1	0.1	0.4	0.2	0.7	-0.3	-0.1
Smoking status: Previous	0.5	0.8	1.6	-1.3	-0.8	0.9	0.0
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.6	-0.4	0.4	0.0	-0.8
Whole body fat-free mass	1.2	7.1	14.9	-3.5	-0.1	-1.0	-3.9
Leg fat-free mass (right)	1.1	6.0	13.1	-3.2	0.4	-0.7	-3.6
Arm fat percentage (left)	0.6	2.5	6.9	-1.6	0.4	0.6	-2.6
Average weekly red wine intake	0.7	1.1	2.6	-0.9	-0.6	0.7	-1.6
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.6	-0.0	0.2	-1.3	-0.9
Mood swings	0.3	0.5	1.1	-0.2	0.2	1.1	0.8
Loneliness, isolation	0.2	0.2	0.8	0.2	-0.1	-0.9	-0.4
Long-standing illness, disability or infirmity	2.7	4.1	6.2	2.4	0.2	2.5	2.1
Ever had bowel cancer screening	1.2	1.4	2.4	-0.9	1.5	1.5	0.0
Diabetes diagnosed by doctor	0.1	0.2	0.7	-0.8	-0.1	-0.3	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.0	-0.9	1.7	0.4	1.6
Friendships satisfaction	0.3	0.3	0.8	-0.1	0.5	-0.5	0.9
Qualifications: nursing, teaching	0.9	1.4	4.3	-0.9	0.4	-2.1	0.5
Commuting to job workplace: Walk	1.0	1.1	2.1	0.4	1.4	0.6	1.4
Eye problems/disorders: Cataract	0.8	0.9	2.1	-0.6	1.0	-0.5	1.4
Mouth/teeth dental problems: Mouth ulcers	7.3	11.7	23.3	2.8	-0.3	4.8	3.9
Medication for cholesterol	0.6	0.9	2.3	0.5	1.5	0.7	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.4	1.2	-0.5	0.5	0.7
Back pain experienced in last month	0.8	1.2	4.2	-0.7	-2.0	0.0	-0.4
Mineral and other dietary supplements	0.3	0.5	1.3	-0.7	-0.1	0.3	1.2
Breast cancer (self-reported)	0.8	0.9	1.9	0.2	-1.1	-1.4	-0.8
Asthma (self-reported)	0.4	0.7	2.0	0.0	-1.4	0.8	0.5
Osteoporosis (self-reported)	1.2	1.5	3.0	-0.7	1.4	1.7	-0.6
Osteoarthritis (self-reported)	0.3	0.4	1.5	1.2	0.1	0.3	0.1
Medication: Aspirin	1.0	1.3	2.8	-1.7	-1.0	-1.3	0.0
Medication: Gliclazide	0.5	0.6	2.0	-0.1	0.5	-0.1	-1.4
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.4	-0.3	-0.2	-0.5
Smoking status: Current	0.5	0.8	1.5	0.9	-1.2	0.7	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	3.0	8.2	0.3	-1.5	-2.9	-1.2
Whole body water mass	1.2	6.8	13.7	-3.5	-0.0	-1.0	-3.7
Leg predicted mass (right)	1.1	6.1	13.3	-3.2	0.4	-0.6	-3.6
Arm fat mass (left)	1.0	4.2	9.5	-2.6	0.5	0.2	-3.1
Number of self-reported non-cancer illnesses	1.8	3.2	5.2	2.3	-0.2	1.8	2.1
Average weekly champagne plus white wine intake	1.1	1.4	4.0	-2.0	0.0	-0.5	-1.2
Miserableness	0.5	0.9	1.7	-0.9	1.0	0.1	1.3
Guilty feelings	0.6	0.9	1.7	0.3	-1.3	-1.2	0.5
Wears glasses or contact lenses	0.8	1.0	3.1	-0.6	-0.6	-1.8	-0.0
Ever taken oral contraceptive pill	0.9	1.0	4.0	-0.1	-2.0	-0.2	0.1
Hearing aid user	0.3	0.3	0.7	0.5	-0.1	0.4	0.8
Mother’s age at death	1.5	1.9	4.1	-0.9	2.0	1.5	0.6
Financial situation satisfaction	0.6	0.8	1.8	0.3	-0.7	-0.9	1.3
Tinnitus: Yes, now most or all of the time	1.6	1.8	3.8	2.0	0.2	1.6	1.0
Commuting to job workplace: Public transport	1.3	1.6	2.2	1.5	1.1	1.5	0.7
Eye problems/disorders: Glaucoma	1.5	1.8	2.9	-0.8	-1.7	1.2	-1.5
Medication: Blood pressure	0.3	0.6	1.3	-0.8	-0.2	-1.1	0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.9	0.5	-0.6	0.6	-1.0
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.0	1.0	-0.9	-0.5	-0.7
High cholesterol (Self-reported)	0.3	0.5	1.1	0.2	1.0	-0.0	1.0
Medication: Bendroflumethiazide	0.4	0.6	1.5	-0.4	0.5	-0.8	1.2
Medication: Paracetamol	1.7	2.6	5.4	2.1	-0.4	2.3	0.7
Medication: Lisinopril	1.0	1.3	3.3	-0.4	-1.8	-1.2	-0.3
Medication: Atorvastatin	1.0	1.2	1.9	-0.1	1.1	-1.4	1.4
Illnesses of father: High blood pressure	1.7	2.1	5.7	-2.4	-0.8	-0.9	-1.2
Alcohol drinker status: Never	0.7	0.9	2.3	-0.8	0.6	-1.5	0.6
Ever smoked	0.5	0.9	1.4	-0.8	-1.2	0.8	-1.0
Basal metabolic rate	1.3	7.3	15.6	-3.6	0.1	-0.8	-4.0
Leg fat percentage (left)	0.6	2.0	3.8	-1.4	0.9	1.2	-1.9
Arm fat-free mass (left)	1.1	5.5	11.4	-3.4	0.3	-0.8	-3.2
Number of operations (self-reported)	5.2	7.7	16.3	3.1	-0.3	4.0	2.2
Average weekly beer plus cider intake	0.2	0.2	0.5	0.7	-0.0	-0.6	-0.4
Irritability	0.2	0.4	1.1	-1.1	-0.5	-0.2	0.2
Risk taking	0.1	0.1	0.3	0.1	0.4	-0.2	-0.6
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.4	0.6	-0.1	0.0	0.5
Fractured/broken bones in last 5 years	1.2	1.5	3.9	1.5	-0.1	-2.0	0.1
Age started oral contraceptive pill	1.5	1.8	3.6	1.6	-1.9	-0.9	-0.4
Diastolic blood pressure, automated reading	0.1	0.3	0.6	-0.2	0.7	0.6	0.3
Ever depressed for a whole week	0.2	0.2	0.6	0.3	-0.8	0.1	0.5
Unable to work because of sickness or disability	1.0	1.3	1.8	1.2	0.9	1.4	1.1
Commuting to job workplace: Cycle	0.5	0.6	1.0	-0.9	0.7	-0.1	-1.0
Myopia	0.4	0.6	1.8	0.5	1.3	0.3	-0.4
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.3	1.7	-0.2	0.6	-1.8
Cholesterol lowering medication	0.1	0.2	0.5	0.2	0.7	0.2	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	-0.6	0.2	1.0	0.8
Pain experienced in last month	0.1	0.2	0.8	0.3	0.2	-0.9	0.2
Supplements: Calcium	0.2	0.2	0.3	0.1	0.6	0.4	-0.4
Basal cell carcinoma (self-reported)	1.1	1.4	4.6	0.2	0.7	2.1	0.6
Heart attack/myocardial infarction (self-reported)	1.8	2.4	3.5	-0.1	1.6	-1.9	1.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.6	0.5	-0.9	-0.4	1.3
Heart disease (siblings)	1.8	2.2	4.9	2.2	-0.9	1.4	-1.1
Alcohol drinker status: Previous	2.5	2.8	5.2	2.2	-1.1	2.3	0.4
Pack years of smoking	0.3	0.4	1.1	-0.2	-0.3	1.0	0.7
Impedance of whole body	0.2	0.9	1.6	1.3	0.5	0.0	1.3
Leg fat mass (left)	0.8	3.0	7.4	-2.1	0.5	0.4	-2.7
Arm predicted mass (left)	1.1	5.4	10.6	-3.2	0.3	-0.8	-3.2