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chr8:47,421,087-49,584,958

Best TWAS P=1.81e-13 · Best GWAS P=5.06e-18 conditioned to 1.56e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	CommonMind	Brain Pre-frontal Cortex	MCM4	0.29	0.10	enet	36	0.17	1.7e-20	7.7	-7.4	1.8e-13	-0.61	0.01	0.99	TRUE
11	ROSMAP	Brain Pre-frontal Cortex	RP11-1134I14.8	0.06	0.04	blup	125	0.05	1.9e-07	8.3	-7.1	1.2e-12	-0.89	0.05	0.95	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LOC100287846	0.02	0.00	blup	149	0.01	2.9e-02	7.4	-6.9	6.2e-12	-0.85	0.10	0.50	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KIAA0146	0.06	0.07	lasso	5	0.07	3.0e-09	5.7	-6.7	2.4e-11	-0.83	0.54	0.46	FALSE
7	GTEx	Esophagus Mucosa	SPIDR	0.09	0.01	enet	17	0.06	1.4e-04	7.1	-6.6	4.3e-11	-0.68	0.17	0.39	FALSE
12	The Cancer Genome Atlas	Breast Invasive Carcinoma	MCM4	0.02	0.01	enet	4	0.02	1.4e-04	6.1	-6.6	5.0e-11	-0.49	0.01	0.81	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	MCM4	0.05	0.04	lasso	2	0.04	5.1e-05	5.3	-6.4	1.4e-10	-0.56	0.01	0.80	FALSE
6	GTEx	Brain Frontal Cortex BA9	SPIDR	0.19	0.12	lasso	18	0.14	1.9e-04	5.7	-6.4	1.6e-10	-0.78	0.24	0.55	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	SPIDR	0.08	0.07	enet	14	0.07	1.3e-09	5.4	-6.4	1.9e-10	-0.72	0.90	0.10	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-697N18.3	0.10	0.12	enet	11	0.11	3.1e-06	4.0	6.3	3.2e-10	0.72	0.10	0.88	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	MCM4	0.20	0.02	bslmm	184	0.08	2.8e-10	4.6	-5.7	1.4e-08	-0.38	0.05	0.94	FALSE
5	GTEx	Adrenal Gland	RP11-697N18.3	0.14	0.01	enet	13	0.08	6.6e-04	7.7	5.5	3.3e-08	0.76	0.04	0.73	FALSE
8	GTEx	Testis	MCM4	0.11	0.00	enet	31	0.01	1.1e-01	4.6	-5.4	6.1e-08	-0.58	0.04	0.70	FALSE
15	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MCM4	0.19	0.10	enet	1	0.10	3.1e-05	5.3	-5.3	1.0e-07	-0.54	0.02	0.80	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KIAA0146	0.03	0.01	blup	42	0.02	2.4e-03	7.3	-5.3	1.3e-07	-0.56	0.01	0.87	FALSE