TWAS
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Usage
Models
Genes
Traits
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Traits
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Blood Red Count
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chr8:60,413,073-61,890,812
Best TWAS P=1.9e-12 · Best GWAS P=9.57e-12 conditioned to 1
60.4M
60.6M
60.8M
61M
61.2M
61.4M
61.6M
61.8M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Lung
CA8
0.14
0.12
enet
10
0.13
5.5e-10
6.7
7.0
1.9e-12
0.95
0.02
0.98
TRUE
4
The Cancer Genome Atlas
Kidney Renal Clear Cell Carcinoma
CA8
0.06
0.02
blup
93
0.04
8.9e-06
6.8
6.1
1.1e-09
0.85
0.01
0.98
FALSE
3
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
CA8
0.05
0.04
blup
93
0.03
6.7e-04
6.7
5.6
2.8e-08
0.88
0.02
0.97
FALSE
2
GTEx
Small Intestine Terminal Ileum
CA8
0.28
0.09
lasso
4
0.12
1.3e-03
1.2
5.2
2.5e-07
0.71
0.04
0.74
FALSE