TWAS hub - MCM4

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2890	0.0670	3.1e-14	0.095	0.136	0.172	0.171	0.149	1.2e-11	3.4e-16	1.7e-20	2.3e-20	9.7e-18
2	GTEx	Cells EBV-transformed lymphocytes	0.1530	0.0750	9.7e-03	0.064	NA	0.118	NA	0.115	3.9e-03	NA	1.1e-04	NA	1.4e-04
3	GTEx	Skin Sun Exposed Lower leg	0.1360	0.0710	1.8e-03	0.044	NA	0.063	NA	0.031	1.5e-04	NA	6.5e-06	NA	1.3e-03
4	GTEx	Testis	0.1070	0.0580	9.7e-03	0.002	NA	0.010	NA	-0.001	2.6e-01	NA	1.1e-01	NA	3.6e-01
5	METSIM	Adipose	0.1359	0.0454	2.4e-06	0.004	0.048	0.061	0.048	0.012	7.8e-02	9.1e-08	1.6e-09	9.6e-08	5.2e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.2041	0.0611	1.5e-07	0.023	0.067	0.067	0.078	0.048	4.9e-04	5.3e-09	5.9e-09	2.9e-10	8.7e-07
7	TCGA	Breast Invasive Carcinoma	0.0248	0.0137	1.7e-03	0.005	0.016	0.017	NA	0.015	2.2e-02	2.1e-04	1.4e-04	NA	3.7e-04
8	TCGA	Brain Lower Grade Glioma	0.0534	0.0298	3.8e-04	0.037	0.030	0.029	NA	0.036	4.4e-05	2.1e-04	2.8e-04	NA	5.2e-05
9	TCGA	Liver Hepatocellular Carcinoma	0.1880	0.0980	1.2e-03	0.100	0.054	0.095	NA	0.083	1.9e-05	1.5e-03	3.1e-05	NA	1.0e-04
10	TCGA	Prostate Adenocarcinoma	0.0453	0.0242	9.9e-04	0.013	0.023	0.019	NA	0.018	1.4e-02	1.6e-03	4.0e-03	NA	5.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Ever had hysterectomy (womb removed)	6.3	7.1	9.8	2.9	2.3	2.5	3.1	2.3	2.2	2.9	3.1	2.8	2.3
Blood Eosinophil Count	4.7	36.4	60.8	-7.8	-5.1	-5.1	-6.6	-6.2	-7.5	-4.7	-5.7	-5.8	-4.8
Pulse wave Arterial Stiffness index	4.4	5.2	10.8	-2.2	-1.8	-1.5	-2.9	-3.3	-2.3	-2.0	-2.1	-1.9	-1.9
Pulse wave peak to peak time	4.4	5.2	11.2	2.3	1.7	1.5	3.0	3.3	2.5	1.9	2.1	1.8	1.9
Lung FVC	4.0	20.1	41.3	4.4	6.4	5.4	3.8	3.4	1.8	3.7	5.2	6.0	2.2
Pulse wave reflection index	4.0	4.9	12.0	-2.1	-0.7	-0.4	-2.4	-3.1	-3.5	-2.3	-1.9	-1.0	-2.6
Age started oral contraceptive pill	4.0	5.0	12.0	-1.2	-0.3	-2.4	-1.0	-2.5	-2.6	-2.6	-2.5	-1.9	-3.5
Fractured/broken bones in last 5 years	3.8	4.9	8.9	-2.2	-2.8	-2.8	-1.9	-1.7	-1.2	-1.8	-2.6	-3.0	-0.9
Illnesses of father: Heart disease	3.7	5.1	9.9	-2.7	-1.7	-2.0	-1.9	-0.6	-1.5	-3.1	-3.0	-2.6	-2.1
Hayfever/allergic rhinitis (self-reported)	3.6	4.8	8.0	-2.5	-1.7	-1.0	-2.2	-2.4	-2.1	-2.8	-2.5	-2.0	-2.3
Risk taking	3.6	5.2	7.4	2.5	1.4	1.8	2.1	2.6	2.3	2.7	2.5	1.9	2.7
Worry too long after embarrassment	3.4	5.7	12.1	-2.0	-1.5	-1.6	-2.3	-2.6	-1.6	-3.5	-3.0	-2.2	-2.7
Mother’s age at death	3.4	4.3	11.0	-2.9	-0.8	-1.7	-2.7	-2.3	-3.3	-1.6	-1.6	-1.3	-0.9
Chronic bronchitis/emphysema (father)	3.3	3.8	8.2	1.5	1.7	1.9	1.4	2.5	1.5	1.7	2.0	2.0	2.9
Blood Red Count	3.1	29.9	54.2	-7.4	-4.0	-4.7	-5.4	-3.7	-5.7	-6.6	-6.4	-5.3	-4.3
Diabetes (father)	3.1	3.9	7.6	2.2	1.3	1.3	1.2	1.9	2.8	1.9	2.1	2.2	2.1
Number of live births	2.9	4.1	7.4	1.4	2.7	2.5	1.4	0.7	-0.1	2.6	2.7	2.7	1.2
Forced vital capacity (FVC)	2.7	10.4	13.8	2.8	1.8	3.7	2.9	3.7	3.5	2.9	3.6	3.7	3.1
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	8.0	-1.8	-1.1	-1.3	-2.0	-1.2	-1.8	-1.6	-1.5	-0.9	-2.8
Birth weight of first child	2.6	4.8	11.8	2.8	1.8	0.3	3.4	2.6	3.2	1.6	1.2	0.3	1.9
Illnesses of siblings: Diabetes	2.6	3.2	6.2	2.0	1.9	2.5	1.8	1.8	1.9	0.8	1.5	1.8	1.1
Number of operations (self-reported)	2.6	3.9	7.0	1.3	1.2	1.7	1.3	2.1	1.7	2.3	2.6	2.6	2.3
Leg pain on walking	2.5	3.1	9.1	-1.6	-0.9	-0.7	-1.9	-2.5	-2.0	-1.5	-1.3	-0.7	-3.0
Qualifications: nursing, teaching	2.5	3.9	8.9	-2.6	-2.3	-1.5	-3.0	-1.8	-1.3	-1.8	-1.9	-1.7	-1.1
Allergy or Eczema	2.4	6.4	13.8	-2.8	-0.8	-1.5	-2.1	-2.2	-3.4	-3.7	-2.9	-2.0	-2.6
Glaucoma (self-reported)	2.4	2.8	6.2	-1.1	-1.8	-1.8	-1.4	-0.8	0.6	-2.2	-2.4	-2.5	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.2	11.0	1.5	3.3	2.6	1.6	1.2	0.1	2.7	2.9	2.9	2.0
Hearing difficulty/problems with background noise	2.3	3.6	8.8	-2.4	-0.3	-0.8	-1.5	-2.2	-3.0	-1.9	-1.9	-1.5	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.3	9.4	1.8	3.1	2.5	1.6	1.5	0.2	2.9	2.9	2.7	2.2
Alcohol drinker status: Never	2.3	2.7	5.7	-0.7	-0.8	-1.8	-0.8	-1.5	-0.9	-2.4	-2.3	-2.0	-2.0
Heart attack/myocardial infarction (self-reported)	2.3	2.9	6.6	-1.7	-0.4	-1.1	-1.2	-2.4	-2.6	-1.5	-1.8	-1.7	-1.7
Neuroticism (Nagel 2018)	2.2	5.2	8.5	-2.2	-0.9	-1.8	-2.0	-2.7	-2.0	-2.9	-2.7	-2.2	-2.6
Heart attack	2.1	2.7	4.7	-1.3	-0.8	-1.3	-1.1	-2.2	-2.0	-1.6	-1.9	-1.9	-1.7
Age at first live birth	2.1	3.8	5.9	-2.2	-2.2	-1.7	-2.4	-1.6	-1.0	-2.4	-2.2	-1.7	-1.6
Suffer from ‘nerves’	2.1	3.3	6.4	-2.5	-1.1	-1.9	-2.1	-1.8	-1.5	-1.8	-2.0	-1.9	-1.1
Mood swings	2.1	3.8	9.6	-1.9	-1.1	-1.8	-2.0	-3.1	-2.3	-1.4	-1.7	-1.9	-1.6
Mouth/teeth dental problems: Mouth ulcers	2.1	3.4	8.1	2.1	1.5	1.0	1.3	2.0	2.8	1.6	1.6	1.2	2.5
Medication: Lisinopril	2.1	2.7	5.0	1.7	1.4	0.8	1.6	1.4	2.2	1.8	1.6	1.3	2.1
Supplements: Calcium	2.1	2.4	6.6	1.7	0.9	1.2	1.6	1.9	2.6	0.9	1.2	1.2	1.4
Major Depression (MDD)	2.0	2.5	5.3	1.3	0.4	1.9	0.3	0.8	1.2	1.9	2.2	2.3	1.9
Impedance of arm (right)	2.0	9.4	19.8	3.5	1.5	2.7	1.9	1.9	2.5	4.4	4.0	3.3	3.4
Blood clot in the leg (DVT)	2.0	2.6	4.7	1.7	0.9	1.8	1.7	1.4	1.1	1.9	2.2	2.1	0.9
Long-standing illness, disability or infirmity	2.0	3.1	6.5	-2.0	-2.0	-1.3	-2.0	-1.1	-0.8	-2.5	-2.2	-1.6	-1.2
Worry (Nagel 2018)	1.9	3.9	7.0	-2.1	-0.6	-1.6	-1.9	-2.6	-1.9	-2.5	-2.2	-1.6	-2.1
Heel T-Score	1.9	15.2	35.8	4.1	6.0	3.8	3.3	3.7	1.9	3.8	4.1	3.9	3.2
Sensitivity / hurt feelings	1.9	3.2	6.0	-1.6	-1.3	-0.5	-1.2	-2.4	-1.8	-2.1	-2.0	-1.6	-2.4
Worrier / anxious feelings	1.9	3.6	9.1	-2.4	-0.2	-0.5	-1.9	-2.4	-3.0	-2.4	-1.7	-1.0	-1.5
Forced vital capacity (FVC), Best measure	1.9	6.9	10.9	1.8	1.6	3.3	2.0	3.1	2.6	2.3	3.0	3.3	2.4
Alzheimer’s Disease (including proxy)	1.8	2.7	4.6	0.8	1.9	1.6	2.0	2.2	0.9	1.6	1.7	1.5	1.6
Nervous feelings	1.8	3.4	7.0	-1.6	-1.1	-2.0	-1.9	-2.7	-1.4	-1.7	-1.8	-1.6	-2.2
Impedance of arm (left)	1.8	8.2	20.1	3.0	1.7	2.2	1.5	1.3	2.1	4.5	3.9	3.1	3.5
Health satisfaction	1.8	2.4	5.0	-1.4	-1.0	-2.0	-2.2	-1.5	-0.6	-1.4	-1.7	-1.8	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	3.7	1.4	0.6	1.9	1.0	1.5	1.1	1.0	1.6	1.8	1.4
Medication: Bendroflumethiazide	1.8	2.7	6.5	0.9	1.6	1.6	0.9	0.9	0.4	2.5	2.2	1.9	2.0
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	4.3	1.4	0.9	1.8	1.4	1.2	0.9	1.8	2.1	2.0	1.0
Ovarian Cancer	1.7	2.2	5.6	2.4	1.9	1.7	1.6	1.2	1.3	0.8	1.2	1.4	0.1
Neuroticism	1.7	4.1	6.8	-2.3	-1.4	-0.9	-2.6	-2.6	-1.9	-2.5	-2.0	-1.4	-2.0
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	10.2	-0.7	-0.5	-3.2	-0.2	-1.3	-0.3	-1.3	-2.0	-2.5	-1.4
Qualifications: None of the above	1.7	3.7	7.7	2.1	1.6	1.0	2.8	2.3	1.4	2.0	1.8	1.2	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.5	11.7	1.1	1.3	3.4	1.4	2.6	2.0	2.0	2.9	3.3	2.2
Knee pain experienced in last month	1.7	2.6	6.0	1.7	2.4	2.2	1.8	1.4	0.6	0.8	1.6	2.0	-0.1
Diastolic blood pressure, automated reading	1.7	5.3	8.8	2.3	1.2	2.1	2.2	3.0	2.1	2.4	2.5	2.2	2.7
Average weekly spirits intake	1.6	2.0	4.1	1.4	1.0	1.3	1.9	2.0	1.6	1.0	1.3	1.6	0.3
Maternal smoking around birth	1.6	2.3	5.5	1.4	0.2	0.2	1.5	2.3	2.2	1.5	0.8	0.0	2.3
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	3.0	0.8	0.8	1.0	1.3	1.7	1.2	1.3	1.6	1.6	1.6
Neuroticism score	1.6	3.4	6.5	-2.1	-1.1	-1.0	-2.3	-2.5	-1.8	-2.1	-1.9	-1.4	-1.6
Forced expiratory volume in 1-second (FEV1)	1.6	5.3	11.2	1.3	1.1	3.3	1.5	2.4	2.0	1.9	2.8	3.1	2.3
Pulse rate, automated reading	1.6	5.2	13.4	2.0	1.8	0.6	1.6	1.5	2.6	3.2	2.6	1.5	3.7
Breast cancer (self-reported)	1.6	1.9	4.1	-0.7	-0.8	-2.0	-0.8	-0.5	-1.2	-1.5	-1.7	-2.0	-1.4
Age at First Birth	1.5	2.2	4.2	-1.8	-1.9	-1.6	-2.0	-1.7	-1.1	-0.9	-1.1	-1.1	-0.7
Stomach or abdominal pain in last month	1.5	1.9	4.4	1.1	1.6	2.1	1.8	0.9	0.9	0.8	1.3	1.7	-0.2
Mouth/teeth dental problems	1.5	2.3	5.6	-1.3	-1.7	-1.3	-0.5	-0.5	-1.1	-2.0	-1.8	-1.4	-2.4
Mouth/teeth dental problems: Loose teeth	1.5	1.7	4.6	-0.1	2.2	1.3	0.9	0.2	-0.9	1.6	1.6	1.5	1.4
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.7	-1.0	-1.1	-0.6	-0.9	-0.7	-1.8	-1.8	-1.6	-1.1	-1.9
Hayfever, allergic rhinitis or eczema	1.4	3.1	7.3	-1.8	-0.3	-1.2	-1.5	-1.4	-2.1	-2.7	-2.1	-1.4	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	8.9	-0.6	2.1	3.0	-0.1	1.0	-0.5	0.7	2.0	2.9	1.1
Commuting to job workplace: Cycle	1.4	1.7	4.0	0.4	1.6	2.0	1.6	1.6	0.6	0.7	1.2	1.7	0.7
Lupus	1.3	2.0	5.0	1.1	0.9	0.7	1.7	2.2	1.6	1.0	1.0	0.7	2.0
Severe depression (siblings)	1.3	1.5	3.7	-1.0	-0.2	0.2	-1.3	-1.6	-0.9	-1.9	-1.2	-0.3	-1.8
Average weekly fortified wine intake	1.3	1.5	4.8	-1.0	-0.8	-0.2	-0.4	-0.4	0.0	-2.2	-1.6	-0.8	-2.2
High blood pressure	1.3	3.5	5.9	1.3	2.4	1.7	1.8	1.9	1.5	2.3	2.0	1.8	1.8
Number of incorrect matches in round	1.3	2.1	7.8	-1.7	-0.4	-1.0	-1.8	-2.8	-1.8	-0.4	-0.8	-0.9	-1.0
Had other major operations	1.3	1.6	4.0	1.3	1.1	1.8	1.2	1.2	1.0	0.3	1.3	2.0	0.1
Exposure to tobacco smoke at home	1.3	1.4	4.0	0.8	1.5	0.9	2.0	1.4	1.1	1.0	0.8	0.4	1.4
High blood pressure (siblings)	1.3	1.8	4.3	0.1	0.8	1.8	-0.2	0.7	0.9	2.1	1.8	1.7	1.7
Exposure to tobacco smoke outside home	1.3	1.7	5.2	1.5	-0.4	0.2	0.8	1.3	2.3	1.7	1.2	0.8	1.4
Medication: Blood pressure	1.3	2.4	5.4	1.2	1.4	1.0	1.4	1.3	1.2	2.3	1.8	1.2	2.1
Alzheimer’s Disease (in father)	1.2	1.3	2.4	0.5	1.1	1.1	1.3	0.9	0.1	1.6	1.6	1.4	1.1
Prostate Cancer	1.2	1.7	4.1	-0.9	-1.2	-1.5	-0.7	0.7	0.6	-2.0	-1.8	-1.6	-0.8
Ulcerative Colitis	1.2	1.8	4.1	-0.9	1.4	0.3	0.1	-1.1	-2.0	-1.9	-1.4	-0.8	-1.9
Lung FEV1/FVC ratio	1.2	6.0	13.3	-3.6	-2.2	-0.5	-2.7	-3.0	-3.6	-1.8	-1.6	-1.3	-2.2
Multivitamins +/- minerals	1.2	1.5	4.9	2.2	0.8	0.2	1.3	0.4	1.7	1.3	1.0	0.5	1.2
Father’s age at death	1.2	1.7	8.3	-1.1	-0.2	-0.0	-1.6	-2.9	-2.0	-0.4	-0.2	-0.0	-0.3
Falls in the last year	1.2	1.6	4.4	2.1	0.8	0.9	1.8	1.1	1.3	1.4	1.1	0.7	0.7
Medication: Amlodipine	1.2	1.7	3.0	1.0	1.6	0.6	1.3	1.7	1.6	1.0	1.1	1.0	1.5
Average weekly beer plus cider intake	1.2	1.8	6.0	0.9	0.5	0.2	0.4	1.3	0.6	2.1	1.8	1.1	2.4
Pain all over the body in last month	1.1	1.2	3.6	0.7	0.2	0.3	1.0	1.8	1.9	0.8	1.0	0.7	1.4
Arm fat percentage (right)	1.1	4.5	11.6	3.4	2.3	2.1	3.1	2.2	2.1	0.6	1.2	1.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.7	-0.4	-0.7	-0.7	-1.1	-1.2	-0.5	-2.1	-1.8	-1.3	-2.2
Medication: Ibuprofen	1.1	1.3	3.1	0.6	1.4	1.4	-0.1	0.0	0.1	1.3	1.6	1.8	1.1
Medication: Omeprazole	1.1	1.3	3.4	-1.7	0.0	-0.2	-1.4	-1.8	-1.8	-0.6	-0.5	-0.1	-1.2
Medication: Atorvastatin	1.1	1.4	4.9	-1.6	-0.4	-0.7	-1.2	-1.8	-2.2	-0.2	-0.4	-0.2	-0.9
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.9	-1.4	0.1	-0.2	-1.4	-2.0	-1.7	-0.7	-0.5	0.0	-1.2
LDL Cholesterol	1.0	1.6	3.4	-1.5	-1.6	-1.8	-1.2	-1.2	-1.3	-0.1	-0.9	-1.5	-0.1
Rheumatoid Arthritis	1.0	1.3	4.2	0.7	1.2	1.5	0.4	0.3	0.2	1.2	1.7	2.0	0.5
Vitamin and mineral supplements	1.0	1.3	3.8	-2.0	-0.7	0.1	-1.3	-0.4	-1.2	-1.8	-1.2	-0.5	-1.0
Taking other prescription medications	1.0	1.5	3.1	-1.5	-1.8	-0.3	-1.4	-1.3	-1.1	-1.5	-1.3	-1.0	-0.5
Hair/balding pattern: Pattern 3	1.0	1.5	2.5	0.7	1.6	1.4	1.0	1.3	0.3	1.1	1.4	1.5	1.4
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.7	0.7	-0.1	1.4	0.5	1.3	1.9	0.7	0.9	1.0	1.0
Medication: Cholesterol lowering	1.0	1.6	6.4	-2.5	-0.3	-1.0	-1.3	-0.9	-2.2	-0.6	-0.6	-0.5	-0.1
Smoking status: Previous	1.0	1.4	4.5	-0.5	-2.1	-1.4	-2.1	-0.8	-0.9	-0.7	-0.7	-0.8	-0.2
Heart disease (siblings)	1.0	1.2	2.0	-1.2	-1.3	-1.1	-1.4	-1.0	-0.7	-1.1	-1.1	-1.0	-0.7
Schizophrenia vs Biploar Disorder	0.9	1.1	2.8	-0.5	-0.8	-1.2	-0.3	-0.7	-0.7	-1.2	-1.4	-1.7	-1.1
Trunk fat percentage	0.9	3.6	8.9	3.0	1.5	1.8	2.7	1.8	2.2	1.2	1.4	1.1	1.4
Townsend deprivation index at recruitment	0.9	1.2	4.0	1.2	-1.0	-0.9	1.1	0.9	2.0	0.9	0.1	-0.9	1.0
Allergy	0.9	2.0	5.6	1.2	-0.4	-0.2	0.7	1.7	2.4	1.7	1.2	0.5	2.1
Medication: Ramipril	0.9	1.2	2.7	-1.4	-0.3	-1.1	-0.6	-1.4	-1.6	-0.7	-1.1	-1.2	-0.5
Arm fat percentage (left)	0.9	3.8	9.4	3.1	2.3	1.9	2.9	1.9	1.9	0.6	1.1	1.3	0.6
Guilty feelings	0.9	1.4	3.0	-0.8	-0.7	-1.1	-0.5	-1.3	-0.4	-1.3	-1.5	-1.7	-1.4
Commuting to job workplace: Public transport	0.9	1.0	3.3	-0.7	-1.1	-0.9	0.0	-1.3	-0.8	-0.4	-1.2	-1.8	0.6
Impedance of whole body	0.9	4.7	17.0	1.5	0.8	0.9	0.7	0.5	0.7	4.1	3.2	2.0	3.4
Verbal and Numeric Reasoning (VNR)	0.8	1.9	5.8	-0.5	-0.6	-1.0	-1.0	-1.3	-1.7	-2.0	-1.3	-0.5	-2.4
HDL Cholesterol	0.8	1.3	4.0	-0.6	-2.0	-1.8	-1.3	-0.6	0.7	-0.0	-0.7	-1.3	0.8
Cardiovascular Disease	0.8	2.6	6.2	0.6	0.4	0.9	0.5	2.5	2.5	2.0	1.6	1.3	1.9
Medication: Co-codamol	0.8	1.0	2.2	1.5	-0.1	0.6	1.2	0.9	0.7	1.5	1.1	0.5	0.9
High blood pressure (mother)	0.8	1.1	2.4	0.4	0.4	0.8	-0.6	0.3	1.3	1.5	1.3	1.3	1.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	2.1	0.2	1.2	1.1	-0.3	0.0	-0.2	1.2	1.4	1.5	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	2.2	0.3	0.7	0.5	-0.0	0.8	1.4	1.5	1.3	1.1	1.5
Mean time to correctly identify matches	0.8	1.5	3.5	-0.2	-0.4	-1.2	-0.2	-1.1	-0.4	-1.6	-1.9	-1.9	-1.6
Comparative height size at age 10	0.8	4.5	19.6	1.8	-2.0	-0.4	1.8	2.2	4.4	1.3	0.7	-0.2	2.8
Age at last live birth	0.8	1.2	2.9	-1.2	-0.7	-0.4	-1.2	-0.9	-1.1	-1.7	-1.2	-0.5	-1.3
Mineral and other dietary supplements	0.8	1.1	2.8	-1.1	-1.0	0.1	-1.1	-0.8	-0.1	-1.7	-1.2	-0.6	-1.4
Osteoarthritis (self-reported)	0.8	1.0	2.4	0.1	-0.5	-1.1	-0.1	-1.0	-0.8	-1.3	-1.3	-1.3	-1.5
Unable to work because of sickness or disability	0.8	1.0	3.6	-0.0	-1.9	-1.3	-0.3	0.8	1.4	0.3	-0.5	-1.2	0.5
Myopia	0.8	1.2	3.6	1.9	-0.5	0.2	1.1	0.8	1.7	1.0	1.0	1.0	0.0
Intelligence (Savage-Jansen 2018)	0.7	2.2	5.7	-1.0	-0.9	-0.5	-1.0	-0.9	-1.5	-2.4	-1.8	-1.1	-2.4
Ulcerative Colitis (UC)	0.7	1.4	2.9	-0.6	1.6	0.4	0.5	-1.1	-1.7	-1.4	-1.2	-0.8	-1.6
Reaction Time	0.7	1.3	3.1	-0.9	-0.3	-1.1	-0.7	-0.8	-0.1	-1.6	-1.8	-1.7	-1.0
Coronary Artery Disease (CAD)	0.7	0.8	2.1	-0.5	-0.4	-1.4	-0.3	-0.4	-0.6	-1.2	-1.1	-1.2	-0.8
Blood Platelet Count	0.7	7.7	21.7	2.1	2.5	2.0	1.7	1.6	2.4	3.8	3.1	2.2	4.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.8	1.4	0.9	-0.2	1.2	0.8	0.5	1.3	1.1	0.8	0.7
Angina	0.7	0.9	1.5	-1.1	-0.2	-0.9	-0.7	-0.4	-1.0	-1.1	-1.1	-0.9	-1.2
Diabetes (mother)	0.7	0.9	2.8	0.6	0.6	0.9	0.3	1.1	1.7	0.9	0.9	0.9	0.8
Sitting height	0.7	5.1	19.4	1.6	-2.3	0.6	1.2	2.6	4.4	1.5	1.0	-0.0	3.4
Trunk fat mass	0.7	2.8	7.1	2.6	0.6	1.4	2.7	1.9	2.5	0.4	0.6	0.4	1.1
Pulse rate	0.7	1.2	4.9	0.0	-0.3	-0.2	0.2	1.0	2.0	1.1	0.8	0.1	2.2
Ever highly irritable/argumentative for 2 days	0.7	0.9	2.0	-0.3	-0.9	-0.5	-1.4	-0.6	0.1	-1.4	-1.2	-0.7	-1.3
Body fat percentage	0.7	2.8	7.2	2.7	1.7	1.4	2.7	1.7	1.6	0.8	1.1	0.9	1.1
Arm fat-free mass (right)	0.7	3.4	7.5	-1.2	-2.7	-1.5	-0.0	0.2	0.9	-2.6	-2.6	-2.6	-1.1
Wheeze or whistling in the chest in last year	0.7	1.2	7.1	-0.4	0.1	0.7	0.2	-0.6	-1.5	-1.2	-0.6	0.2	-2.7
Eye problems/disorders: None of the above	0.7	0.8	2.0	1.1	1.2	0.8	1.4	0.1	0.1	1.2	0.9	0.6	-0.1
Hypertension (Self-reported)	0.7	2.0	3.2	0.8	1.7	1.0	1.3	1.8	1.5	1.6	1.4	1.2	1.5
Smoking status: Current	0.7	1.1	3.0	-0.6	0.9	-0.2	1.1	1.5	0.7	1.7	0.6	-0.5	1.6
Ever taken oral contraceptive pill	0.7	0.8	1.9	-1.2	-1.4	-0.3	-0.9	-1.0	-1.1	-0.4	-0.6	-0.8	-0.5
Illnesses of father: High blood pressure	0.7	0.9	2.7	0.8	0.0	-0.7	-0.4	0.1	1.6	1.2	1.0	0.7	1.4
Mean Putamen Volume	0.6	0.7	1.6	1.3	-1.1	-0.1	0.4	-0.3	0.9	-0.5	-0.9	-1.2	0.4
Fasting Glucose	0.6	0.7	2.2	-0.9	-1.5	-0.9	-0.6	-0.6	-0.2	-0.6	-0.9	-1.1	-0.5
Systolic Blood Pressure	0.6	3.0	12.7	1.0	0.8	0.6	0.8	2.2	1.8	1.9	1.4	0.8	3.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.2	0.2	0.6	1.2	-0.2	0.7	-0.1	0.5	1.1	1.5	0.6
Current tobacco smoking	0.6	1.0	2.6	-0.7	1.0	-0.5	0.9	1.3	0.5	1.6	0.4	-0.7	1.4
Arm fat mass (right)	0.6	2.6	7.4	2.5	1.0	1.4	2.7	2.0	2.2	-0.3	0.2	0.3	0.4
Gout (self-reported)	0.6	0.8	3.8	-0.9	-2.0	-0.4	-1.0	-0.8	-0.5	0.2	-0.3	-0.6	0.7
Birth weight	0.6	1.4	4.7	1.7	1.4	0.9	2.2	0.8	1.2	-0.2	-0.1	-0.1	-1.4
Chronic bronchitis/emphysema (mother)	0.6	0.8	2.8	-0.3	-1.7	-0.2	-0.5	0.4	-0.1	-1.5	-1.1	-0.9	-0.0
Number of full brothers	0.6	0.7	3.0	-1.7	-0.1	0.3	-0.7	-0.9	-1.4	-0.5	-0.3	-0.1	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.6	2.1	0.9	-1.1	-0.9	0.4	0.4	1.5	0.5	-0.3	-0.9	0.1
Shortness of breath walking on level ground	0.6	0.8	2.9	1.7	-0.1	0.9	-0.1	0.7	1.7	-0.0	0.2	0.5	-0.2
Neck or shoulder pain in last month	0.6	0.9	4.8	-0.3	-1.4	-0.8	-2.2	-0.7	-0.4	-0.7	-0.5	-0.2	-0.4
Migraine (self-reported)	0.6	0.8	2.2	0.7	-0.7	1.5	-0.5	0.6	0.8	0.4	0.9	1.1	1.2
Arm predicted mass (right)	0.6	3.2	6.8	-1.2	-2.6	-1.4	0.0	0.0	0.7	-2.6	-2.6	-2.6	-1.2
Alcohol intake frequency.	0.6	1.3	3.6	-0.8	-0.5	-0.7	0.5	-0.2	-1.2	-1.6	-1.7	-1.9	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.2	-0.8	-1.1	-0.3	-1.8	-0.7	-0.9	0.2	0.4	0.6	0.4
Average weekly red wine intake	0.6	0.8	2.1	1.4	-0.2	0.8	1.2	0.5	1.4	-0.5	-0.2	0.0	-1.2
Commuting to job workplace: Walk	0.6	0.7	1.3	0.5	1.1	0.9	0.1	-0.2	-0.2	1.1	1.1	1.0	1.0
Eye problems/disorders: Cataract	0.6	0.7	1.4	-0.9	-1.0	-1.2	-0.7	-0.2	-0.4	-0.8	-1.0	-1.0	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.2	0.0	-0.3	-0.2	-0.2	-1.1	-0.2	-1.5	-1.2	-0.9	-1.2
Average weekly champagne plus white wine intake	0.6	0.8	1.9	-1.3	-0.2	0.9	-0.2	-0.5	-1.3	1.4	0.9	0.6	0.8
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.9	-0.4	0.9	0.1	-0.5	-1.7	-1.4	0.2	-0.2	-0.5	-0.8
Arm fat-free mass (left)	0.6	3.2	7.9	-0.7	-2.7	-1.0	0.2	0.5	1.1	-2.8	-2.6	-2.4	-1.1
Irritability	0.6	1.0	2.2	-1.0	-0.3	-0.2	-1.2	-1.4	-1.5	-1.0	-0.9	-0.8	-0.9
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.8	1.1	0.6	1.4	1.0	0.7	0.6	0.1	0.6	1.1	-0.7
Ever depressed for a whole week	0.6	0.8	1.9	0.0	0.8	1.4	-0.0	-0.0	0.2	1.0	1.1	1.1	1.2
Cholesterol lowering medication	0.6	0.8	1.6	-0.8	0.3	-0.7	-1.1	-1.2	-0.1	-1.3	-1.0	-0.7	-1.1
Alcohol drinker status: Previous	0.6	0.7	3.2	0.8	0.5	1.1	1.8	0.3	-0.4	0.7	0.6	0.3	0.2
Arm predicted mass (left)	0.6	3.1	7.6	-0.7	-2.6	-1.1	0.3	0.4	1.0	-2.8	-2.5	-2.4	-1.2
Depressed Affect (Nagel 2018)	0.5	0.9	2.1	-0.9	-0.3	-0.2	-1.2	-1.4	-1.0	-1.1	-1.0	-0.8	-1.1
Depression (Nagel 2018)	0.5	0.8	2.0	-0.6	-0.2	-0.3	0.2	0.4	0.1	-1.4	-1.3	-1.1	-1.4
HbA1C	0.5	0.6	1.4	1.2	0.8	-0.1	1.1	0.2	1.2	0.8	0.2	-0.3	0.5
Height	0.5	9.8	49.1	0.3	-7.0	-3.2	-0.4	0.5	3.9	-0.7	-2.3	-4.0	1.3
Hearing difficulty/problems: Yes	0.5	0.7	2.7	-0.9	0.3	-1.1	-0.5	-0.6	-1.6	-0.8	-0.7	-0.7	-0.3
Relative age of first facial hair	0.5	1.0	3.9	-0.3	-1.4	-2.0	-0.7	-0.6	-0.2	-0.4	-0.9	-1.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.2	0.9	-1.0	-0.5	0.4	0.2	1.1	-1.1	-0.7	-0.3	-0.9
Serious illness, injury or assault to yourself	0.5	0.7	2.3	-0.6	-1.5	-0.7	-0.4	-0.8	-0.4	-0.4	-0.8	-1.2	-0.6
Impedance of leg (left)	0.5	2.2	8.9	-0.6	-0.3	-0.8	-0.2	-0.4	-1.2	3.0	1.7	0.4	2.8
Past tobacco smoking	0.5	0.9	3.2	0.7	1.8	1.1	1.5	0.4	0.9	0.2	0.5	0.9	-0.3
Had menopause	0.5	0.6	2.8	1.1	1.7	0.0	1.2	-0.0	-0.5	0.4	0.4	0.3	0.1
Trunk fat-free mass	0.5	3.0	8.0	-0.6	-2.8	-0.8	0.5	0.9	1.6	-2.5	-2.3	-2.2	-0.9
Medication: Lansoprazole	0.5	0.6	1.2	0.0	-0.0	1.1	0.6	0.9	0.4	0.8	1.0	1.1	0.5
Prospective memory result	0.5	0.6	1.6	-0.2	0.2	0.1	-1.0	0.0	0.3	1.2	1.0	0.7	1.3
Trunk predicted mass	0.5	3.1	8.4	-0.6	-2.9	-0.8	0.5	0.9	1.7	-2.5	-2.3	-2.2	-0.9
Standing height	0.5	4.6	20.5	0.6	-4.5	-0.8	0.6	1.5	3.8	0.5	-0.4	-1.5	2.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.4	-0.2	0.9	0.7	-0.7	-0.1	-0.1	1.1	1.0	0.9	1.6
Emphysema/chronic bronchitis	0.5	0.5	1.6	-0.0	-1.1	-1.1	-0.1	-0.2	-0.3	-0.2	-0.8	-1.2	-0.6
Medication for pain relief, constipation, heartburn	0.5	0.9	2.7	1.1	-0.6	-0.6	1.6	1.5	1.2	0.3	-0.3	-0.7	-0.2
Angina (self-reported)	0.5	0.7	1.2	-0.8	0.1	-0.9	-0.5	-0.4	-0.9	-1.0	-1.0	-0.8	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	5.2	-1.5	-2.3	-0.4	-0.6	0.4	0.9	-0.4	-0.7	-0.9	0.3
Ever had bowel cancer screening	0.5	0.6	2.6	1.6	0.5	0.4	1.2	0.0	0.2	-0.1	0.0	0.2	-1.3
Whole body water mass	0.5	2.7	6.5	-0.1	-2.5	-0.4	0.7	1.0	2.0	-2.4	-2.1	-1.9	-0.9
Arm fat mass (left)	0.5	2.2	6.4	2.3	1.0	1.3	2.5	1.8	2.1	-0.4	0.1	0.3	0.3
Number of self-reported non-cancer illnesses	0.5	0.8	2.2	-0.6	-1.5	-0.7	-1.2	-0.3	0.4	-1.3	-1.1	-0.9	-0.3
Hearing aid user	0.5	0.6	2.1	0.5	1.2	1.5	0.2	0.2	0.2	-0.4	0.3	1.1	-0.8
Eye problems/disorders: Glaucoma	0.5	0.6	3.3	0.8	0.4	0.4	0.7	0.6	1.8	-0.5	-0.5	-0.6	0.7
High cholesterol (Self-reported)	0.5	1.0	2.6	-1.6	-1.3	-1.1	-1.6	-0.3	-0.4	-0.4	-0.7	-0.9	-0.1
Medication: Paracetamol	0.5	0.8	2.5	-0.9	0.1	1.3	-0.7	-0.7	-1.6	0.0	0.6	1.0	0.8
Pain experienced in last month	0.5	0.9	3.2	-0.1	-1.2	-1.8	0.2	-0.2	-0.2	-0.2	-1.1	-1.7	-0.3
Crohns Disease (2017)	0.4	1.0	2.7	1.1	1.4	-0.1	1.7	1.3	0.9	0.6	0.4	0.3	0.5
Irritable Bowel Disease (IBD)	0.4	0.8	2.8	0.1	1.7	-0.2	1.2	0.0	-0.7	-0.9	-0.9	-0.8	-1.3
Bipolar Disorder (2011)	0.4	0.3	0.9	0.3	0.9	0.2	1.0	0.7	0.3	0.4	0.5	0.5	0.6
Body Mass Index (BMI) (2010)	0.4	0.5	2.7	0.5	0.9	-0.2	1.7	0.6	0.5	0.1	-0.1	-0.4	0.3
Neuroticism (2016)	0.4	0.6	1.1	-0.3	-1.0	-0.2	-0.7	-0.9	-0.9	-0.7	-0.7	-0.6	-1.0
Primary Biliary Cirrhosis	0.4	0.5	1.1	1.1	0.1	0.4	0.5	1.0	0.8	0.7	0.7	0.7	0.6
Waist Hip Ratio (WHR)	0.4	1.9	5.8	0.2	-0.9	2.0	-1.4	-0.9	-0.6	1.3	1.9	2.4	0.2
Smoking Status	0.4	1.0	4.2	-0.9	-0.2	-0.3	-0.1	1.0	-0.1	1.8	0.8	-0.4	2.1
Systolic blood pressure, automated reading	0.4	1.3	3.7	1.3	0.6	0.1	0.9	1.8	1.2	0.8	0.7	0.4	1.9
Impedance of leg (right)	0.4	2.1	8.6	-0.6	-0.2	-0.9	-0.1	-0.4	-1.1	2.9	1.5	0.1	2.7
Leg fat-free mass (left)	0.4	2.2	8.0	1.2	-1.5	0.6	1.4	1.4	2.8	-1.7	-1.2	-0.9	-0.7
Qualifications: CSEs or equivalent	0.4	0.6	2.0	0.2	0.9	0.5	-0.4	-0.0	0.3	0.8	0.9	0.9	1.4
Leg predicted mass (left)	0.4	2.2	8.2	1.2	-1.6	0.6	1.4	1.5	2.9	-1.6	-1.2	-0.9	-0.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.1	-1.1	-0.5	-0.7	-0.5	-0.9	-1.0	-0.2	-0.4	-0.7	0.2
Medication: Simvastatin	0.4	0.6	2.2	-1.5	-0.2	-0.6	-0.8	0.9	0.4	-0.6	-0.5	-0.5	0.6
Time employed in main current job	0.4	0.4	1.4	1.2	0.1	-0.2	1.0	1.0	0.7	0.1	0.2	0.2	-0.6
Asthma	0.4	0.8	2.5	0.4	0.7	1.2	0.1	-0.8	-1.0	-0.6	0.1	1.0	-1.6
Depression (self-reported)	0.4	0.5	1.2	-0.3	-0.5	-0.5	-1.0	0.5	1.1	0.8	0.3	-0.1	0.9
Loud music exposure frequency	0.4	0.4	1.7	0.9	0.6	-0.8	0.4	0.6	1.3	0.2	0.1	-0.1	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	3.2	0.1	-0.2	-0.0	-0.2	-0.7	-0.4	-1.5	-0.9	-0.5	-1.8
Number of children fathered	0.4	0.4	1.6	-1.3	-0.8	0.7	0.1	0.7	-0.6	0.4	0.1	-0.1	0.7
Medication: Allopurinol	0.4	0.5	1.4	-1.1	-1.2	-0.6	-0.3	0.0	-0.2	-0.3	-0.7	-0.9	0.6
Whole body fat mass	0.4	1.8	5.7	2.1	0.5	1.0	2.4	1.7	2.0	-0.2	0.1	-0.0	0.6
Had major operations	0.4	0.5	1.3	-0.0	0.5	0.9	0.8	0.1	-0.3	1.2	0.8	0.5	0.8
Family relationship satisfaction	0.4	0.5	1.7	0.3	-0.7	-1.0	-0.2	0.0	0.9	-0.5	-0.8	-1.3	0.4
Supplements: Vitamin C	0.4	0.5	1.7	0.5	0.3	0.5	0.4	0.7	-0.1	1.3	1.0	0.6	0.6
Whole body fat-free mass	0.4	2.6	6.2	-0.0	-2.5	-0.3	0.7	1.0	2.1	-2.3	-2.0	-1.8	-0.9
Leg fat-free mass (right)	0.4	2.1	8.3	1.1	-1.5	0.8	1.2	1.5	2.9	-1.7	-1.1	-0.6	-0.7
Asthma (self-reported)	0.4	0.7	1.9	0.6	0.8	1.2	0.2	-0.6	-0.9	-0.5	0.3	1.2	-1.4
Medication: Gliclazide	0.4	0.4	1.3	0.5	-0.3	-0.7	0.5	1.2	0.9	0.2	-0.0	-0.4	1.0
Illnesses of father: None of the above (group 1)	0.4	0.5	0.9	0.6	1.0	0.6	0.9	-0.7	-0.4	0.7	0.7	0.7	-0.6
Leg predicted mass (right)	0.4	2.2	8.9	1.2	-1.4	0.9	1.3	1.5	3.0	-1.6	-1.0	-0.6	-0.6
Wears glasses or contact lenses	0.4	0.5	1.9	-0.0	1.4	0.1	-0.3	-1.0	-1.1	-0.2	-0.2	0.1	-0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.4	0.2	0.8	-0.9	0.0	-0.1	-0.9	0.9	0.7	0.3	1.2
Basal metabolic rate	0.4	2.2	5.2	0.4	-2.2	-0.1	1.0	1.3	2.3	-2.0	-1.7	-1.6	-0.6
Schizophrenia (2018)	0.3	0.5	2.3	0.1	0.9	-0.2	0.3	-0.6	-0.6	1.5	0.7	0.1	1.0
Schizophrenia (2014)	0.3	0.6	2.7	0.1	0.5	-0.4	0.7	-0.0	-0.3	1.6	0.7	-0.2	1.4
Triglycerides	0.3	0.4	1.8	-0.4	1.3	1.0	0.3	0.1	-0.7	-0.3	0.3	0.6	0.6
Chronotype (morning person)	0.3	0.8	2.2	-1.3	-0.0	-1.5	-0.4	-0.3	-1.1	0.2	-0.2	-0.8	1.4
Medication for hormone replacement therapy	0.3	0.3	0.9	0.0	0.6	-0.3	0.5	0.2	-0.1	1.0	0.5	0.1	1.0
Supplements: Zinc	0.3	0.3	1.0	0.3	-0.3	-0.4	-0.5	0.5	0.8	0.3	0.4	0.2	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	-1.0	-1.0	-0.2	-0.2	0.7	0.6	-0.4	-0.6	-0.7	-0.5
Supplements: Glucosamine	0.3	0.4	0.9	0.3	0.4	0.7	0.3	0.0	-0.9	1.0	0.8	0.8	0.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.1	0.5	-0.4	0.2	0.0	0.3	-0.2	1.1	0.7	0.2	0.9
Waist circumference	0.3	1.0	2.8	1.5	0.8	1.7	1.4	0.8	1.2	-0.3	0.3	0.6	0.2
Alcohol usually taken with meals	0.3	0.5	1.4	0.6	-0.7	0.8	1.1	0.7	1.2	0.1	0.1	0.2	0.4
Diabetes (self-reported)	0.3	0.4	1.1	-0.0	0.3	-0.7	-0.2	-0.6	0.1	-1.0	-1.0	-1.1	0.1
Weight	0.3	1.7	6.4	1.5	-0.8	0.5	1.7	1.6	2.5	-1.0	-0.7	-0.6	0.3
Hip circumference	0.3	1.4	5.0	1.4	1.1	0.8	2.2	1.1	1.7	-0.8	-0.6	-0.6	0.1
Alcohol intake versus 10 years previously	0.3	0.5	1.3	-0.7	-0.4	-0.9	0.3	0.1	-0.6	0.3	-0.3	-1.1	1.1
Happiness	0.3	0.4	0.7	-0.3	0.8	0.1	-0.8	-0.7	-0.6	0.8	0.6	0.4	0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.6	-0.6	-0.9	-0.6	-1.0	-0.8	0.1	-1.2	-0.9	-0.5	-0.7
Illnesses of mother	0.3	0.4	1.9	0.3	0.3	0.4	1.4	0.2	-0.0	0.1	0.2	0.2	-1.2
Length of working week for main job	0.3	0.3	1.1	0.3	0.8	0.1	0.5	0.9	1.0	-0.5	-0.2	-0.1	0.4
Breastfed as a baby	0.3	0.4	2.7	-0.1	0.0	-0.7	0.4	1.6	0.5	-0.1	-0.1	-0.2	-0.0
Tense / ‘highly strung’	0.3	0.5	2.9	0.8	0.3	-0.9	-0.5	-1.7	0.2	0.3	0.3	0.4	-0.2
Hair/balding pattern: Pattern 4	0.3	0.6	2.1	0.4	1.4	1.2	0.4	1.1	0.4	-0.1	0.4	0.9	0.3
Peak expiratory flow (PEF)	0.3	0.8	2.7	-1.6	-1.1	0.8	-1.4	0.3	-0.3	-0.6	0.3	0.9	0.2
Medication: Paracetamol	0.3	0.6	1.5	-0.8	-0.5	0.7	-0.7	-0.8	-1.2	0.2	0.4	0.4	1.1
Headache pain in last month	0.3	0.6	2.3	-0.4	0.6	1.5	-0.7	-0.0	-0.2	0.0	0.7	1.3	0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.8	0.1	0.6	1.2	0.1	0.4	0.5	-0.3	0.6	1.1	1.3
Medication: Ventolin 100micrograms inhaler	0.3	0.3	1.5	-1.2	0.4	-0.1	0.1	-0.6	-1.1	-0.3	-0.2	-0.2	0.2
Leg fat percentage (right)	0.3	1.0	3.7	1.4	1.4	0.4	1.9	1.1	0.3	0.2	0.3	0.2	0.6
Qualifications: College or University degree	0.3	0.8	2.0	-0.8	-1.1	-1.4	-1.3	-0.7	-0.1	-0.7	-0.8	-0.8	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.3	0.1	-0.1	-0.1	-1.1	-0.0	0.9	0.5	0.6	0.7	0.7
Leg fat mass (right)	0.3	1.0	3.7	1.4	0.4	0.3	1.9	1.4	1.2	-0.4	-0.2	-0.3	0.4
Chest pain or discomfort	0.3	0.4	2.6	0.1	0.5	-0.3	0.2	0.2	-0.4	-1.0	-0.3	0.3	-1.6
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.3	-0.1	0.2	-0.2	-0.6	0.4	0.6	-0.9	-0.2	0.5	-1.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	-0.4	-1.0	-0.9	-0.5	-0.1	-0.7	0.4	-0.1	-0.5	0.1
Loneliness, isolation	0.3	0.4	1.2	0.1	-0.2	0.4	0.6	0.7	1.1	0.5	0.1	-0.3	1.1
Friendships satisfaction	0.3	0.4	1.9	-0.4	0.2	-0.6	-1.4	-0.4	-0.1	-0.8	-0.4	-0.1	-0.6
Back pain experienced in last month	0.3	0.4	1.2	-0.4	-0.7	0.8	-0.7	0.6	1.1	-0.4	-0.0	0.3	0.5
Medication: Aspirin	0.3	0.4	1.3	-0.1	1.1	0.3	-1.0	-0.4	-0.5	0.2	0.4	0.8	-0.2
Miserableness	0.3	0.4	2.4	-1.6	-0.8	-0.1	-1.1	0.0	-0.0	-0.0	-0.2	-0.3	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.9	-0.3	-0.2	-1.4	-0.4	0.5	0.8	-0.0	-0.4	-0.8	-0.4
Leg fat percentage (left)	0.3	1.0	3.6	1.4	1.5	0.5	1.9	1.1	0.3	0.1	0.3	0.2	0.5
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.2	-0.3	-1.5	-0.7	-0.7	-1.0	-0.7	-1.3	-1.0	-0.8	-1.1
Leg fat mass (left)	0.3	1.1	3.9	1.5	0.6	0.4	2.0	1.4	1.3	-0.4	-0.1	-0.2	0.5
Bipolar Disorder (2018)	0.2	0.2	0.6	-0.2	-0.8	-0.6	-0.1	0.4	-0.2	-0.2	-0.3	-0.7	0.7
Bipolar Disorder or Schizophrenia	0.2	0.4	1.5	-0.1	0.2	-0.6	0.1	-0.2	-0.6	1.0	0.4	-0.3	1.2
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	0.2	0.5	0.6	0.3	0.7	0.3	0.5	0.5	0.4	0.6
Crohns Disease (2012)	0.2	0.3	0.6	0.7	0.4	-0.1	0.8	0.8	0.2	0.5	0.3	0.2	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.2	0.3	1.1	-0.2	-0.0	0.2	0.5	0.3	0.3	0.3	-0.1
Blood White Count	0.2	1.1	2.8	-1.6	1.1	0.6	-0.2	0.1	-1.7	1.1	0.8	0.7	1.5
BMI	0.2	1.1	2.9	1.4	0.7	0.7	1.7	1.5	1.3	-1.0	-0.2	0.3	-0.5
Number of treatments/medications taken	0.2	0.4	1.6	-1.3	-0.7	-0.2	-1.1	-0.6	-0.3	-0.3	-0.4	-0.5	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	-0.2	-0.4	0.2	0.5	0.6	0.7	-0.5	-0.6	-0.7	-0.2
Pack years adult smoking proportion	0.2	0.3	0.8	-0.6	0.1	-0.9	0.1	-0.5	-0.1	0.2	-0.4	-0.9	0.6
Hand grip strength (right)	0.2	0.5	2.2	-1.5	-0.4	0.8	-0.2	-0.1	-0.8	-0.7	-0.4	-0.1	-0.7
Relative age voice broke	0.2	0.3	0.6	0.4	0.8	-0.1	0.6	-0.8	-0.2	-0.2	-0.5	-0.6	-0.6
Age when periods started (menarche)	0.2	0.5	2.3	-0.2	0.4	0.3	0.7	-0.5	-1.5	-0.9	-0.4	-0.0	-0.9
Medication: Levothyroxine sodium	0.2	0.4	0.9	-0.9	0.1	0.3	-0.9	-0.8	-0.7	-0.7	-0.2	0.2	0.3
Body mass index (BMI)	0.2	1.0	2.4	1.2	1.2	0.9	1.6	1.0	0.7	-1.4	-0.6	-0.1	-0.8
Fluid intelligence score	0.2	0.4	1.4	0.7	0.5	-0.1	0.5	-0.2	-0.3	-1.1	-0.4	0.1	-1.2
Illnesses of siblings	0.2	0.3	1.2	0.2	-0.4	-1.1	0.4	0.2	-0.2	-0.3	-0.6	-1.0	-0.4
Lung cancer (father)	0.2	0.3	0.9	0.6	-0.5	0.3	-0.7	0.0	0.8	0.3	0.0	-0.2	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.8	-1.4	0.5	-0.1	-0.7	-0.1	-0.6	-0.0	0.2	0.5	0.4
Comparative body size at age 10	0.2	0.5	1.4	1.2	0.3	0.7	0.8	0.7	1.2	-0.3	0.0	0.3	-0.8
Medication: Seretide 50 evohaler	0.2	0.3	1.4	-0.3	-0.3	-0.6	0.2	1.2	0.6	-0.1	-0.1	-0.3	0.6
Heart disease (mother)	0.2	0.2	0.8	-0.9	0.2	-0.3	-0.4	0.0	-0.5	-0.5	-0.6	-0.7	0.2
Number of full sisters	0.2	0.2	0.6	-0.8	-0.8	-0.2	-0.2	0.1	0.0	0.2	-0.0	-0.2	0.6
Medication: Aspirin	0.2	0.3	1.5	0.3	1.2	0.3	-0.6	0.2	0.2	0.3	0.5	0.8	-0.1
Osteoporosis (self-reported)	0.2	0.3	1.1	0.4	0.1	-1.0	-0.6	-0.5	0.4	-0.7	-0.4	-0.1	-0.5
Financial situation satisfaction	0.2	0.2	0.6	-0.1	0.5	0.1	-0.6	-0.5	0.6	-0.8	-0.3	0.0	-0.7
Medication: Blood pressure	0.2	0.3	0.5	0.3	0.5	0.1	0.1	0.6	0.7	0.5	0.6	0.7	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	1.3	0.1	1.1	0.5	0.5	0.7	-0.0	-0.0	0.1	0.1	0.2
Pack years of smoking	0.2	0.2	0.7	-0.5	-0.0	-0.8	-0.1	-0.6	-0.2	0.3	-0.1	-0.6	0.7
Breast Cancer	0.1	0.2	0.5	-0.7	0.5	-0.3	-0.4	-0.4	-0.6	-0.7	-0.2	0.2	-0.4
Hypothyroidism (self reported)	0.1	0.3	1.7	-0.4	-0.0	0.2	-0.3	-0.5	-0.3	-1.3	-0.7	-0.1	-0.7
Respiratory disease	0.1	0.2	0.4	0.6	-0.4	0.5	0.4	0.6	0.3	0.1	0.3	0.5	-0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.7	0.1	0.3	-0.2	-0.8	-0.3	0.8	-0.4	-0.4	-0.4	0.6
Hair Pigment	0.1	2.0	5.9	0.3	0.6	1.3	1.3	1.1	0.4	2.0	1.7	1.2	2.4
Tanning	0.1	1.8	5.9	0.8	-0.2	0.1	1.0	0.7	1.1	2.4	1.7	0.6	2.3
Hand grip strength (left)	0.1	0.3	1.2	-0.9	-0.3	1.1	0.2	0.6	-0.3	-0.1	0.2	0.6	-0.2
Medication: Metformin	0.1	0.1	0.2	0.4	0.2	-0.2	-0.1	-0.5	0.4	0.1	-0.2	-0.3	0.4
Fed-up feelings	0.1	0.1	0.4	-0.0	0.2	0.4	-0.3	-0.2	-0.1	-0.4	0.2	0.6	-0.1
Medication: Atenolol	0.1	0.2	0.3	0.2	0.5	0.5	0.5	0.4	-0.2	0.6	0.4	0.3	0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.3	0.1	0.5	-0.3	0.2	0.3	0.2	0.5	0.7	0.6
Financial difficulties in last 2 years	0.1	0.2	0.4	0.2	0.6	-0.3	0.6	0.4	0.7	0.2	-0.0	-0.2	0.2
Noisy workplace	0.1	0.2	0.5	-0.0	-0.7	-0.6	0.1	0.3	0.1	-0.4	-0.4	-0.5	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	1.1	0.4	0.4	0.2	-0.2	0.4	1.0	-0.3	0.0	0.4	0.3
Overall health rating	0.1	0.2	0.4	0.4	-0.4	-0.5	0.2	-0.2	0.6	-0.1	-0.4	-0.7	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.6	0.3	-0.2	-0.8	-0.3	-0.1	-0.1	-0.3	-0.6	-0.6	-0.4
Diabetes diagnosed by doctor	0.1	0.2	0.5	0.6	0.3	-0.3	-0.1	0.1	0.7	-0.5	-0.5	-0.5	0.4
Medication for cholesterol	0.1	0.1	0.4	0.5	0.0	0.4	0.3	-0.3	-0.5	0.2	0.3	0.3	-0.6
Ever smoked	0.1	0.2	0.6	-0.2	-0.6	-0.4	-0.5	0.2	-0.8	0.4	0.3	0.1	0.1
Mouth/teeth dental problems: Dentures	0.0	0.1	0.4	0.5	0.3	0.1	0.6	-0.0	0.2	0.2	0.1	-0.1	0.2

Hub : Genes

MCM4

Models

Trait associations