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chr8:40,811,597-43,099,391

Best TWAS P=8.56e-49 · Best GWAS P=3.61e-39 conditioned to 0.174

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	SMIM19	0.18	0.20	lasso	6	0.22	1.1e-17	-13.05	-13.4	7.0e-41	0.94	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	SMIM19	0.26	0.28	lasso	4	0.28	1.0e-14	-12.65	-12.0	2.9e-33	0.96	0.04	0.96	FALSE
3	GTEx	Adrenal Gland	SMIM19	0.24	0.09	lasso	5	0.08	9.7e-04	-12.65	-12.2	3.2e-34	0.98	0.02	0.98	FALSE
4	GTEx	Artery Aorta	SLC20A2	0.22	0.09	lasso	8	0.12	2.7e-07	-9.52	-11.6	2.4e-31	0.74	0.09	0.90	FALSE
5	GTEx	Artery Aorta	SMIM19	0.32	0.36	lasso	6	0.36	1.0e-20	-13.06	-13.3	3.1e-40	0.97	0.01	0.99	FALSE
6	GTEx	Artery Coronary	SMIM19	0.18	0.28	lasso	2	0.28	7.4e-10	-13.00	-13.0	6.5e-39	1.00	0.01	0.99	FALSE
7	GTEx	Artery Tibial	SMIM19	0.29	0.35	lasso	8	0.35	3.2e-28	-13.05	-12.8	1.7e-37	0.97	0.01	0.99	FALSE
8	GTEx	Brain Caudate basal ganglia	SMIM19	0.19	0.17	lasso	5	0.14	6.1e-05	-12.59	-11.6	4.0e-31	0.93	0.02	0.96	FALSE
9	GTEx	Brain Cerebellar Hemisphere	SMIM19	0.32	0.35	enet	23	0.34	1.2e-09	-12.65	-11.8	4.1e-32	0.93	0.02	0.98	FALSE
10	GTEx	Brain Cerebellum	SMIM19	0.24	0.23	lasso	4	0.22	3.0e-07	-13.05	-13.2	4.7e-40	0.99	0.01	0.98	FALSE
11	GTEx	Brain Cortex	SMIM19	0.31	0.22	enet	16	0.28	1.8e-08	-13.04	-12.1	8.6e-34	0.96	0.02	0.98	FALSE
12	GTEx	Brain Frontal Cortex BA9	SMIM19	0.41	0.32	lasso	9	0.38	5.4e-11	-13.05	-13.1	2.5e-39	0.98	0.01	0.99	FALSE
13	GTEx	Brain Hippocampus	SMIM19	0.26	0.14	lasso	4	0.13	6.7e-04	-12.48	-12.4	3.4e-35	0.87	0.03	0.88	FALSE
14	GTEx	Brain Hypothalamus	SMIM19	0.18	0.19	lasso	3	0.13	6.1e-04	-13.05	-13.0	6.5e-39	1.00	0.02	0.90	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	SMIM19	0.33	0.31	lasso	3	0.31	6.5e-09	-13.00	-13.0	1.1e-38	0.99	0.02	0.98	FALSE
16	GTEx	Brain Putamen basal ganglia	SMIM19	0.33	0.21	lasso	3	0.21	8.1e-06	-13.03	-13.2	6.8e-40	0.99	0.01	0.98	FALSE
17	GTEx	Breast Mammary Tissue	SMIM19	0.18	0.17	lasso	5	0.17	3.6e-09	-13.05	-13.2	1.2e-39	0.94	0.01	0.99	FALSE
18	GTEx	Breast Mammary Tissue (Female)	SMIM19	0.29	0.21	lasso	6	0.16	1.2e-05	-12.52	-13.2	5.8e-40	0.91	0.02	0.97	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	SMIM19	0.27	0.32	enet	17	0.32	3.4e-11	-12.61	-12.6	3.3e-36	0.92	0.02	0.98	FALSE
20	GTEx	Cells Transformed fibroblasts	SLC20A2	0.14	0.11	enet	13	0.14	1.7e-10	8.10	-10.2	2.8e-24	0.91	0.25	0.75	FALSE
21	GTEx	Cells Transformed fibroblasts	SMIM19	0.26	0.30	lasso	8	0.31	2.0e-23	-13.05	-13.3	4.0e-40	0.97	0.01	0.99	FALSE
22	GTEx	Colon Sigmoid	SMIM19	0.34	0.24	lasso	8	0.24	6.2e-09	-13.05	-13.1	2.7e-39	0.95	0.01	0.99	FALSE
23	GTEx	Colon Transverse	SMIM19	0.37	0.38	lasso	4	0.34	5.3e-17	-13.05	-13.2	8.0e-40	0.97	0.01	0.99	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	SMIM19	0.22	0.26	lasso	3	0.23	7.1e-09	-13.05	-13.1	6.3e-39	1.00	0.01	0.99	FALSE
25	GTEx	Esophagus Mucosa	SMIM19	0.24	0.25	lasso	4	0.30	3.3e-20	-13.09	-13.1	2.5e-39	0.96	0.02	0.98	FALSE
26	GTEx	Esophagus Muscularis	SMIM19	0.35	0.34	enet	17	0.39	3.2e-25	-12.65	-13.4	7.2e-41	0.97	0.02	0.98	FALSE
27	GTEx	Heart Atrial Appendage	SMIM19	0.48	0.44	enet	18	0.42	2.6e-20	-13.03	-12.4	2.7e-35	0.98	0.01	0.99	FALSE
28	GTEx	Heart Left Ventricle	SMIM19	0.35	0.42	enet	14	0.43	1.2e-24	-13.04	-12.8	2.9e-37	0.96	0.01	0.99	FALSE
29	GTEx	Lung	SLC20A2	0.06	0.03	enet	11	0.01	7.3e-02	8.09	-8.4	5.3e-17	0.83	0.08	0.83	FALSE
30	GTEx	Lung	SMIM19	0.20	0.17	lasso	6	0.17	2.4e-13	-13.05	-12.8	1.3e-37	0.97	0.01	0.99	FALSE
31	GTEx	Muscle Skeletal	SMIM19	0.18	0.20	lasso	5	0.22	8.1e-21	-13.05	-13.3	1.3e-40	0.98	0.01	0.99	FALSE
32	GTEx	Nerve Tibial	ANK1	0.16	0.00	enet	14	0.02	1.6e-02	-5.34	-5.2	2.0e-07	0.05	0.00	0.98	TRUE
33	GTEx	Nerve Tibial	SMIM19	0.30	0.35	enet	22	0.36	5.7e-27	-13.05	-13.4	3.2e-41	0.95	0.01	0.99	FALSE
34	GTEx	Ovary	SMIM19	0.36	0.38	lasso	4	0.37	3.8e-10	-13.05	-13.2	9.5e-40	0.97	0.01	0.99	FALSE
35	GTEx	Pituitary	SMIM19	0.29	0.27	lasso	5	0.23	1.6e-06	-13.00	-13.2	1.5e-39	0.98	0.02	0.98	FALSE
36	GTEx	Prostate	SMIM19	0.29	0.15	enet	13	0.20	1.0e-05	-13.09	-12.8	2.1e-37	0.98	0.02	0.98	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	SMIM19	0.20	0.19	lasso	5	0.20	2.7e-11	-13.00	-13.4	7.8e-41	0.98	0.01	0.99	FALSE
38	GTEx	Skin Sun Exposed Lower leg	SMIM19	0.15	0.14	lasso	10	0.15	3.6e-12	-13.05	-13.5	2.1e-41	0.93	0.01	0.99	FALSE
39	GTEx	Spleen	SMIM19	0.21	0.17	lasso	5	0.18	2.1e-05	-13.05	-13.2	9.3e-40	0.99	0.02	0.97	FALSE
40	GTEx	Stomach	SMIM19	0.21	0.14	lasso	5	0.16	7.0e-08	-13.04	-13.2	1.3e-39	0.95	0.01	0.99	FALSE
41	GTEx	Testis	SMIM19	0.18	0.12	lasso	6	0.13	1.7e-06	-12.65	-12.4	1.5e-35	0.98	0.01	0.99	FALSE
42	GTEx	Thyroid	SMIM19	0.39	0.42	lasso	4	0.46	2.7e-39	-12.65	-13.2	1.3e-39	0.98	0.01	0.99	FALSE
43	GTEx	Uterus	SMIM19	0.27	0.20	enet	14	0.20	7.8e-05	-13.05	-13.7	1.2e-42	0.95	0.01	0.91	FALSE
44	GTEx	Whole Blood	SMIM19	0.13	0.10	enet	16	0.09	2.9e-08	-12.59	-10.2	1.2e-24	0.81	0.03	0.97	FALSE
45	METSIM	Adipose	POLB	0.03	0.01	bslmm	293	0.01	2.3e-03	-3.12	8.3	7.7e-17	-0.50	0.14	0.14	FALSE
46	METSIM	Adipose	SLC20A2	0.07	0.06	lasso	5	0.07	1.3e-10	-7.61	-9.1	9.1e-20	0.84	0.04	0.96	FALSE
47	METSIM	Adipose	SMIM19	0.16	0.15	enet	29	0.15	3.3e-21	-13.05	-13.2	1.1e-39	0.93	0.01	0.99	FALSE
48	NTR	Blood	POLB	0.01	0.00	blup	289	0.00	3.1e-02	-0.21	6.0	1.5e-09	-0.40	0.04	0.06	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	SMIM19	0.29	0.40	enet	12	0.43	4.7e-61	-12.52	-13.2	1.1e-39	0.96	0.02	0.98	FALSE
50	YFS	Blood	SLC20A2	0.05	0.04	blup	293	0.04	6.1e-14	-7.62	-7.7	1.2e-14	0.79	0.05	0.95	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C8orf40	0.07	0.09	blup	37	0.08	1.8e-07	-12.13	-14.0	1.1e-44	0.87	0.04	0.96	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	C8orf40	0.03	0.03	blup	37	0.03	9.7e-08	-12.17	-14.4	4.8e-47	0.80	0.03	0.97	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC20A2	0.01	0.00	blup	62	0.01	1.8e-02	-12.48	13.0	6.9e-39	-0.93	0.02	0.87	FALSE
54	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C8orf40	0.09	0.06	blup	37	0.08	1.2e-04	-12.52	-12.3	1.5e-34	0.97	0.02	0.96	FALSE
55	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	IKBKB	0.09	0.01	enet	5	0.05	1.6e-03	4.83	-5.5	4.2e-08	0.17	0.02	0.16	TRUE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	C8orf40	0.14	0.14	lasso	3	0.18	2.3e-10	-12.61	-12.5	1.3e-35	0.96	0.03	0.97	FALSE
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C8orf40	0.05	0.05	enet	9	0.06	5.9e-07	-13.09	-12.9	6.4e-38	0.89	0.02	0.98	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C8orf40	0.12	0.15	enet	9	0.16	4.8e-18	-13.05	-12.7	5.0e-37	0.97	0.01	0.99	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC20A2	0.03	0.01	blup	62	0.02	2.6e-03	-7.61	-7.7	1.9e-14	0.74	0.03	0.65	FALSE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C8orf40	0.18	0.29	lasso	4	0.27	1.2e-15	-13.05	-13.1	5.8e-39	0.94	0.01	0.99	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	C8orf40	0.05	0.08	enet	9	0.09	2.9e-10	-13.04	-12.9	8.1e-38	0.92	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C8orf40	0.07	0.10	lasso	2	0.07	3.6e-04	-12.65	-13.7	8.3e-43	0.94	0.02	0.94	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	C8orf40	0.05	0.10	blup	37	0.11	2.5e-12	-13.03	-13.1	2.0e-39	0.98	0.02	0.98	FALSE
64	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C8orf40	0.04	0.03	blup	37	0.04	1.9e-05	-12.48	-12.6	2.9e-36	0.98	0.02	0.98	FALSE
65	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C8orf40	0.22	0.07	blup	37	0.09	1.6e-04	-13.04	-13.7	7.3e-43	0.90	0.02	0.94	FALSE
66	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C8orf40	0.06	0.07	lasso	1	0.06	1.9e-03	-13.00	-13.0	1.2e-38	1.00	0.01	0.78	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	C8orf40	0.03	0.02	blup	34	0.02	2.7e-03	-13.09	-14.5	1.2e-47	0.88	0.01	0.88	FALSE
68	The Cancer Genome Atlas	Soft Tissue Sarcoma	C8orf40	0.15	0.12	blup	37	0.15	2.8e-09	-13.04	-14.7	8.6e-49	0.86	0.01	0.99	TRUE
69	The Cancer Genome Atlas	Skin Cutaneous Melanoma	C8orf40	0.11	0.06	blup	37	0.02	9.4e-02	-13.05	-12.9	7.0e-38	0.98	0.01	0.86	FALSE
70	The Cancer Genome Atlas	Stomach Adenocarcinoma	C8orf40	0.05	0.04	lasso	2	0.02	1.2e-02	-13.05	-13.0	8.7e-39	1.00	0.01	0.88	FALSE
71	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C8orf40	0.18	0.20	lasso	4	0.20	9.4e-08	-12.65	-13.0	1.2e-38	0.98	0.02	0.98	FALSE
72	The Cancer Genome Atlas	Thyroid Carcinoma	C8orf40	0.12	0.29	lasso	4	0.28	6.7e-28	-13.04	-13.1	2.1e-39	0.95	0.01	0.99	FALSE